3.4.17.20 Ala-Ser-His-Leu-Gly-Leu-Ala-Arg + H2O reaction is much more efficient than reaction with EC 3.4.17.3 Homo sapiens Ala-Ser-His-Leu-Gly-Leu-Ala + Arg - ? 365034 3.4.17.20 anaphylatoxin C3a + H2O - Homo sapiens ? - ? 383062 3.4.17.20 anaphylatoxin C3a + H2O inactivation of the inflammatory mediator Homo sapiens ? - ? 383062 3.4.17.20 anaphylatoxin C5a + H2O - Homo sapiens ? - ? 383063 3.4.17.20 anaphylatoxin C5a + H2O inactivation of the inflammatory mediator Homo sapiens ? - ? 383063 3.4.17.20 anisylazoformyl-Lys + H2O - Homo sapiens anisylazoformic acid + Lys - ? 365030 3.4.17.20 Arg6-Leu5-enkephalin + H2O i.e. Tyr-Gly-Gly-Phe-Leu-Arg Homo sapiens Tyr-Gly-Gly-Phe-Leu + Arg - ? 15065 3.4.17.20 Arg6-Met5-enkephalin + H2O i.e. Tyr-Gly-Gly-Phe-Met-Arg Homo sapiens Tyr-Gly-Gly-Phe-Met + Arg - ? 15067 3.4.17.20 benzoyl-o-cyano-Phe-Arg + H2O - Homo sapiens benzoyl-o-cyano-Phe + Arg - ? 449666 3.4.17.20 biotinyl-(epsilon-aminocaproic acid)-(epsilon-aminocaproic acid)-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Arg-OH + H2O - Homo sapiens biotinyl-(epsilon-aminocaproic acid)-(epsilon-aminocaproic acid)-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH + Arg - ? 365032 3.4.17.20 bradykinin + H2O i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg Homo sapiens Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg - ? 15064 3.4.17.20 complement component C3a octapeptide + H2O removal of terminal arginine, low activity Homo sapiens ? - ? 384463 3.4.17.20 complement component C5a octapeptide + H2O removal of terminal arginine Homo sapiens ? - ? 384464 3.4.17.20 Fibrin + H2O - Homo sapiens ? - ? 16541 3.4.17.20 fibrin + H2O - Homo sapiens Lys + ? - ? 365031 3.4.17.20 fibrin + H2O attenuates clot lysis by removing lysine residues from a fibrin clot Homo sapiens Lys + ? - ? 365031 3.4.17.20 fibrin + H2O anti-fibrinolytic activity Homo sapiens fibrin + Lys - ? 383158 3.4.17.20 fibrin + H2O cleavage of C-terminal Lys, regulation, overview Mus musculus fibrin + Lys the cleaved fibrin cannot be bound by plasminogen and the plasminogen activator in contrast to the uncleaved fibrin, fibrinolysis and plasmin regulation cycle involving the enzyme, overview ? 383158 3.4.17.20 fibrin + H2O cleavage of C-terminal Lys, regulation, overview Homo sapiens fibrin + Lys the cleaved fibrin cannot be bound by plasminogen and the plasminogen activator in contrast to the uncleaved fibrin, fibrinolysis and plasmin regulation cycle involving the enzyme, overview ? 383158 3.4.17.20 fibrin + H2O partially degraded fibrin in fibrin clots, cleavage of C-terminal Lys Homo sapiens fibrin + Lys - ? 383158 3.4.17.20 fibrin + H2O cleavage of C-terminal Lys Mus musculus fibrin + Lys - ? 383158 3.4.17.20 fibrin + H2O cleavage of C-terminal Lys Homo sapiens fibrin + Lys - ? 383158 3.4.17.20 fibrin + H2O - Homo sapiens fibrin + L-Lys - ? 410820 3.4.17.20 Fibrin, partially degraded + H2O - Homo sapiens Fibrin, partially degraded + L-Lys + L-Arg - ? 15058 3.4.17.20 Fibrin, partially degraded + H2O - Homo sapiens ? - ? 369530 3.4.17.20 Fibrin, partially degraded + H2O the enzyme suppresses the ability of fibrin to catalyze plasminogen activation and thus delays clot lysis Homo sapiens ? - ? 369530 3.4.17.20 Fibrin, partially degraded + H2O inhibition of fibrinolysis Homo sapiens ? - ? 369530 3.4.17.20 Fibrin, partially degraded + H2O molecular connection between coagulation and fibrinolysis Homo sapiens ? - ? 369530 3.4.17.20 Glu-plasminogen + H2O - Homo sapiens Glu + plasmin - ? 383171 3.4.17.20 hippuryl-Arg + H2O - Cavia porcellus hippuric acid + Arg - ? 64979 3.4.17.20 hippuryl-Arg + H2O - Homo sapiens hippuric acid + Arg - ? 64979 3.4.17.20 hippuryl-Arg + H2O - Rattus norvegicus hippuric acid + Arg - ? 64979 3.4.17.20 hippuryl-Arg + H2O - Oryctolagus cuniculus hippuric acid + Arg - ? 64979 3.4.17.20 hippuryl-Arg + H2O - Mus musculus hippuric acid + Arg - ? 64979 3.4.17.20 hippuryl-Arg + H2O - Bos taurus hippuric acid + Arg - ? 