3.1.4.11 1-acyl-2-arachidonoylphosphatidylinositol + H2O - Homo sapiens ? - ? 411142 3.1.4.11 1-acyl-2-linoleoylphosphatidylinositol + H2O - Homo sapiens ? - ? 411143 3.1.4.11 1-phosphatidyl-1D-myo-inositol - Equus caballus 1D-myo-inositol 1-phosphate + diacylglycerol in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate ? 411166 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Phaseolus vulgaris 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Pisum sativum 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Nicotiana tabacum 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Glycine max 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Arabidopsis thaliana 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Brassica napus 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Bacillus cereus 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Medicago sativa 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Solanum lycopersicum 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Oryza sativa 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Citrus limon 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Bacillus thuringiensis 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Rubia tinctorum 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Nicotiana benthamiana 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Capsicum chinense 1D-myo-inositol 1-phosphate + diacylglycerol - ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O - Homo sapiens 1D-myo-inositol 1-phosphate + diacylglycerol in almost equal amounts with 1D-myo-inositol 1,2-cyclic phosphate ? 411165 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Phaseolus vulgaris 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Drosophila sp. (in: flies) 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Bos taurus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Triticum aestivum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Pisum sativum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Nicotiana tabacum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Glycine max 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Arabidopsis thaliana 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Lysinibacillus sphaericus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Brassica napus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Dictyostelium discoideum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Aplysia californica 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Medicago sativa 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Felis catus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Solanum lycopersicum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Oryza sativa 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Chlorocebus aethiops 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Lytechinus pictus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Mytilus galloprovincialis 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Citrus limon 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Streptomyces antibioticus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Rubia tinctorum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Digitaria sanguinalis 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Peganum harmala 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Nicotiana benthamiana 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Misgurnus mizolepis 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Toxoplasma gondii 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Oryza sativa Japonica Group 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Vigna radiata 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Capsicum chinense 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Pseudomonas sp. 62186 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Saccharomyces cerevisiae 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Solanum lycopersicum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O AtPLC2, preferred substrate, N-terminal EF-hand-like domain is required for catalytic activity but not for lipid binding Arabidopsis thaliana 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain organization of the PLC isoenzymes beta, gamma, delta and epsilon, distinct regulatory domains Mammalia 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structure of PLC-epsilon, contains RasGEF and RA domains Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structure of PLCdelta1 Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structure of PLCgamma2, roles of the different domains Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structure of PLCzeta Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structures of PLC-beta, -gamma and -delta isoenzymes Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structures of PLC–beta, -gamma and -delta isoenzymes Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain Bos taurus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, preferred substrate to phosphatidylinositol, domain structure Trypanosoma cruzi 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC-beta1 