3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O - Homo sapiens 2-oleylglycerol + oleate - ? 371519 3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O - Rattus norvegicus 2-oleylglycerol + oleate - ? 371519 3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O - Bos taurus 2-oleylglycerol + oleate - ? 371519 3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O - Rattus norvegicus ? - ? 380830 3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O - Homo sapiens ? - ? 380830 3.1.1.79 1,2-dioleoyl-sn-glycerol + H2O - Rattus norvegicus 2-oleoylglycerol + oleate - ? 415987 3.1.1.79 1,2-dioleoylglycerol + H2O - Rattus norvegicus 2-oleoylglycerol + oleate mayor end product of trioleoylglycerol and 1,2-dioleoylglycerol hydrolysis ? 370760 3.1.1.79 1-naphthyl acetate + H2O - Streptomyces coelicolor 1-naphthol + acetate - ? 12515 3.1.1.79 2-monooleoylglycerol + H2O - Rattus norvegicus glycerol + oleate - ? 370778 3.1.1.79 2-naphthyl acetate + H2O - Streptomyces coelicolor 2-naphthol + acetate - ? 36028 3.1.1.79 2-naphthyl acetate + H2O - Bjerkandera adusta 2-naphthol + acetate - ? 36028 3.1.1.79 4-methylumbelliferyl acetate + H2O - uncultured bacterium 4-methylumbelliferol + acetate - ? 363951 3.1.1.79 4-nitrophenol caprylate + H2O - Saccharolobus solfataricus 4-nitrophenol + caprylate - ? 446755 3.1.1.79 4-nitrophenol caprylate + H2O - Saccharolobus solfataricus P1 4-nitrophenol + caprylate - ? 446755 3.1.1.79 4-nitrophenol caprylate + H2O - Saccharolobus solfataricus DSM1616 4-nitrophenol + caprylate - ? 446755 3.1.1.79 4-nitrophenyl acetate + H2O - Streptomyces coelicolor 4-nitrophenol + acetate - ? 12514 3.1.1.79 4-nitrophenyl acetate + H2O - uncultured bacterium 4-nitrophenol + acetate - ? 12514 3.1.1.79 4-nitrophenyl acetate + H2O - Bjerkandera adusta 4-nitrophenol + acetate - ? 12514 3.1.1.79 4-nitrophenyl butanoate + H2O - Bjerkandera adusta 4-nitrophenol + butanoate - ? 363828 3.1.1.79 4-nitrophenyl butanoate + H2O - Halalkalibacterium halodurans 4-nitrophenol + butanoate - ? 363828 3.1.1.79 4-nitrophenyl butanoate + H2O - Halalkalibacterium halodurans DSM 18197 4-nitrophenol + butanoate - ? 363828 3.1.1.79 4-nitrophenyl butyrate + H2O - Streptomyces coelicolor 4-nitrophenol + butyrate - ? 115376 3.1.1.79 4-nitrophenyl butyrate + H2O - uncultured bacterium 4-nitrophenol + butyrate - ? 115376 3.1.1.79 4-nitrophenyl butyrate + H2O - Streptomyces coelicolor ? - ? 383918 3.1.1.79 4-nitrophenyl caprate + H2O - Halalkalibacterium halodurans 4-nitrophenol + caprate - ? 364083 3.1.1.79 4-nitrophenyl caproate + H2O - Streptomyces coelicolor 4-nitrophenol + caproate - ? 363887 3.1.1.79 4-nitrophenyl caproate + H2O - uncultured organism 4-nitrophenol + caproate - ? 363887 3.1.1.79 4-nitrophenyl caproate + H2O - Streptomyces coelicolor ? - ? 408148 3.1.1.79 4-nitrophenyl caprylate + H2O - Halalkalibacterium halodurans 4-nitrophenol + caprylate - ? 363889 3.1.1.79 4-nitrophenyl caprylate + H2O - Halalkalibacterium halodurans DSM 18197 4-nitrophenol + caprylate - ? 363889 3.1.1.79 4-nitrophenyl myristate + H2O - Halalkalibacterium halodurans 4-nitrophenol + myristate - ? 364082 3.1.1.79 4-nitrophenyl myristate + H2O - Halalkalibacterium halodurans DSM 18197 4-nitrophenol + myristate - ? 364082 3.1.1.79 4-nitrophenyl oleate + H2O - Rattus norvegicus 4-nitrophenol + oleate - ? 364073 3.1.1.79 4-nitrophenyl pentanoate + H2O - Psychrobacter sp. 4-nitrophenol + pentanoate - ? 115378 3.1.1.79 4-nitrophenyl pentanoate + H2O - Psychrobacter sp. TA144 4-nitrophenol + pentanoate - ? 