3.4.21.26	(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O	specific substrate, UAMC-00682	Homo sapiens	?	-	?	418185	
3.4.21.26	(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O	specific substrate, UAMC-00682	Rattus norvegicus	?	-	?	418185	
3.4.21.26	18 kD protein of photosystem II + H2O	-	Spinacia oleracea	?	-	?	65067	
3.4.21.26	2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen	Sus scrofa	2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394127	
3.4.21.26	2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen	Sus scrofa	2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394128	
3.4.21.26	2-aminobenzoyl-EGPQGLLGA-3-nitrotyrosyl-NH2 + H2O	-	Homo sapiens	?	-	?	431309	
3.4.21.26	2-aminobenzoyl-FFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O	-	Homo sapiens	?	-	?	365320	
3.4.21.26	2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O	-	Homo sapiens	2-aminobenzoyl-FP + Q-(N-(2,4-dinitrophenyl)ethylenediamine)	-	?	365318	
3.4.21.26	2-aminobenzoyl-FSQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O	-	Homo sapiens	?	-	?	365319	
3.4.21.26	2-aminobenzoyl-Glu-Gly-L-Phe-Gly-L-Pro-L-Phe-Gly-L-4-nitrophenylalanine-L-Ala + H2O	-	Homo sapiens	2-aminobenzoyl-Glu-Gly-L-Phe-Gly-L-Pro + L-Phe-Gly-L-4-nitrophenylalanine-L-Ala	-	?	431311	
3.4.21.26	2-aminobenzoyl-Glu-Gly-Phe-Ser-Pro-Phe(NO2)-Arg-Ala + H2O	-	Sus scrofa	2-aminobenzoyl-Glu-Gly-Phe-Ser-Pro + Phe(NO2)-Arg-Ala	-	?	365360	
3.4.21.26	2-aminobenzoyl-Glu-Phe-Ser-Pro-Phe(NO2)-Arg-Ala + H2O	-	Sus scrofa	2-aminobenzoyl-Glu-Phe-Ser-Pro + Phe(NO2)-Arg-Ala	-	?	365364	
3.4.21.26	2-aminobenzoyl-Gly-Glu-Ser-Pro-Phe(NO2)-Arg-Ala + H2O	-	Sus scrofa	2-aminobenzoyl-Gly-Glu-Ser-Pro + Phe(NO2)-Arg-Ala	-	?	365363	
3.4.21.26	2-aminobenzoyl-Gly-L-Phe-Gly-L-Pro-L-Phe-Gly-L-4-nitrophenylalanine-L-Ala + H2O	-	Homo sapiens	2-aminobenzoyl-Gly-L-Phe-Gly-L-Pro + L-Phe-Gly-L-4-nitrophenylalanine-L-Ala	-	?	431312	
3.4.21.26	2-aminobenzoyl-Gly-L-Phe-L-Arg-L-Pro-L-4-nitrophenylalanine-L-Arg-L-Ala + H2O	-	Homo sapiens	2-aminobenzoyl-Gly-L-Phe-L-Arg-L-Pro + L-4-nitrophenylalanine-L-Arg-L-Ala	-	?	431313	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Arg-Pro-Phe(NO2)-Arg-Ala + H2O	-	Sus scrofa	2-aminobenzoyl-Gly-Phe-Arg-Pro + Phe(NO2)-Arg-Ala	-	?	365361	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Glu-Pro-Phe(NO2)-Arg-Ala + H2O	-	Sus scrofa	2-aminobenzoyl-Gly-Phe-Glu-Pro + Phe(NO2)-Arg-Ala	-	?	365362	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala + H2O	-	Pyrococcus furiosus	?	-	?	394129	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O	-	Sus scrofa	2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2	-	?	365312	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O	the enzyme binds no more than six residues, P4-P2' even from a longer substrate	Sus scrofa	2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2	-	?	365312	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	a fluorescence resonance energy transfer peptide	Sus scrofa	2-aminobenzoyl-Gly-Phe-Ser-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394130	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen	Sus scrofa	2-aminobenzoyl-Gly-Phe-Ser-Pro + Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394131	
3.4.21.26	2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-Gly-GLu-Ile-Lys-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen	Sus scrofa	2-aminobenzoyl-Gly-Phe-Ser-Pro + Phe-Arg-Ser-Ser-Arg-Ile-Gly-GLu-Ile-Lys-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394132	
3.4.21.26	2-aminobenzoyl-Gly-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	a fluorescence resonance energy transfer peptide	Sus scrofa	2-aminobenzoyl-Gly-Pro + Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394133	
3.4.21.26	2-aminobenzoyl-Gly-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen	Sus scrofa	2-aminobenzoyl-Gly-Pro + Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394133	
3.4.21.26	2-aminobenzoyl-Gly-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	a fluorescence resonance energy transfer peptide	Sus scrofa	2-aminobenzoyl-Gly-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394134	
3.4.21.26	2-aminobenzoyl-Gly-Pro-Phe-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	a fluorescence resonance energy transfer peptide	Sus scrofa	2-aminobenzoyl-Gly-Pro + Phe-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394135	
3.4.21.26	2-aminobenzoyl-Gly-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O	a fluorescence resonance energy transfer peptide	Sus scrofa	2-aminobenzoyl-Gly-Ser-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine	-	?	394136	
3.4.21.26	2-aminobenzoyl-L-Ser-L-Pro-L-4-nitrophenylalanine-L-Ala + H2O	-	Homo sapiens	2-aminobenzoyl-L-Ser-L-Pro + 4-nitrophenylalanine-L-Ala	-	?	431314	
3.4.21.26	2-aminobenzoyl-RPPGFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O	-	Homo sapiens	?	-	?	365317	
3.4.21.26	2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O	-	Homo sapiens	2-aminobenzoyl-RPP + GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)	-	?	365315	
3.4.21.26	2-aminobenzoyl-SPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O	-	Homo sapiens	?	-	?	365316	
3.4.21.26	4-((4-(dimethylamino)phenyl)azo)benzoyl-GPQGLLGA-L-glutamyl-gamma-(2-(1-sulfonyl-5-naphthyl)-aminoethylamide)-NH2 + H2O	-	Homo sapiens	?	-	?	431355	
3.4.21.26	Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O	about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Homo sapiens	Abz-Ala-Ala-Pro + 4-nitrophenylalanine	-	?	449420	
3.4.21.26	Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O	about 50% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Schistosoma mansoni	Abz-Ala-Ala-Pro + 4-nitrophenylalanine	-	?	449420	
3.4.21.26	Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O	about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Homo sapiens	Abz-Ala-Pro + L-Ala-4-nitrophenylalanine	-	?	449426	
3.4.21.26	Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O	about 27% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Schistosoma mansoni	Abz-Ala-Pro + L-Ala-4-nitrophenylalanine	-	?	449426	
3.4.21.26	Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O	about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Homo sapiens	Abz-Ala-Pro + Gly-4-nitrophenylalanine	-	?	449428	
3.4.21.26	Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O	about 40% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Schistosoma mansoni	Abz-Ala-Pro + Gly-4-nitrophenylalanine	-	?	449428	
3.4.21.26	Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O	about 2% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Homo sapiens	Abz-Gly-Gly-Pro + 4-nitrophenylalanine	-	?	449446	
3.4.21.26	Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O	about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Schistosoma mansoni	Abz-Gly-Gly-Pro + 4-nitrophenylalanine	-	?	449446	
3.4.21.26	Abz-Gly-L-Phe-L-Arg-L-Pro-L-Phe(NO2)-L-Arg-L-Ala + H2O	-	Homo sapiens	Abz-Gly-L-Phe-L-Arg-L-Pro + L-Phe(NO2)-L-Arg-L-Ala	-	?	431470	
3.4.21.26	Abz-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-L-Ser-L-Ser-L-Arg-L-Ile-Gly-L-Glu-L-Ile-L-Lys-L-Glu-L-Glu-L-Gln-N-(2,4-dinitrophenyl)-ethylenediamine + H2O	-	Homo sapiens	Abz-Gly-L-Phe-L-Ser-L-Pro + L-Phe-L-Arg-L-Ser-L-Ser-L-Arg-L-Ile-Gly-L-Glu-L-Ile-L-Lys-L-Glu-L-Glu-L-Gln-N-(2,4-dinitrophenyl)-ethylenediamine	-	?	431471	
3.4.21.26	Abz-Gly-Pro-4-nitrophenylalanine + H2O	about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Schistosoma mansoni	Abz-Gly-Pro + 4-nitrophenylalanine	-	?	449447	
3.4.21.26	Abz-Gly-Pro-4-nitrophenylalanine + H2O	about 7% activity compared to Abz-Lys-Pro-4-nitrophenylalanine	Homo sapiens	Abz-Gly-Pro + 4-nitrophenylalanine	-	?	449447	
3.4.21.26	Abz-Lys-Pro-4-nitrophenylalanine + H2O	100% activity	Homo sapiens	Abz-Lys-Pro + 4-nitrophenylalanine	-	?	449459	
3.4.21.26	Abz-Lys-Pro-4-nitrophenylalanine + H2O	100% activity	Schistosoma mansoni	Abz-Lys-Pro + 4-nitrophenylalanine	-	?	449459	
3.4.21.26	AbzGFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	AbzGFGP + FGF(p-NO2)A-NH2	-	?	412165	
3.4.21.26	Ac-CDPGYIGSR-NH2 + H2O	substrate specificity studies on membrane PE as compared with POP. ZPP-sensitive cleavage of both occurred	Sus scrofa	?	-	?	399834	
3.4.21.26	Ala-Ala-Pro-4-nitroanilide + H2O	-	Aspergillus niger	Ala-Ala-Pro + 4-nitroaniline	-	?	361592	
3.4.21.26	Ala-Gly-Pro-beta-naphthylamide + H2O	-	Lyophyllum cinerascens	Ala-Gly-Pro + 2-naphthylamine	-	?	365355	
3.4.21.26	Ala-Pro-4-nitroanilide + H2O	-	Pyrococcus furiosus	Ala-Pro + 4-nitroaniline	-	?	36580	
3.4.21.26	Ala-Pro-p-nitroanilide + H2O	-	Pyrococcus furiosus	Ala-Pro + p-nitroaniline	-	?	361609	
3.4.21.26	alpa2-antiplasmin + H2O	not a robust substrate in vitro, the enzyme cleaves after Pro12 in the T9S10G11P12-N13 Q14E15Q16E17 sequence	Homo sapiens	?	-	?	417883	
3.4.21.26	alpha-gliadin + H2O	i.e. PQPQLPYPQPQLPY	Sphaerobacter thermophilus	?	-	?	449547	
3.4.21.26	alpha-gliadin + H2O	i.e. PQPQLPYPQPQLPY	Sphaerobacter thermophilus DSM 20745	?	-	?	449547	
3.4.21.26	alpha-gliadin + H2O	i.e. PQPQLPYPQPQLPY	Sphaerobacter thermophilus S 6022	?	-	?	449547	
3.4.21.26	alpha-melanocyte-stimulating hormone + H2O	-	Mus musculus	?	-	?	393933	
3.4.21.26	alpha-melanocyte-stimulating hormone + H2O	-	Homo sapiens	?	-	?	393933	