64979 3.4.17.20 hippuryl-arginine + H2O substrate is used to measure the TAFI activation by plasmin Homo sapiens hippuric acid + L-arginine - ? 405427 3.4.17.20 Hippuryl-L-Arg + H2O - Homo sapiens Hippuric acid + L-Arg - ? 15059 3.4.17.20 hippuryl-L-arginine + H2O - Homo sapiens hippuric acid + L-arginine - ? 384860 3.4.17.20 Hippuryl-L-argininic acid + H2O - Homo sapiens Hippuric acid + argininic acid - ? 15063 3.4.17.20 Hippuryl-L-Lys + H2O - Homo sapiens Hippuric acid + L-Lys - ? 15060 3.4.17.20 hippuryl-L-lysine + H2O - Homo sapiens hippuric acid + L-lysine - ? 384861 3.4.17.20 His-Lys-Asp-Met-Gln-Leu-Gly-Arg + H2O i.e. C5a, reaction is much more efficient than reaction with EC 3.4.17.3 Homo sapiens His-Lys-Asp-Met-Gln-Leu-Gly + Arg - ? 365033 3.4.17.20 His-Lys-Asp-Met-Gln-Leu-Gly-Arg + H2O i.e. C5a, the enzyme significantly contributes to the inactivation of C5a, the most potent of the complement derived anaphylatoxins Homo sapiens His-Lys-Asp-Met-Gln-Leu-Gly + Arg - ? 365033 3.4.17.20 Lys-plasminogen + H2O - Homo sapiens Lys + plasmin - ? 383235 3.4.17.20 Lys-plasminogen + H2O preferred substrate Homo sapiens Lys + plasmin - ? 383235 3.4.17.20 Lys6-Leu5-enkephalin + H2O i.e. Tyr-Gly-Gly-Phe-Leu-Lys Homo sapiens Tyr-Gly-Gly-Phe-Leu + Lys - ? 15066 3.4.17.20 Lys6-Met5-enkephalin + H2O i.e. Tyr-Gly-Gly-Phe-Met-Lys Homo sapiens Tyr-Gly-Gly-Phe-Met + Lys - ? 15068 3.4.17.20 additional information no substrates are hippuryl-L-Phe, hippurylphenyllactic acid, hippuryl-Gly-Phe Homo sapiens ? - ? 89 3.4.17.20 additional information removal of Lys or Arg from carboxy-terminus of peptides, specific for basic amino acids at carboxy-terminus Homo sapiens ? - ? 89 3.4.17.20 additional information pro-carboxypeptidase R is an acute phase protein under inflammatory conditions Mus musculus ? - ? 89 3.4.17.20 additional information pro-carboxypeptidase R production is increased under inflammatory conditions Rattus norvegicus ? - ? 89 3.4.17.20 additional information inhibition of the enzyme leads to facilitated induction of coronary artery thrombolysis involving the plasminogen activator Canis lupus familiaris ? - ? 89 3.4.17.20 additional information the activated enzyme shows anti-fibrinolytic and fibrin clot lysis activity Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme circulates as inactive zymogen in the blood stream becoming activated upon blood clotting, the enzyme inhibits fibrinolysis by cleaving C-terminal lysine from the surface of partially degraded fibrin, which stimulates the tissue-type plasminogen activator-mediated conversion of plasminogen to plasmin, the enzyme might also be involved in regulation of inflammation and tissue repair, enzyme regulation overview Mus musculus ? - ? 89 3.4.17.20 additional information the enzyme circulates as inactive zymogen in the blood stream becoming activated upon blood clotting, the enzyme inhibits fibrinolysis by cleaving C-terminal lysine from the surface of partially degraded fibrin, which stimulates the tissue-type plasminogen activator-mediated conversion of plasminogen to plasmin, the enzyme might also be involved in regulation of inflammation and tissue repair, enzyme regulation overview Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme down-regulates fibrinolysis by removing carboxy-terminal lysine residues, which are ligands for plasminogen and tissue-type plasminogen activator, from partially degraded fibrin, pharmacological profile and pathphysiological role of the enzyme in rat thrombolysis Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme down-regulates fibrinolysis by removing carboxy-terminal lysine residues, which are ligands for plasminogen and tissue-type plasminogen activator, from partially degraded fibrin, pharmacological profile and pathphysiological role of the enzyme in rat thrombolysis Rattus norvegicus ? - ? 