Bos taurus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC-delta1, structure of the catalytic domain, His-311 and His-356 act as general acid-base catalysts Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol 4- and 5-phosphoryl groups of inositol 1,4,5-trisphosphate interact with the side chains of Lys-32 and Lys-57 and with those of Lys-30, Arg-40 and Lys-57 of PLC-delta1, respectively ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O inositol phosphate/diacylglycerol signaling pathway, TcPI-PLC is lipid modified in vivo, TcPI-PLC is developmentally regulated, its expression is induced during the differentiation of trypomastigotes into amastigotes at an early stage in the transformation process Trypanosoma cruzi 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O key enzyme in signal transduction generating the intracellular second messengers DAG and IP3 Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O part of the phosphoinositide signal transduction pathway Peganum harmala 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O plays a role in various signal transduction pathways, DsPLC2 plays a role in an early event in the light induction process of C4 photosynthesis Digitaria sanguinalis 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol the products act as second messengers in cell signalling ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes Bos taurus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLCbeta1 is involved in nuclear inositol lipid signaling Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O regulation of PLC isoenzymes, cellular signaling Mammalia 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol intracellular messengers ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O sperm-specific PLCzeta induces intracellular Ca2+ oscillations and subsequent early embryonic development when expressed in mouse eggs, PLCzeta may be the physiological mammalian egg-activating sperm factor Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O amino acids Pro500 and His503 are critical for binding of PLC-gamma1 to one of its substrates, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in the membrane Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC beta1b Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC-delta1 Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC-gamma1 Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PI-PLC beta1 could have a role in muscle hypertrophy taking place in human muscular dystrophy Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PI-PLC beta1 is essential in the IGF-1 mitogenic signaling pathway Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate Streptomyces antibioticus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O interaction analysis, modeling and binding kinetics of substrate and enzyme PH-PLCdelta1, overview. PH-PLCdelta1 binds specifically to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, breaking up clusters and expelling nonspecifically associated peptide from the surface Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Saccharomyces cerevisiae PLC1p 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Rattus norvegicus PLCepsilon 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC-delta1, structure of the catalytic domain, His-311 and His-356 act as general acid-base catalysts Rattus norvegicus PLC-delta1 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol 4- and 5-phosphoryl groups of inositol 1,4,5-trisphosphate interact with the side chains of Lys-32 and Lys-57 and with those of Lys-30, Arg-40 and Lys-57 of PLC-delta1, respectively ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Mytilus galloprovincialis Lam 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 364602 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Mus musculus 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol - ? 446018 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Homo sapiens 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol - ? 446018 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O - Aedes aegypti 1D-myo-inositol 1,4,5-triphosphate + diacylglycerol - ? 446018 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Phaseolus vulgaris 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Homo sapiens 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Pisum sativum 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Nicotiana tabacum 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Glycine max 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Arabidopsis thaliana 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Brassica napus 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Medicago sativa 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Solanum lycopersicum 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Oryza sativa 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Citrus limon 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Rubia tinctorum 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Nicotiana benthamiana 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O - Capsicum chinense 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O preferred substrate Oryza sativa Japonica Group 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O preferred substrate. With 1-phosphatidyl-1D-myo-inositol 4-phosphate, the enzyme displays a more than 3fold higher hydrolyzing activity compared to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Oryza sativa Japonica Group 1D-myo-inositol 1,4-bisphosphate + diacylglycerol - ? 