3.4.23.24 2-methoxy-2,4-diphenyl-3(2H)furanone + H2O - [Candida] glabrata ? - ? 449079 3.4.23.24 2-methoxy-2,4-diphenyl-3(2H)furanone + H2O - [Candida] glabrata T-1639 ? - ? 449079 3.4.23.24 4-(4-dimethylaminophenylazo)benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-[5-(2-aminoethyl)-amino]naphthalene-1-sulfonic acid + H2O - Candida albicans 4-(4-dimethylaminophenylazo)benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His + Thr-[5-(2-aminoethyl)-amino]naphthalene-1-sulfonic acid - ? 383875 3.4.23.24 4-(4-dimethylaminophenylazo)benzoyl-gamma-aminobutyryl-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-[5-(2-aminoethyl)-amino]naphthalene-1-sulfonic acid + H2O - Candida albicans ? - ? 383876 3.4.23.24 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys-Leu-Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid + H2O Sapp2p preferentially cleaves the Lys-Leu bond Candida parapsilosis 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys + Leu-Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid - ? 411296 3.4.23.24 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys-Leu-Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid + H2O Sapp2p preferentially cleaves the Lys-Leu bond Candida parapsilosis P-69 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys + Leu-Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid - ? 411296 3.4.23.24 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys-Leu-Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid + H2O Sapp1p preferentially cleaves the Leu-Val bond Candida parapsilosis 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys-Leu + Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid - ? 411297 3.4.23.24 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys-Leu-Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid + H2O Sapp1p preferentially cleaves the Leu-Val bond Candida parapsilosis P-69 4-(4-dimethylaminophenylazo)benzyl-Glu-His-Val-Lys-Leu + Val-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid - ? 411297 3.4.23.24 4-(4-dimethylaminophenylazo)benzyl-Pro-Lys-Val-Glu-Leu-Thr-Gly-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid + H2O the substrate is hydrolyzed preferentially at the Glu-Leu bond, however, when reaction times are prolonged, additional cleavage occurs at the Lys-Val position Candida parapsilosis 4-(4-dimethylaminophenylazo)benzyl-Pro-Lys-Val-Glu + Leu-Thr-Gly-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid - ? 411298 3.4.23.24 4-(4-dimethylaminophenylazo)benzyl-Pro-Lys-Val-Glu-Leu-Thr-Gly-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid + H2O the substrate is hydrolyzed preferentially at the Glu-Leu bond, however, when reaction times are prolonged, additional cleavage occurs at the Lys-Val position Candida parapsilosis P-69 4-(4-dimethylaminophenylazo)benzyl-Pro-Lys-Val-Glu + Leu-Thr-Gly-Glu-5-(2-aminoethylamino)-1-naphthalenesulfonic acid - ? 411298 3.4.23.24 Ala-Thr-His-Gln-Val-Tyr-4-nitrophenylalanine-Val-Arg-Lys-Ala + H2O - Candida parapsilosis Ala-Thr-His-Gln-Val-Tyr + 4-nitrophenylalanine-Val-Arg-Lys-Ala - ? 384139 3.4.23.24 Albumin + H2O - Candida albicans ? - ? 16041 3.4.23.24 Albumin + H2O low side-chain specificity, preferential attack on hydrophobic amino acid residues Candida albicans ? - ? 