3.4.21.26	alpha-melanocyte-stimulating hormone + H2O	-	Rattus norvegicus	?	-	?	393933	
3.4.21.26	alpha-melanocyte-stimulating hormone + H2O	-	Sus scrofa	?	-	?	393933	
3.4.21.26	alpha-melanocyte-stimulating hormone + H2O	acetyl-SYSMEHFRWGKPV	Schistosoma mansoni	acetyl-SYSMEHFRWGKP + L-Val	-	?	449550	
3.4.21.26	alpha-MSH(1-13) + H2O	increased ratio between substrate and product in pituitaries of prolyl endopeptidase deficient mice compared to wild type mice	Mus musculus	alpha-MSH(1-12) + Pro	-	?	411614	
3.4.21.26	alpha-synuclein + H2O	-	Homo sapiens	?	-	?	402418	
3.4.21.26	alpha-synulein + H2O	the enzyme binds to alpha-synuclein and enhances its dimerization	Sus scrofa	?	-	?	430877	
3.4.21.26	alpha2-gliadin 33-mer + H2O	the enzyme is able to break down 63% of the 33-mer after 8 h of incubation and it is almost completely degraded after 12 h	Myxococcus xanthus	?	-	?	431587	
3.4.21.26	angiotensin I + H2O	-	Mus musculus	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Homo sapiens	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Rattus norvegicus	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Bos taurus	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Oryctolagus cuniculus	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Canis lupus familiaris	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Elizabethkingia meningoseptica	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	-	Sus scrofa	?	-	?	16449	
3.4.21.26	angiotensin I + H2O	DRVYIHPFHL	Schistosoma mansoni	DRVYIHP + FHL	-	?	449566	
3.4.21.26	angiotensin II + H2O	-	Mus musculus	?	-	?	16269	
3.4.21.26	angiotensin II + H2O	-	Homo sapiens	?	-	?	16269	
3.4.21.26	angiotensin II + H2O	-	Rattus norvegicus	?	-	?	16269	
3.4.21.26	angiotensin II + H2O	-	Ovis aries	?	-	?	16269	
3.4.21.26	angiotensin II + H2O	-	Sus scrofa	?	-	?	16269	
3.4.21.26	angiotensin II + H2O	DRVYIHPF	Schistosoma mansoni	DRVYIHP + L-Phe	-	?	448449	
3.4.21.26	Arg-Pro-4-nitroanilide + H2O	-	Pyrococcus furiosus	Arg-Pro + 4-nitroaniline	-	?	36585	
3.4.21.26	Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O	i.e. alphaS1-casein(1-9), cleavage at Pro5-Ile6	Lactobacillus helveticus	Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln	-	?	365357	
3.4.21.26	Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O	i.e. alphaS1-casein(1-9), cleavage at Pro5-Ile6	Lactobacillus helveticus CNRZ32	Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln	-	?	365357	
3.4.21.26	Arg-Pro-p-nitroanilide + H2O	-	Pyrococcus furiosus	Arg-Pro + p-nitroaniline	-	?	361608	
3.4.21.26	arginine-vasopressin + H2O	-	Mus musculus	?	-	?	393942	
3.4.21.26	arginine-vasopressin + H2O	-	Homo sapiens	?	-	?	393942	
3.4.21.26	arginine-vasopressin + H2O	-	Rattus norvegicus	?	-	?	393942	
3.4.21.26	arginine-vasopressin + H2O	-	Sus scrofa	?	-	?	393942	
3.4.21.26	Asp-Pro-4-nitroanilide + H2O	-	Pyrococcus furiosus	Asp-Pro + 4-nitroaniline	-	?	73940	
3.4.21.26	Asp-Pro-p-nitroanilide + H2O	-	Pyrococcus furiosus	Asp-Pro + p-nitroaniline	-	?	364859	
3.4.21.26	azocasein + H2O	-	Pyrococcus furiosus	?	-	?	15347	
3.4.21.26	azocasein + H2O	poor substrate	Pyrococcus furiosus	?	-	?	15347	
3.4.21.26	barley malt + H2O	-	Sphaerobacter thermophilus	?	-	?	449626	
3.4.21.26	barley malt + H2O	-	Sphaerobacter thermophilus DSM 20745	?	-	?	449626	
3.4.21.26	barley malt + H2O	-	Sphaerobacter thermophilus S 6022	?	-	?	449626	
3.4.21.26	benzyloxycarbonyl-Ala-Ala-4-nitroanilide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Ala-Ala + 4-nitroaniline	-	?	423061	
3.4.21.26	benzyloxycarbonyl-Ala-Ala-beta-naphthylamide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Ala-Ala + beta-naphthylamine	-	?	365347	
3.4.21.26	benzyloxycarbonyl-Ala-Ala-p-nitroanilide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Ala-Ala + p-nitroaniline	-	?	365311	
3.4.21.26	benzyloxycarbonyl-Ala-Ala-p-nitrophenol + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Ala-Ala + p-nitrophenol	-	?	365348	
3.4.21.26	benzyloxycarbonyl-Ala-Gly-Pro-beta-naphthylamide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Ala-Gly-Pro + beta-naphthylamine	-	?	365351	
3.4.21.26	benzyloxycarbonyl-Ala-Gly-Pro-beta-naphthylamide + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Ala-Gly-Pro + beta-naphthylamine	-	?	365351	
3.4.21.26	benzyloxycarbonyl-Ala-Gly-Pro-p-nitrophenol + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Ala-Gly-Pro + p-nitrophenol	-	?	365332	
3.4.21.26	benzyloxycarbonyl-Ala-Pro-2-naphthylamide + H2O	-	Mus musculus	?	-	?	65058	
3.4.21.26	benzyloxycarbonyl-Ala-Pro-4-nitroanilide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Ala-Pro + 4-nitroaniline	-	?	423062	
3.4.21.26	benzyloxycarbonyl-Ala-Pro-beta-naphthylamide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Ala-Pro + beta-naphthylamine	-	?	365349	
3.4.21.26	benzyloxycarbonyl-Ala-Pro-p-nitroanilide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Ala-Pro + p-nitroaniline	-	?	365309	
3.4.21.26	benzyloxycarbonyl-Ala-Pro-p-nitroanilide + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Ala-Pro + p-nitroaniline	-	?	365309	
3.4.21.26	benzyloxycarbonyl-Ala-Pro-p-nitrophenol + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Ala-Pro + p-nitrophenol	-	?	365330	
3.4.21.26	benzyloxycarbonyl-D-Ala-Gly-Pro-beta-naphthylamide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-D-Ala-Gly-Pro + beta-naphthylamine	-	?	365352	
3.4.21.26	benzyloxycarbonyl-D-Ala-Gly-Pro-beta-naphthylamide + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-D-Ala-Gly-Pro + beta-naphthylamine	-	?	365352	
3.4.21.26	benzyloxycarbonyl-D-Ala-Gly-Pro-p-nitrophenol + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-D-Ala-Gly-Pro + p-nitrophenol	-	?	365333	
3.4.21.26	benzyloxycarbonyl-D-Ala-Pro-beta-naphthylamide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-D-Ala-Pro + beta-naphthylamine	-	?	365350	
3.4.21.26	benzyloxycarbonyl-Gly-Gly-Pro-p-nitrophenol + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Gly-Pro + p-nitrophenol	-	?	365331	
3.4.21.26	benzyloxycarbonyl-Gly-Gly-Pro-p-nitrophenol + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Gly-Pro + p-nitrophenol	-	?	365331	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-2-naphthylamide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Gly-L-Pro + 2-naphthylamine	-	?	384269	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	?	-	?	384284	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Elizabethkingia meningoseptica	?	-	?	384284	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?	418490	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Eurygaster integriceps	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?	418490	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Coprinopsis clastophylla	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?	418490	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Sphaerobacter thermophilus	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?	418490	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Sphaerobacter thermophilus DSM 20745	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?	418490	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O	-	Sphaerobacter thermophilus S 6022	benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline	-	?	418490	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Sus scrofa	?	-	?	384285	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	384286	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Coprinopsis clastophylla	benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	384286	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-beta-naphthylamide + H2O	-	Mus musculus	?	-	?	384287	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-doxorubicin + H2O	-	Homo sapiens	benzyloxycarbonyl-Gly-L-Pro + doxorubicin	-	?	384288	
3.4.21.26	benzyloxycarbonyl-Gly-L-Pro-melphalan + H2O	-	Homo sapiens	benzyloxycarbonyl-Gly-L-Pro + melphalan	-	?	384289	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O	-	Mus musculus	?	-	?	65057	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O	-	Bos taurus	?	-	?	65057	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O	-	Agaricus bisporus	?	-	?	65057	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O	-	Aeromonas hydrophila	?	-	?	65057	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-2-naphthylamide + H2O	-	Rattus norvegicus	benzyloxycarbonyl-Gly-Pro + 2-naphthylamine	-	?	365327	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-2-naphthylamide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Gly-Pro + 2-naphthylamine	-	?	365327	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O	-	Mus musculus	?	-	?	65059	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O	-	Homo sapiens	?	-	?	65059	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin	-	?	365345	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin	-	?	365345	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O	-	Aspergillus niger	benzyloxycarbonyl-Gly-Pro + 4-nitroaniline	-	?	394270	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Gly-Pro + 4-nitroaniline	-	?	394270	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O	-	Flavobacterium sp.	benzyloxycarbonyl-Gly-Pro + 4-nitroaniline	-	?	394270	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Gly-Pro + 4-nitrophenol	-	?	394271	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Ala + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Ala	-	?	