446020 3.1.4.11 1D-myo-inositol 1,4,5-trisphosphate fluorescent derivative WH-15 + H2O - Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + quinomethide + 6-aminoquinoline + ? - ir 446588 3.1.4.11 arachidonoyl-phosphatidylinositol + H2O - Homo sapiens 1,2-diarachidonoyl-sn-glycerol + 1D-myo-inositol 1-phosphate - ? 411644 3.1.4.11 arachidonoylphosphatidylinositol + H2O - Rattus norvegicus myo-inositol 1-phosphate + 1,2-diarachidonoylglycerol - ? 364605 3.1.4.11 butyl-fluorescein myo-inositol phosphate + H2O - Lysinibacillus sphaericus ? - ? 447250 3.1.4.11 diarachidonoylphosphatidylinositol + H2O - Oryctolagus cuniculus 1,2-diacylglycerol + 1D-myo-inositol 1-phosphate a mixture of 86% myoinositol 1-phosphate and 14% myoinositol 1,2-cyclic phosphate ? 411982 3.1.4.11 dibutyrylphosphatidylinositol + H2O - Listeria monocytogenes ? - ? 400839 3.1.4.11 glycosylphosphatidylinositol + H2O catalytic mechanism Bacillus cereus ? - ? 364607 3.1.4.11 GPI-renal dipeptidase - Sus scrofa ? - ? 392158 3.1.4.11 additional information not: phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine Glycine max ? - ? 89 3.1.4.11 additional information PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5’-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane Staphylococcus aureus ? - ? 89 3.1.4.11 additional information PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5’-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane Bacillus thuringiensis ? - ? 89 3.1.4.11 additional information PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5’-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane Clostridium novyi ? - ? 89 3.1.4.11 additional information PI-PLC has a high affinity for the glycosylphosphatidylinositol anchor of GPI-anchored proteins, e.g. 5’-nucleotidase and alkaline phosphatase, and catalyzes cleavage in vitro to release a soluble protein and diacylglycerol, which remains in the membrane, enzyme structure Bacillus cereus ? - ? 89 3.1.4.11 additional information PLCepsilon contains a GTP exchange factor and two C-terminal Ras-binding domains Rattus norvegicus ? - ? 89 3.1.4.11 additional information the activation of the gamma1 isoenzyme is a biologically important event in zona pellucida-stimulated inositol phospholipid metabolism with a potential role in signal transduction leading to acrosomal exocytosis Mus musculus ? - ? 89 3.1.4.11 additional information regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and betagamma subunits is dependent of enzyme subtype and concentration of Mg2+ Rattus norvegicus ? - ? 89 3.1.4.11 additional information the inositol lipid breakdown is controlled by different phosphoinositidase C isoenzymes in various cell compartments Rattus norvegicus ? - ? 89 3.1.4.11 additional information the activation of the enzyme by m3-mascarinic acid receptor stimulation is mediated via alpha-subunit of the Gq/11 family of G-proteins Rattus norvegicus ? - ? 89 3.1.4.11 additional information perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown Rattus norvegicus ? - ? 89 3.1.4.11 additional information the enzyme may participate in signal transduction over the plant plasma membrane Triticum aestivum ? - ? 89 3.1.4.11 additional information plays a critical role in signal transduction in the receptor-activated human platelets Homo sapiens ? - ? 89 3.1.4.11 additional information transformation-linked and progression-linked signal transduction enzyme Rattus norvegicus ? - ? 89 3.1.4.11 additional information hepatocyte growth factor can activate phosphoinositidase C in rat hepatocytes Rattus norvegicus ? - ? 89 3.1.4.11 additional information AtPLC1S is involved in stress responses, AtPLC2 not Arabidopsis thaliana ? - ? 89 3.1.4.11 additional information AtPLC2 is constitutively expressed Arabidopsis thaliana ? - ? 89 3.1.4.11 additional information cellular signaling Rattus norvegicus ? - ? 89 3.1.4.11 additional information cellular signaling, regulation of PLC activity Homo sapiens ? - ? 89 3.1.4.11 additional information PLC delta1 is required for skin stem cell lineage commitment Mus musculus ? - ? 89 3.1.4.11 additional information PLC plays a key role in photoreceptor response Drosophila sp. (in: flies) ? - ? 89 3.1.4.11 additional information PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development Mus musculus ? - ? 89 3.1.4.11 additional information PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways Rattus norvegicus ? - ? 89 3.1.4.11 additional information PLCgamma isoforms are regulated through activation of tyrosine kinase-linked receptors, importance of PLCgamma2 in B-cell signal transduction Homo sapiens ? - ? 