16041 3.4.23.24 Albumin + H2O cleavage by Sap2p shows a low side-chain specificity Candida albicans ? - ? 16041 3.4.23.24 Albumin + H2O - Candida albicans CBS-2730 ? - ? 16041 3.4.23.24 Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O - Candida albicans ? - ? 366955 3.4.23.24 Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O - Candida albicans H12 ? - ? 366955 3.4.23.24 azocasein + H2O - Candida albicans ? - ? 15347 3.4.23.24 Azocoll + H2O - Candida albicans ? - ? 15352 3.4.23.24 Bovine serum albumin + H2O - Candida albicans Hydrolyzed bovine serum albumin - ? 15513 3.4.23.24 Bovine serum albumin + H2O - Candida albicans H12 Hydrolyzed bovine serum albumin - ? 15513 3.4.23.24 Bovine serum albumin + H2O - Candida albicans ? - ? 16295 3.4.23.24 Bovine serum albumin + H2O - Candida tropicalis ? - ? 16295 3.4.23.24 Bovine serum albumin + H2O - Candida parapsilosis ? - ? 16295 3.4.23.24 Bovine serum albumin + H2O - Metschnikowia pulcherrima ? - ? 16295 3.4.23.24 Bovine serum albumin + H2O - Candida albicans 11 ? - ? 16295 3.4.23.24 Bovine serum albumin + H2O - Metschnikowia pulcherrima KSY 188-5 ? - ? 16295 3.4.23.24 Bovine serum albumin + H2O - Candida albicans CBS 5982 ? - ? 16295 3.4.23.24 casein + H2O - Candida tropicalis ? - ? 15445 3.4.23.24 casein + H2O - Metschnikowia pulcherrima ? - ? 15445 3.4.23.24 casein + H2O - Candida parapsilosis ? - ? 15445 3.4.23.24 casein + H2O isoforms Sap1, Sap2, Sap3, and Sap9 cleave casein Candida albicans ? - ? 15445 3.4.23.24 casein + H2O isozyme Sap6 shows highest activity towards casein Candida albicans ? - ? 15445 3.4.23.24 casein + H2O - Candida tropicalis ATCC 750 ? - ? 15445 3.4.23.24 casein + H2O - Candida parapsilosis CDC-317 ? - ? 15445 3.4.23.24 casein + H2O - Metschnikowia pulcherrima KSY 188-5 ? - ? 15445 3.4.23.24 Collagen + H2O - Metschnikowia pulcherrima ? - ? 16347 3.4.23.24 Collagen + H2O - Metschnikowia pulcherrima KSY 188-5 ? - ? 16347 3.4.23.24 complement component 3b + H2O substrate for isoforms Sapp1p and Sapp2p Candida parapsilosis ? - ? 448514 3.4.23.24 complement component 4b + H2O substrate for isoforms Sapp1p and Sapp2p Candida parapsilosis ? - ? 448515 3.4.23.24 complement component C3b + H2O - Candida albicans ? - ? 369709 3.4.23.24 complement component C4b + H2O - Candida albicans ? - ? 369710 3.4.23.24 complement component C5 + H2O - Candida albicans ? - ? 431738 3.4.23.24 complement components C3b + H2O substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 Candida albicans ? - ? 411889 3.4.23.24 complement components C4b + H2O substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 Candida albicans ? - ? 411890 3.4.23.24 complement components C5 + H2O substrate for isoforms Sap1, Sap2, Sap3, but not for Sap9 Candida albicans ? - ? 411891 3.4.23.24 Dabcyl-EHVKLVE-EDANS + H2O - Candida parapsilosis ? - ? 418566 3.4.23.24 dabcyl-Glu-His-Val-Lys-Leu-Val-Glu-EDANS - Candida parapsilosis dabcyl-Glu-His-Val-Lys-COOH + Leu-Val-Glu-EDANS - ? 391791 3.4.23.24 dabcyl-Glu-His-Val-Lys-Leu-Val-Glu-EDANS - Candida parapsilosis CP386/IDE98 dabcyl-Glu-His-Val-Lys-COOH + Leu-Val-Glu-EDANS - ? 391791 3.4.23.24 dabcyl-Glu-His-Val-Lys-Leu-Val-Glu-EDANS + H2O - Candida parapsilosis dabcyl-Glu-His-Val-Lys-Leu + Val-Glu-EDANS - ? 