3.5.4.4 2',3'-deoxyadenosine + H2O 1.7% of the activity with adenosine Gallus gallus 2',3'-deoxyinosine + NH3 - ? 371557 3.5.4.4 2',3'-dideoxyadenosine + H2O - Escherichia coli 2',3'-dideoxyinosine + NH3 - ? 141054 3.5.4.4 2',3'-dideoxyadenosine + H2O - Pseudarthrobacter oxydans 2',3'-dideoxyinosine + NH3 - ? 141054 3.5.4.4 2',3'-isopropylideneadenosine + H2O - Streptomyces sp. 2',3'-isopropylideneinosine + NH3 - ? 141043 3.5.4.4 2',3'-isopropylideneadenosine + H2O - Micrococcus sodonensis 2',3'-isopropylideneinosine + NH3 - ? 141043 3.5.4.4 2',3'-isopropylideneadenosine + H2O - Nocardioides sp. 2',3'-isopropylideneinosine + NH3 - ir 141043 3.5.4.4 2',3'-isopropylideneadenosine + H2O - Nocardioides sp. J-326TK 2',3'-isopropylideneinosine + NH3 - ir 141043 3.5.4.4 2',3'-isopropylideneadenosine + H2O - Streptomyces sp. J-845S 2',3'-isopropylideneinosine + NH3 - ? 141043 3.5.4.4 2',3'-O-isopropylidenadenosine + H2O modeling studies Bos taurus 2',3'-O-isopropylideninosine + NH3 - ? 403657 3.5.4.4 2',3'-O-isopropylidene adenosine + H2O - Bos taurus 2',3'-O-isopropylidene inosine + NH3 - ? 403337 3.5.4.4 2',3'-O-methoxymethylideneadenosine + H2O modeling studies Bos taurus 2',3'-O-methoxymethylideneinosine + NH3 - ? 403658 3.5.4.4 2'-dAMP + H2O - Kitasatospora aureofaciens 2'-dIMP + NH3 - ? 141048 3.5.4.4 2'-deoxyadenosine + H2O - Mus musculus 2'-deoxyinosine + NH3 - ir 141041 3.5.4.4 2'-deoxyadenosine + H2O - Escherichia coli 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Homo sapiens 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Homo sapiens 2'-deoxyinosine + NH3 - ir 141041 3.5.4.4 2'-deoxyadenosine + H2O - Rattus norvegicus 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Bos taurus 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Bos taurus 2'-deoxyinosine + NH3 - ir 141041 3.5.4.4 2'-deoxyadenosine + H2O - Trichomonas vaginalis 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Bacillus cereus 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Azotobacter vinelandii 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Streptomyces coelicolor 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Plasmodium falciparum 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Streptomyces sp. 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Klebsiella sp. 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Micrococcus sodonensis 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Pseudarthrobacter oxydans 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Nocardioides sp. 2'-deoxyinosine + NH3 - ir 141041 3.5.4.4 2'-deoxyadenosine + H2O - Hyalomma dromedarii 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Plasmodium yoelii 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Gallus gallus 2'-deoxyinosine + NH3 - ir 141041 3.5.4.4 2'-deoxyadenosine + H2O 118.9% of the activity with adenosine Gallus gallus 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O 79.2% of the activity with adenosine Gallus gallus 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O 82.8% of the activity with adenosine Homo sapiens 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O the enzyme plays an important role in the immune system Homo sapiens 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O ADAII shows 88% of the activity with adenosine Fasciola gigantica 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Nocardioides sp. J-326TK 2'-deoxyinosine + NH3 - ir 141041 3.5.4.4 2'-deoxyadenosine + H2O - Klebsiella sp. LF 1202 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Azotobacter vinelandii 0 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyadenosine + H2O - Streptomyces sp. J-845S 2'-deoxyinosine + NH3 - ? 141041 3.5.4.4 2'-deoxyguanosine + H2O ADAII shows 41% of the activity with adenosine Fasciola gigantica 2'-deoxyxanthosine + NH3 - ? 141004 3.5.4.4 2,6-diaminopurine arabinoside + H2O - Pseudarthrobacter oxydans arabinoguanosine + NH3 - ? 403390 3.5.4.4 2,6-diaminopurine riboside + H2O - Pseudarthrobacter oxydans guanosine + NH3 - ? 