89 3.1.4.11 additional information PLCgamma2 regulation, role in B-cell signalling Homo sapiens ? - ? 89 3.1.4.11 additional information PsPLC delta isoform is regulated by light in a tissue specific manner and may be involved in important functions Pisum sativum ? - ? 89 3.1.4.11 additional information activation of phospholipase C is a vital step in the neuronal protective adenosine-induced signal transduction pathway, conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures Rattus norvegicus ? - ? 89 3.1.4.11 additional information Galpha12712- and Rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors Rattus norvegicus ? - ? 89 3.1.4.11 additional information Gi-coupled receptors can inhibit PLC-epsilon, most likely by suppressing formation of cyclic AMP required for Epac-mediated Rap2B activation Homo sapiens ? - ? 89 3.1.4.11 additional information interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division Homo sapiens ? - ? 89 3.1.4.11 additional information interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division Rattus norvegicus ? - ? 89 3.1.4.11 additional information involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly Homo sapiens ? - ? 89 3.1.4.11 additional information phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy Mus musculus ? - ? 89 3.1.4.11 additional information phospholipase C is a key factor determining the photoreceptor sensitivity Drosophila sp. (in: flies) ? - ? 89 3.1.4.11 additional information PI-PLC activity might be regulated by a heterotrimeric G protein Lilium davidii ? - ? 89 3.1.4.11 additional information PIP2-PLC is involved in the signal pathway that leads to the acquisition of heat acclimation Pisum sativum ? - ? 89 3.1.4.11 additional information PLC activity is under tight dynamic control of the Ca2+ concentration. In insulin-secreting beta-cells, this mechanism provides a link between Ca2+ influx and release from intracellular stores that may be important in the regulation of insulin secretion Rattus norvegicus ? - ? 89 3.1.4.11 additional information PLC is involved in activation of the muscarinic receptor-operated cationic current in guinea pig ileal smooth muscle cells Oryctolagus cuniculus ? - ? 89 3.1.4.11 additional information PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways Mus musculus ? - ? 89 3.1.4.11 additional information PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways Homo sapiens ? - ? 89 3.1.4.11 additional information PLC-eta may perform fundamental roles in the brain Homo sapiens ? - ? 89 3.1.4.11 additional information PLC-eta may perform fundamental roles in the brain Mus musculus ? - ? 89 3.1.4.11 additional information PLCgamma2 is crucial for development of the NL cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NL cell function in vivo Mus musculus ? - ? 89 3.1.4.11 additional information recombinant PLCzeta protein induces Ca2+ oscillations in mouse eggs Mus musculus ? - ? 89 3.1.4.11 additional information reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders Rattus norvegicus ? - ? 89 3.1.4.11 additional information regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells Homo sapiens ? - ? 89 3.1.4.11 additional information signaling of myelin phagocytosis mediated by complement-receptor-3 alone and by complement-receptor-3 combined with scavenger-receptor-AI/II involves phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C, the cascade phosphatidylinositol 3-kinase -> phosphoinositide-specific phospholipase-Cgamma -> protein kinase-C, and wide range modulation by protein kinase-C Mus musculus ? - ? 89 3.1.4.11 additional information significant role for PpPLC1 in cytokinin signalling and gravitropism Physcomitrium patens ? - ? 89 3.1.4.11 additional information suPLCbeta is activated by G protein betagamma subunits Lytechinus pictus ? - ? 89 3.1.4.11 additional information the enzyme is involved in cytokinin and gravity responses Physcomitrium patens ? - ? 89 3.1.4.11 additional information the neuron-specific enzyme may be important for the formation and/or maintenance of the neuronal network in the postnatal brain Mus musculus ? - ? 89 3.1.4.11 additional information the Vr-PLC3 protein is specifically activated by drought and salt stress in an abscisic acid-independent manner, with its induction being faster in roots than in leaf tissue Vigna radiata ? - ? 89 3.1.4.11 additional information when expressed in plasma membrane, TcPI-PLC is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi, an essential step for the intracellular replication of these parasites Trypanosoma cruzi ? - ? 89 3.1.4.11 additional information wild-type Rac GTPase with guanosine 5'-(3-O-thio)triphosphate causes a marked stimulation of PLCgamma2 but has no effect on the activity of PLCgamma1. The mechanism of PLCgamma2 activation by Rac GTPase involves neither protein phosphorylation nor PI3K-mediated generation of phosphatidylinositol 3,4,5-trisphosphate Homo sapiens ? - ? 89 3.1.4.11 additional information absolute requirement for PLC-gamma1 in villin-induced cell migration Mus musculus ? - ? 