89 3.4.17.20 additional information the enzyme inhibits fibrinolysis Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme inhibits fibrinolysis and has a distinct role in haemostasis and a possible risk factor for thrombotic disease involving the polymorphism at position 325, overview, the plasminogen activation system plays a role in enzyme regulation Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme is involved and important in control of clot stability determined by clot formation and fibrinolysis, overview Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme is involved in blood clot lysis Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme is involved in the regulation of the coagulation and fibrinolytic systems preventing blood loss at sites of vessel wall damage and maintainthe fluidity of the blood in the body Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme is partially accountable for the antifibrinolytic activity in amniotic fluid Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme might be the primary in vivo regulator of complement component C5a-mediated inflammation in the circulation, the enzyme cleaves terminal lysine from the surface of fibrin clots preventing the binding and activation of plasminogen and inhibiting whole blood clot lysis Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme, activated by thrombin, protects the fibrin clot against lysis, altered enzyme activity is involved in bleeding and thrombotic disorders, the enzyme is involved in wound healing and inflammation, overview Mus musculus ? - ? 89 3.4.17.20 additional information the enzyme, activated by thrombin, protects the fibrin clot against lysis, altered enzyme activity is involved in bleeding and thrombotic disorders, the enzyme is involved in wound healing and inflammation, overview Homo sapiens ? - ? 89 3.4.17.20 additional information thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy Homo sapiens ? - ? 89 3.4.17.20 additional information thrombin activatable fibrinolysis inhibitor, TAFI, plays a role in the delicate balance between coagulation and fibrinolysis, the stability of the fibrin clot, inflammation, thrombosis, and in Behcets disease, vascular involvement pattern in patients, overview Homo sapiens ? - ? 89 3.4.17.20 additional information enzyme assay using a specific chromogenic dipeptide substrate Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme binds alpha2-macroglobulin and pregnancy zone protein, which does not inhibit the enzyme Homo sapiens ? - ? 89 3.4.17.20 additional information the enzyme binds to plasminogen and fibrinogen Homo sapiens ? - ? 89 3.4.17.20 additional information TFAI binds heparin Homo sapiens ? - ? 89 3.4.17.20 additional information TFAI binds heparin Bos taurus ? - ? 89 3.4.17.20 additional information the effects of the carboxypeptidase U system on the regulation of fibrinolysis is investigated and compared in four different in vitro models of fibrinolysis Homo sapiens ? - ? 89 3.4.17.20 N-benzoyl-2'-cyano-L-Phe-L-Arg + H2O selective CPU substrate Homo sapiens N-benzoyl-2'-cyano-L-Phe + L-Arg - ? 412510 3.4.17.20 N-benzoyl-Gly-L-Arg + H2O - Homo sapiens N-benzoyl-Gly + L-Arg - ? 36724 3.4.17.20 N-[3-(2-Furylacryloyl)]-L-Ala-L-Arg + H2O - Homo sapiens N-[3-(2-Furylacryloyl)]-L-Ala + L-Arg - ? 15062 3.4.17.20 N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys + H2O - Homo sapiens N-[3-(2-Furylacryloyl)]-L-Ala + L-Lys - ? 15061 3.4.17.20 osteopontin + H2O - Homo sapiens ? - ? 367210 3.4.17.20 osteopontin + H2O thrombin-cleaved substrate Homo sapiens ? - ? 367210 3.4.17.20 p-anisylazoformyl-L-arginine + H2O substrate is used to measure the TAFI activation by thrombin and thrombin-thrombomodulin Homo sapiens p-anisylazoformic acid + L-arginine - ? 406272 3.4.17.20 [3-(2-furylacryloyl)]-L-alanyl-L-arginine + H2O - Homo sapiens [3-(2-furylacryloyl)]-L-alanine + L-arginine - ? 385982 3.4.17.20 [3-(2-furylacryloyl)]-L-phenylalanyl-L-phenylalanine + H2O - Homo sapiens [3-(2-furylacryloyl)]-L-phenylalanine + L-phenylalanine - ? 385983