3.4.21.68 (p-F)-FPRANSNH-C2H5 + H2O - Homo sapiens (p-F)-FPR + ANSNH-C2H5 - ? 365740 3.4.21.68 acetyl-FTAR-4-nitroanilide + H2O - Homo sapiens acetyl-FTAR + 4-nitroaniline - ? 449498 3.4.21.68 acetyl-FYAR-4-nitroanilide + H2O - Homo sapiens acetyl-FYAR + 4-nitroaniline - ? 449500 3.4.21.68 acetyl-GTAR-4-nitroanilide + H2O - Homo sapiens acetyl-GTAR + 4-nitroaniline - ? 449504 3.4.21.68 acetyl-GTGR-4-nitroanilide + H2O - Homo sapiens acetyl-GTGR + 4-nitroaniline - ? 449505 3.4.21.68 acetyl-QYAR-4-nitroanilide + H2O - Homo sapiens acetyl-QYAR + 4-nitroaniline - ? 449512 3.4.21.68 Asp-Gly-Arg-p-nitroanilide + H2O - Homo sapiens Asp-Gly-Arg + p-nitroaniline - ? 365783 3.4.21.68 benzyl-TAR-4-nitroanilide + H2O - Homo sapiens benzyl-TAR + 4-nitroaniline - ? 449643 3.4.21.68 benzyloxycarbonyl-Asp(O-tert-butyl)-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-Asp(O-tert-butyl)-Gly-Arg + p-nitroaniline - ? 365767 3.4.21.68 benzyloxycarbonyl-Asp-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-Asp-Gly-Arg + p-nitroaniline - ? 365766 3.4.21.68 benzyloxycarbonyl-D-Arg-Gly-Arg-4-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-D-Arg-Gly-Arg + 4-nitroaniline - ? 453036 3.4.21.68 benzyloxycarbonyl-D-Asp(O-tert-butyl)-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-D-Asp(O-tert-butyl)-Gly-Arg + p-nitroaniline - ? 365768 3.4.21.68 benzyloxycarbonyl-D-Glu(O-tert-butyl)-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-D-Glu-Gly-Arg + p-nitroaniline - ? 365770 3.4.21.68 benzyloxycarbonyl-D-Glu-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-D-Glu-Gly-Arg + p-nitroaniline - ? 365771 3.4.21.68 benzyloxycarbonyl-D-Phe-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-D-Phe-Gly-Arg + p-nitroaniline - ? 365765 3.4.21.68 benzyloxycarbonyl-Glu(O-tert-butyl)-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-Glu(O-tert-butyl)-Gly-Arg + p-nitroaniline - ? 365769 3.4.21.68 benzyloxycarbonyl-Glu-Gly-Arg-4-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-Glu-Gly-Arg + 4-nitroaniline - ? 453037 3.4.21.68 benzyloxycarbonyl-pyroglutamic acid-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-pyroglutamic acid-Gly-Arg + p-nitroaniline - ? 365772 3.4.21.68 benzyloxycarbonyl-Val-Gly-Arg-p-nitroanilide + H2O - Homo sapiens benzyloxycarbonyl-Val-Gly-Arg + p-nitroaniline - ? 365764 3.4.21.68 Boc-(p-F)-FPRANSNH-C2H5 + H2O - Homo sapiens Boc-(p-F)-FPR + ANSNH-C2H5 - ? 365739 3.4.21.68 Boc-D-FLRANSNH-C3H7 + H2O - Homo sapiens Boc-D-FLR + ANSNH-C3H7 - ? 365743 3.4.21.68 Boc-D-FPRANSNH-C6H11 + H2O - Homo sapiens Boc-D-FPR + ANSNH-C6H11 - ? 365736 3.4.21.68 Boc-D-FVRANSNH-C2H5 + H2O - Homo sapiens Boc-D-FVR + ANSNH-C2H5 - ? 365741 3.4.21.68 Boc-D-LGRANSNH-C6H11 + H2O - Homo sapiens Boc-D-LGR + ANSNH-C6H11 - ? 365730 3.4.21.68 Boc-D-LPRANSNH-C3H7 + H2O - Homo sapiens Boc-D-LPR + ANSNH-C3H7 - ? 365734 3.4.21.68 Boc-D-LSRANSNH-C3H7 + H2O - Homo sapiens Boc-D-LSR + ANSNH-C3H7 - ? 365732 3.4.21.68 Boc-D-VGRANSNH-C4H9 + H2O - Homo sapiens Boc-D-VGR + ANSNH-C4H9 - ? 365745 3.4.21.68 Boc-D-VPRANSNH-C4H9 + H2O - Homo sapiens Boc-D-VPR + ANSNH-C4H9 - ? 365749 3.4.21.68 Boc-L-FPRANSNH-C2H5 + H2O - Homo sapiens Boc-L-FPR + ANSNH-C2H5 - ? 365738 3.4.21.68 Boc-L-VGRANSNH-C4H9 + H2O - Homo sapiens Boc-L-VGR + ANSNH-C4H9 - ? 