89 3.1.4.11 additional information activation of PLCgamma by GTP during initial stages of formation of nuclear envelope provides a mechanism for temporal control of assembly of nuclear envelope Lytechinus pictus ? - ? 89 3.1.4.11 additional information activation of PLCgamma by GTP during initial stages of formation of nuclear envelope provides a mechanism for temporal control of assembly of nuclear envelope Strongylocentrotus purpuratus ? - ? 89 3.1.4.11 additional information inhibition of phosphatidylinositol 3-kinase may go through phosphoinositide-specific phospholipase C pathway leading to increase of expression of the inducible nitric oxide synthase, indicating that phosphatidylinositol 3-kinase and phosphoinositide-specific phospholipase C may counteract to regulate the metabolism of phosphatidylinositol (4,5)-bisphosphate depending on cell types or their conditions Mus musculus ? - ? 89 3.1.4.11 additional information inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter Rattus norvegicus ? - ? 89 3.1.4.11 additional information overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation Mus musculus ? - ? 89 3.1.4.11 additional information overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation Rattus norvegicus ? - ? 89 3.1.4.11 additional information phosphatidylinositol-phospholipase C plays a critical role, most likely through activation of protein kinase C pathway, in TLR4 mediated immune responses of avian macrophage cells to lipopolysaccharides Gallus gallus ? - ? 89 3.1.4.11 additional information phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport Homo sapiens ? - ? 89 3.1.4.11 additional information PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways Homo sapiens ? - ? 89 3.1.4.11 additional information PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways Rattus norvegicus ? - ? 89 3.1.4.11 additional information PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulationlikely mediates G-protein-coupled receptor signalling pathways Chlorocebus aethiops ? - ? 89 3.1.4.11 additional information PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells Homo sapiens ? - ? 89 3.1.4.11 additional information PLC-dsu is unlikely to be directly involved in the process of egg activation but may play a role in mediating extracellular signals transmitted via the phosphatidylinositol 3'-kinase pathway Strongylocentrotus purpuratus ? - ? 89 3.1.4.11 additional information PLCepsilon is required for thrombin- but not lysophosphatidic acid-induced sustained ERK activation and DNA synthesis, providing a novel mechanism for G protein-coupled receptor and Rho signaling to cell proliferation. PLCepsilon has a role as a guanine nucleotide exchange factor for Rap1 Mus musculus ? - ? 89 3.1.4.11 additional information suppression of Pi-PLC promotes apoptosis of vascular endothelial cells by inhibiting phosphorylation of Akt, elevating P53 expression, and affecting the cell cycle distribution. phosphatidyl-specific phospholipase C and phosphatidylcholine-specific phospholipase C might control the apoptosis by jointly regulating akt phosphorylation, P53 expression and affecting cell cycle in vascular endothelial cells Homo sapiens ? - ? 89 3.1.4.11 additional information PLCgamma2 is essential for RANK (Receptor activator of NF-kB) signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation Mus musculus ? - ? 89 3.1.4.11 additional information the enzymes acting against [3H] inositol-phosphatidylinositol (PtdIns) and [3H] inositolphosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in the cat carotid bodies (CB) are investigated using labelled phospholipids as a source of the substrate. Analysis of water soluble inositol metabolites indicates that PtdIns is degraded exclusively by the enzyme since the inositolmonophosphate (IP1) is detected as a single product. In case of PtdIns(4,5)P2 hydrolysis by carotid bodies (CB) enzymes there are all 3 inositol phosphates: IP3, IP2, IP1 Felis catus ? - ? 89 3.1.4.11 additional information water-soluble synthetic short-chain phosphatidylinositol and inositol 1,2-(cyclic)-phosphate along with PI/detergent mixed micelles and PI/PC vesicles are used as substrates Listeria monocytogenes ? - ? 89 3.1.4.11 additional information enzyme is phosphatidylinositol-specific and does not act on phosphatidylethanolamine and phosphatidylcholine Bos taurus ? - ? 89 3.1.4.11 additional information enzyme is specific for phosphoinositides Oryctolagus cuniculus ? - ? 89 3.1.4.11 additional information PLC activity in vascular smooth muscle cells can be divided into two types based on their calcium and pH requirements, substrate preferences, and molecular weights Rattus norvegicus ? - ? 89 3.1.4.11 additional information several different assay conditions for both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate are tested on samples of crude supernatant for their ability to support PLC activity Rattus norvegicus ? - ? 89 3.1.4.11 additional information the injection fraction shows no activity against phosphatidylcholine Rattus norvegicus ? - ? 89 3.1.4.11 additional information enzyme is not active with phosphatidylcholine and phosphatidylethanolamine as substrate Oryctolagus cuniculus ? - ? 