365334	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Ala + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + Ala	-	?	365334	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Ala + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Ala	-	?	365334	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Agaricus bisporus	benzyloxycarbonyl-Gly-Pro + beta-naphthylamine	-	?	365346	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + beta-naphthylamine	-	?	365346	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + beta-naphthylamine	-	?	365346	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Sus scrofa	benzyloxycarbonyl-Gly-Pro + beta-naphthylamine	-	?	365346	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Mus musculus	benzyloxycarbonyl-Gly-Pro + 2-naphthylamine	-	?	365358	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O	-	Sus scrofa	benzyloxycarbonyl-Gly-Pro + 2-naphthylamine	-	?	365358	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-D-Ala + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + D-Ala	-	?	365335	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-D-Leu + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + D-Leu	-	?	365338	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Leu	-	?	365337	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + Leu	-	?	365337	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu	-	?	365337	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Leu-Ala	-	?	365340	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + Leu-Ala	-	?	365340	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu-Ala	-	?	365340	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Leu-D-Ala	-	?	365341	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + Leu-D-Ala	-	?	365341	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu-D-Ala	-	?	365341	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Leu-Gly	-	?	365339	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + Leu-Gly	-	?	365339	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu-Gly	-	?	365339	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Leu-Gly-Ala	-	?	365343	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu-Gly-Ala	-	?	365343	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly-D-Ala + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu-Gly-D-Ala	-	?	365344	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Leu-Gly-Gly	-	?	365342	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Leu-Gly-Gly	-	?	365342	
3.4.21.26	Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O	-	Lyophyllum cinerascens	Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro	-	?	17153	
3.4.21.26	Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O	enzyme from kidney	Ovis aries	Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro	-	?	17153	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Gly-Pro + p-nitroaniline	-	?	365310	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + p-nitroaniline	-	?	365310	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + p-nitroaniline	-	?	365310	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + p-nitrophenol	-	?	365329	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O	-	Sus scrofa	benzyloxycarbonyl-Gly-Pro + p-nitrophenol	-	?	365329	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + p-nitrophenol	-	?	365329	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Phe + H2O	-	Elizabethkingia meningoseptica	benzyloxycarbonyl-Gly-Pro + Phe	-	?	365336	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Phe + H2O	-	Lyophyllum cinerascens	benzyloxycarbonyl-Gly-Pro + Phe	-	?	365336	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-Phe + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Gly-Pro + Phe	-	?	365336	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-SBzl + H2O	-	Sus scrofa	benzyloxycarbonyl-Gly-Pro + phenyl-methanethiol	-	?	365359	
3.4.21.26	benzyloxycarbonyl-Gly-Pro-thiobenzyl ester + H2O	-	Pyrococcus furiosus	benzyloxycarbonyl-Gly-Pro + phenylmethanethiol	-	?	394272	
3.4.21.26	benzyloxycarbonyl-glycyl-l-prolyl-4-nitroanilide + H2O	-	Elizabethkingia meningoseptica	?	-	?	394273	
3.4.21.26	benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O	-	Ovis aries	?	-	?	65056	
3.4.21.26	benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O	-	Pyrococcus furiosus	?	-	?	65056	
3.4.21.26	benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O	-	Trichormus variabilis	?	-	?	65056	
3.4.21.26	benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O	-	Elizabethkingia meningoseptica	?	-	?	65056	
3.4.21.26	benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O	-	Novosphingobium capsulatum	?	-	?	65056	
3.4.21.26	benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O	-	Trichormus variabilis ATC29413	?	-	?	65056	
3.4.21.26	benzyloxycarbonyl-L-Ala-L-Ala-L-Pro p-nitroanilide + H2O	-	Pseudomonas sp.	?	-	?	65060	
3.4.21.26	benzyloxycarbonyl-L-Ala-L-Ala-L-Pro p-nitroanilide + H2O	-	Pseudomonas sp. KU-22	?	-	?	65060	
3.4.21.26	benzyloxycarbonyl-Pro-p-nitrophenol + H2O	enzyme from kidney	Ovis aries	benzyloxycarbonyl-Pro + p-nitrophenol	-	?	365328	
3.4.21.26	beta-amyloid + H2O	-	Homo sapiens	?	-	?	384309	
3.4.21.26	beta-endorphin + H2O	-	Mus musculus	?	-	?	367385	
3.4.21.26	beta-endorphin + H2O	-	Homo sapiens	?	-	?	367385	
3.4.21.26	beta-endorphin + H2O	-	Rattus norvegicus	?	-	?	367385	
3.4.21.26	beta-endorphin + H2O	-	Sus scrofa	?	-	?	367385	
3.4.21.26	beta-endorphin + h2O	-	Trypanosoma brucei brucei	Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro + Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala + Ile-Ile-Lys-Asn-Ala + Tyr-Lys-Lys-Gly-Glu	-	?	445994	
3.4.21.26	bradykinin + H2O	-	Mus musculus	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Homo sapiens	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Rattus norvegicus	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Bos taurus	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Oryctolagus cuniculus	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Ovis aries	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Canis lupus familiaris	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Elizabethkingia meningoseptica	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Sus scrofa	?	-	?	16889	
3.4.21.26	bradykinin + H2O	-	Trypanosoma brucei brucei	Arg-Pro-Pro + Gly-Phe-Ser-Pro + Phe-Arg	-	?	445995	
3.4.21.26	bradykinin + H2O	RPPGFSPFR	Schistosoma mansoni	RPP + GFSP + L-Phe-L-Arg	-	?	449716	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Mus musculus	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Homo sapiens	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Rattus norvegicus	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Bos taurus	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Oryctolagus cuniculus	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Canis lupus familiaris	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Elizabethkingia meningoseptica	?	-	?	410767	
3.4.21.26	bradykinin potentiating peptide + H2O	-	Sus scrofa	?	-	?	410767	
3.4.21.26	calcitonin gene-related peptide + H2O	assay at pH 7.0, 37°C	Mus musculus	?	-	?	393950	
3.4.21.26	casein + H2O	-	Aspergillus oryzae	?	-	?	15445	
3.4.21.26	Collagen + H2O	-	Mus musculus	?	-	?	16347	
3.4.21.26	Collagen + H2O	-	Aspergillus oryzae	?	-	?	16347	
3.4.21.26	Collagen + H2O	the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells	Trypanosoma cruzi	?	-	?	16347	
3.4.21.26	Collagen + H2O	host-derived substrate	Trypanosoma cruzi	?	-	?	16347	
3.4.21.26	collagen + H2O	after enzyme activation with LPS	Homo sapiens	N-acetyl-Pro-Gly-Pro + ?	-	?	411882	
3.4.21.26	collagen + H2O	after enzyme activation with LPS	Homo sapiens	Pro-Gly-Pro + ?	-	?	411883	
3.4.21.26	collagen I + H2O	assay at pH 8.0, 37°C	Trypanosoma brucei brucei	?	-	?	36832	
3.4.21.26	collagens + H2O	in host extracellular matrix	Trypanosoma cruzi	?	-	?	393958	
3.4.21.26	collagens + H2O	mammalian substrate	Trypanosoma cruzi	?	-	?	393958	
3.4.21.26	DRVYIHPF + H2O	-	Bos taurus	DRVYIHP + L-Phe	-	?	65077	
3.4.21.26	EYYDPNYLRT + H2O	-	Elizabethkingia meningoseptica	EYDP + NYLRT	-	?	65070	
3.4.21.26	Fibronectin + H2O	in host extracellular matrix	Trypanosoma cruzi	?	-	?	15394	
3.4.21.26	Fibronectin + H2O	the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells	Trypanosoma cruzi	?	-	?	15394	
3.4.21.26	Fibronectin + H2O	host-derived substrate	Trypanosoma cruzi	?	-	?	15394	
3.4.21.26	Fibronectin + H2O	mammalian substrate	Trypanosoma cruzi	?	-	?	15394	
3.4.21.26	fish muscle collagen + H2O	the enzyme hydrolysis site is at the carboxyl terminus of prolyl residues	Decapterus maruadsi	?	-	?	448587	
3.4.21.26	furylacryloyl-Ala-Pro + H2O	-	Escherichia coli	?	-	?	65069	
3.4.21.26	FVNEHLCGSHLVQALTLVCGQRGFFYTPLA + H2O	-	Bos taurus	FVNEHLCGSHLVQALTLVCGQRGFFYTP + LA	-	?	65076	
3.4.21.26	gamma-hordein + H2O	i.e. SQQQFPQPQQPFPQQP	Sphaerobacter thermophilus	?	-	?	449939	
3.4.21.26	gamma-hordein + H2O	i.e. SQQQFPQPQQPFPQQP	Sphaerobacter thermophilus DSM 20745	?	-	?	449939	
3.4.21.26	gamma-hordein + H2O	i.e. SQQQFPQPQQPFPQQP	Sphaerobacter thermophilus S 6022	?	-	?	449939	
3.4.21.26	GEPGPPGPA + H2O	-	Homo sapiens	GEP + GPPGP + L-Ala	-	?	431876	
3.4.21.26	GFSPFRQED + H2O	-	Homo sapiens	GFSP + FRQED	-	?	431882	
