3.2.2.16 5'-(4-fluorosulfonylbenzoyl)adenosine + H2O - Oryza sativa 5-fluorosulfonylbenzoyl-D-ribose + adenine - ? 390989 3.2.2.16 5'-adenosylcysteine + H2O - Oryza sativa adenine + S-ribosylcysteine - ? 390981 3.2.2.16 5'-butylthioadenosine + H2O - Arabidopsis thaliana 5-butylthio-D-ribose + adenine - ? 390983 3.2.2.16 5'-butylthioadenosine + H2O - Oryza sativa 5-butylthio-D-ribose + adenine - ? 390983 3.2.2.16 5'-butylthioadenosine + H2O 25% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + 5-butylthio-D-ribose - ? 403984 3.2.2.16 5'-chloroadenosine + H2O - Arabidopsis thaliana 5-chloro-D-ribose + adenine - ? 390985 3.2.2.16 5'-chloroadenosine + H2O 4% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + 5-chloro-D-ribose - ? 403985 3.2.2.16 5'-deoxy-5'-(difluoromethylthio)adenosine + H2O DFMTA, fluorinated substrate analogue Escherichia coli 5-deoxy-5-(difluoromethylthio)-D-ribose + adenine - ? 115967 3.2.2.16 5'-deoxy-5'-(difluoromethylthio)adenosine + H2O DFMTA, fluorinated substrate analogue Escherichia coli B / ATCC 11303 5-deoxy-5-(difluoromethylthio)-D-ribose + adenine - ? 115967 3.2.2.16 5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O MFMTA , fluorinated analogue of MTA Escherichia coli 5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine - ? 115966 3.2.2.16 5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O MFMTA , fluorinated analogue of MTA Escherichia coli B / ATCC 11303 5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine - ? 115966 3.2.2.16 5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O TFMTA, fluorinated substrate analogue Escherichia coli 5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine - ? 115968 3.2.2.16 5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O TFMTA, fluorinated substrate analogue Escherichia coli B / ATCC 11303 5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine - ? 115968 3.2.2.16 5'-deoxy-5'-isobutylthio-adenosine + H2O 1-butanol buffer/propan-2-ol buffer Lupinus luteus 5-isobutylthio-D-ribose + adenine - ? 115950 3.2.2.16 5'-deoxy-5'-methylthioadenosine + H2O - Escherichia coli 5-methylthio-D-ribose + adenine - ? 115945 3.2.2.16 5'-deoxy-5'-methylthioadenosine + H2O - Lupinus luteus 5-methylthio-D-ribose + adenine - ? 115945 3.2.2.16 5'-deoxy-5'-methylthioadenosine + H2O - Persea americana 5-methylthio-D-ribose + adenine - ? 115945 3.2.2.16 5'-deoxy-5'-methylthioadenosine + H2O - Glycine max ? - ? 427319 3.2.2.16 5'-deoxy-5'-propylthioadenosine + H2O - Lupinus luteus 5-propylthio-D-ribose + adenine - ? 115946 3.2.2.16 5'-deoxy-5'-propylthioadenosine + H2O 1-butanol buffer/propan-2-ol buffer Lupinus luteus 5-propylthio-D-ribose + adenine - ? 115946 3.2.2.16 5'-deoxy-5'-S-adenosyl-L-cysteine + H2O relative activity 95.2% Homo sapiens S-(5-deoxy-5-D-ribosyl)-L-cysteine + adenine - ? 115964 3.2.2.16 5'-deoxy-5'-S-adenosyl-L-homocysteine + H2O substrate analogue, relative activity 95.8% Homo sapiens S-(5-deoxy-5-D-ribosyl)-L-homoscysteine + adenine - ? 115963 3.2.2.16 5'-deoxy-5'-thioethanoladenosine + H2O relative activity 98% Homo sapiens ? - ? 115965 3.2.2.16 5'-deoxyadenosine + H2O - Staphylococcus aureus 5-deoxy-D-ribose + adenine - ? 115955 3.2.2.16 5'-deoxyadenosine + H2O - Helicobacter pylori 5-deoxy-D-ribose + adenine - ? 115955 3.2.2.16 5'-deoxyadenosine + H2O 1-butanol buffer Lupinus luteus 5-deoxy-D-ribose + adenine - ? 115955 3.2.2.16 5'-deoxyadenosine + H2O i.e. DOA, MTAN can rapidly hydrolyse DOA Escherichia coli 5-deoxy-D-ribose + adenine - ? 115955 3.2.2.16 5'-deoxyadenosine + H2O - Staphylococcus aureus NCTC 8325 5-deoxy-D-ribose + adenine - ? 115955 3.2.2.16 5'-deoxyadenosine + H2O - Staphylococcus aureus RN4220 5-deoxy-D-ribose + adenine - ? 115955 3.2.2.16 5'-ethylthio-2-aminoadenosine + H2O 1-butanol buffer/propan-2-ol buffer Lupinus luteus 5-ethylthio-D-ribose + 2-aminoadenosine - ? 115957 3.2.2.16 5'-ethylthioadenosine + H2O - Arabidopsis thaliana 5-ethylthio-D-ribose + adenine - ? 115948 3.2.2.16 5'-ethylthioadenosine + H2O - Oryza sativa 5-ethylthio-D-ribose + adenine - ? 