115378 3.1.1.79 4-nitrophenyl stearate + H2O - Halalkalibacterium halodurans 4-nitrophenol + stearate - ? 364135 3.1.1.79 alpha-naphtyl acetate + H2O - Streptomyces coelicolor ? - ? 408377 3.1.1.79 cholesterol oleate + H2O - Rattus norvegicus cholesterol + oleate - ? 115427 3.1.1.79 cholesteryl ester + H2O - Mus musculus cholesterol + a carboxylate - ? 370891 3.1.1.79 cholesteryl oleate + H2O - Rattus norvegicus cholesterol + oleic acid - ? 92857 3.1.1.79 cholesteryl oleate + H2O - Homo sapiens cholesterol + oleate - ? 360772 3.1.1.79 cholesteryl oleate + H2O - Rattus norvegicus cholesterol + oleate - ? 360772 3.1.1.79 cholesteryl oleate + H2O - Bos taurus cholesterol + oleate - ? 360772 3.1.1.79 cholesteryl oleate + H2O - Homo sapiens ? - ? 400666 3.1.1.79 coconut oil + H2O - Halalkalibacterium halodurans laurate + ? - ? 447325 3.1.1.79 cod liver oil + H2O - Halalkalibacterium halodurans oleate + ? - ? 447326 3.1.1.79 diacylglycerol + H2O - Mus musculus monoacylglycerol + a carboxylate - ? 360692 3.1.1.79 diacylglycerol + H2O - Homo sapiens monoacylglycerol + a carboxylate - ? 360692 3.1.1.79 diacylglycerol + H2O - Rattus norvegicus monoacylglycerol + a carboxylate - ? 360692 3.1.1.79 diacylglycerol + H2O - Bos taurus monoacylglycerol + a carboxylate - ? 360692 3.1.1.79 dioleoylglycerol + H2O - Sus scrofa oleoylglycerol + oleate - ? 370936 3.1.1.79 dioleoylglycerol + H2O - Rattus norvegicus monooleoylglycerol + oleate - ? 373109 3.1.1.79 monoacylglycerol + H2O - Mus musculus glycerol + a carboxylate - ? 360694 3.1.1.79 monoacylglycerol + H2O - Rattus norvegicus glycerol + a carboxylate - ? 360694 3.1.1.79 monoacylglycerol + H2O - Bos taurus glycerol + a carboxylate - ? 360694 3.1.1.79 oleoylglycerol + H2O - Sus scrofa glycerol + oleate - ? 371083 3.1.1.79 p-nitrophenyl acetate + H2O - Bos taurus p-nitrophenol + acetate - ? 36053 3.1.1.79 p-nitrophenyl butyrate + H2O - Homo sapiens p-nitrophenol + butanoate - ? 36036 3.1.1.79 p-nitrophenyl butyrate + H2O - Rattus norvegicus p-nitrophenol + butanoate - ? 36036 3.1.1.79 p-nitrophenyl butyrate + H2O - Bos taurus p-nitrophenol + butanoate - ? 36036 3.1.1.79 p-nitrophenyl laurate + H2O - Bos taurus p-nitrophenol + laurate - ? 374169 3.1.1.79 p-nitrophenyl palmitate + H2O - Bos taurus p-nitrophenol + palmitate - ? 374173 3.1.1.79 palm oil + H2O - Halalkalibacterium halodurans palmitate + ? - ? 447964 3.1.1.79 rac 1,2(2,3)-sn diolein + H2O - Homo sapiens ? - ? 417561 3.1.1.79 triacylglycerol + H2O - Mus musculus diacylglycerol + a carboxylate - ? 360693 3.1.1.79 triacylglycerol + H2O - Homo sapiens diacylglycerol + a carboxylate - ? 360693 3.1.1.79 triacylglycerol + H2O - Rattus norvegicus diacylglycerol + a carboxylate - ? 360693 3.1.1.79 triacylglycerol + H2O - Bos taurus diacylglycerol + a carboxylate - ? 360693 3.1.1.79 tributanoylglycerol + H2O - Homo sapiens dibutanoylglycerol + butanoate - ? 374765 3.1.1.79 tributyrin + H2O - Saccharolobus solfataricus dibutyrin + butyrate - ? 363949 3.1.1.79 tributyrin + H2O - Saccharolobus solfataricus P1 dibutyrin + butyrate - ? 363949 3.1.1.79 tributyrin + H2O - Saccharolobus solfataricus DSM1616 dibutyrin + butyrate - ? 363949 3.1.1.79 tributyrin + H2O - Homo sapiens dibutanoylglycerol + butanoate - ? 382895 3.1.1.79 tricaproyl glycerol + H2O - Halalkalibacterium halodurans dicaproyl glycerol + caprate - ? 448174 3.1.1.79 trioctanoin + H2O - Homo sapiens dioctanoylglycerol + octanoate - ? 