3.4.21.26	Gliadin + H2O	digestion of the gliadin peptide in short peptides with both enzymes S28A and S28B, occur from its N terminus	Aspergillus oryzae	?	-	?	16536	
3.4.21.26	gliadins + H2O	in host gut	Elizabethkingia meningoseptica	?	-	?	393996	
3.4.21.26	gliadins + H2O	mammalian substrate	Elizabethkingia meningoseptica	?	-	?	393996	
3.4.21.26	gluten + H2O	-	Aspergillus niger	?	-	?	393997	
3.4.21.26	gluten + H2O	-	Pyrococcus furiosus	?	-	?	393997	
3.4.21.26	gluten + H2O	-	Myxococcus xanthus	?	-	?	393997	
3.4.21.26	gluten + H2O	-	Elizabethkingia meningoseptica	?	-	?	393997	
3.4.21.26	gluten + H2O	-	Novosphingobium capsulatum	?	-	?	393997	
3.4.21.26	gluten + H2O	-	Eurygaster integriceps	?	-	?	393997	
3.4.21.26	gluten + H2O	activity in the human host gastrointestinal tract, overview	Aspergillus niger	?	-	?	393997	
3.4.21.26	gluten + H2O	degradation of gluten in the human host's intestinal tract, i.e. stomach, duodenum, jejunum, and ileum	Aspergillus niger	?	-	?	393997	
3.4.21.26	gluten + H2O	determination of activity in a dynamic system that closely mimics the human gastrointestinal tract, overview	Aspergillus niger	?	-	?	393997	
3.4.21.26	gluten peptide + H2O	-	Pyrococcus furiosus	?	-	?	393998	
3.4.21.26	gluten peptide + H2O	-	Myxococcus xanthus	?	-	?	393998	
3.4.21.26	gluten peptide + H2O	-	Elizabethkingia meningoseptica	?	-	?	393998	
3.4.21.26	gluten peptide + H2O	-	Novosphingobium capsulatum	?	-	?	393998	
3.4.21.26	gluten peptides + H2O	-	Aspergillus niger	?	-	?	393999	
3.4.21.26	gluten peptides + H2O	activity in the human host gastrointestinal tract, overview	Aspergillus niger	?	-	?	393999	
3.4.21.26	gluten peptides + H2O	degradation of gluten peptides in the human host's intestinal tract, i.e. stomach, duodenum, jejunum, and ileum	Aspergillus niger	?	-	?	393999	
3.4.21.26	gluten peptides + H2O	determination of activity in a dynamic system that closely mimics the human gastrointestinal tract, overview	Aspergillus niger	?	-	?	393999	
3.4.21.26	Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	Gly-L-Pro + 4-nitroaniline	-	?	405299	
3.4.21.26	Gly-L-Pro-4-nitroanilide + H2O	-	Rattus norvegicus	Gly-L-Pro + 4-nitroaniline	-	?	405299	
3.4.21.26	Gly-L-Pro-4-nitroanilide + H2O	-	Amanita bisporigera	Gly-L-Pro + 4-nitroaniline	-	?	405299	
3.4.21.26	Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Mus musculus	Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	405301	
3.4.21.26	Gly-Pro-4-methoxy-beta-naphthylamide + H2O	-	Mus musculus	Gly-Pro + 4-methoxy-beta-naphthylamine	-	?	381976	
3.4.21.26	Gly-Pro-4-nitroanilide + H2O	-	Pyrococcus furiosus	Gly-Pro + 4-nitroaniline	-	?	36559	
3.4.21.26	Gly-Pro-4-nitrophenyl ester + H2O	-	Sus scrofa	Gly-Pro + 4-nitrophenol	-	?	449992	
3.4.21.26	Gly-Pro-4-nitrophenyl ester + H2O	-	Homo sapiens	Gly-Pro + 4-nitrophenol	-	?	449992	
3.4.21.26	Gly-Pro-p-nitroanilide + H2O	-	Pyrococcus furiosus	Gly-Pro + p-nitroaniline	-	?	361612	
3.4.21.26	GnRH + H2O	-	Trypanosoma brucei brucei	pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro + Gly-NH2	-	?	412112	
3.4.21.26	gonadotropin releasing hormone + H2O	-	Mus musculus	?	-	?	394000	
3.4.21.26	gonadotropin releasing hormone + H2O	-	Homo sapiens	?	-	?	394000	
3.4.21.26	gonadotropin releasing hormone + H2O	-	Rattus norvegicus	?	-	?	394000	
3.4.21.26	gonadotropin releasing hormone + H2O	-	Sus scrofa	?	-	?	394000	
3.4.21.26	GTAGPNQEQE + H2O	-	Homo sapiens	GTAGP + NQEQE	-	?	431926	
3.4.21.26	GTSGPNQEQE + H2O	-	Homo sapiens	GTSGP + NQEQE	-	?	431928	
3.4.21.26	H-(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412124	
3.4.21.26	H-Abz-GFGP-OH + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412125	
3.4.21.26	H-Abz-GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412126	
3.4.21.26	H-F(p-NO2)GFGP-OH + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412127	
3.4.21.26	H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-HMBA-PEGA + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-HMBA-PEGA	-	?	412128	
3.4.21.26	H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-NH2	-	?	412129	
3.4.21.26	H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-HMBA-PEGA + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-HMBA-PEGA	-	?	412130	
3.4.21.26	H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-NH2	-	?	412131	
3.4.21.26	H-F(p-NO2)GFGPFGK(Abz)A-HMBA-PEGA + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	H-F(p-NO2)GFGP + FGK(Abz)A-HMBA-PEGA	-	?	412132	
3.4.21.26	H-F(p-NO2)GFGPFGK(Abz)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	H-F(p-NO2)GFGP + FGK(Abz)A-NH2	-	?	412133	
3.4.21.26	H-FGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412134	
3.4.21.26	H-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412135	
3.4.21.26	H-MDPVDPNIE-OH + H2O	substrate specificity studies on membrane PE as compared with POP. ZPP-sensitive cleavage of both occurred	Sus scrofa	?	-	?	401106	
3.4.21.26	H-O2Oc-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412136	
3.4.21.26	H2N-QLQPFPQPQLPY-OH + H2O	substrate specificity studies on membrane PE as compared with POP. ZPP-sensitive cleavage of both occurred	Sus scrofa	?	-	?	401108	
3.4.21.26	hemoglobin beta-chain + H2O	-	Sus scrofa	?	-	?	65046	
3.4.21.26	IGF-1 + H2O	H-Gly-Pro-Glu-OH	Myxococcus xanthus	?	-	?	397457	
3.4.21.26	IGF-1 + H2O	H-Gly-Pro-Glu-OH	Myxococcus xanthus ATCC 25232	?	-	?	397457	
3.4.21.26	insulin + H2O	-	Ovis aries	?	-	?	36836	
3.4.21.26	insulin + H2O	-	Elizabethkingia meningoseptica	?	-	?	36836	
3.4.21.26	ISRPPGFSPFR + H2O	-	Bos taurus	ISRPP + GFSPFR	-	?	65075	
3.4.21.26	IWGIGCNPWTAEHVDQTLASGNDIC + H2O	a peptide with 25 amino acids (25mer, sequence IWGIGCNPWTAEHVDQTLASGNDIC) is utilized by the enzyme as a substrate for the macrocyclization reaction. During the macrocyclase reaction, the enzyme generates an eight-amino acid cyclic peptide from the N-terminal residues (the core, sequence IWGIGCNP), cleaving off the 17-C-terminal amino acid recognition sequence (peptide tail, sequence WTAEHVDQTLASGNDIC)	Galerina marginata	cyclic IWGIGCNP + WTAEHVDQTLASGNDIC	-	?	450096	
3.4.21.26	L-Ala-4-nitroanilide + H2O	-	Pleurotus eryngii	L-Ala + 4-nitroaniline	-	?	382096	
3.4.21.26	L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae	L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline	-	?	450124	
3.4.21.26	L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae	L-Ala-L-Ala-L-Pro + 4-nitroaniline	-	?	384970	
3.4.21.26	L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae WX2011	L-Ala-L-Ala-L-Pro + 4-nitroaniline	-	?	384970	
3.4.21.26	L-Ala-L-Pro-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae	L-Ala-L-Pro-L-Pro + 4-nitroaniline	-	?	450125	
3.4.21.26	L-His-4-nitroanilide + H2O	worst substrate	Pleurotus eryngii	L-His + 4-nitroaniline	-	?	450162	
3.4.21.26	L-Leu-4-nitroanilide + H2O	-	Pleurotus eryngii	L-Leu + 4-nitroaniline	-	?	364760	
3.4.21.26	L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O	about 3% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin	Schistosoma mansoni	L-Lys-L-Pro + 7-amino-4-methylcoumarin	-	?	450173	
3.4.21.26	L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O	about 5% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin	Homo sapiens	L-Lys-L-Pro + 7-amino-4-methylcoumarin	-	?	450173	
3.4.21.26	L-Met-4-nitroanilide + H2O	-	Pleurotus eryngii	L-Met + 4-nitroaniline	-	?	382149	
3.4.21.26	L-Phe-4-nitroanilide + H2O	best substrate	Pleurotus eryngii	L-Phe + 4-nitroaniline	-	?	382152	
3.4.21.26	L-Pro-4-nitroanilide + H2O	-	Pleurotus eryngii	L-Pro + 4-nitroaniline	-	?	382167	
3.4.21.26	L-Tyr-4-nitroanilide + H2O	second best substrate	Pleurotus eryngii	L-Tyr + 4-nitroaniline	-	?	382184	
3.4.21.26	LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF + H2O	-	Aspergillus oryzae	?	-	?	450236	
3.4.21.26	Luliberin + H2O	-	Mus musculus	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Homo sapiens	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Rattus norvegicus	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Bos taurus	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Oryctolagus cuniculus	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Canis lupus familiaris	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Elizabethkingia meningoseptica	?	-	?	16614	
3.4.21.26	Luliberin + H2O	-	Sus scrofa	?	-	?	16614	
3.4.21.26	luteinizing-hormone-releasing hormone + H2O	pEHWSYGLRPG	Schistosoma mansoni	pEHWSYGLRP + Gly	-	?	450240	
3.4.21.26	LVVYPWTQRF + H2O	-	Elizabethkingia meningoseptica	LVVYP + WTQRF	-	?	365314	
3.4.21.26	LVVYPWTQRF + H2O	prolyl endopeptidase activity could be the first step of the degradation of LVV-hemorphin-7	Elizabethkingia meningoseptica	LVVYP + WTQRF	-	?	365314	
3.4.21.26	Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	as active as potentiator B	Homo sapiens	Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg	-	?	365325	
3.4.21.26	Me-O-succinyl-Ala-Ala-Val p-nitroanilide + H2O	-	Bos taurus	Me-O-succinyl-Ala-Ala + Val p-nitroanilide	-	?	65073	
3.4.21.26	melanotropin + H2O	-	Mus musculus	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Homo sapiens	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Rattus norvegicus	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Bos taurus	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Oryctolagus cuniculus	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Canis lupus familiaris	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Elizabethkingia meningoseptica	?	-	?	410897	