115948 3.2.2.16 5'-ethylthioadenosine + H2O 1-butanol buffer Lupinus luteus 5-ethylthio-D-ribose + adenine - ? 115948 3.2.2.16 5'-ethylthioadenosine + H2O 40% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + 5-ethylthio-D-ribose - ? 115983 3.2.2.16 5'-ethylthioinosine + H2O 1-butanol buffer Lupinus luteus 5-ethylthio-D-ribose + hypoxanthine - ? 115958 3.2.2.16 5'-iodoadenosine + H2O 28% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + 5-iodo-D-ribose - ? 403989 3.2.2.16 5'-iodothioadenosine + H2O - Arabidopsis thaliana 5-iodothio-D-ribose + adenine - ? 390992 3.2.2.16 5'-iodothioadenosine + H2O - Oryza sativa 5-iodothio-D-ribose + adenine - ? 390992 3.2.2.16 5'-isobutylthio-3-deaza-adenosine + H2O 1-butanol buffer/propan-2-ol buffer Lupinus luteus 5-isobutylthio-D-ribose + 3-deazadenosine - ? 115956 3.2.2.16 5'-isobutylthioadenosine + H2O - Arabidopsis thaliana 5-isobutylthioribose + adenine - ? 390995 3.2.2.16 5'-isobutylthioadenosine + H2O 17% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + 5-isobutylthio-D-ribose - ? 403990 3.2.2.16 5'-isobutylthioadenosine + H2O 52% activity compared to 5'-methylthioadenosine Escherichia coli ? - ? 428094 3.2.2.16 5'-isobutylthioinosine + H2O 1-butanol buffer Lupinus luteus 5-isobutylthio-D-ribose + hypoxanthine - ? 115960 3.2.2.16 5'-isopropylthioadenosine + H2O - Oryza sativa 5-isopropylthio-D-ribose + adenine - ? 390996 3.2.2.16 5'-methylthioadenosine + H2O - Escherichia coli 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Escherichia coli 5-methylthio-D-ribose + adenine - ir 115979 3.2.2.16 5'-methylthioadenosine + H2O - Lupinus luteus 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Arabidopsis thaliana 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Streptococcus pneumoniae 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Vibrio cholerae serotype O1 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Oryza sativa 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Staphylococcus aureus 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O 100% activity Arabidopsis thaliana 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O Pfs protein and Bgp protein display 100% activity towards 5'-methylthioadenosine Borreliella burgdorferi 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Vibrio cholerae serotype O1 N16961 5-methylthio-D-ribose + adenine - ? 115979 3.2.2.16 5'-methylthioadenosine + H2O - Bacillus subtilis ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Escherichia coli ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Homo sapiens ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Lupinus luteus ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Pisum sativum ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Solanum lycopersicum ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Cucumis sativus ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Ochromonas malhamensis ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Persea americana ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Catharanthus roseus ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Acetabularia acetabulum ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O 100% activity Escherichia coli ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines Solanum lycopersicum ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines Persea americana ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Escherichia coli B / ATCC 11303 ? - ? 369811 3.2.2.16 5'-methylthioadenosine + H2O - Escherichia coli adenine + S-methyl-5-thio-D-ribose - ? 430830 3.2.2.16 5'-methylthioadenosine + H2O - Glycine max adenine + S-methyl-5-thio-D-ribose - ? 430830 3.2.2.16 5'-methylthioadenosine + H2O - Salmonella enterica adenine + S-methyl-5-thio-D-ribose - ? 430830 3.2.2.16 5'-methylthioadenosine + H2O - Vibrio cholerae serotype O1 adenine + S-methyl-5-thio-D-ribose - ? 430830 3.2.2.16 5'-methylthioadenosine + H2O - Mycobacterium tuberculosis adenine + S-methyl-5-thio-D-ribose - ? 430830 3.2.2.16 5'-methylthioadenosine + H2O - Helicobacter pylori adenine + S-methyl-5-thio-D-ribose - ? 