3.4.11.3 alpha-L-Asp1-Val5-angiotensin II + H2O transformation to beta form Homo sapiens beta-Asp1-Val5-angiotensin II - ir 36274 3.4.11.3 angiotensin III + H2O - Homo sapiens ? - ? 36290 3.4.11.3 angiotensin III + H2O P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin Homo sapiens ? - ? 36290 3.4.11.3 angiotensin III + H2O the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III Homo sapiens ? - ? 36290 3.4.11.3 Arg-4-methylcoumaryl-7-amide + H2O - Homo sapiens Arg + 7-amino-4-methylcoumarin - ? 36958 3.4.11.3 Arg-4-nitroanilide + H2O - Homo sapiens Arg + 4-nitroaniline - ? 36587 3.4.11.3 arginine vasopressin + H2O - Homo sapiens ? - ? 404360 3.4.11.3 Cys-4-nitroanilide + H2O - Homo sapiens Cys + 4-nitroaniline - ? 364818 3.4.11.3 Cys-4-nitroanilide + H2O - Saccharomyces cerevisiae Cys + 4-nitroaniline - ? 364818 3.4.11.3 L-Ala-2-naphthylamide + H2O - Homo sapiens L-Ala + 2-naphthylamine - ? 36267 3.4.11.3 L-alanine-p-nitroanilide + H2O - Sus scrofa L-alanine + p-nitroaniline - ? 36273 3.4.11.3 L-alanine-p-nitroanilide + H2O - Macaca radiata L-alanine + p-nitroaniline - ? 36273 3.4.11.3 L-Arg-2-naphthylamide + H2O - Homo sapiens L-Arg + 2-naphthylamine - ? 36317 3.4.11.3 L-Arg-vasopressin + H2O - Homo sapiens L-Arg + vasopressin - ? 394372 3.4.11.3 L-arginine-7-amido-4-methylcoumarin + H2O - Homo sapiens L-arginine + 7-amino-4-methylcoumarin - ? 432003 3.4.11.3 L-benzyl-L-Cys-2-naphthylamide + H2O - Homo sapiens L-benzyl-L-Cys + 2-naphthylamine - ? 36265 3.4.11.3 L-benzyl-L-cysteine-p-nitroanilide + H2O - Homo sapiens L-benzyl-L-cysteine + p-nitroaniline - ? 36269 3.4.11.3 L-Cys-beta-naphthylamide + H2O - Rattus norvegicus L-Cys + beta-naphthylamine - ? 450149 3.4.11.3 L-Cys-beta-naphthylamide + H2O - Rattus norvegicus Wistar L-Cys + beta-naphthylamine - ? 450149 3.4.11.3 L-cystine di-beta-naphthylamide + H2O - Rattus norvegicus ? - ? 384987 3.4.11.3 L-cystine di-beta-naphthylamide + H2O - Bothrops jararaca ? - ? 384987 3.4.11.3 L-cystine-di-beta-naphthylamide + 2 H2O - Rattus norvegicus L-cystine + 2 beta-naphthylamine - ? 450151 3.4.11.3 L-cystine-di-beta-naphthylamide + 2 H2O in the presence of thiol, the substrate is converted to L-cystine beta-naphthylamide Rattus norvegicus L-cystine + 2 beta-naphthylamine - ? 450151 3.4.11.3 L-cystine-di-beta-naphthylamide + 2 H2O in the presence of thiol, the substrate is converted to L-cystine beta-naphthylamide Rattus norvegicus Wistar L-cystine + 2 beta-naphthylamine - ? 450151 3.4.11.3 L-cystine-di-beta-naphthylamide + 2 H2O - Rattus norvegicus Wistar-Kyoto L-cystine + 2 beta-naphthylamine - ? 450151 3.4.11.3 L-cystine-di-p-nitroanilide + H2O - Homo sapiens L-cystine + p-nitroaniline - ? 36268 3.4.11.3 L-cystine-di-p-nitroanilide + H2O - Saccharomyces cerevisiae L-cystine + p-nitroaniline - ? 36268 3.4.11.3 L-Leu-2-naphthylamide + H2O - Homo sapiens L-Leu + 2-naphthylamine - ? 36264 3.4.11.3 L-Leu-2-naphthylamide + H2O - Mus musculus 2-naphthylamine + L-Leu - ? 412275 3.4.11.3 L-Leu-4-nitroanilide + H2O - Cricetulus griseus L-Leu + 4-nitroaniline - ? 364760 3.4.11.3 L-Leu-4-nitroanilide + H2O - Mus musculus L-Leu + 4-nitroaniline - ? 364760 3.4.11.3 L-Leu-4-nitroanilide + H2O - Homo sapiens L-Leu + 4-nitroaniline - ? 364760 3.4.11.3 L-Leu-4-nitroanilide + H2O - Sus scrofa L-Leu + 4-nitroaniline - ? 364760 3.4.11.3 L-Leu-4-nitroanilide + H2O - Bos taurus L-Leu + 4-nitroaniline - ? 364760 3.4.11.3 L-Leu-enkephalin + H2O - Homo sapiens L-Leu + enkephalin - ? 394376 3.4.11.3 L-Leu-p-nitroanilide + H2O - Homo sapiens L-Leu + p-nitroaniline - ? 392384 3.4.11.3 L-leucine-7-amido-4-methylcoumarin + H2O - Homo sapiens L-leucine + 7-amino-4-methylcoumarin - ? 418764 3.4.11.3 L-leucine-p-nitroanilide + H2O - Cricetulus griseus L-leucine + p-nitroaniline - ? 