3.4.21.26	melanotropin + H2O	-	Sus scrofa	?	-	?	410897	
3.4.21.26	membrane-associated glycoprotein neural cell adhesion molecule + H2O	-	Homo sapiens	?	-	?	448766	
3.4.21.26	Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O	as active as potentiator B	Homo sapiens	Met-Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg	-	?	365326	
3.4.21.26	additional information	-	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	-	Agaricus bisporus	?	-	?	89	
3.4.21.26	additional information	requirement for a trans peptide bond immediately preceding the active bond	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	cleavage of Pro-X bond	Ovis aries	?	-	?	89	
3.4.21.26	additional information	cleavage of Pro-X bond	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	and more slowly Ala-X bond	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	succinyl and isoaspartyl containing	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	not: (7-D-Pro)oxytocin and high molecular weight proteins even after denaturation	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	substrate specificity, overview	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	no activity with Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr and pGly-His-Trp-Ser-tyr-Gly-leu-Arg-Pro-Gly-NH2	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	no hydrolysis of benzyloxycarbonyl-D-Pro-p-nitrophenol, negligibly small hydrolysis rate with benzyloxycarbonyl-D-Ala-Pro-p-nitrophenol	Ovis aries	?	-	?	89	
3.4.21.26	additional information	no hydrolysis of Pro-beta-naphthylamide, benzyloxycarbonyl-Pro-beta-naphthylamide, benzyloxycarbonyl-Ala-p-nitrophenol, Gly-Prp-beta-naphthylamide, Ala-Ala-beta-naphthylamide, benzyloxycarbonyl-Gly-Pro-D-Ala	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	no hydrolysis of Pro-beta-naphthylamide, benzyloxycarbonyl-Pro-beta-naphthylamide, Gly-Pro-beta-naphthylamide, benzyloxycarbonyl-Gly-D-Pro-p-nitroanilide, benzyloxycarbonyl-D-Ala-Pro-beta-naphthylamide and benzyloxycarbonyl-Gly-Pro-D-Ala	Lyophyllum cinerascens	?	-	?	89	
3.4.21.26	additional information	specifically hydrolyzes Pro-Xaa bonds, exerts a low specificity towards residues in position P1', except for Glu and P2 and does not cleave the proline bonds in long substrates such as ribonuclease	Xanthomonas sp.	?	-	?	89	
3.4.21.26	additional information	the enzyme plays a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)	Lactobacillus helveticus	?	-	?	89	
3.4.21.26	additional information	tissue-dependent peptide hydrolysis evoked by prolyl endopeptidase activity is involved in the water-electrolyte homeostasis	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	enzyme regulation, overview	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	splice variant PRPL A, no cleavage of peptide substrates containing a P1 basic residue, very slow reaction with activated ester substrate 4-methylumbelliferyl-p-guanidinobenzoate	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	substrates require a proline in position P1, with the exception of N-succinyl-L-Ala-L-Ala-L-Ala-7-amino-4-methylcoumarin	Trypanosoma cruzi	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview	Pyrococcus furiosus	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview	Myxococcus xanthus	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview	Dictyostelium discoideum	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview	Platyrrhini	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview	Mus musculus	?	-	?	89	
3.4.21.26	additional information	cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in neuronal degeneration and Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	enzyme inhibition leads to inhibition of lithium effects, the loss of enzyme activity evokes a 4fold increase in the inositol-3-phosphate concentration counteracting the Li+ ions, enzyme regulation, overview	Dictyostelium discoideum	?	-	?	89	
3.4.21.26	additional information	enzyme inhibitors are able to prevent the in vitro invasion of rodent muscle cells by trypomastigotes	Trypanosoma cruzi	?	-	?	89	
3.4.21.26	additional information	POP activity levels are lowered in different stages of depression, whereas activity is increased in patients with mania and schizophrenia, the antidepressant fluoxetine and the antimanic drug valproic acid both restore POP activity to normal levels	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme in the brain dopaminergix system is involved in the pathogenesis of doamine deficiency-dependent depressive states, and is activated in association with development of MPTP-induced depressive syndrome in the brain frontal cortex, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme induces cleavage of gluten-derived peptides predigested by pepsin and pancreatic enzymes an exhibiting a detoxifying effect in the host's gut	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	the enzyme is a proline-specific endopeptidase with a serine-type mechanism	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation probably involving gluten, prep expression is downregulated in coelic disease patients in complete remission, overview	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview	Mus musculus	?	-	?	89	
3.4.21.26	additional information	the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	the enzyme is associated with cognitive functions and inositol 1,4,5-triphosphate signaling, and plays a role in modifying neuropeptide levels, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition also positively affects neurodiseases, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition positively affects neurodiseases, overview	Mus musculus	?	-	?	89	
3.4.21.26	additional information	the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition positively affects neurodiseases, overview	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme is involved with the inactivation of regulatory neuropeptides	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme is involved with the inactivation of regulatory neuropeptides, enzyme activity is correlated to an increase in protein secretion, suggesting that the enzyme may be involved in regulating secretory processes	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme plays a role in inositol 1,4,5-triphosphate signaling and in the actions of antidepressants, POP inhibitors have antiamnesic and neuroprotective properties, overview	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme plays a role in inositol 1,4,5-triphosphate signaling and in the actions of antidepressants, POP inhibitors have antiamnesic and neuroprotective properties, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme removes most of the gut-digestion-resistant gliadin peptides in the host gut luman of coeliac disease patients, overview, enzyme regulation, overview	Flavobacterium sp.	?	-	?	89	
3.4.21.26	additional information	no activity with gluten in celiac sprue patients, substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	no activity with gluten in celiac sprue patients, substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	no activity with gluten in celiac sprue rats, substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	POP is a proline-specific peptidase that hydrolyzes oligopeptides after prolyl residues, the S1 binding site of POP has evolved to fit the pyrrolidine ring of an L-prolyl residue	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Mus musculus	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Pyrococcus furiosus	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Dictyostelium discoideum	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Myxococcus xanthus	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Platyrrhini	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	substrate specificity with exclusion of peptides with more than 30 amino acids, overview	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids	Mus musculus	?	-	?	89	
3.4.21.26	additional information	substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	substrate specificity, overview, the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, the S2' subsite had the highest specificity of the S1'-S3' subsites, this subsite prefers Pro residues, followed by Leu, Met, Phe, and Ala residues, the S1' subsite has lower specificity than the S2', with the strongest preference for hydrophobic, e.g. Leu, and aromatic, e.g. Phe, residues, and the greatest discrimination against Pro residues	Elizabethkingia meningoseptica	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves at the C-terminal side of proline residues, the bacterial enzyme is also capable of cleaving Ala-Xaa and Val-Xaa bonds, no activity with large proteins with over 30 amino acids	Flavobacterium sp.	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves at the C-terminal side of proline residues, the bacterial enzyme is also capable of cleaving Ala-Xaa and Val-Xaa bonds, no activity with large proteins with over 30 amino acids	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, and hydrolyse several peptide hormones and neuropeptides in vitro	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, general acid/base catalysis is the rate-limiting step, overview	Pyrococcus furiosus	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, overview	Trypanosoma cruzi	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, overview	Myxococcus xanthus	?	-	?	89	