403391 3.5.4.4 2,6-diaminopurine-2',3'-dideoxyriboside + H2O - Pseudarthrobacter oxydans 2',3'-dideoxyguanosine + NH3 - ? 403392 3.5.4.4 2,6-diaminopurine-2'-deoxyriboside + H2O - Pseudarthrobacter oxydans 2'-deoxyguanosine + NH3 - ? 403393 3.5.4.4 2-amino-6-chloropurine riboside + H2O - Micrococcus sodonensis guanosine + Cl- - ? 141045 3.5.4.4 2-amino-6-chloropurine riboside + H2O - Pseudarthrobacter oxydans guanosine + ? - ? 403414 3.5.4.4 2-amino-6-methoxypurine riboside + H2O - Pseudarthrobacter oxydans guanosine + ? - ? 403416 3.5.4.4 3'-deoxyadenosine + H2O - Escherichia coli 3'-deoxyinosine + NH3 - ? 141042 3.5.4.4 3'-deoxyadenosine + H2O - Micrococcus sodonensis 3'-deoxyinosine + NH3 - ? 141042 3.5.4.4 3'-deoxyadenosine + H2O 2.4% of the activity with adenosine Gallus gallus 3'-deoxyinosine + NH3 - ? 141042 3.5.4.4 5'-AMP + H2O - Streptomyces sp. 5'-IMP + NH3 - ? 141046 3.5.4.4 5'-AMP + H2O - Kitasatospora aureofaciens 5'-IMP + NH3 - ? 141046 3.5.4.4 5'-AMP + H2O - Nocardioides sp. 5'-IMP + NH3 - ir 141046 3.5.4.4 5'-AMP + H2O 1.4% of the activity with adenosine Gallus gallus 5'-IMP + NH3 - ? 141046 3.5.4.4 5'-AMP + H2O - Nocardioides sp. J-326TK 5'-IMP + NH3 - ir 141046 3.5.4.4 5'-AMP + H2O - Streptomyces sp. J-845S 5'-IMP + NH3 - ? 141046 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium knowlesi 5'-methylthioinosine + NH3 - ? 394664 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium falciparum 5'-methylthioinosine + NH3 - ? 394664 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium berghei 5'-methylthioinosine + NH3 - ? 394664 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium vivax 5'-methylthioinosine + NH3 - ? 394664 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium vivax 5'-methylthioinosine + NH3 - ir 394664 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium cynomolgi 5'-methylthioinosine + NH3 - ? 394664 3.5.4.4 5'-methylthioadenosine + H2O - Plasmodium falciparum 5'-methylthioinosine + NH3 - ir 394664 3.5.4.4 5'-methylthioadenosine + H2O adenosine deaminase has a secondary function in recycling methylthiopurines from the polyamine biosynthetic pathway Plasmodium vivax 5'-methylthioinosine + NH3 - ir 394664 3.5.4.4 6-chloropurine riboside + H2O - Homo sapiens inosine + Cl- - ? 141044 3.5.4.4 6-chloropurine riboside + H2O - Micrococcus sodonensis inosine + Cl- - ? 141044 3.5.4.4 6-chloropurine riboside + H2O - Argopecten irradians concentricus inosine + Cl- - ? 141044 3.5.4.4 6-chloropurinriboside + H2O - Homo sapiens inosine + Cl- - ? 453394 3.5.4.4 6-methoxypurinriboside - Homo sapiens ? - ? 141058 3.5.4.4 6-methylaminopurine ribonucleoside + H2O - Escherichia coli inosine + methylamine - ? 141052 3.5.4.4 adenine + H2O - Escherichia coli hypoxanthine + NH3 - ? 116412 3.5.4.4 adenine + H2O - Schizosaccharomyces pombe hypoxanthine + NH3 - ? 116412 3.5.4.4 adenine + H2O ADAII shows 70% of the activity with adenosine Fasciola gigantica hypoxanthine + NH3 - ? 116412 3.5.4.4 adenine + H2O - Arabidopsis thaliana ? + NH3 - ? 404233 3.5.4.4 adenine arabinoside + H2O - Escherichia coli inosine arabinoside + NH3 - ? 141053 3.5.4.4 adenine arabinoside + H2O - Klebsiella sp. inosine arabinoside + NH3 - ? 141053 3.5.4.4 adenine arabinoside + H2O - Klebsiella sp. LF 1202 inosine arabinoside + NH3 - ? 141053 3.5.4.4 adenosine + H2O - Gallus gallus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Mus musculus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Mus musculus inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Escherichia coli inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Homo sapiens inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Rattus norvegicus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Rattus norvegicus inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Sus scrofa inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Sus scrofa inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Bos taurus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Bos taurus inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Oryctolagus cuniculus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Ovis