382142 3.4.11.3 L-Lys-2-naphthylamide + H2O - Homo sapiens L-Lys + 2-naphthylamine - ? 36266 3.4.11.3 L-lysine-p-nitroanilide + H2O - Sus scrofa L-lysine + p-nitroaniline - ? 36271 3.4.11.3 L-lysine-p-nitroanilide + H2O - Saccharomyces cerevisiae L-lysine + p-nitroaniline - ? 36271 3.4.11.3 L-lysine-p-nitroanilide + H2O - Streptococcus thermophilus L-lysine + p-nitroaniline - ? 36271 3.4.11.3 L-lysine-p-nitroanilide + H2O - Macaca radiata L-lysine + p-nitroaniline - ? 36271 3.4.11.3 L-methionine-p-nitroanilide + H2O - Sus scrofa L-methionine + p-nitroaniline - ? 36272 3.4.11.3 L-Phe-7-amido-4-methylcoumarin + H2O - Homo sapiens L-Phe + 7-amino-4-methylcoumarin - ? 382153 3.4.11.3 L-Trp-2-naphthylamide + H2O - Homo sapiens L-Trp + 2-naphthylamine - ? 392438 3.4.11.3 Leu-4-methylcoumaryl-7-amide + H2O - Homo sapiens Leu + 7-amino-4-methylcoumarin - ? 355555 3.4.11.3 Leu-4-nitroanilide + H2O - Homo sapiens Leu + 4-nitroaniline - ? 36360 3.4.11.3 leucyl-beta-naphthylamide + H2O - Rattus norvegicus leucine + beta-naphthylamine - ? 450219 3.4.11.3 LGGGGGL + H2O hydrolysis of poly-glycine peptides, overview Homo sapiens L-Leu + GGGGGL - ? 450222 3.4.11.3 Lys-4-methylcoumaryl-7-amide + H2O - Homo sapiens Lys + 7-amino-4-methylcoumarin - ? 355557 3.4.11.3 lysine-vasopressin + H2O - Homo sapiens ? - ? 452883 3.4.11.3 Met-4-methylcoumaryl-7-amide + H2O - Homo sapiens Met + 7-amino-4-methylcoumarin - ? 364816 3.4.11.3 additional information broad specificity Homo sapiens ? - ? 89 3.4.11.3 additional information S-benzyl-Cys-Pro-Leu-Gly(NH2) Homo sapiens ? - ? 89 3.4.11.3 additional information peptides having proline as the second amino acid residue Homo sapiens ? - ? 89 3.4.11.3 additional information not: L-Asp-beta-naphthylamide, L-Glu-beta-naphthylamide Homo sapiens ? - ? 89 3.4.11.3 additional information glycyl-p-nitroanilide Homo sapiens ? - ? 89 3.4.11.3 additional information hydrolyses neutral, aromatic, basic and acidic N-terminal amino acids from peptides Homo sapiens ? - ? 89 3.4.11.3 additional information N-terminal aspartic acid bound via its beta-carboxyl group in a peptide bond Homo sapiens ? - ? 89 3.4.11.3 additional information activity is greatly increased in rats with mammary tumors. The activity may be involved in the promotion and progression of breast cancer through oxytocin, vasopressin and/or renin-angiotensin system misregulation Rattus norvegicus ? - ? 89 3.4.11.3 additional information in individuals with type 2 diabetes the insulin-stimulated translocation of IRAP to the cell-surface of muscle and fat cells is impaired. This defect may lead to decreased cleavage and consequently increased action of peptide hormones that are substrates for IRAP. Impaiered IRAP action may thus play a role in the development of complications in type 2 diabetes Homo sapiens ? - ? 89 3.4.11.3 additional information IRAP is required for maintenance of key constituents of endosome-derived vesicles in cardiac muscle cells Mus musculus ? - ? 89 3.4.11.3 additional information the enzyme is involved in the metabolism of angiotensin Rattus norvegicus ? - ? 89 3.4.11.3 additional information the enzyme plays a role as a mediator for the effects of angiotensin IV and related peptides on extracellular dopamine levels in striatum Rattus norvegicus ? - ? 89 3.4.11.3 additional information the enzyme plays an imprtant role for IRAP in reproductive physiology in regulating the action of peptide hormones Ovis aries ? - ? 89 3.4.11.3 additional information the enzyme plays diverse physiological roles in the rat central nervous system Rattus norvegicus ? - ? 89 3.4.11.3 additional information involvement of the enzyme in memory processing. AT4 ligands, upon binding to the catalytic site of insulin-regulated aminopeptidase, enhance spatial learning, facilitate memory retention and retrieval and reverse amnesia Homo sapiens ? - ? 