411960 3.4.23.24 dabcyl-Glu-His-Val-Lys-Leu-Val-Glu-EDANS + H2O - Candida parapsilosis P-69 dabcyl-Glu-His-Val-Lys-Leu + Val-Glu-EDANS - ? 411960 3.4.23.24 dabcyl-Pro-Lys-Val-Glu-Leu-Thr-Gly-Glu-EDANS - Candida parapsilosis dabcyl-Pro-Lys-Val-Glu-COOH + Leu-Thr-Gly-Glu-EDANS - ? 391794 3.4.23.24 dabcyl-Pro-Lys-Val-Glu-Leu-Thr-Gly-Glu-EDANS - Candida parapsilosis CP386/IDE98 dabcyl-Pro-Lys-Val-Glu-COOH + Leu-Thr-Gly-Glu-EDANS - ? 391794 3.4.23.24 E-cadherin + H2O Candida albicans strains JKC19 and SC5314 degrade E-cadherin at pH 4.0, the 10fold concentrated growth media of the strains HLC-52, HLC-54, 32723 and B1134 cause degradation at pH 4.0, strains HLC-52 and HLC-54 also at pH 6.0 Candida albicans ? - ? 367535 3.4.23.24 ELSKRSSPS + H2O 98% conversion Candida parapsilosis ELSK + L-Arg + SSPS - ? 412028 3.4.23.24 ELSKRSSPS + H2O 98% conversion Candida parapsilosis P-69 ELSK + L-Arg + SSPS - ? 412028 3.4.23.24 factor H + H2O substrate for isoforms Sapp1p and Sapp2p Candida parapsilosis ? - ? 400926 3.4.23.24 factor H + H2O the enzyme cleaves and inactivates factor H, diminishing its complement regulatory activity Candida albicans ? - ? 400926 3.4.23.24 factor H-related protein 5 + H2O substrate for isoform Sapp2p Candida parapsilosis ? - ? 448577 3.4.23.24 fluorescein-labeled casein + H2O - Candida albicans ? - ? 449923 3.4.23.24 fluorescein-labeled casein + H2O - Candida albicans CAI4 ? - ? 449923 3.4.23.24 FRETS-25Ala + H2O isozyme Sap1 shows highest activity towards FRETS-25Ala Candida albicans ? - ? 418634 3.4.23.24 FRETS-25Xaa + H2O all Sap isozymes prefer Arg and Lys at the Xaa position Candida albicans ? - ? 418635 3.4.23.24 Hemoglobin + H2O - Candida albicans ? - ? 15450 3.4.23.24 Hemoglobin + H2O - Metschnikowia pulcherrima ? - ? 15450 3.4.23.24 Hemoglobin + H2O - Metschnikowia pulcherrima KSY 188-5 ? - ? 15450 3.4.23.24 hide powder azure + H2O - Candida albicans ? - ? 15924 3.4.23.24 Human stratum corneum + H2O - Candida albicans ? - ? 16351 3.4.23.24 Keratin + H2O - Candida albicans ? - ? 16346 3.4.23.24 Keratin + H2O - Metschnikowia pulcherrima ? - ? 16346 3.4.23.24 Keratin + H2O - Metschnikowia pulcherrima KSY 188-5 ? - ? 16346 3.4.23.24 L-Arg-7-amido-4-methylcoumarin + H2O - [Candida] glabrata L-Arg + 7-amino-4-methylcoumarin - ? 382105 3.4.23.24 L-Arg-7-amido-4-methylcoumarin + H2O - [Candida] glabrata T-1639 L-Arg + 7-amino-4-methylcoumarin - ? 382105 3.4.23.24 LPVNATSE + H2O 28% conversion Candida parapsilosis LPVN + ATSE - ? 412387 3.4.23.24 LPVNATSE + H2O 28% conversion Candida parapsilosis P-69 LPVN + ATSE - ? 412387 3.4.23.24 LTEKRDSIS + H2O 100% conversion Candida parapsilosis LTEKR + L-Asp + Ser-Ile-Ser - ? 412388 3.4.23.24 LTEKRDSIS + H2O 100% conversion Candida parapsilosis P-69 LTEKR + L-Asp + Ser-Ile-Ser - ? 412388 3.4.23.24 Lys-Pro-Ala-Arg-Phe-Nph-Arg-Leu + H2O - Candida albicans ? - ? 385107 3.4.23.24 Lys-Pro-Ala-Arg-Phe-Nph-Arg-Leu + H2O - Candida albicans Lys-Pro-Ala-Arg-Phe + Nph-Arg-Leu - ? 385108 3.4.23.24 Lys-Pro-Ala-Glu-Phe-4-nitrophenylalanine-Ala-Leu + H2O - Candida parapsilosis Lys-Pro-Ala-Glu-Phe + 4-nitrophenylalanine-Ala-Leu - ? 