aries inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Plasmodium knowlesi inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Halobacterium salinarum inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Haloferax volcanii inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Trichomonas vaginalis inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Bacillus cereus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Azotobacter vinelandii inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Streptomyces coelicolor inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Candida albicans inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Plasmodium falciparum inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Streptomyces sp. inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Kitasatospora aureofaciens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Plasmodium berghei inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Klebsiella sp. inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Camelus dromedarius inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Micrococcus sodonensis inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Danio rerio inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Coturnix coturnix inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Argopecten irradians concentricus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Nocardioides sp. inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Aspergillus terricola inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Biomphalaria glabrata inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Hyalomma dromedarii inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Plasmodium vivax inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Plasmodium gallinaceum inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Plasmodium yoelii inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Trypanosoma evansi inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Fasciola gigantica inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Plasmodium vivax inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Gallus gallus inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Plasmodium cynomolgi inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Plasmodium falciparum inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O preferred substrate Fasciola gigantica inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O isozyme ADA2 is important in lymphocyte activation, and may be active in sites of inflammation and during hypoxia and in areas of tumor growth with elevated adenosine levels and acidic pH, overview Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O key enzyme in controlling intra- and extracellular adenosine levels Biomphalaria glabrata inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O the enzyme activity is correlated with the content in malonaldehyde in nasal polyps and nasal mucosa, overview Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O the enzyme expression and activity is suppressed in normal pregnancy, but not in woman with recurrent spontaneous abortion Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O the enzyme is crucial for purine metabolism and normal immune competence Mus musculus inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O the enzyme is involved in differentiation and maturation of the lymphoid system, the enzyme activity is decreased in multiple sclerosis patients irrespective of whether patients have relapsing-remitting or chronic progressive multiple sclerosis, overview Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O the enzyme is involved in the bile duct-inflammation and fibrosis caused chronic fascioliasis including an atrophy of the liver parenchyma and liver cirrhosis Ovis aries inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O the enzyme plays an important role in the immune system Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O adenosine deaminase is involved in purine metabolism and is a key enzyme for the