382902 3.1.1.79 triolein + H2O - Mus musculus diolein + oleate - ? 363933 3.1.1.79 triolein + H2O - Rattus norvegicus diolein + oleate - ? 363933 3.1.1.79 triolein + H2O - Rattus norvegicus Wistar diolein + oleate - ? 363933 3.1.1.79 triolein + H2O - Trematomus newnesi 1,2-dioleoylglycerol + oleate - ? 374771 3.1.1.79 triolein + H2O - Mus musculus dioleoylglycerol + oleate - ? 374772 3.1.1.79 triolein + H2O - Rattus norvegicus dioleoylglycerol + oleate - ? 374772 3.1.1.79 triolein + H2O - Bos taurus dioleoylglycerol + oleate - ? 374772 3.1.1.79 triolein + H2O - Mycobacterium tuberculosis dioleoylglycerol + oleate - ? 374772 3.1.1.79 trioleoyl glycerol + H2O - Halalkalibacterium halodurans dioleoyl glycerol + oleate - ? 448183 3.1.1.79 trioleoylglycerol + H2O - Rattus norvegicus 1,2-dioleoylglycerol + oleate - ? 371198 3.1.1.79 trioleoylglycerol + H2O - Homo sapiens dioleoylglycerol + oleate - ? 371199 3.1.1.79 trioleoylglycerol + H2O - Rattus norvegicus dioleoylglycerol + oleate - ? 371199 3.1.1.79 trioleoylglycerol + H2O - Sus scrofa dioleoylglycerol + oleate - ? 371199 3.1.1.79 trioleoylglycerol + H2O - Homo sapiens ? - ? 393715 3.1.1.79 tripalmitoyl glycerol + H2O - Halalkalibacterium halodurans dipalmitoyl glycerol + palmitate - ? 448185 3.1.1.79 tripropionin + H2O - Homo sapiens dipropanoylglycerol + propanoate - ? 382904 3.1.1.79 vinyl acetate + H2O - Homo sapiens acetate + ethylenol - ? 382963 3.1.1.79 vinyl butyrate + H2O - Homo sapiens vinyl alcohol + butanoate - ? 374909 3.1.1.79 vinyl butyrate + H2O - Homo sapiens butanoate + ethylenol - ? 382964 3.1.1.79 vinyl laurate + H2O - Homo sapiens laurate + ethylenol - ? 382965 3.1.1.79 vinyl propionate + H2O - Homo sapiens propanoate + ethylenol - ? 382966 3.1.1.79 testosterone oleate + H2O 1.4% of activity with 1-oleoyl-2-oleylglycerol Bos taurus testosterone + oleate - ? 374705 3.1.1.79 dehydroepiandrosterone oleate + H2O 12.9% of activity with 1-oleoyl-2-oleylglycerol Bos taurus dehydroepiandrosterone + oleate - ? 373028 3.1.1.79 vinyl laurate + H2O 15% of activity with vinylbutyrate Homo sapiens vinyl alcohol + laurate - ? 374910 3.1.1.79 estradiol-17-beta-oleate + H2O 17.9% of activity with 1-oleoyl-2-oleylglycerol Bos taurus 17-beta-estradiol + oleate - ? 373164 3.1.1.79 estradiol-17-beta-palmitate + H2O 18.3% of activity with 1-oleoyl-2-oleylglycerol Bos taurus 17-beta-estradiol + palmitate - ? 373165 3.1.1.79 cholesteryl oleate + H2O 18.5% of activity with 1-oleoyl-2-oleylglycerol Bos taurus cholesterol + oleate - ? 360772 3.1.1.79 dioleoyl glycerol + H2O 21% of activity with vinylbutyrate Homo sapiens monooleoylglycerol + oleate - ? 373108 3.1.1.79 olive oil + H2O 3% of activity with vinylbutyrate Homo sapiens ? - ? 364063 3.1.1.79 trioctanoyl glycerol + H2O 3% of activity with vinylbutyrate Homo sapiens dioctanoylglycerol + octanoate - ? 374770 3.1.1.79 1-monooleoylglycerol + H2O 3times higher activity than with 2-oleoylglycerol Rattus norvegicus glycerol + oleate - ? 370762 3.1.1.79 tripropionyl glycerol + H2O 4% of activity with vinylbutyrate Homo sapiens dipropionylglycerol + propionate - ? 374774 3.1.1.79 vinyl propionate + H2O 50% of activity with vinylbutyrate Homo sapiens vinyl alcohol + propionate - ? 363893 3.1.1.79 vinyl acetate + H2O 67% of activity with vinylbutyrate Homo sapiens vinyl alcohol + acetate - ? 363892 3.1.1.79 4-nitrophenyl palmitate + H2O 70% of the activity with 4-nitrophenyl laurate Halalkalibacterium halodurans 4-nitrophenol + palmitate - ? 