365747 3.4.21.68 casein + H2O - Mus musculus ? - ? 15445 3.4.21.68 casein + H2O casein zymography assay Rattus norvegicus ? - ? 15445 3.4.21.68 casein + H2O endogenous TPA activities in the ipsilateral ischemic hemisphere are measured using casein-zymography Rattus norvegicus ? - ? 15445 3.4.21.68 casein + H2O endogenous TPA activities in the ipsilateral ischemic hemisphere are measured using casein-zymography Rattus norvegicus Sprague-Dawley ? - ? 15445 3.4.21.68 casein + H2O casein zymography assay Rattus norvegicus Sprague-Dawley ? - ? 15445 3.4.21.68 casein + H2O - Mus musculus C57BL/6 ? - ? 15445 3.4.21.68 cyclohexylglycyl-Gly-Arg-p-nitroanilide + H2O - Homo sapiens cyclohexylglycyl-Gly-Arg + p-nitroaniline - ? 365781 3.4.21.68 D-Asp(O-tert-butyl)-Gly-Arg-4-nitroanilide + H2O - Homo sapiens D-Asp(O-tert-butyl)-Gly-Arg + 4-nitroaniline - ? 453038 3.4.21.68 D-Asp-Gly-Arg-p-nitroanilide + H2O - Homo sapiens D-Asp-Gly-Arg + p-nitroaniline - ? 365784 3.4.21.68 D-cyclohexylglycyl-Gly-Arg-p-nitroanilide + H2O - Homo sapiens D-cyclohexylglycyl-Gly-Arg + p-nitroaniline - ? 365282 3.4.21.68 D-FLRANSNH-C3H7 + H2O - Homo sapiens D-FLR + ANSNH-C3H7 - ? 365744 3.4.21.68 D-FPR ANSNH-C6H11 + H2O - Homo sapiens D-FPR + ANSNH-C6H11 - ? 365737 3.4.21.68 D-FPRANSN-(CH2)6 + H2O - Homo sapiens D-FPR + ANSN-(CH2)6 - ? 365759 3.4.21.68 D-FPRANSN-C2H5 + H2O - Homo sapiens D-FPR + ANSN-C2H5 - ? 365760 3.4.21.68 D-FPRANSN-C2H5-C2H5 + H2O - Homo sapiens D-FPR + ANSN-C2H5-C2H5 - ? 453033 3.4.21.68 D-FPRANSNH-c-C6H11 + H2O - Homo sapiens D-FPR + ANSNH-c-C6H11 - ? 365758 3.4.21.68 D-FPRANSNH-C2H4OCH3 + H2O - Homo sapiens D-FPR + ANSNH-C2H4OCH3 - ? 365756 3.4.21.68 D-FPRANSNH-C6H5CH2 + H2O - Homo sapiens D-FPR + ANSNH-C6H5CH2 - ? 365755 3.4.21.68 D-FPRANSNH-CH2COOCH3 + H2O - Homo sapiens D-FPR + ANSNH-CH2COOCH3 - ? 365757 3.4.21.68 D-FPRANSNH-i-C3H7 + H2O - Homo sapiens D-FPR + ANSNH-i-C3H7 - ? 365751 3.4.21.68 D-FPRANSNH-n-C4H9 + H2O - Homo sapiens D-FPR + ANSNH-n-C4H9 - ? 365752 3.4.21.68 D-FPRANSNH-n-C6H13 + H2O - Homo sapiens D-FPR + ANSN-H-n-C6H13 - ? 365754 3.4.21.68 D-FPRANSNH-t-C4H9 + H2O - Homo sapiens D-FPR + ANSNH-t-C4H9 - ? 365753 3.4.21.68 D-FVRANSNH-C2H5 + H2O - Homo sapiens D-FVR + ANSNH-C2H5 - ? 365742 3.4.21.68 D-Glu-Gly-Arg-p-nitroanilide + H2O - Homo sapiens D-Glu-Gly-Arg + p-nitroaniline - ? 365786 3.4.21.68 D-Glu-Phe-Lys-p-nitroanilide + H2O - Homo sapiens D-Glu-Phe-Lys + p-nitroaniline - ? 394301 3.4.21.68 D-hexahydrotyrosyl-Gly-Arg-p-nitroanilide + H2O - Homo sapiens D-hexahydrotyrosyl-Gly-Arg + p-nitroaniline - ? 365782 3.4.21.68 D-Ile-Pro-Arg-4-nitroanilide + H2O - Homo sapiens D-Ile-Pro-Arg + 4-nitroaniline - ? 361879 3.4.21.68 D-Ile-Pro-Arg-p-nitroanilide + H2O - Homo sapiens D-Ile-Pro-Arg + p-nitroaniline - ? 372926 3.4.21.68 D-LGRANSNH-C6H11 + H2O - Homo sapiens D-LGR + ANSNH-C6H11 - ? 365731 3.4.21.68 D-LPRANSNH-C3H7 + H2O - Homo sapiens D-LPR + ANSNH-C3H7 - ? 365735 3.4.21.68 D-LSRANSNH-C3H7 + H2O - Homo sapiens D-LSR + ANSNH-C3H7 - ? 365733 3.4.21.68 D-Lys-Gly-Arg-p-nitroanilide + H2O - Homo sapiens D-Lys-Gly-Arg + p-nitroaniline - ? 365787 3.4.21.68 D-norleucyl-hexahydrotyrosol-lysine-p-nitroanilide + H2O - Bos taurus D-norleucyl-hexahydrotyrosol-lysine + p-nitroaniline - ? 