89 3.1.4.11 additional information no activity is detectable towards either phosphatidylcholine or phosphatidylethanolamine Sus scrofa ? - ? 89 3.1.4.11 additional information no detectable activity against phosphatidylcholine or phosphatidylethanolamine Apium graveolens Dulce Group ? - ? 89 3.1.4.11 additional information no phospholipase A2 activity is found in the purified enzymes Homo sapiens ? - ? 89 3.1.4.11 additional information phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine are no substrates Bos taurus ? - ? 89 3.1.4.11 additional information Isc1 only exerts IPC-PLC activity Cryptococcus neoformans ? - ? 89 3.1.4.11 additional information PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho Mus musculus ? - ? 89 3.1.4.11 additional information PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho Homo sapiens ? - ? 89 3.1.4.11 additional information PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho Rattus norvegicus ? - ? 89 3.1.4.11 additional information synthesis of a short-chain (dihexanoyl) analogues of phosphatidylinositol, which exist as monomers at the concentrations used for the kinetic measurements, the cleavage proceeds with the release of the cyclic phosphorothioate Streptomyces antibioticus ? - ? 89 3.1.4.11 additional information the enzyme displays scarcely any activity towards 1-phosphatidyl-1D-myo-inositol or phosphatidylcholine Oryza sativa Japonica Group ? - ? 89 3.1.4.11 additional information PLCepsilon contains a GTP exchange factor and two C-terminal Ras-binding domains Rattus norvegicus PLCepsilon ? - ? 89 3.1.4.11 additional information PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways Rattus norvegicus PLCepsilon ? - ? 89 3.1.4.11 additional information Isc1 only exerts IPC-PLC activity Cryptococcus neoformans H99 ? - ? 89 3.1.4.11 phosphatidylinositol + H2O - Mus musculus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Homo sapiens ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Sus scrofa ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Bos taurus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Toxoplasma gondii ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O no activity Oryctolagus cuniculus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O phosphatidylinositol 4,5-bisphosphate is a better substrate Rattus norvegicus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O at neutral pH and low Ca2+ concentration the membrane bound enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate in preference to phosphatidylinositol Mus musculus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O 7% of the activity with phosphatidylinositol 4,5-diphosphate Homo sapiens ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively Saccharomyces cerevisiae ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O phosphatidylinositol monolayer at an air/water interface Sus scrofa ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O PLC-delta1, structure of the catalytic domain Rattus norvegicus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O low molecular weight PLC hydrolyzes both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate, high molecular PLC shows much greater activity against phosphatidylinositol than phosphatidylinositol 4,5-bisphosphate Rattus norvegicus ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus Sprague-Dawley ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Mus musculus C57BL ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O PLC-delta1, structure of the catalytic domain Rattus norvegicus PLC-delta1 ? - ? 73209 3.1.4.11 phosphatidylinositol + H2O - Glycine max myo-inositol 1-phosphate + diacylglycerol - ? 364604 3.1.4.11 phosphatidylinositol + H2O 60-350times lower specific activity than with phosphatidylinositol 4,5-bisphosphate Arabidopsis thaliana myo-inositol 1-phosphate + diacylglycerol - ? 364604 3.1.4.11 phosphatidylinositol + H2O phosphatidylinositol 4,5-bisphosphate is preferred to phosphatidylinositol Trypanosoma cruzi myo-inositol 1-phosphate + diacylglycerol - ? 364604 3.1.4.11 phosphatidylinositol + H2O phosphatidylinositol-specific, catalytic mechanism Bacillus cereus diacylglycerol + myo-inositol 1-phosphate - ? 364608 3.1.4.11 phosphatidylinositol + H2O - Listeria monocytogenes diacylglycerol + inositol 1,2-(cyclic)-phosphate - ? 401657 3.1.4.11 phosphatidylinositol + H2O - Sus scrofa 1,2-diacylglycerol + 1D-myo-inositol 1-phosphate 1D-myo-inositol 1,2-cyclic phosphate is also formed ? 412694 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol - ? 412695 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol 1D-myo-inositol 1,2-cyclic-phosphate is also formed ? 412695 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol in vitro also 1D-myo-inositol 1,2-cyclic phosphate formed ? 412695 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol in vitro also inositol cyclic monophosphate formed ? 412695 3.1.4.11 phosphatidylinositol + H2O - Homo sapiens 1D-myo-inositol 1-phosphate + diacylglycerol in vitro myo-inositol 1,2-cyclic phosphate also formed ? 