363890 3.1.1.79 4-nitrophenyl palmitate + H2O 70% of the activity with 4-nitrophenyl laurate Halalkalibacterium halodurans DSM 18197 4-nitrophenol + palmitate - ? 363890 3.1.1.79 tributanoyl glycerol + H2O 8% of activity with vinylbutyrate Homo sapiens dibutanoylglycerol + butanoate - ? 374764 3.1.1.79 trioleoylglycerol + H2O approx. 16% of activity with dioleoylglcerol Rattus norvegicus dioleoylglycerol + oleate - ? 371199 3.1.1.79 cholesteryl oleate + H2O approx. 55% of activity with dioleoylglcerol Rattus norvegicus cholesterol + oleate - ? 360772 3.1.1.79 trihexadecenoin + H2O below 30% conversion Malassezia globosa dihexadecenoin + hexadecenoate - ? 448178 3.1.1.79 4-nitrophenyl laurate + H2O best substrate Halalkalibacterium halodurans 4-nitrophenol + laurate - ? 363891 3.1.1.79 4-nitrophenyl laurate + H2O best substrate Halalkalibacterium halodurans DSM 18197 4-nitrophenol + laurate - ? 363891 3.1.1.79 4-nitrophenyl valerate + H2O best substrate uncultured organism 4-nitrophenol + valerate - ? 363886 3.1.1.79 dilinolein + H2O complete conversion Malassezia globosa monolineoylglycerol + linoleate - ? 447462 3.1.1.79 dilinolein + H2O complete conversion Malassezia globosa CBS 7966 monolineoylglycerol + linoleate - ? 447462 3.1.1.79 dilinolein + H2O complete conversion Malassezia globosa ATCC MYA-4612 monolineoylglycerol + linoleate - ? 447462 3.1.1.79 dipalmitin + H2O complete conversion Malassezia globosa monopalmitoylglycerol + palmitate - ? 447471 3.1.1.79 dipalmitin + H2O complete conversion Malassezia globosa CBS 7966 monopalmitoylglycerol + palmitate - ? 447471 3.1.1.79 dipalmitin + H2O complete conversion Malassezia globosa ATCC MYA-4612 monopalmitoylglycerol + palmitate - ? 447471 3.1.1.79 dipalmitolein + H2O complete conversion Malassezia globosa monopalmitoleoylglycerol + palmitoleate - ? 447472 3.1.1.79 dipalmitolein + H2O complete conversion Malassezia globosa CBS 7966 monopalmitoleoylglycerol + palmitoleate - ? 447472 3.1.1.79 dipalmitolein + H2O complete conversion Malassezia globosa ATCC MYA-4612 monopalmitoleoylglycerol + palmitoleate - ? 447472 3.1.1.79 distearin + H2O complete conversion Malassezia globosa monostearoylglycerol + stearate - ? 447475 3.1.1.79 distearin + H2O complete conversion Malassezia globosa CBS 7966 monostearoylglycerol + stearate - ? 447475 3.1.1.79 distearin + H2O complete conversion Malassezia globosa ATCC MYA-4612 monostearoylglycerol + stearate - ? 447475 3.1.1.79 trihexadecenoin + H2O complete conversion Malassezia globosa dihexadecenoin + hexadecenoate - ? 448178 3.1.1.79 trilinolein + H2O complete conversion Malassezia globosa 1,2-dilinoleoylglycerol + oleate - ? 448179 3.1.1.79 tripalmitin + H2O complete conversion Malassezia globosa 1,2-dipalmitoylglycerol + palmitate - ? 448184 3.1.1.79 tristearin + H2O complete conversion Malassezia globosa 1,2-distearoylglycerol + stearate - ? 448186 3.1.1.79 additional information Est22 hydrolyzes 4-nitrophenyl esters up to C8, while the enzymatic activity decreases significantly with increasing chain length uncultured bacterium ? - ? 89 3.1.1.79 additional information expressed at a higher level in oxidative fibres than in glycolytic fibres. The two physiological stimuli adrenaline and contraction increase enzyme activity in muscle, and the effects are partially additive. Adrenaline acts via beta-adrenergic activation of cAMP-dependent protein kinase, while the effect of contractions is mediated by protein kinase C, at least partly via the extracellular signal-regulated kinase pathway. Endurance training diminishes the sensitivity of muscle hormone-sensitive lipase to adrenaline but increases the contraction-mediated activation Rattus norvegicus ? - ? 