394306 3.4.21.68 D-Phe-Gly-Arg-p-nitroanilide + H2O - Homo sapiens D-Phe-Gly-Arg + p-nitroaniline - ? 365780 3.4.21.68 D-Val-L-Leu-L-Lys-p-nitroanilide + H2O - Homo sapiens D-Val-L-Leu-L-Lys + p-nitroaniline - ? 394307 3.4.21.68 D-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O - Homo sapiens ? - ? 404922 3.4.21.68 D-Val-Leu-Lys-p-nitroanilide + H2O - Homo sapiens D-Val-Leu-Lys + p-nitroaniline - ? 36961 3.4.21.68 D-valyl-L-leucyl-L-lysine 4-nitroanilide + H2O - Bos taurus D-valyl-L-leucyl-L-lysine + 4-nitroaniline - ? 394309 3.4.21.68 D-VGRANSNH-C4H9 + H2O - Homo sapiens D-VGR + ANSNH-C4H9 - ? 365746 3.4.21.68 D-VPRANSNH-C4H9 + H2O - Homo sapiens D-VPR + ANSNH-C4H9 - ? 365750 3.4.21.68 Glu-Gly-Arg-p-nitroanilide + H2O - Homo sapiens Glu-Gly-Arg + p-nitroaniline - ? 365785 3.4.21.68 Glu-plasminogen + H2O - Homo sapiens plasmin + ? - ? 405283 3.4.21.68 glutaryl-Gly-7-Arg-amido-4-methylcoumarin + H2O - Homo sapiens ? - ? 405292 3.4.21.68 L-FPRANSN-C2H5 + H2O - Homo sapiens L-FPR + ANSN-C2H5 - ? 453034 3.4.21.68 L-VGRANSNH-C4H9 + H2O - Homo sapiens L-VGR + ANSNH-C4H9 - ? 365748 3.4.21.68 Laminin + H2O tPA amplifies excitotoxic neuronal death by degrading laminin and disruption of pro-survival cell-matrix signaling Mus musculus ? - ? 16571 3.4.21.68 Lys-Lys-Cys-Pro-Gly-Arg-Val-Val-Gly-Gly-Cys-Val-Ala-His + H2O - Homo sapiens ? - ? 15553 3.4.21.68 Lys-Lys-Ser-Pro-Gly-Arg-Val-Val-Gly-Gly-Ser-Val-Ala-His + H2O - Homo sapiens ? - ? 15550 3.4.21.68 Lys-plasminogen + H2O - Homo sapiens plasmin + ? - ? 365761 3.4.21.68 methyloxycarbonyl-D-cyclohexylalanyl-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methyloxycarbonyl-D-cyclohexylglycyl-Gly-Arg + p-nitroaniline - ? 365776 3.4.21.68 methyloxycarbonyl-D-cyclohexylglycyl-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methyloxycarbonyl-D-cyclohexylglycyl-Gly-Arg + p-nitroaniline - ? 365777 3.4.21.68 methyloxycarbonyl-D-hexahydrotyrosyl-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methyloxycarbonyl-D-hexahydrotyrosyl-Gly-Arg + p-nitroaniline - ? 365778 3.4.21.68 methyloxycarbonyl-D-Leu-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methyloxycarbonyl-D-Leu-Gly-Arg + p-nitroaniline - ? 365775 3.4.21.68 methyloxycarbonyl-D-Nle-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methyloxycarbonyl-D-Nle-Gly-Arg + p-nitroaniline - ? 365774 3.4.21.68 methyloxycarbonyl-D-Val-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methyloxycarbonyl-D-Nle-Gly-Arg + p-nitroaniline - ? 365773 3.4.21.68 methylsulfonyl-D-cyclohexylglycyl-Arg-7-amido-4-methylcoumarin + H2O chromogenic substrate Rattus norvegicus methylsulfonyl-D-cyclohexylglycyl-Arg + 7-amino-4-methylcoumarin - ? 410899 3.4.21.68 methylsulfonyl-D-cyclohexylglycyl-Arg-7-amido-4-methylcoumarin + H2O chromogenic substrate Homo sapiens methylsulfonyl-D-cyclohexylglycyl-Arg + 7-amino-4-methylcoumarin - ? 410899 3.4.21.68 methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine-p-nitroanilide + H2O a chromogenic substrate Homo sapiens methylsulfonyl-D-cyclohexyltyrosyl-glycyl-arginine + p-nitroaniline - ? 412454 3.4.21.68 methylsulfonyl-D-Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O - Mus musculus methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin - ? 