385109 3.4.23.24 Lys-Pro-Leu-Glu-Met-4-nitrophenylalanine-Ala-Leu + H2O - Candida parapsilosis Lys-Pro-Leu-Glu-Met + 4-nitrophenylalanine-Ala-Leu - ? 385111 3.4.23.24 macrophage factor H-receptor CR3 + H2O the enzyme cleaves and inactivates macrophage factor H-receptor CR3 Candida albicans ? - ? 448742 3.4.23.24 macrophage factor H-receptor CR4 + H2O the enzyme cleaves and inactivates macrophage factor H-receptor CR4 Candida albicans ? - ? 448743 3.4.23.24 additional information substrate specificity Candida albicans ? - ? 89 3.4.23.24 additional information trypsinogen kinase activity Candida albicans ? - ? 89 3.4.23.24 additional information not: horse ferritin Candida albicans ? - ? 89 3.4.23.24 additional information synthetic anilides Candida albicans ? - ? 89 3.4.23.24 additional information clots milk at pH 5.5 Candida albicans ? - ? 89 3.4.23.24 additional information the enzyme plays an important role in superficial infection by affecting the human stratum corneum of the skin and nail Candida albicans ? - ? 89 3.4.23.24 additional information the enzyme enables Candida albicans to use exogenous proteins as the sole source of nitrogen Candida albicans ? - ? 89 3.4.23.24 additional information candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function Candida albicans ? - ? 89 3.4.23.24 additional information candidapepsin is implicated in the degradation of host proteins involved in defense and barrier function. Sap2p degrades the Fc portion of IgG, IgA, complement factor C3 and endogenous protease inhibitors in human serum Candida albicans ? - ? 89 3.4.23.24 additional information distinct secreted aspartic proteinase plays a crucial role in the induction of chemokine response during Candida albicans vaginal infections Candida albicans ? - ? 89 3.4.23.24 additional information isoenzyme SAP1 is related to the vaginopathic potential of Candida albicans Candida albicans ? - ? 89 3.4.23.24 additional information isoenzyme SAP2 is related to the vaginopathic potential of Candida albicans Candida albicans ? - ? 89 3.4.23.24 additional information isoenzyme SAP3 is related to the vaginopathic potential of Candida albicans Candida albicans ? - ? 89 3.4.23.24 additional information isoenzyme SAP4 is correlated with systemic infections by Candida albicans Candida albicans ? - ? 89 3.4.23.24 additional information isoenzyme SAP5 is correlated with systemic infections by Candida albicans Candida albicans ? - ? 89 3.4.23.24 additional information isoenzyme SAP6 is correlated with systemic infections by Candida albicans Candida albicans ? - ? 89 3.4.23.24 additional information extremely broad specificity range Candida albicans ? - ? 89 3.4.23.24 additional information sapp2p fails to cleave Lys-Pro-Ala-Glu-Phe-Phe(p-NO2)-Ala-Leu Candida parapsilosis ? - ? 89 3.4.23.24 additional information Candida albicans strain SC5314 Sap1-6 mutants do not degrade E-cadherin Candida albicans ? - ? 89 3.4.23.24 additional information Candida glabrata does not degrade E-cadherin [Candida] glabrata ? - ? 89 3.4.23.24 additional information isoform Sapp2p has a more restricted substrate specificity and significantly lower catalytic activity than isoform Sapp1p Candida parapsilosis ? - ? 89 3.4.23.24 additional information no hydrolysis of PMVELPGE, PMVELHGE, PMVELGGE, PMVEMWGE, LPVNATSE, LTEKRDSIS, and ELSKRSSPS Candida parapsilosis ? - ? 