3.4.19.15	an N6-[small archaeal modifier protein]-[protein]-L-lysine + H2O	Hvo_2505 mixed with Ta0895_VSGG-Ta0547 results cleavage products at 18 kDa (Ta0547) and 14 kDa (Ta0895_VSGG). Hvo_2505 is active at 24°C, 37°C and 48°C cleaving a substantial percentage of Ta0895_VAGG-ScRpn11 and Ta0895_VSGG-Ta0547. No cleavage activity is detected at lower (10°C) temperature. Inactive on Ta1019-ScRpn11 and Mbur_1415-ScRpn11 fusion protein substrates	Haloferax volcanii	a [protein]-L-lysine + a small archaeal modifier protein	-	?	449564	
3.4.19.15	an N6-[small archaeal modifier protein]-[protein]-L-lysine + H2O	Hvo_2505 mixed with Ta0895_VSGG-Ta0547 results cleavage products at 18 kDa (Ta0547) and 14 kDa (Ta0895_VSGG). Hvo_2505 is active at 24°C, 37°C and 48°C cleaving a substantial percentage of Ta0895_VAGG-ScRpn11 and Ta0895_VSGG-Ta0547. No cleavage activity is detected at lower (10°C) temperature. Inactive on Ta1019-ScRpn11 and Mbur_1415-ScRpn11 fusion protein substrates	Haloferax volcanii ATCC 29605	a [protein]-L-lysine + a small archaeal modifier protein	-	?	449564	
3.4.19.15	additional information	the enzyme can cleave proteins attached to SAMP1 by linear and isopeptide bonds. The enzyme is inactive in hydrolyzing the amide bond that links aminomethylcoumarin to the C-terminus of monomeric ubiquinone or diglycine	Haloferax volcanii	?	-	?	89	
3.4.19.15	additional information	JAMM1 is a metalloprotease with relatively broad substrate specificity, able to cleave a wide variety of proteins conjugated to SAMP3 as well as SAMP1/2	Haloferax volcanii	?	-	?	89	
3.4.19.15	additional information	JAMM1 is a metalloprotease with relatively broad substrate specificity, able to cleave a wide variety of proteins conjugated to SAMP3 as well as SAMP1/2	Haloferax volcanii DSM 3757	?	-	?	89	
3.4.19.15	additional information	the enzyme can cleave proteins attached to SAMP1 by linear and isopeptide bonds. The enzyme is inactive in hydrolyzing the amide bond that links aminomethylcoumarin to the C-terminus of monomeric ubiquinone or diglycine	Haloferax volcanii DSM 3757	?	-	?	89	
3.4.19.15	N6-SAMP1-[molybdopterin synthase MoaE]-L-lysine + H2O	-	Haloferax volcanii	SAMP1 + [molybdopterin synthase MoaE]-L-lysine	-	?	429318	
3.4.19.15	N6-SAMP1-[molybdopterin synthase MoaE]-L-lysine + H2O	the enzyme cleaves isopeptide-liked SAMP1 from molybdopterin synthase MoaE. It also cleaves linear fusions of SAMP to molybdopterin synthase MoaE	Haloferax volcanii	SAMP1 + [molybdopterin synthase MoaE]-L-lysine	-	?	429318	
3.4.19.15	N6-SAMP1-[molybdopterin synthase MoaE]-L-lysine + H2O	-	Haloferax volcanii DSM 3757	SAMP1 + [molybdopterin synthase MoaE]-L-lysine	-	?	429318	
3.4.19.15	N6-SAMP1-[molybdopterin synthase MoaE]-L-lysine + H2O	the enzyme cleaves isopeptide-liked SAMP1 from molybdopterin synthase MoaE. It also cleaves linear fusions of SAMP to molybdopterin synthase MoaE	Haloferax volcanii DSM 3757	SAMP1 + [molybdopterin synthase MoaE]-L-lysine	-	?	429318	
3.4.19.15	N6-SAMP1-[protein]-L-lysine + H2O	broad spectrum of activity in removing SAMP1/2 from diverse proteins. HvJAMM1 is unable to hydrolyze bovine serum albumin, hemoglobin, creatine phosphokinase, carbonic anhydrase, beta-amylase or cytochrome c. Long-term incubation with the enzyme has little if any impact on the level or length of these proteins	Haloferax volcanii	SAMP1 + [protein]-L-lysine	-	?	430452	
3.4.19.15	N6-SAMP1-[protein]-L-lysine + H2O	broad spectrum of activity in removing SAMP1/2 from diverse proteins. HvJAMM1 is unable to hydrolyze bovine serum albumin, hemoglobin, creatine phosphokinase, carbonic anhydrase, beta-amylase or cytochrome c. Long-term incubation with the enzyme has little if any impact on the level or length of these proteins	Haloferax volcanii DSM 3757	SAMP1 + [protein]-L-lysine	-	?	430452	
3.4.19.15	N6-SAMP2-[protein]-L-lysine + H2O	broad spectrum of activity in removing SAMP1/2 from diverse proteins. HvJAMM1 is unable to hydrolyze bovine serum albumin, hemoglobin, creatine phosphokinase, carbonic anhydrase, beta-amylase or cytochrome c. Long-term incubation with the enzyme has little if any impact on the level or length of these proteins	Haloferax volcanii	SAMP2 + [protein]-L-lysine	-	?	430453	
3.4.19.15	N6-SAMP2-[protein]-L-lysine + H2O	broad spectrum of activity in removing SAMP1/2 from diverse proteins. HvJAMM1 is unable to hydrolyze bovine serum albumin, hemoglobin, creatine phosphokinase, carbonic anhydrase, beta-amylase or cytochrome c. Long-term incubation with the enzyme has little if any impact on the level or length of these proteins	Haloferax volcanii DSM 3757	SAMP2 + [protein]-L-lysine	-	?	430453	
3.4.19.15	N6-[SAMP1]-[MoaE]-L-lysine + H2O	MoaE, i.e. molybdopterin synthase large subunit homolog. Residue K240 of MoaE is isopeptide-linked to SAMP1	Haloferax volcanii	[MoaE]-L-lysine + SAMP1	-	?	434036	
3.4.19.15	N6-[SAMP1]-[MoaE]-L-lysine + H2O	MoaE, i.e. molybdopterin synthase large subunit homolog. Residue K240 of MoaE is isopeptide-linked to SAMP1	Haloferax volcanii DSM 3757	[MoaE]-L-lysine + SAMP1	-	?	434036	
3.4.19.15	N6-[SAMP3]-[MoaE]-L-lysine + H2O	MoaE, i.e. molybdopterin synthase large subunit homolog	Haloferax volcanii	[MoaE]-L-lysine + SAMP3	SAMP3 protein conjugates are dependent on the ubiquitin-activating E1 enzyme homolog of archaea (UbaA) for synthesis and are cleaved by the JAMM/MPN+ domain metalloprotease JAMM1	?	434037	
3.4.19.15	N6-[SAMP3]-[MoaE]-L-lysine + H2O	MoaE, i.e. molybdopterin synthase large subunit homolog	Haloferax volcanii DSM 3757	[MoaE]-L-lysine + SAMP3	SAMP3 protein conjugates are dependent on the ubiquitin-activating E1 enzyme homolog of archaea (UbaA) for synthesis and are cleaved by the JAMM/MPN+ domain metalloprotease JAMM1	?	434037