control of the cellular levels of adenosine Hyalomma dromedarii inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O adenosine deamination is involved in the essential pathway of purine salvage in Plasmodium falciparum, and inhibition of purine salvage results in parasite death Plasmodium falciparum inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O metabolization of extracellular adenosine leads to exacerbation of inflammation Homo sapiens inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O the enzyme is important in thymocyte development, especially in late stages, overview Mus musculus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O detailed quantitative structure-activity relationship, QSAR, nonlinear modeling and analysis, descriptor generation and selection, overview Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O metabolization of extracellular adenosine Homo sapiens inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O ADA, nucleotide metabolism Pseudarthrobacter oxydans inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O 1.4% of the activity of adenine Saccharomyces cerevisiae inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O 2.0% of the activity of adenine Schizosaccharomyces pombe inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O 30% of the activity of adenine Arabidopsis thaliana inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O adenosine deaminase markedly enhances the agonist and antagonist affinity and abolishes the negative cooperativity on agonist binding to human striatial adenosine A1 receptors Homo sapiens inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O catalytic efficiency of the enzyme for 5'-deoxyadenosine is 1000fold higher than for S-methyl-5'-thioadenosine, and 10000fold hgher than with S-adenosyl-L-homocysteine or adenosine Methanocaldococcus jannaschii inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O key enzyme involved in the purine metabolism Bos taurus inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O the enzyme shows no activity with 5'-methylthioinosine Homo sapiens inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Nocardioides sp. J-326TK inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O - Klebsiella sp. LF 1202 inosine + NH3 - ir 141006 3.5.4.4 adenosine + H2O catalytic efficiency of the enzyme for 5'-deoxyadenosine is 1000fold higher than for S-methyl-5'-thioadenosine, and 10000fold hgher than with S-adenosyl-L-homocysteine or adenosine Methanocaldococcus jannaschii DSM 2661 inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Azotobacter vinelandii 0 inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Mus musculus C57BL/6 inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O the enzyme is important in thymocyte development, especially in late stages, overview Mus musculus C57BL/6 inosine + NH3 - ? 141006 3.5.4.4 adenosine + H2O - Streptomyces sp. J-845S inosine + NH3 - ? 141006 3.5.4.4 adenosine 3'-monophosphate + H2O 56% of the activity of adenine Arabidopsis thaliana inosine 3'-monophosphate + NH3 - ? 141111 3.5.4.4 adenosine 3'-phosphate + H2O 3.3% of the activity of adenine Saccharomyces cerevisiae inosine 3'-phosphate + NH3 - ? 404235 3.5.4.4 adenosine 3'-phosphate + H2O 4.5% of the activity of adenine Schizosaccharomyces pombe inosine 3'-phosphate + NH3 - ? 404235 3.5.4.4 adenosine-3'-monophosphate + H2O - Streptomyces sp. IMP-3'-monophosphate + NH3 - ? 141055 3.5.4.4 adenosine-3'-monophosphate + H2O - Nocardioides sp. IMP-3'-monophosphate + NH3 - ir 141055 3.5.4.4 adenosine-3'-monophosphate + H2O - Streptomyces sp. J-845S IMP-3'-monophosphate + NH3 - ? 141055 3.5.4.4 ADP + H2O - Kitasatospora aureofaciens 5'-IDP + NH3 - ? 141047 3.5.4.4 ADP + H2O - Nocardioides sp. 5'-IDP + NH3 - ir 141047 3.5.4.4 ADP + H2O - Nocardioides sp. J-326TK 5'-IDP + NH3 - ir 141047 3.5.4.4 arabinoadenosine + H2O - Pseudarthrobacter oxydans arabinoinosine + NH3 - ? 404342 3.5.4.4 ATP + H2O - Kitasatospora aureofaciens ITP + NH3 - ? 141049 3.5.4.4 ATP + H2O - Nocardioides sp. ITP + NH3 - ir 141049 3.5.4.4 ATP + H2O 3.3% of the activity of adenine Schizosaccharomyces pombe ITP + NH3 - ? 