430830 3.2.2.16 5'-methylthioarabinosyladenine + H2O 1-butanol buffer/propan-2-ol buffer Lupinus luteus 5-methylthioarabinose + adenine - ? 115954 3.2.2.16 5'-methylthioinosine + H2O - Lupinus luteus 5-methylthio-D-ribose + hypoxanthine - ? 115947 3.2.2.16 5'-methylthioinosine + H2O maximal velocity about 50-times lower than for 5'-methylthioadenosine Lupinus luteus 5-methylthio-D-ribose + hypoxanthine - ? 115947 3.2.2.16 5'-n-butylthioadenosine + H2O 1-butanol buffer Lupinus luteus 5-n-butylthio-D-ribose + adenine - ? 115949 3.2.2.16 5'-n-butylthioadenosine + H2O 40% activity compared to 5'-methylthioadenosine Escherichia coli ? - ? 428095 3.2.2.16 5'-n-butylthioinosine + H2O 1-butanol buffer Lupinus luteus 5-n-butylthio-D-ribose + hypoxanthine - ? 115959 3.2.2.16 5'-phenylthioadenosine + H2O - Arabidopsis thaliana 5-phenylthio-D-ribose + adenine - ? 390998 3.2.2.16 5'-phenylthioadenosine + H2O - Oryza sativa 5-phenylthio-D-ribose + adenine - ? 390998 3.2.2.16 5'-phenylthioadenosine + H2O 12% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + 5-phenylthio-D-ribose - ? 403991 3.2.2.16 5'-propylthioadenosine + H2O - Oryza sativa 5-propylthio-D-ribose + adenine - ? 390999 3.2.2.16 6-amino-6-deoxyfutalosine + H2O - Helicobacter pylori 3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine - ? 430835 3.2.2.16 6-amino-6-deoxyfutalosine + H2O - Helicobacter pylori adenine + dehypoxanthinyl futalosine - ? 431434 3.2.2.16 adenosine + H2O - Arabidopsis thaliana adenine + D-ribose - ? 94810 3.2.2.16 additional information broad substrate specificity Helicobacter pylori ? - ? 89 3.2.2.16 additional information enzyme is involved in two catabolic reactions: irreversible cleavage of the glycosidic bond of 5'-methylthioadenoside and cleavago of the glcyosidic bond of S-adenosylhomocysteine Escherichia coli ? - ? 89 3.2.2.16 additional information key role in biological methylation, polyamine biosynthesis, methionine recycling and bacterial quorum sensing Escherichia coli ? - ? 89 3.2.2.16 additional information no substrate: S-adenosylhomocysteine, adenosine Arabidopsis thaliana ? - ? 89 3.2.2.16 additional information no activity towards S-adenosyl-L-homocysteine and adenosine Arabidopsis thaliana ? - ? 89 3.2.2.16 additional information AtMTAN2 is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview Arabidopsis thaliana ? - ? 89 3.2.2.16 additional information MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview Escherichia coli ? - ? 89 3.2.2.16 additional information dynamics are an important factor in substrate selection in MTAN, overview. Substrate binding induces a favourable entropic change in AtMTAN1 Arabidopsis thaliana ? - ? 89 3.2.2.16 additional information MTAN restores the activity of three S-adenosyl-L-methionine utilizing enzymes, biotin synthase, lipoyl synthase and tyrosine lyase, that are inhibited by the highly reactive 5'-deoxyadenosyl radical, overview Escherichia coli ? - ? 89 3.2.2.16 additional information substrate binding, specificity and dynamics, overview. Substrate binding induces a unfavourable entropic change Escherichia coli ? - ? 89 3.2.2.16 additional information substrate specificities of isozymes, isozyme AtMTAN2 is also active with S-adenosyl-L-homocysteine, EC 3.2.2.9, overview. Isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not Arabidopsis thaliana ? - ? 89 3.2.2.16 additional information no activity toward 5'-methylthioinosine, 5'-isobutylthioinosine, 5'-isobutylthio-3-deaza-adenosine, 5'-methylthio-3-deaza-adenosine, 5'-chloroformycin, 5'-methylthioformycin, 5'-ethylthiotubercidin, S-tubercidinylhomocysteine, S-inosyl-L-homocysteine, S-guanosyl-L-homocysteine, S-cytidylhomocysteine, S-8-aza adenosyl-L-homocysteine, S-n-methyl-3-deaza-adenosyl-L-homocysteine, S-n6-dimethyl-3-deaza-adenosyl-L-homocysteine, sinefungin, S-adenosyl-L-homocysteine dialdehyde, and acyclic adenosyl-L-homocysteine Escherichia coli ? - ? 89 3.2.2.16 additional information the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine Escherichia coli ? - ? 