394416 3.4.21.68 methylsulfonyl-D-Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin - ? 394416 3.4.21.68 methylsulfonyl-D-Phe-Gly-Arg-p-nitroanilide + H2O - Homo sapiens methylsulfonyl-D-Phe-Gly-Arg + p-nitroaniline - ? 365788 3.4.21.68 MMP-9 + H2O tPA directly or by activation of MMP-9, can have beneficial effects on recovery after stroke by promoting neurovascular repair through vascular endothelial growth factor Homo sapiens ? - ? 405870 3.4.21.68 additional information cleaves linear and cyclic peptides containing its normal target sequence from plasminogen Homo sapiens ? - ? 89 3.4.21.68 additional information single-chain t-PA, sct-PA can be converted to two-chain forrm, tct-PA, by activation cleavage at the arg275-Ile276 peptide bond Homo sapiens ? - ? 89 3.4.21.68 additional information single-chain t-PA, sct-PA can be converted to two-chain forrm, tct-PA, by activation cleavage at the arg275-Ile276 peptide bond, no hydrolysis of Boc-L-FLRANSNH-C3H7, L-FLRANSNH-C3H7, Boc-D-VSRANSNH-(i-C3H7), D-VSRANSNH-(i-C3H7), BOC-D-VLRANSN-H4H9, D-VLRANSN-H4H9, Boc-D-PGRANSNH-(i-C3H7), D-PGRANSNH-(i-C3H), Boc-D-PPRANSNH-(i-C3H7), D-PPRANSNH-(i-C3H7), Boc-D-SPRANSNH-CH2C6H5, D-SPRANSNH-CH2C6H5, Boc-L-SPRANSNH-CH2C6H5, L-SPRANSNH-CH2C6H5, Boc-L-(Obz)SPRANSNH-CH2C6H5, L-(Obz)SPRANSNH-CH2C6H5, (Z)-L-(Boc)EGRANSNH-C3H7, (Z)-L-EGRANSNH-CH7, L-EGRANSNH-C3H7, (Z)-L-(Boc)EPRANSNH-C3H7, (Z)-L-EPR-ANSNH-C3H7, and L-EPRANSNH-C3H7 Homo sapiens ? - ? 89 3.4.21.68 additional information addition of human recombinant tPA after ischemia, in a mouse model of transient 30-min-suture middle cerebral artery occlusion, enhances ischemic damage both in vitro and in vivo, but XG-102 is able to induce a significant neuroprotection. Addition of recombinant tPA after oxygen and glucose deprivation enhances neuronal death in CA1 Homo sapiens ? - ? 89 3.4.21.68 additional information t-PA treatment promotes metalloproteinase-9, metalloproteinase-8, and tissue inhibitor metalloproteinase-2 release from human neutrophils ex vivo within 10 and 30 min. t-PA treatment also promotes metalloproteinase-9 release in formyl peptide-preactivated neutrophils. t-PA treatment stimulates neutrophil degranulation synthetic construct ? - ? 89 3.4.21.68 additional information tPA facilitates Ca2+ influx via NMDA receptors and dopaminergic transmission via D1 receptors and long-term potentiation in the hippocampus. tPA promotes degradation of the extracellular matrix, which is important for synaptic remodeling and formation of new axonal varicosities Homo sapiens ? - ? 89 3.4.21.68 additional information tPA induces N27 neuroblast cell death in a dose-and time-dependent manner synthetic construct ? - ? 89 3.4.21.68 additional information tPA is a survival factor that prevents renal interstitial fibroblasts (cell line NRK-49F) and myofibroblasts from apoptosis induced by staurosporine and oxidative stress through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism. Antiapoptotic effect of tPA is independent of its protease activity Homo sapiens ? - ? 89 3.4.21.68 additional information the kringle domains 1 and 2 of tissue-type plasminogen activator, TK1–2, interact with endothelial vein cells via integrin and the kringle domain DGDA amino acid sequence, overview Homo sapiens ? - ? 