141049 3.5.4.4 ATP + H2O 3.3% of the activity of adenine Saccharomyces cerevisiae ITP + NH3 - ? 141049 3.5.4.4 ATP + H2O 68% of the activity of adenine Arabidopsis thaliana ITP + NH3 - ? 141049 3.5.4.4 cAMP + H2O - Streptomyces sp. ? - ? 141056 3.5.4.4 double-stranded RNA + H2O - Xenopus laevis ? - ? 141057 3.5.4.4 formycin A + H2O - Azotobacter vinelandii 2-(hydroxymethyl)-5-(1H-pyrazolo[4,3-d]pyrimidin-3-yl)tetrahydrofuran-3,4-diol + NH3 - ? 141050 3.5.4.4 formycin A + H2O - Azotobacter vinelandii 0 2-(hydroxymethyl)-5-(1H-pyrazolo[4,3-d]pyrimidin-3-yl)tetrahydrofuran-3,4-diol + NH3 - ? 141050 3.5.4.4 guanine + H2O ADAII shows 47% of the activity with adenosine Fasciola gigantica xanthine + NH3 - ? 141029 3.5.4.4 guanosine + H2O ADAII shows 75% of the activity with adenosine Fasciola gigantica xanthosine + NH3 - ? 141003 3.5.4.4 additional information regulatory role of dipeptidyl peptidase IV on adenosine deaminase activity Bos taurus ? - ? 89 3.5.4.4 additional information the enzyme is involved in purine metabolism and plays an important role in the mechanism of the immune system Gallus gallus ? - ? 89 3.5.4.4 additional information activity with 3'-deoxyadenosine, 2',3'-deoxyadenosine and 2'-O-methyladenosine is less than 0.5% of the activity with adenine Homo sapiens ? - ? 89 3.5.4.4 additional information no activity with 2'-O-methyladenosine Gallus gallus ? - ? 89 3.5.4.4 additional information no activity with 3'-deoxyadenosine, 2',3'-deoxyadenosine and 2'-O-methyladenosine Gallus gallus ? - ? 89 3.5.4.4 additional information the enzyme may facilitate catalysis via the formation of a stabilizing conformation at the reaction transition state Bos taurus ? - ? 89 3.5.4.4 additional information the enzyme is bound and complexed by the cell membraneous dipeptidyl peptidase IV, which is identical to the activated immune cell antigen CD26, playing a role in the immune system, overview Bos taurus ? - ? 89 3.5.4.4 additional information the large isozyme is bound and complexed by the cell membraneous dipeptidyl peptidase IV, which is identical to the activated immune cell antigen CD26, playing a role in the immune system, overview Homo sapiens ? - ? 89 3.5.4.4 additional information substrate specificities of the large and the small isozyme, overview Homo sapiens ? - ? 89 3.5.4.4 additional information substrate specificities of the large and the small isozyme, overview Bos taurus ? - ? 89 3.5.4.4 additional information adenosine deaminase inhibition enhances the efficiency of signal transduction and inotropic response mediated by A1 adenosine receptor in hyperthyroid guinea pig atrium via elevated intracellular adenosine levels, overview Cavia porcellus ? - ? 89 3.5.4.4 additional information adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions, enzyme inhibition reduces inflammation in experimental colitis, overview Rattus norvegicus ? - ? 89 3.5.4.4 additional information no activity with 5'-methylthioadenosine Homo sapiens ? - ? 89 3.5.4.4 additional information no activity with 5'-methylthioadenosine Bos taurus ? - ? 89 3.5.4.4 additional information does not cleave cytokinins Arabidopsis thaliana ? - ? 89 3.5.4.4 additional information ADA is associated with the Galphai-3 protein-coupled A1 receptor Sus scrofa ? - ? 89 3.5.4.4 additional information Plasmodium gallinaceum ADA does not have significant activity for 5'-methylthioadenosine Plasmodium gallinaceum ? - ? 89 3.5.4.4 N6-isopentenyladenosine + H2O 1.9% of the activity of adenine Schizosaccharomyces pombe ? - ? 406062 3.5.4.4 N6-isopentenyladenosine + H2O 1.2% of the activity of adenine Saccharomyces cerevisiae inosine + 3-methylbut-3-en-1-amine - ? 406063 3.5.4.4 viramidine + H2O the enzyme catalyzes viramidine deamination to ribavirin in vivo as a prodrug conversion to active drug, pharmacokinetic analysis, overview Rattus norvegicus ribavirin + NH3 - ? 395017 3.5.4.4 viramidine + H2O substrate and product determination by LC-MS Rattus norvegicus ribavirin + NH3 - ? 395017