3.4.21.B26	ANKKPPLPKRVRRQIHATPTP + H2O	a peptide representing alpha-dystroglycan amino acids 299-319 that encompasses the predicted PC6-cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP)	Homo sapiens	ANKKPPLPKRVRR + QIHATPTP	-	?	449570	
3.4.21.B26	endothelial lipase + H2O	-	Mus musculus	?	-	?	391906	
3.4.21.B26	human immunodeficiency virus type 1 Vpr + H2O	undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr	Mus musculus	?	-	?	398907	
3.4.21.B26	Lefty protein + H2O	-	Mus musculus	?	-	?	392472	
3.4.21.B26	additional information	no substrate: amyloid-beta precursor protein	Mus musculus	?	-	?	89	
3.4.21.B26	additional information	both isoforms can cleave a number of fluorogenic substrates of general formula Arg/Lys-(Xaa)n-(Arg)-, where n= 2, 4, or 6	Homo sapiens	?	-	?	89	
3.4.21.B26	additional information	death at birth of the PC5/6-deficient embryos	Mus musculus	?	-	?	89	
3.4.21.B26	additional information	substrate cleavage analysis. Strong preference of Arg at position P1 and P4	Homo sapiens	?	-	?	89	
3.4.21.B26	additional information	development of a high-throughput immunohistochemic assay for human proprotein convertase 5/6 for detecting uterine receptivity, method evaluation, overview	Homo sapiens	?	-	?	89	
3.4.21.B26	osteopontin + H2O	Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype	Mus musculus	?	-	?	367210