3.4.21.26	additional information	the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, the loops connecting the peptidase and propeller domains act like a hinge, holding the structure together as the domains move apart, creating a large opening, overview	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Mus musculus	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Pyrococcus furiosus	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Dictyostelium discoideum	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Myxococcus xanthus	?	-	?	89	
3.4.21.26	additional information	the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	the enzyme shows endopeptidase activity with peptides no longer than 3 amino acids	Mus musculus	?	-	?	89	
3.4.21.26	additional information	the enzyme shows endopeptidase activity with peptides no longer than 3 amino acids	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	the enzyme shows endopeptidase activity with peptides no longer than 30 amino acids	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the serine protease cleaves at the C-terminal side of proline residues and more slowly of alanine residues of peptides with no more than 30 amino acids	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	ability to cleave immunotoxic gluten peptides endoproteolytically, attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten	Novosphingobium capsulatum	?	-	?	89	
3.4.21.26	additional information	cleaves short proline-containing neuropeptides, and is involved in memory and learning	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	hydrolyzes proline-containing peptides shorter than 30 amino acids	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	is involved in thalamocortical and corticothalamic signal processing	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	prolyl oligopeptidase binds to the growth-38 associated protein GAP-43, which is a key regulator of synaptic plasticity	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	stimulates the aggregation of alpha-synuclein	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	leginsulin appears to be a possible candidate for the POP substrate	Arabidopsis thaliana	?	-	?	89	
3.4.21.26	additional information	leginsulin appears to be a possible candidate for the POP substrate	Linum usitatissimum	?	-	?	89	
3.4.21.26	additional information	substance P, arginine-vasopressin, thyroliberin and gonadoliberin are proposed physiological substrates of this protease. No ZPP-sensitive cleavage occurred with the 33-mer, PEP-3, PEP-26, PEP-48_2, and PEP-50	Sus scrofa	?	-	?	89	
3.4.21.26	additional information	fibroblast activation protein prefers uncharged residues, including small or bulky hydrophobic amino acids, but not charged amino acids, especially acidic residue at P1’, P3 and P4 sites. Fibroblast activation protein cannot cleave interleukins	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	the recombinant prolyl oligopeptidase is not able to cleave whole 43-mer thymosin beta4, while it is effective at hydrolyzing somatostatin-28 (1-12)	Rattus norvegicus	?	-	?	89	
3.4.21.26	additional information	prolyl oligopeptidase colocalizes with alpha-synuclein, beta-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinsons and Alzheimers diseases	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	does not cleave GASGPAGPA	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	no activity toward L-Pro-4-nitroanilide, Gly-L-Pro-4-nitroanilide, Z-Pro-nitrophenyl ester, Z-Gly-Gly-nitrophenyl ester, Z-Phe-Arg-7-amido-4-methylcoumarin, Z-Leu-Leu-Glu-7-amido-4-methylcoumarin, Z-Val-Lys-Met-7-amido-4-methylcoumarin, Z-Leu-Leu-Leu-7-amido-4-methylcoumarin, and Z-Tyr-Val-Ala-Asp-4-nitroanilide	Coprinopsis clastophylla	?	-	?	89	
3.4.21.26	additional information	no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin	Homo sapiens	?	-	?	89	
3.4.21.26	additional information	no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin	Schistosoma mansoni	?	-	?	89	
3.4.21.26	additional information	no activity with Ala-Pro-4-nitroanilide, Arg-Pro-4-nitroanilide, Val-Ala-4-nitroanilide, Gly-Pro-4-nitroanilide, Leu-4-nitroanilide, Pro-4-nitroanilide, Glu-4-nitroanilide, and Glu-Ala-4-nitroanilide	Myxococcus xanthus	?	-	?	89	
3.4.21.26	additional information	no activity with human hemoglobin, human serum albumin, human collagen type I, and human collagen type IV	Schistosoma mansoni	?	-	?	89	
3.4.21.26	additional information	no activity with L-Ala-L-Pro-4-nitroanilide and L-Ala-L-Pro-L-Phe-4-nitroanilide 	Aspergillus oryzae	?	-	?	89	
3.4.21.26	additional information	no activity with Ala-Pro-4-nitroanilide, Arg-Pro-4-nitroanilide, Val-Ala-4-nitroanilide, Gly-Pro-4-nitroanilide, Leu-4-nitroanilide, Pro-4-nitroanilide, Glu-4-nitroanilide, and Glu-Ala-4-nitroanilide	Myxococcus xanthus ATCC 25232	?	-	?	89	
3.4.21.26	additional information	the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)	Lactobacillus helveticus CNRZ32	?	-	?	89	
3.4.21.26	N-benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O	-	Elizabethkingia meningoseptica	?	-	?	74319	
3.4.21.26	N-benzyloxycarbonyl-Ala-Ala-p-nitrophenyl ester + H2O	-	Elizabethkingia meningoseptica	?	-	?	65053	
3.4.21.26	N-benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Sus scrofa	?	-	?	385271	
3.4.21.26	N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O	-	Sus scrofa	N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol	-	?	450357	
3.4.21.26	N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O	-	Homo sapiens	N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol	-	?	450357	
3.4.21.26	N-benzyloxycarbonyl-Gly-Pro-Ala + H2O	-	Ovis aries	?	-	?	65049	
3.4.21.26	N-benzyloxycarbonyl-Gly-Pro-p-nitrophenyl ester + H2O	-	Elizabethkingia meningoseptica	?	-	?	65052	
3.4.21.26	N-carbobenzoxy-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-carbobenzoxy-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	432204	
3.4.21.26	N-carbobenzoxy-Gly-Pro-7-amido-4-methyl-coumarin + H2O	-	Sus scrofa	?	-	?	401460	
3.4.21.26	N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O	-	Mus musculus	N-carbobenzyloxy-Ala-Pro + 2-naphthylamine	-	?	394442	
3.4.21.26	N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O	-	Homo sapiens	N-carbobenzyloxy-Ala-Pro + 2-naphthylamine	-	?	394442	
3.4.21.26	N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O	-	Rattus norvegicus	N-carbobenzyloxy-Ala-Pro + 2-naphthylamine	-	?	394442	
3.4.21.26	N-carbobenzyloxy-glycyl-proline-4-methyloumarin-7-amide + H2O	-	Aspergillus niger	N-carbobenzyloxy-glycyl-proline + 7-amino-4-methylcoumarin	-	?	394443	
3.4.21.26	N-Suc-Ala-Ala-Ala-7-amido-4-methylcoumarin + H2O	assay at pH 7.5, 25°C	Trypanosoma brucei brucei	N-Suc-Ala-Ala-Ala + 7-amino-4-methylcoumarin	-	?	412561	
3.4.21.26	N-Suc-Gly-Pro-7-amido-4-methylcoumarin + H2O	assay at pH 7.5, 25°C	Trypanosoma brucei brucei	N-Suc-Gly-Pro + 7-amino-4-methylcoumarin	-	?	412562	
3.4.21.26	N-Suc-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O	assay at pH 7.5, 25°C	Trypanosoma brucei brucei	N-Suc-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin	-	?	412563	
3.4.21.26	N-succinyl-Ala-Ala-Ala-4-nitroanilide	-	Homo sapiens	N-succinyl-Ala-Ala-Ala + 4-nitroaniline	-	?	394447	
3.4.21.26	N-succinyl-Ala-Pro-4-nitroanilide + H2O	-	Thermococcus onnurineus	N-succinyl-Ala-Pro + 4-nitroaniline	-	?	394448	
3.4.21.26	N-succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	24% of the activity with N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin	Trypanosoma cruzi	?	-	?	385326	
3.4.21.26	N-succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	418894	
3.4.21.26	N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Trypanosoma cruzi	?	-	?	385327	
3.4.21.26	N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin	-	?	394449	
3.4.21.26	N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Sus scrofa	N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin	-	?	394449	
3.4.21.26	N-succinyl-Gly-Pro-OH + H2O	-	Homo sapiens	?	-	?	394450	
3.4.21.26	N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O	-	Mus musculus	N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin	-	?	394451	
3.4.21.26	N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O	-	Homo sapiens	N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin	-	?	394451	
3.4.21.26	N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O	-	Rattus norvegicus	N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin	-	?	394451	
3.4.21.26	N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin	-	?	418895	
3.4.21.26	N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O	-	Rattus norvegicus	N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin	-	?	418895	
3.4.21.26	N-succinyl-L-Ala-L-Ala-L-Ala-7-amido-4-methylcoumarin + H2O	13% of the activity with N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin	Trypanosoma cruzi	?	-	?	385328	
3.4.21.26	Nalpha-benzyl-Gly-Pro-Leu-Gly + H2O	-	Elizabethkingia meningoseptica	?	-	?	65051	