89 3.4.21.68 additional information both plasminogen activation and fibrin lysis by tPA. Lysis of fibrin clots performed using confocal microscopy in conjunction with tPA-GFP added to clots formed of fibrin100 and fibrin5. The front of the fibrin clot moves faster in fibrin5 than in fibrin100. There are also morphologic differences that develop in the 2 fibrins as indicated by the pattern of fluorescence, which reflects tPA distribution. Specifically, it can be seen that a granular pattern develops in the fibrin5 lysis series in contrast to the homogeneous fluorescence pattern that is maintained in the fibrin100 series. Binding analysis of tPA to aggregates formed in fibrin5, using orange fluorescent fibrinogen converted to fluorescent fibrin100 and fibrin5 Homo sapiens ? - ? 89 3.4.21.68 additional information ZIP4 physically interacts with tPA, immunohistochemic analysis, overview Mus musculus ? - ? 89 3.4.21.68 additional information assay on fibrinolytic activity Homo sapiens ? - ? 89 3.4.21.68 additional information the amidolytic assay can be adapted to accurately detect changes in net tPA activity in mouse brain tissues, examination of differences in net tPA activity in the cerebral cortex, sub-cortical structures and cerebellum in wild-type and tPA knockout mice, and in transgenic T4 mice selectively overexpressing tPA in neurons, overview Mus musculus ? - ? 89 3.4.21.68 additional information the fibrinolytic activity of tPA is determined by the fibrin clot lysis assay using fibrin-containing agarose plates Homo sapiens ? - ? 89 3.4.21.68 additional information the enzyme converts plasminogen into plasmin Homo sapiens ? - ? 89 3.4.21.68 additional information measurement of the remaining activity of immobilized enzyme tPA by two different assays: the S-2288TM assay, which measures the amidolytic activity towards chromogenic substrate, and the fibrinolytic activity assay in fibrin-containing agarose gels Homo sapiens ? - ? 89 3.4.21.68 additional information substrate specificity of enzyme tissue-type plasminogen activator, comparison with urokinase-type plasminogen activator, EC 3.4.21.73. The urokinase-type plasminogen activator shows much higher activity towards the peptide substrates Homo sapiens ? - ? 89 3.4.21.68 additional information the amidolytic assay can be adapted to accurately detect changes in net tPA activity in mouse brain tissues, examination of differences in net tPA activity in the cerebral cortex, sub-cortical structures and cerebellum in wild-type and tPA knockout mice, and in transgenic T4 mice selectively overexpressing tPA in neurons, overview Mus musculus C57/BL6J ? - ? 89 3.4.21.68 additional information ZIP4 physically interacts with tPA, immunohistochemic analysis, overview Mus musculus C57BL/6 ? - ? 89 3.4.21.68 N-methyl-D-aspartate receptor + H2O usage of total rat brain lysates or MBP-ATD2B fusion proteins, the recombinant human enzyme shows cleavage of the ATD sequence in the NR2B subunit N-terminus of N-methyl-D-aspartate (NMDA) receptor. Enzyme-mediated degradation of NR2B is plasmin-independent. The enzyme cleaves the MBP-ATD2B fusion protein Homo sapiens ? an Arg27-Arg67-truncated NR2B-containing NMDA receptor might be formed ? 