89 3.4.11.3 additional information IRAP is involved in glucose transporter GLUT4 storage vesicle trafficking Mus musculus ? - ? 89 3.4.11.3 additional information vasopressinase cannot degrade 1-deamino-8D-arginine vasopressin Homo sapiens ? - ? 89 3.4.11.3 additional information no activity with 1-deamino-8-D-arginine vasopressin Homo sapiens ? - ? 89 3.4.11.3 additional information recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4 Mus musculus ? - ? 89 3.4.11.3 additional information recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4 Mus musculus C57BL/6J ? - ? 89 3.4.11.3 oxytocin + H2O - Homo sapiens acyclic peptide + H2O - ? 36262 3.4.11.3 oxytocin + H2O - Rattus norvegicus acyclic peptide + H2O - ? 36262 3.4.11.3 oxytocin + H2O - Macaca fuscata fuscata acyclic peptide + H2O - ? 36262 3.4.11.3 oxytocin + H2O - Homo sapiens acyclic peptide + H2O tyrosyl-isoleucyl-glutaminyl-asparaginyl-S-(S-cysteine)cysteinyl-prolyl-leucyl-glycinamide, first product ? 36262 3.4.11.3 oxytocin + H2O cleavage of bond between N-terminal cysteine and adjacent tyrosine Homo sapiens acyclic peptide + H2O - ? 36262 3.4.11.3 oxytocin + H2O - Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O - Rattus norvegicus ? - ? 65396 3.4.11.3 oxytocin + H2O - Mus musculus ? N-terminal processing ? 65396 3.4.11.3 oxytocin + H2O in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O P-LAP in HUVEC cells regulates effects of oxytocin with resolution Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O cleavage sites: Cys-/-Tyr-/-Ile-/-Gln-/-Asn-/-Cys-Pro-Leu-Gly-NH2 Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O cleavage sites: Cys-/-Tyr-/-Phe-/-Gln-Asn-Cys-Pro-Arg-Gly-NH2 Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O enzyme opens the N-terminal cystine loop of oxytocin Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O a macrocyclic IRAP substrate Homo sapiens ? - ? 65396 3.4.11.3 oxytocin + H2O - Rattus norvegicus Wistar ? - ? 65396 3.4.11.3 Peptides + H2O enzyme plays a role in general metabolism of peptides during pregnancy Homo sapiens ? - ? 16310 3.4.11.3 S-benzyl-Cys-4-methylcoumaryl-7-amide + H2O - Homo sapiens S-benzyl-Cys + 7-amino-4-methylcoumarin - ? 364817 3.4.11.3 S-benzyl-cysteine-4-methylcoumarin 7-amide + H2O - Homo sapiens S-benzyl-cysteine + 7-amino-4-methylcoumarin - ? 36275 3.4.11.3 S-benzyl-L-cysteine-p-nitroanilide + H2O - Homo sapiens S-benzyl-L-cysteine + p-nitroaniline - ? 36270 3.4.11.3 S-benzyl-L-cysteine-p-nitroanilide + H2O - Sus scrofa S-benzyl-L-cysteine + p-nitroaniline - ? 36270 3.4.11.3 S-benzyl-L-cysteine-p-nitroanilide + H2O - Macaca radiata S-benzyl-L-cysteine + p-nitroaniline - ? 36270 3.4.11.3 somatostatin + H2O - Mus musculus ? - ? 366788 3.4.11.3 Vasopressin + H2O - Homo sapiens ? - ? 16659 3.4.11.3 Vasopressin + H2O - Rattus norvegicus ? - ? 16659 3.4.11.3 Vasopressin + H2O - Mus musculus ? - ? 16659 3.4.11.3 Vasopressin + H2O P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin Homo sapiens ? - ? 16659 3.4.11.3 Vasopressin + H2O the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III Homo sapiens ? - ? 16659 3.4.11.3 Vasopressin + H2O a macrocyclic IRAP substrate Homo sapiens ? - ? 16659 3.4.11.3 Vasopressin + H2O inactivation of vasopressin Mus musculus ? - ? 16659 3.4.11.3 Vasopressin + H2O - Rattus norvegicus Wistar ? - ? 16659 3.4.11.3 Vasopressin + H2O - Mus musculus C57BL/6J ? - ? 16659 3.4.11.3 Vasopressin + H2O inactivation of vasopressin Mus musculus C57BL/6J ? - ? 16659 3.4.11.3 vasopressin + H2O - Homo sapiens hydrolyzed vasopressin - ? 36263 3.4.11.3 vasopressin + H2O - Rattus norvegicus hydrolyzed vasopressin - ? 36263 3.4.11.3 vasopressin + H2O vasopressin is a physiological substrate Mus musculus hydrolyzed vasopressin N-terminal processing ? 36263