3.4.22.B6 2-aminobenzoyl-Phe-Arg-Ala-(2,4-dinitrophenyl)-epsilon-NH2-lysine + H2O - Trypanosoma congolense ? - ? 390620 3.4.22.B6 Abz-FRF(NO2)A + H2O - Arabidopsis thaliana ? - ? 449439 3.4.22.B6 Abz-GIVRAK(Dnp) + H2O - Arabidopsis thaliana ? - ? 449442 3.4.22.B6 Arg-Arg-7-amido-4-methylcoumarin + H2O - Caenorhabditis elegans Arg-Arg + 7-amino-4-methylcoumarin - ? 411647 3.4.22.B6 benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O - Leishmania major benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin - ? 362355 3.4.22.B6 benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O - Trypanosoma congolense CBZ-Arg-Arg + 7-amino-4-methylcoumarin - ? 391422 3.4.22.B6 benzyloxycarbonyl-Arg-Arg-p-nitroanilide + H2O - Callosobruchus maculatus benzyloxycarbonyl-Arg-Arg + p-nitroaniline - ? 36941 3.4.22.B6 benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O - Leishmania major benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin - ? 361886 3.4.22.B6 benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O - Trypanosoma congolense benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin - ? 361886 3.4.22.B6 Boc-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O - Trichobilharzia regenti Boc-Val-Leu-Lys + 7-amino-4-methylcoumarin - ? 404549 3.4.22.B6 fibronectin + H2 - Angiostrongylus cantonensis ? - ? 428621 3.4.22.B6 Gelatin + H2O - Caenorhabditis elegans ? - ? 16570 3.4.22.B6 hemoglobinase + H2O degradation Angiostrongylus cantonensis ? - ? 431937 3.4.22.B6 human IgG + H2O degradation Angiostrongylus cantonensis ? - ? 189962 3.4.22.B6 IEC-6 monolayer + H2O enzyme hydrolyzes the extracellular matrix of rat intestine epithelial cell line IEC-6 monolayer that the intercellular space of the IEC-6 monolayer increases while the shape of the adherent cells partly rounds up Angiostrongylus cantonensis ? - ? 450065 3.4.22.B6 Laminin + H2O - Angiostrongylus cantonensis ? - ? 16571 3.4.22.B6 additional information the enzyme does not readily hyrolyze benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin which is cleaved by cathespsin B. The substrate specificity is attributed to Gly234 at the S2 subsite of LmajcatB, which forms a larger, more hydrophobic pocket compared with mammalian cathepsin B Leishmania major ? - ? 89 3.4.22.B6 additional information the enzyme is not able to cleave synthetic substrates having an Arg in position P2 Leishmania major ? - ? 89 3.4.22.B6 additional information the enzyme is involved in lethal N-methyl-D-aspartate-induced collapse and F-actib loss of dendritic spines, sub-lethal ecitosis injury to dendrites can elicit loss or shrinkage of dendritic spines, specific enzyme inhibitors attenuate the effect, overview Homo sapiens ? - ? 89 3.4.22.B6 additional information the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole Leishmania amazonensis ? - ? 89 3.4.22.B6 additional information the enzyme is involved in yolk protein degradation during embryogenesis Helicoverpa armigera ? - ? 89 3.4.22.B6 additional information the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection Leishmania major ? - ? 89 3.4.22.B6 additional information the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection, the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole Leishmania mexicana ? - ? 89 3.4.22.B6 additional information CmSvp may contribute to insect counter-defense, in part by inhibiting CmCatB expression under normal growth conditions, but releasing the inhibition when insects are challenged by dietary protease inhibitors Callosobruchus maculatus ? - ? 89 3.4.22.B6 additional information strongly induces cathepsin B-like cysteine protease 1c transcripts when fed diet containing a soybean cysteine protease inhibitor soyacystatin N. The scN-activated and developmentally regulated CmCatB1 expression pattern suggests it may have a unique function in insect counter-defence against antinutritional factors. CmCatB1 confers inhibitor-insensitive enzymatic activity to cowpea bruchids, which is crucial for insect survival when challenged by dietary protease inhibitors Callosobruchus maculatus ? - ? 89 3.4.22.B6 additional information CmCatB2 may be an inactive protease isoform resulting from splicing errors Callosobruchus maculatus ? - ? 89 3.4.22.B6 additional information no hydrolysis of benzoyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin and benzoyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin Trypanosoma congolense ? - ? 89 3.4.22.B6 additional information collagen type IV, elastin, keratin, fibrinogen type III and myelin basic protein are degraded Trichobilharzia regenti ? - ? 89 3.4.22.B6 myristoylated-alanine-rich C-kinase + H2O specific degradation, the enzyme degrades the protein involved in actin cytoskeleton regulation Homo sapiens ? - ? 380667 3.4.22.B6 myristoylated-alanine-rich C-kinase substrate + H2O i.e. MARCKS, specific degradation Homo sapiens ? - ? 382324 3.4.22.B6 Nalpha-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O - Trypanosoma congolense Nalpha-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin - ? 453119 3.4.22.B6 Phe-Arg-7-amido-4-methylcoumarin + H2O - Caenorhabditis elegans Phe-Arg + 7-amino-4-methylcoumarin - ? 412677 3.4.22.B6 protein rGSII-D88N + H2O legume lectin Callosobruchus maculatus ? - ? 406510 3.4.22.B6 Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O - Caenorhabditis elegans Tyr-Val-Ala-Asp + 7-amino-4-methylcoumarin - ? 413017 3.4.22.B6 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O - Angiostrongylus cantonensis Z-Arg-Arg + 7-amino-4-methylcoumarin - ? 385950 3.4.22.B6 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O - Trichobilharzia regenti Z-Arg-Arg + 7-amino-4-methylcoumarin - ? 385950 3.4.22.B6 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O - Trypanosoma brucei Z-Arg-Arg + 7-amino-4-methylcoumarin - ? 385950 3.4.22.B6 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O - Diaphorina citri Z-Arg-Arg + 7-amino-4-methylcoumarin - ? 385950 3.4.22.B6 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O - Arabidopsis thaliana Z-Arg-Arg + 7-amino-4-methylcoumarin - ? 385950 3.4.22.B6 Z-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O - Trichobilharzia regenti Z-Gly-Pro-Arg + 7-amino-4-methylcoumarin - ? 390095 3.4.22.B6 Z-Leu-Arg-7-amido-4-methylcoumarin + H2O - Eimeria tenella Z-Leu-Arg + 7-amino-4-methylcoumarin - ? 385963 3.4.22.B6 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O - Trypanosoma brucei Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972 3.4.22.B6 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O - Trichobilharzia regenti Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972 3.4.22.B6 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O - Eimeria tenella Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972 3.4.22.B6 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O - Diaphorina citri Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972 3.4.22.B6 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O - Arabidopsis thaliana Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972