432224 3.4.21.68 N-methyl-D-aspartate receptor NR1 subunit + H2O - Mus musculus ? - ? 418014 3.4.21.68 N-methyl-D-aspartate receptor NR1 subunit + H2O - Mus musculus Swiss ? - ? 418014 3.4.21.68 PAR-1 + H2O toxic effects of tPA in stroke can be mediated through activation of PAR-1 Mus musculus ? - ? 406329 3.4.21.68 Peptide S-2288 + H2O chromogenic substrate Homo sapiens ? - ? 15552 3.4.21.68 pGlu-Gly-Arg-4-nitroanilide + H2O - Homo sapiens pGlu-Gly-Arg + 4-nitroaniline - ? 453039 3.4.21.68 Phe-Gly-Arg-p-nitroanilide + H2O - Homo sapiens Phe-Gly-Arg + p-nitroaniline - ? 365779 3.4.21.68 plasmin + H2O - Homo sapiens ? - ? 36775 3.4.21.68 plasminogen + H2O - Mammalia plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Mus musculus plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Escherichia coli plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Rattus norvegicus plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Oryctolagus cuniculus plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - synthetic construct plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Homo sapiens plasmin + ? plasmin is a potent broad-spectrum protease that cleaves fibrin and is able to degrade several components of the extracellular matrix by activating procollagenases and matrix metalloproteinases ? 15549 3.4.21.68 plasminogen + H2O cleavage of an Arg-Val bond near the carboxy-terminal end Homo sapiens plasmin + ? Glu-plasmin consists of two polypeptides, MW 25000 and 65000, linked together by two disulfide bonds ? 15549 3.4.21.68 plasminogen + H2O cleavage of Arg560-Val561 Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O Glu-plasminogen is the native form of human plasminogen Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O Glu-plasminogen is the native form of human plasminogen Homo sapiens plasmin + ? Glu-plasmin consists of two polypeptides, MW 25000 and 65000, linked together by two disulfide bonds ? 15549 3.4.21.68 plasminogen + H2O cleavage of the Arg561-Val562 bond of plasminogen, converting the zymogen into the active serine protease plasmin Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O single-chain tPA mediated activation Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O critical role in fibrinolysis Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O activation Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O 37°C, pH 7.6 Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O 37°C, pH 8.0 Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O pH 7.4, 37°C Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O patients suffering intracranial hemorrhage or cerebral infarction after receiving 100 mg t-PA for acute myocardial infarction Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O the tPA plasminogen proteolytic cascade is involved in the cleavage of probrain-derived neurotrophic factor to brain-derived neurotrophic factor, by which the direction of brain-derived neurotrophic factor action is controlled. Brain-derived neurotrophic factor is important for the pathogenesis of major depressive disorder Homo sapiens plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O in situ zymography assay Mus musculus plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Rattus norvegicus Sprague-Dawley plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Mus musculus CD-1 plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Mus musculus C57/BL6J plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O in situ zymography assay Mus musculus C57/BL6J plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Mus musculus C57BL/6 plasmin + ? - ? 