3.4.21.26	Nalpha-benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O	-	Ovis aries	?	-	?	65050	
3.4.21.26	Nalpha-benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O	-	Elizabethkingia meningoseptica	?	-	?	65050	
3.4.21.26	neurotensin + H2O	-	Mus musculus	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Homo sapiens	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Rattus norvegicus	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Bos taurus	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Oryctolagus cuniculus	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Ovis aries	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Canis lupus familiaris	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Elizabethkingia meningoseptica	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Sus scrofa	?	-	?	15385	
3.4.21.26	neurotensin + H2O	-	Trypanosoma brucei brucei	pGlu-Leu-Tyr-Glu-Asn-Lys-Pro + Arg-Arg-Pro + Tyr-Ile-Leu	-	?	445993	
3.4.21.26	neurotensin + H2O	pELYENKPRRPYIL	Schistosoma mansoni	pELYENKP + RRP + YIL	-	?	450408	
3.4.21.26	oxytocin + H2O	-	Ovis aries	CYIQNCP + L-Leu-Gly	-	?	65061	
3.4.21.26	oxytocin + H2O	CYIQNCPLG	Schistosoma mansoni	CYIQNCP + L-Leu-Gly	-	?	65061	
3.4.21.26	oxytocin + H2O	-	Mus musculus	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Homo sapiens	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Rattus norvegicus	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Bos taurus	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Oryctolagus cuniculus	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Canis lupus familiaris	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Elizabethkingia meningoseptica	?	-	?	65396	
3.4.21.26	oxytocin + H2O	-	Sus scrofa	?	-	?	65396	
3.4.21.26	oxytoxin + H2O	-	Mus musculus	?	-	?	394036	
3.4.21.26	oxytoxin + H2O	-	Homo sapiens	?	-	?	394036	
3.4.21.26	oxytoxin + H2O	-	Rattus norvegicus	?	-	?	394036	
3.4.21.26	oxytoxin + H2O	-	Sus scrofa	?	-	?	394036	
3.4.21.26	PEGA(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412662	
3.4.21.26	PEGA-K(ABz)-GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412663	
3.4.21.26	PEGA-O2Oc-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O	assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min	Sus scrofa	?	-	?	412664	
3.4.21.26	peptide QATVGDVNTDRPGLLDLK + H2O	i.e. octadecaneuropeptide ODN, the biologically active fragment of diazepam-binding inhibitor, the Ala2 residue is preferred by the enzyme for cleavage, while the Pro-Gly bind is not cleaved, overview	Flavobacterium sp.	TVGDVNTDRPGLLDLK + GDVNTDRPGLLDLK + QA + QATV	-	?	394467	
3.4.21.26	Peptides + H2O	involved in process of fertilization, between chorion elevation and cell cleavage	Halocynthia roretzi	?	-	?	16310	
3.4.21.26	Peptides + H2O	metabolism of peptides containing altered aspartyl residues	Homo sapiens	?	-	?	16310	
3.4.21.26	pGlu-Gly-Leu-Pro-Pro-Arg-Pro + H2O	i.e. potentiator B	Homo sapiens	pGlu-Gly-Leu-Pro-Pro + Arg-Pro	-	?	365323	
3.4.21.26	pGlu-Gly-Leu-Pro-Pro-Gly-Pro + H2O	i.e. potentiator C, as active as potentiator B	Homo sapiens	pGlu-Gly-Leu-Pro-Pro + Gly-Pro	-	?	365324	
3.4.21.26	polysialylated membrane-associated glycoprotein neural cell adhesion molecule + H2O	-	Homo sapiens	?	-	?	450481	
3.4.21.26	RPKPQQFFGLM + H2O	-	Homo sapiens	L-Arg-L-Pro + L-Lys-L-Pro + QQFFGLM	-	?	432350	
3.4.21.26	RPPGFSPFR + H2O	i.e. bradykinin, 90% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro	Homo sapiens	?	-	?	365321	
3.4.21.26	RPPGFSPFR-amide + H2O	i.e. bradykinin, 70% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro	Homo sapiens	RPP + GFSPFR-amide	-	?	365322	
3.4.21.26	somatostatin-28 (1-12) + H2O	-	Rattus norvegicus	?	-	?	419076	
3.4.21.26	SPRY2 + H2O	not an in vivo substrate of fibroblast activation protein	Homo sapiens	?	-	?	419079	
3.4.21.26	Substance P + H2O	-	Mus musculus	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Homo sapiens	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Rattus norvegicus	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Sus scrofa	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Bos taurus	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Oryctolagus cuniculus	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Canis lupus familiaris	?	-	?	17205	
3.4.21.26	Substance P + H2O	-	Elizabethkingia meningoseptica	?	-	?	17205	
3.4.21.26	Substance P + H2O	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2	Myxococcus xanthus	?	-	?	17205	
3.4.21.26	Substance P + H2O	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2	Myxococcus xanthus ATCC 25232	?	-	?	17205	
3.4.21.26	substance P + H2O	RPKPQQFFGLM	Schistosoma mansoni	RPKP + QQFFGLM	-	?	450673	
3.4.21.26	Suc-Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Mus musculus	?	-	?	401929	
3.4.21.26	succinyl-Ala-Pro-4-nitrophenyl ester + H2O	-	Sus scrofa	succinyl-Ala-Pro + 4-nitrophenol	-	?	450680	
3.4.21.26	succinyl-Ala-Pro-4-nitrophenyl ester + H2O	-	Homo sapiens	succinyl-Ala-Pro + 4-nitrophenol	-	?	450680	
3.4.21.26	succinyl-Ala-Pro-p-nitroanilide + H2O	-	Novosphingobium capsulatum	?	-	?	401936	
3.4.21.26	succinyl-D-Ala-Pro-4-nitroanilide + H2O	-	Myxococcus xanthus	benzyloxycarbonyl-D-Ala-Pro + 4-nitroaniline	-	?	432406	
3.4.21.26	succinyl-Gly-L-Pro-4-nitroanilide + H2O	-	Myxococcus xanthus	succinyl-Gly-L-Pro + 4-nitroaniline	-	?	450681	
3.4.21.26	succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Rattus norvegicus	succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	419095	
3.4.21.26	succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Sus scrofa	succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	419095	
3.4.21.26	succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Mus musculus	succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	450682	
3.4.21.26	succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O	-	Homo sapiens	?	-	?	65054	
3.4.21.26	succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O	-	Bos taurus	?	-	?	65054	
3.4.21.26	succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O	-	Sarcophaga peregrina	?	-	?	65054	
3.4.21.26	succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O	-	Sus scrofa	succinyl-Gly-Pro + 7-amino-4-methylcoumarin	-	?	365313	
3.4.21.26	succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	succinyl-Gly-Pro + 7-amino-4-methylcoumarin	-	?	401937	
3.4.21.26	succinyl-Gly-Pro-Leu-Gly-Pro-4-methylcoumaryl-7-amide	-	Homo sapiens	?	-	?	65078	
3.4.21.26	succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O	about 58% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin	Homo sapiens	succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin	-	?	450683	
3.4.21.26	succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O	about 65% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin	Schistosoma mansoni	succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin	-	?	450683	
3.4.21.26	succinyl-Gly-Pro-Leu-Gly-Pro-methylcoumaryl-7-amide + H2O	-	Sarcophaga peregrina	?	-	?	65055	
3.4.21.26	succinyl-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae	succinyl-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline	-	?	450686	
3.4.21.26	succinyl-L-Ala-L-Pro-4-nitroanilide + H2O	-	Myxococcus xanthus	succinyl-L-Ala-L-Pro + 4-nitroaniline	-	?	450693	
3.4.21.26	succinyl-L-Arg-L-Pro-4-nitroanilide + H2O	-	Myxococcus xanthus	succinyl-L-Arg-L-Pro + 4-nitroaniline	-	?	450694	
3.4.21.26	tasidotin + H2O	assay at pH 6.8, 37°C	Elizabethkingia meningoseptica	tert-butylamine + ?	-	?	412948	
3.4.21.26	tau protein + H2O	-	Homo sapiens	?	-	?	393638	
3.4.21.26	tert-butyloxycarbonyl-Ala-Ala p-nitroanilide + H2O	-	Bos taurus	?	-	?	65071	
3.4.21.26	tert-butyloxycarbonyl-Ala-Ala-Pro-Ala p-nitroanilide + H2O	-	Bos taurus	tert-butyloxycarbonyl-Ala-Ala-Pro + Ala + p-nitoaniline	-	?	65072	
3.4.21.26	thymosin beta4 + H2O	-	Homo sapiens	acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ?	-	?	418101	
3.4.21.26	thymosin beta4 + H2O	prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-Ser-Asp-Lys-Pro from thymosin beta4 and has autoregulatory effect in the first step	Rattus norvegicus	acetyl-N-Ser-Asp-Lys-Pro + ?	-	?	419145	
3.4.21.26	thyroliberin + H2O	-	Mus musculus	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Homo sapiens	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Rattus norvegicus	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Bos taurus	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Oryctolagus cuniculus	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Canis lupus familiaris	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Elizabethkingia meningoseptica	?	-	?	365353	
3.4.21.26	thyroliberin + H2O	-	Sus scrofa	?	-	?	365353	
3.4.21.26	thyrotropin releasing hormone + H2O	-	Mus musculus	?	-	?	394072	
3.4.21.26	thyrotropin releasing hormone + H2O	-	Homo sapiens	?	-	?	394072	
3.4.21.26	thyrotropin releasing hormone + H2O	-	Rattus norvegicus	?	-	?	394072	
3.4.21.26	thyrotropin releasing hormone + H2O	-	Sus scrofa	?	-	?	394072	
3.4.21.26	thyrotropin-releasing hormone + H2O	-	Bos taurus	?	-	?	65047	
3.4.21.26	TRH + H2O	-	Trypanosoma brucei brucei	L-pyroglutamyl-L-histidyl-L-proline + NH3	-	?	412998	
