3.4.24.85 anti-sigma factor RsiV + H2O - Bacillus thuringiensis ? - ? 448452 3.4.24.85 anti-sigma factor RsiV + H2O - Bacillus thuringiensis AW43 ? - ? 448452 3.4.24.85 ATF-6 + H2O endoplasmic reticulum membrane-anchored transcription factor, sequential processing by enzyme and S1P endopeptidase. Bulky ATF6 luminal domain blocks cleavage by enzyme, cleavage by S1P endopeptidase reduces the size of the luminal domain and prepares for hydrolysis by enzyme Homo sapiens ? - ? 384225 3.4.24.85 ATF6 + H2O - Cricetulus griseus ? - ? 359040 3.4.24.85 ATF6 + H2O - Escherichia coli ? - ? 359040 3.4.24.85 ATF6 + H2O cleavage in site-2 is required for induction of IRE1-alpha and ER-stress activated target genes Cricetulus griseus ? - ? 359040 3.4.24.85 ATF6 protein + H2O - Homo sapiens ? - ? 419351 3.4.24.85 ATF6 protein + H2O - Methanocaldococcus jannaschii ? - ? 419351 3.4.24.85 beta-casein + H2O - Synechocystis sp. ? - ? 36618 3.4.24.85 beta-lactamase signal peptide + H2O cleaves within the hydrophobic core at Pro12-Phe13. Cleavage of signal peptide requires a preceding processing of preproteins by Lep Escherichia coli ? - ? 419368 3.4.24.85 cAD1 pheromone + H2O - Enterococcus faecalis ? - ? 391553 3.4.24.85 cAD1 protein + H2O - Enterococcus faecalis ? - ? 419372 3.4.24.85 cCF10 protein + H2O - Enterococcus faecalis ? - ? 419383 3.4.24.85 CED-9 + H2O artificial protein substrate, Caenorhabditis elegans protein 9, homolog to human Bcl-2 Homo sapiens ? - ? 433555 3.4.24.85 CED-9 protein + H2O - Homo sapiens ? - ? 449742 3.4.24.85 CED-9 protein + H2O - Methanocaldococcus jannaschii ? - ? 449742 3.4.24.85 cPD1 protein + H2O - Enterococcus faecalis ? - ? 419392 3.4.24.85 CREBH + H2O - Homo sapiens ? - ? 449780 3.4.24.85 CREBH + H2O - Methanocaldococcus jannaschii ? - ? 449780 3.4.24.85 CREBH protein + H2O - Homo sapiens ? - ? 419393 3.4.24.85 FtsL protein + H2O - Bacillus subtilis ? - ? 419420 3.4.24.85 HurR protein + H2O - Bordetella bronchiseptica ? - ? 419431 3.4.24.85 iAD1 protein + H2O - Enterococcus faecalis ? - ? 419433 3.4.24.85 iCF10 protein + H2O - Enterococcus faecalis ? - ? 419435 3.4.24.85 LivK signal peptide + H2O - Bacillus subtilis ? - ? 419453 3.4.24.85 membrane-bound inactive transcription factor fragment bZIP28X1 + H2O transcription factor bZIP28 is cleaved within the transmembrane domain, and the N-terminal portion containing the bZIP domain is released from the membrane to translocate into the nucleus, where it activates the ER stress-responsive genes Arabidopsis thaliana ? - ? 448767 3.4.24.85 membrane-bound inactive transcription factor fragment bZIP28X2 + H2O transcription factor bZIP28 is cleaved within the transmembrane domain, and the N-terminal portion containing the bZIP domain is released from the membrane to translocate into the nucleus, where it activates the ER stress-responsive genes Arabidopsis thaliana ? - ? 448768 3.4.24.85 additional information SREBP asparagine-495 and proline-496 seem to be necessary for cleavage by S2P, and it is conserved in all known SREBPs, the movement of the NP sequence within the transmembrane domain does not eliminate cleavage, nor does it change the site of cleavage Homo sapiens ? - ? 89 3.4.24.85 additional information YaeL is required for the activation of sigma factor E in response to stress by site-2 cleavage of RseA that acts as an anti-sigma factor E Escherichia coli ? - ? 89 3.4.24.85 additional information in most cases, substrate cleavage by the enzyme requires a preceding truncation of the same substrate by another aqueous protease Methanocaldococcus jannaschii ? - ? 89 3.4.24.85 MSIQHFRVALIPFFAAFCLPVFA + H2O - Escherichia coli MSIQHFRVALIP + FFAAFCLPVFA - ? 