15549 3.4.21.68 plasminogen + H2O - Bos taurus ? - ? 74447 3.4.21.68 plasminogen + H2O responsible for practically all vascular fibrinolysis through activation of plasminogen Homo sapiens ? - ? 74447 3.4.21.68 plasminogen + H2O participation in the destruction of the follicle wall Homo sapiens ? - ? 74447 3.4.21.68 plasminogen + H2O - Homo sapiens plasminon + ? - ? 410942 3.4.21.68 Plasminogen-activator-inhibitor 1 + H2O PAI-1 may occur in three interconvertible conformations: latent, inhibitor and substrate Homo sapiens ? - ? 15551 3.4.21.68 Plasminogen-activator-inhibitor 1 + H2O treatment with 0.1% SDS, PAI-1 loses its inhibitory activity and is cleaved as a substrate in the reactive centre Escherichia coli ? - ? 15551 3.4.21.68 platelet-derived growth factor C + H2O - Mus musculus ? - ? 382586 3.4.21.68 pyro-Glu-Pro-Arg-4-nitroanilide + H2O - Homo sapiens pyro-Glu-Pro-Arg + 4-nitroaniline - ? 431810 3.4.21.68 S-2288TM + H2O amidolytic activity of recombinant tPA bound to polyacrylic acid-coated magnetite is 87% of that of free recombinant tPA. Amidolytic activity of recombinant tPA immobilized on magnetic nanoparticles coated with dextran is only 11-24% of recombinant tPA bound to polyacrylic acid-coated magnetite synthetic construct ? - ? 406602 3.4.21.68 spectrozyme tPA + H2O - Homo sapiens ? - ? 365762 3.4.21.68 tert-butyloxycarbonyl-Gly-Gly-Arg-p-nitroanilide + H2O - Homo sapiens tert-butyloxycarbonyl-Gly-Gly-Arg + p-nitroaniline - ? 365763 3.4.21.68 thrombin + H2O - Homo sapiens ? - ? 402947 3.4.21.68 Val-Leu-Lys-p-nitroanilide + H2O i.e. S-2251 Homo sapiens p-nitroaniline + ? - ? 365729 3.4.21.68 Val-Leu-Lys-p-nitroanilide + H2O i.e. S-2251 Bos taurus p-nitroaniline + ? - ? 365729 3.4.21.68 Z-Pyr-Gly-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens Z-Pyr-Gly-Arg + 7-amino-4-methylcoumarin - ? 450850 3.4.21.68 [SNase]-PFGRSA + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PFGR + [SNase]-Ser-Ala - ? 365789 3.4.21.68 [SNase]-PFGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PFGR + [SNase]-Ser-Ala-Gly - ? 365790 3.4.21.68 [SNase]-PGPFGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PGPFGR + [SNase]-Ser-Ala-Gly - ? 365792 3.4.21.68 [SNase]-PGPFGRSAGG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PGPFGR + [SNase]-Ser-Ala-Gly-Gly - ? 365793 3.4.21.68 [SNase]-PGSGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PGSGR + [SNase]-Ser-Ala-Gly - ? 365796 3.4.21.68 [SNase]-PHYGRSGG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PHYGR + [SNase]-Ser-Gly-Gly - ? 365794 3.4.21.68 [SNase]-PPFGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PPFGR + [SNase]-Ser-Ala-Gly - ? 365791 3.4.21.68 [SNase]-PQRGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PQRGR + [SNase]-Ser-Ala-Gly - ? 365795