3.4.21.26	tuftsin + H2O	-	Mus musculus	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Homo sapiens	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Rattus norvegicus	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Bos taurus	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Oryctolagus cuniculus	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Canis lupus familiaris	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Elizabethkingia meningoseptica	?	-	?	361470	
3.4.21.26	tuftsin + H2O	-	Sus scrofa	?	-	?	361470	
3.4.21.26	Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O	i.e. N-acetyl-beta-casein-(f203-209)-p-nitroanilide, cleavage at: Pro196-Val197, Pro200-Val201 and Pro206-Ile207	Lactobacillus helveticus	?	-	?	365356	
3.4.21.26	Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O	i.e. N-acetyl-beta-casein-(f203-209)-p-nitroanilide, cleavage at: Pro196-Val197, Pro200-Val201 and Pro206-Ile207	Lactobacillus helveticus CNRZ32	?	-	?	365356	
3.4.21.26	urotensin II + H2O	human substrate, cleavage at the canonical post-proline site	Flavobacterium sp.	?	-	?	394077	
3.4.21.26	Vasopressin + H2O	-	Mus musculus	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Homo sapiens	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Rattus norvegicus	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Bos taurus	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Oryctolagus cuniculus	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Canis lupus familiaris	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Elizabethkingia meningoseptica	?	-	?	16659	
3.4.21.26	Vasopressin + H2O	-	Sus scrofa	?	-	?	16659	
3.4.21.26	vasopressin + H2O	-	Ovis aries	inactivated vasopressin + dipeptide	-	?	65062	
3.4.21.26	vassopresin + H2O	CYFQNCPRG	Schistosoma mansoni	CYFQNCP + L-Arg-Gly	-	?	450799	
3.4.21.26	VHLTPVGL + H2O	-	Bos taurus	VHLTP + VGL	-	?	65074	
3.4.21.26	wheat gluten + H2O	-	Myxococcus xanthus	?	-	?	449023	
3.4.21.26	wheat gluten + H2O	-	Myxococcus xanthus ATCC 25232	?	-	?	449023	
3.4.21.26	Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450833	
3.4.21.26	Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450833	
3.4.21.26	Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 87% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450835	
3.4.21.26	Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450835	
3.4.21.26	Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450836	
3.4.21.26	Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 40% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450836	
3.4.21.26	Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 10% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450837	
3.4.21.26	Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 5% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450837	
3.4.21.26	Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450839	
3.4.21.26	Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450839	
3.4.21.26	Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 18% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450840	
3.4.21.26	Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450840	
3.4.21.26	Z-Gly-L-Pro-4-nitroanilide + H2O	-	Homo sapiens	Z-Gly-L-Pro + 4-nitroaniline	-	?	402266	
3.4.21.26	Z-Gly-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae	Z-Gly-L-Pro + 4-nitroaniline	-	?	402266	
3.4.21.26	Z-Gly-L-Pro-4-nitroanilide + H2O	highest activity	Myxococcus xanthus	Z-Gly-L-Pro + 4-nitroaniline	-	?	402266	
3.4.21.26	Z-Gly-L-Pro-4-nitroanilide + H2O	highest activity	Myxococcus xanthus ATCC 25232	Z-Gly-L-Pro + 4-nitroaniline	-	?	402266	
3.4.21.26	Z-Gly-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae WX2011	Z-Gly-L-Pro + 4-nitroaniline	-	?	402266	
3.4.21.26	Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Z-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	419206	
3.4.21.26	Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O	100% activity	Schistosoma mansoni	Z-Gly-L-Pro + 7-amino-4-methylcoumarin	-	?	419206	
3.4.21.26	Z-Gly-Pro-2-naphthylamide + H2O	-	Homo sapiens	Z-Gly-Pro + 2-naphthylamine	-	?	432497	
3.4.21.26	Z-Gly-Pro-2-naphthylamide + H2O	-	Sus scrofa	Z-Gly-Pro + 2-naphthylamine	-	?	432497	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	pH 7.0, room temperature	Carica papaya	4-nitroaniline + Z-Gly-Pro	-	?	406910	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	assay at 37°C	Homo sapiens	Z-Gly-Pro + p-nitroaniline	-	?	413098	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	assay at 37°C	Conocybe apala	Z-Gly-Pro + p-nitroaniline	-	?	413098	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	assay at pH 5.0, 37°C	Aspergillus niger	Z-Gly-Pro + p-nitroaniline	-	?	413098	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	assay at pH 8.0, 34°C	Aeromonas caviae	Z-Gly-Pro + p-nitroaniline	-	?	413098	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	chromogenic assay, assay at pH 7.0, 37°C, reaction stopped by addition of sodium acetate	Elizabethkingia meningoseptica	Z-Gly-Pro + p-nitroaniline	-	?	413098	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	assay at pH 7.0, 30°C	Mus musculus	Z-glycyl-L-proline + 4-nitroaniline	-	?	413099	
3.4.21.26	Z-Gly-Pro-4-nitroanilide + H2O	-	Setaria cervi	Z-Gly-Pro + 4-nitroaniline	-	?	450841	
3.4.21.26	Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 22% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450842	
3.4.21.26	Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450842	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin	assay at pH 7.0, 30°C	Sus scrofa	Z-Gly-Pro + 7-amino-4-methylcoumarin	-	?	413102	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin	assay at pH 8.0, 37°C, reaction stopped with sodium acetate	Homo sapiens	Z-Gly-Pro + 7-amino-4-methylcoumarin	-	?	413102	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin	fluorogenic assay, assay at pH 6.8, 37°C, reaction stopped by addition of acetic acid	Elizabethkingia meningoseptica	Z-Gly-Pro + 7-amino-4-methylcoumarin	-	?	413102	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	z-Gly-Pro + 7-amino-4-methylcoumarin	-	?	413100	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin + H2O	assay at pH 7.0, 37°C	Mus musculus	z-Gly-Pro + 7-amino-4-methylcoumarin	-	?	413100	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin + H2O	assay at pH 7.0, 30°C	Homo sapiens	z-Gly-Pro + 7-amino-4-methylcoumarin	-	?	413100	
3.4.21.26	Z-Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	?	-	?	432498	
3.4.21.26	Z-Gly-Pro-p-nitroanilide + H2O	-	Sus scrofa	Z-Gly-Pro + p-nitroaniline	-	?	402267	
3.4.21.26	Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 58% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450843	
3.4.21.26	Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450843	
3.4.21.26	Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450844	
3.4.21.26	Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 92% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450844	
3.4.21.26	Z-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae	Z-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline	-	?	432500	
3.4.21.26	Z-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O	-	Aspergillus oryzae WX2011	Z-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline	-	?	432500	
3.4.21.26	Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450845	
3.4.21.26	Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450845	
3.4.21.26	Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	100% activity	Homo sapiens	Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450846	
3.4.21.26	Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	100% activity	Schistosoma mansoni	Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450846	
3.4.21.26	Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 67% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450847	
3.4.21.26	Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 68% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450847	
3.4.21.26	Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 48% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450848	
3.4.21.26	Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450848	
3.4.21.26	Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450849	
3.4.21.26	Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450849	
3.4.21.26	Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450851	
3.4.21.26	Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450851	
3.4.21.26	Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450852	
3.4.21.26	Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 75% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450852	
3.4.21.26	Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 23% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450853	
3.4.21.26	Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450853	
3.4.21.26	Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450854	
3.4.21.26	Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450854	
3.4.21.26	Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Homo sapiens	Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450855	
3.4.21.26	Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O	about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin	Schistosoma mansoni	Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin	-	?	450855