89 3.2.2.16 additional information the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine Salmonella enterica ? - ? 89 3.2.2.16 additional information the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine Vibrio cholerae serotype O1 ? - ? 89 3.2.2.16 additional information the enzyme also shows weak hydrolytic activity with S-adenosylhomocysteine Burkholderia thailandensis ? - ? 89 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Escherichia coli adenine + S-ribosyl-L-homocysteine - ? 115980 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Streptococcus pneumoniae adenine + S-ribosyl-L-homocysteine - ? 115980 3.2.2.16 S-adenosyl-L-homocysteine + H2O 14% activity compared to 5'-methylthioadenosine Arabidopsis thaliana adenine + S-ribosyl-L-homocysteine - ? 115980 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Staphylococcus aureus S-D-ribosyl-L-homocysteine + adenine - ir 431188 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Brucella melitensis S-D-ribosyl-L-homocysteine + adenine - ir 431188 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Staphylococcus aureus S-ribosyl-L-homocysteine + adenine - ? 431189 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Helicobacter pylori S-ribosyl-L-homocysteine + adenine - ? 431189 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Staphylococcus aureus NCTC 8325 S-ribosyl-L-homocysteine + adenine - ? 431189 3.2.2.16 S-adenosyl-L-homocysteine + H2O - Staphylococcus aureus RN4220 S-ribosyl-L-homocysteine + adenine - ? 431189 3.2.2.16 S-adenosylhomocysteine + H2O - Escherichia coli adenine + S-ribosylhomocysteine - ? 371155 3.2.2.16 S-adenosylhomocysteine + H2O - Escherichia coli adenine + S-ribosylhomocysteine - ir 371155 3.2.2.16 S-adenosylhomocysteine + H2O - Arabidopsis thaliana adenine + S-ribosylhomocysteine - ? 371155 3.2.2.16 S-adenosylhomocysteine + H2O 15.9% of the rate with 5'-methylthioadenosine Oryza sativa adenine + S-ribosylhomocysteine - ? 371155 3.2.2.16 S-adenosylmercaptoethanol + H2O 1-butanol buffer/propan-2-ol buffer Lupinus luteus ? - ? 115951 3.2.2.16 S-inosylmercaptoethanol + H2O propan-2-ol buffer Lupinus luteus ? - ? 115961 3.2.2.16 S-isobutyl-5'-thioadenosine + H2O - Oryza sativa 5-S-(2-methylpropyl)-5-thio-beta-D-ribofuranose + adenine - ? 390994 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Staphylococcus aureus S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Escherichia coli S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Arabidopsis thaliana S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Arabidopsis thaliana S-methyl-5-thio-D-ribose + adenine - ir 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Neisseria meningitidis S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Mycobacterium tuberculosis S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Salmonella enterica S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Vibrio cholerae serotype O1 S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Helicobacter pylori S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Brucella melitensis S-methyl-5-thio-D-ribose + adenine - ir 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Vibrio cholerae S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O preferred substrate Arabidopsis thaliana S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O preferred substrate Burkholderia thailandensis S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Staphylococcus aureus NCTC 8325 S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Staphylococcus aureus RN4220 S-methyl-5-thio-D-ribose + adenine - ? 411011 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Staphylococcus aureus adenine + S-methyl-5-thio-D-ribose - ? 434796 3.2.2.16 S-methyl-5'-thioadenosine + H2O almost completely preferred substrate Burkholderia thailandensis adenine + S-methyl-5-thio-D-ribose - ? 434796 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Staphylococcus aureus NCTC 8325 adenine + S-methyl-5-thio-D-ribose - ? 434796 3.2.2.16 S-methyl-5'-thioadenosine + H2O - Staphylococcus aureus RN4220 adenine + S-methyl-5-thio-D-ribose - ? 434796