3.4.23.38 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe + Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O - Plasmodium falciparum ? - ? 363151 3.4.23.38 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O - Plasmodium falciparum ? - ? 363166 3.4.23.38 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O - Plasmodium falciparum 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe + Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid - ? 454033 3.4.23.38 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O - Plasmodium falciparum 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Nle-Phe + Leu-Ser-Phe-Pro-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid - ? 363150 3.4.23.38 Ala-Leu-Glu-Arg-Thr-Phe-Leu-Ser-Phe-Pro-Thr + H2O - Plasmodium falciparum Ala-Leu-Glu-Arg-Thr-Phe + Leu-Ser-Phe-Pro-Thr - ? 363158 3.4.23.38 EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH + H2O - Plasmodium falciparum ? - ? 391900 3.4.23.38 Hemoglobin + H2O - Plasmodium falciparum ? - ? 15450 3.4.23.38 Hemoglobin + H2O enzyme is involved in initial steps of Plasmodium hemoglobin degradation Plasmodium falciparum ? - ? 15450 3.4.23.38 Hemoglobin + H2O the enzyme initiates the hemoglobin degradation pathway in Plasmodium Plasmodium falciparum ? - ? 15450 3.4.23.38 Hemoglobin + H2O during the infection of erythrocytes by the human malaria parasite Plasmodium falciparum, up to 80% of the host cell hemoglobin is degraded to provide amino acids for parasite nutrition. Plasmepsin I and plasmepsin II are believed to be responsible for initiating the catabolic process Plasmodium falciparum ? - ? 15450 3.4.23.38 hemoglobin alpha-chain + H2O - Plasmodium falciparum ? - ? 363148 3.4.23.38 hemoglobin alpha-chain + H2O cleavage of the Phe33-/-Leu34- bond Plasmodium falciparum ? - ? 363148 3.4.23.38 hemoglobin alpha-chain + H2O cleavage sites: Phe33-/-Leu34, Phe46-/-Asp47, Phe98-/-Lys99 Plasmodium falciparum ? - ? 363148 3.4.23.38 hemoglobin beta-chain + H2O cleavage sites: Leu31-/-Leu32, Phe41-/-Phe43, Ala129-/-Tyr130 Plasmodium falciparum ? - ? 65046 3.4.23.38 human hemoglobin + H2O - Plasmodium falciparum ? - ? 365218 3.4.23.38 Leu-Glu-Arg-Ile-Phe-(p-nitro)Phe-Ser-Phe + H2O - Plasmodium falciparum Leu-Glu-Arg-Ile-Phe + (p-nitro)Phe-Ser-Phe - ? 405712 3.4.23.38 Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe + H2O - Plasmodium falciparum Leu-Glu-Arg-Ile-Phe + Phe(NO2)-Ser-Phe - ? 363153 3.4.23.38 Leu-Glu-Arg-Val-Phe-Phe(NO2)-Ser-Phe + H2O - Plasmodium falciparum Leu-Glu-Arg-Val-Phe + Phe(NO2)-Ser-Phe - ? 363152 3.4.23.38 Lys-Glu-Leu-Val-Phe-(p-nitro)Phe-Ala-Leu-Lys + H2O - Plasmodium falciparum Lys-Glu-Leu-Val-Phe + (p-nitro)Phe-Ala-Leu-Lys - ? 405746 3.4.23.38 Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O - Plasmodium falciparum Lys-Glu-Leu-Val-Phe + Phe(NO2)-Ala-Leu-Lys - ? 363155 3.4.23.38 Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys + H2O - Plasmodium falciparum Lys-Glu-Phe-Asn-Phe + Phe(NO2)-Ala-Leu-Lys - ? 363156 3.4.23.38 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O - Plasmodium falciparum Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys - ? 363154 3.4.23.38 Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys + H2O - Plasmodium falciparum Lys-Glu-Phe-Val-Phe + Phe(NO2)-Arg-Leu-Lys - ? 363157 3.4.23.38 Lys-Pro-Ile-Leu-Phe-(p-nitro)Phe-Arg-Leu + H2O - Plasmodium falciparum Lys-Pro-Ile-Leu-Phe + (p-nitro)Phe-Arg-Leu - ? 405747 3.4.23.38 Lys-Pro-Ile-Leu-Phe-Nph-Arg-Leu + H2O - Plasmodium falciparum ? - ? 392508 3.4.23.38 Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu + H2O - Plasmodium falciparum Lys-Pro-Ile-Lys-Phe + Phe(NO2)-Arg-Leu - ? 363170 3.4.23.38 additional information plasmepsin I is 5 to 9times less effective than plasmepsin II at cleaving substrates which mimic the proposed initial cleavage site in the alpha-chain of hemoglobin Plasmodium falciparum ? - ? 89 3.4.23.38 additional information plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell Plasmodium falciparum ? - ? 89 3.4.23.38 additional information S1' subsite prefers hydrophobic residues and the S2' subsite shifts its preferences more to polar residues. Serine is a preferred P1' substitution Plasmodium falciparum ? - ? 89