89 3.4.23.24 additional information isoform Sap9 preferentially cleaves a peptide backbone at adjacent basic residues e.g. Lys-Arg or Arg-Arg when these are followed by an acidic amino acid residue Candida albicans ? - ? 89 3.4.23.24 additional information sapp2p fails to cleave Lys-Pro-Ala-Glu-Phe-Phe(p-NO2)-Ala-Leu Candida parapsilosis CP386/IDE98 ? - ? 89 3.4.23.24 additional information isoform Sapp2p has a more restricted substrate specificity and significantly lower catalytic activity than isoform Sapp1p Candida parapsilosis P-69 ? - ? 89 3.4.23.24 additional information no hydrolysis of PMVELPGE, PMVELHGE, PMVELGGE, PMVEMWGE, LPVNATSE, LTEKRDSIS, and ELSKRSSPS Candida parapsilosis P-69 ? - ? 89 3.4.23.24 additional information trypsinogen kinase activity Candida albicans CBS-2730 ? - ? 89 3.4.23.24 additional information not: horse ferritin Candida albicans CBS-2730 ? - ? 89 3.4.23.24 additional information clots milk at pH 5.5 Candida albicans CBS-2730 ? - ? 89 3.4.23.24 Myeloma proteins of the type A1 and A2 + H2O - Candida albicans ? - ? 16340 3.4.23.24 Myeloma proteins of the type A1 and A2 + H2O - Candida albicans CBS-2730 ? - ? 16340 3.4.23.24 oxidized insulin B chain + H2O cleavage sites of Sap2p: FV-/-NQHLCGSHL-/-V-/-EA-/-LYLVCGERGFF-/-YTPKA Candida albicans ? - ? 37092 3.4.23.24 Oxidized insulin B-chain + H2O low side-chain specificity, preferential attack on hydrophobic amino acid residues Candida albicans ? - ? 15443 3.4.23.24 PMVELAGE + H2O cleavage of Sapp2p, 81% conversion Candida parapsilosis PMVE + L-Leu + AGE - ? 412711 3.4.23.24 PMVELAGE + H2O cleavage of Sapp2p, 81% conversion Candida parapsilosis P-69 PMVE + L-Leu + AGE - ? 412711 3.4.23.24 PMVELAGE + H2O cleavage of Sapp1p, 100% conversion Candida parapsilosis PMVEL + AGE - ? 412712 3.4.23.24 PMVELGGE + H2O 100% conversion Candida parapsilosis PMVEL + GGE - ? 412713 3.4.23.24 PMVELHGE + H2O 100% conversion Candida parapsilosis PMVEL + HGE - ? 412714 3.4.23.24 PMVELPGE + H2O 100% conversion Candida parapsilosis PMVEL + PGE - ? 412715 3.4.23.24 PMVELQGE + H2O cleavage of Sapp2p, 18% conversion Candida parapsilosis PMVE + L-Leu + QGE - ? 412716 3.4.23.24 PMVELQGE + H2O cleavage of Sapp1p, 100% conversion Candida parapsilosis PMVEL + QGE - ? 412717 3.4.23.24 PMVELTGE + 2 H2O cleavage of Sapp2p, 35% conversion Candida parapsilosis PMVE + L-Leu + TGE - ? 412718 3.4.23.24 PMVELTGE + H2O cleavage of Sapp1p, 100% conversion Candida parapsilosis PMVEL + TGE - ? 412719 3.4.23.24 PMVELWGE + H2O cleavage of Sapp2p, 40% conversion Candida parapsilosis PMVE + L-Leu + WGE - ? 412720 3.4.23.24 PMVELWGE + H2O cleavage of Sapp1p, 76% conversion Candida parapsilosis PMVEL + WGE - ? 412721 3.4.23.24 PMVEMWGE + H2O 100% conversion Candida parapsilosis PMVEM + WGE - ? 412722 3.4.23.24 PMVMLWGE + H2O 13% conversion Candida parapsilosis PMVML + WGE - ? 412723 3.4.23.24 PMVMLWGE + H2O 98% conversion Candida parapsilosis PMVML + WGE - ? 412723 3.4.23.24 protein + H2O - Candida albicans hydrolyzed protein - ? 74163 3.4.23.24 protein + H2O - Candida albicans H12 hydrolyzed protein - ? 74163 3.4.23.24 Proteinase inhibitors of human serum + H2O - Candida albicans ? - ? 16341