419465 3.4.24.85 MtuA protein + H2O - Streptococcus uberis ? - ? 419466 3.4.24.85 MucA protein + H2O - Pseudomonas aeruginosa ? - ? 419467 3.4.24.85 N-terminus of anti-sigma factor RsiP + H2O - Bacillus thuringiensis ? - ? 448802 3.4.24.85 N-terminus of anti-sigma factor RsiP + H2O - Bacillus thuringiensis AW43 ? - ? 448802 3.4.24.85 OASIS protein + H2O - Homo sapiens ? - ? 419498 3.4.24.85 PBP3 protein + H2O - Mycobacterium tuberculosis ? - ? 419525 3.4.24.85 PodJ protein + H2O - Caulobacter vibrioides ? - ? 393257 3.4.24.85 PodJS + H2O truncated form of transmembrane protein PodJ which provides the spatial cues for biogenesis of several polar organelles. Enzyme cleaves within or near the transmembrane segment of PodJS releasing it into cytoplasm for complete proteolysis Caulobacter vibrioides ? - ? 383291 3.4.24.85 pro-deltaK protein + H2O - Bacillus subtilis deltaK protein + N-terminal fragment of 20 amino acids of pro-deltaK protein - ? 419536 3.4.24.85 pro-sigma K + H2O - Bacillus subtilis ? - ? 393333 3.4.24.85 RseA protein + H2O - Escherichia coli ? - ? 393439 3.4.24.85 RsiW protein + H2O - Bacillus subtilis ? - ? 393440 3.4.24.85 Sre1 protein + H2O - Cryptococcus neoformans ? - ? 419604 3.4.24.85 SREBP NH2-522 fragment + H2O - Drosophila melanogaster NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Bacillus subtilis NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Escherichia coli NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Homo sapiens NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Rattus norvegicus NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Methanothermobacter thermautotrophicus NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Arabidopsis thaliana NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Giardia intestinalis NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Enterococcus faecalis NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Caenorhabditis elegans NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Mycobacterium leprae NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Mycobacterium tuberculosis NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Plasmodium falciparum NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Caulobacter vibrioides NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Methanocaldococcus jannaschii NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Synechocystis sp. NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Thermotoga maritima NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Vibrio cholerae serotype O1 NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Deinococcus radiodurans NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Treponema pallidum NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Pyrobaculum aerophilum NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Halalkalibacterium halodurans NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Halobacterium sp. NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O - Thermoplasma volcanium NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP NH2-522 fragment + H2O cleavage at site-2 between 484-485 aa of SREBP cannot occur without prior cleavage at site-1 and is dependent on 478DRSR sequence Homo sapiens NH2-484 fragment + 38 aa fragment - ? 359039 3.4.24.85 SREBP-1 + H2O - Homo sapiens ? - ? 448966 3.4.24.85 SREBP-1 + H2O - Methanocaldococcus jannaschii ? - ? 448966 3.4.24.85 SREBP-2 + H2O - Methanocaldococcus jannaschii ? - ? 448967 3.4.24.85 sterol regulatory element binding protein + H2O - Homo sapiens ? - ? 419605 3.4.24.85 TcpP protein + H2O - Vibrio cholerae serotype O1 ? - ? 393642