412695 3.1.4.11 phosphatidylinositol + H2O enzyme hydrolyses both membrane-bound and extracted phosphatidylinositol Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol in vitro myo-inositol 1,2-cyclic phosphate, myo-inositol 1-phosphate, and glycerophosphoinositol in the molar proportions approx. 2:1:1 ? 412695 3.1.4.11 phosphatidylinositol + H2O enzyme is phosphatidylinositol specific Bos taurus 1D-myo-inositol 1-phosphate + diacylglycerol - ? 412695 3.1.4.11 phosphatidylinositol + H2O - Rattus norvegicus 1D-myo-inositol 1-phosphate + glycerophosphoinositol + phosphate + ? ratio between products decreased with increasing pH, 1D-myo-inositol 1,2-cyclic phosphate is also formed ? 412698 3.1.4.11 phosphatidylinositol + H2O - Homo sapiens 1D-myo-inositol-1-phosphate + diacylglycerol in vitro 1D-myo-inositol-1,2-cyclic phosphate is also formed ? 412699 3.1.4.11 phosphatidylinositol + H2O - Apium graveolens Dulce Group diacylglycerol + 1D-myo-inositol 1-phosphate the lipoidal product of hydrolysis is diacylglycerol, the water-soluble products are 1D-myo-inositol 1,2-cyclic phosphate and 1D-myo-inositol 1-phosphate in the approximate proportions of 60% and 40%, respectively ? 412700 3.1.4.11 phosphatidylinositol + H2O enzyme is specific for phosphatidylinositol Rattus norvegicus diacylglycerol + 1D-myo-inositol 1-phosphate - ? 412700 3.1.4.11 phosphatidylinositol + H2O Pi-PLC (membrane) and Pi-PLC (cytosol) are specific for this substrate Homo sapiens diacylglycerol + 1D-myo-inositol 1-phosphate - ? 412700 3.1.4.11 phosphatidylinositol 4,5-bisphosphate demonstration of the role of PLC in Ca2+-induced inactivation of TRPV6 Homo sapiens inositol 1,4,5-trisphosphate - ? 401660 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Mus musculus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Homo sapiens D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Sus scrofa D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Bos taurus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Triticum aestivum D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Oryctolagus cuniculus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Dictyostelium discoideum D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Crithidia fasciculata D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Commelina communis D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Coffea arabica D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Saccharomyces cerevisiae D-myo-inositol 1,4,5-trisphosphate + diacylglycerol Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol isoenzyme PLC beta1 produces 21% inositol 1:2,4,5 cyclic trisphosphate at pH 5.5 and 7.5% at pH 7.0 ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O preferentially hydrolyzed Homo sapiens D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O membrane-bound enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate in preference to phosphatidylinositol Mus musculus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility Homo sapiens D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility Oryctolagus cuniculus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O the enzyme generates two second messengers: D-myo-inositol 1,4,5-trisphosphate and diacylglycerol Saccharomyces cerevisiae D-myo-inositol 1,4,5-trisphosphate + diacylglycerol - ? 93594 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O - Bos taurus ? - ? 412701 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O enzyme activities for phosphatidylinositol 4,5-bisphosphate are strongly dependent on the relative levels of calcium and pH in the assay buffer Rattus norvegicus ? - ? 412701 3.1.4.11 phosphatidylinositol 4,5-bisphosphate + H2O PLC4 and PLC6 encode catalytically active enzymes that convert phosphatidylinositol into diacylglycerol Solanum lycopersicum diacylglycerol + 1D-myo-inositol 1,4,5-triphosphate - ? 412702 3.1.4.11 phosphatidylinositol 4-phosphate - Rattus norvegicus ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate - Triticum aestivum ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility Homo sapiens ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility Rattus norvegicus ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility Oryctolagus cuniculus ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate phosphatidylinositol 4,5-bisphosphate is a better substrate Homo sapiens ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate 20% of the activity with phosphatidylinositol 4,5-diphosphate Homo sapiens ? - ? 93595 3.1.4.11 phosphatidylinositol 4-phosphate + H2O - Rattus norvegicus 1D-myo-inositol 4,5-bisphosphate + diacylglycerol - ? 364603 3.1.4.11 phosphatidylinositol 4-phosphate + H2O - Glycine max 1D-myo-inositol 4,5-bisphosphate + diacylglycerol - ? 364603 3.1.4.11 phosphatidylinositol 4-phosphate + H2O - Bos taurus ? - ? 364606 3.1.4.11 phosphatidylinositol 4-phosphate + H2O PLC-delta1, structure of the catalytic domain Rattus norvegicus ? - ? 364606 3.1.4.11 phosphatidylinositol 4-phosphate + H2O PLC-delta1, structure of the catalytic domain Rattus norvegicus PLC-delta1 ? - ? 364606 3.1.4.11 soybean oil + H2O - Pseudomonas sp. 62186 ? - ? 364064