89 3.1.1.79 4-nitrophenyl acetate + H2O high activity uncultured organism 4-nitrophenol + acetate - ? 12514 3.1.1.79 4-nitrophenyl butyrate + H2O high activity uncultured organism 4-nitrophenol + butyrate - ? 115376 3.1.1.79 additional information hormone-sensitive lipase is a key enzyme of acylglycerol metabolism in white adipose tissue. The hormone-sensitive lipase activity in white adipose tissue is important for metabolic plasticity and inflammation. Hormone-sensitive lipase-mediated lipolysis and subsequent downstream free fatty acid signaling are important components of adipose tissue remodeling following acute and chronic beta3-adrenergic receptor activation Mus musculus ? - ? 89 3.1.1.79 additional information hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis Mus musculus ? - ? 89 3.1.1.79 additional information hormone-sensitive lipase may be the rate-limiting enzyme controlling the cellular catabolism of diacylglycerol in adipose tissue and that of cholesteryl esters in macrophage foam cells and steroidogenic tissues releasing the cholesterol required for adrenal steroidogenesis Homo sapiens ? - ? 89 3.1.1.79 additional information hypothesis that HSL functions as a cholesterol ester hydrolase rather than as a lipase with regard to GSIS and beta-cells Mus musculus ? - ? 89 3.1.1.79 additional information in the skeletal muscle at rest there is a high constitutive level of hormone-sensitive lipase activity, which is not a function of biopsy freezing. The combination of low adrenaline and Ca2+ levels and resting levels of insulin appears to dictate the levels of activity of hormone-sensitive lipase at rest. During the onset of low and moderate aerobic exercise enzyme activity is activated by contractions, in the apparent absence of increases in circulating adrenaline. However, adrenaline may contribute to the early activation of the enzyme during intense aerobic exercise. The contraction-induced activation appears to be related to the increase in protein kinase C and extracellular signal regulated kinase activity associated with Ca2+ and/or other unknown activators. As low- and moderate-intensity exercise continues beyond a few min, activation by adrenaline through the cAMP cascade and protein kinase A also appears to occur. With prolonged moderate-intensity exercise beyond 1–2 h and sustained high-intensity exercise, HSL activity decreases despite continuing increases in adrenaline, possibly as a result of increasing accumulation of free AMP, activation of AMP-activated kinase and phosphorylation of inhibitory sites on the hormone-sensitive lipase. Intramuscular factors dominate the control of hormone-sensitive lipase activity, with hormonal factors playing a smaller role Homo sapiens ? - ? 89 3.1.1.79 additional information key enzyme in fatty acid mobilization Rattus norvegicus ? - ? 89 3.1.1.79 additional information Lip2 substrate specificity, overview Malassezia globosa ? - ? 89 3.1.1.79 additional information Lip2 substrate specificity, overview Malassezia globosa CBS 7966 ? - ? 89 3.1.1.79 additional information Lip2 substrate specificity, overview Malassezia globosa ATCC MYA-4612 ? - ? 89 3.1.1.79 additional information Lip3 substrate specificity, overview Malassezia globosa ? - ? 89 3.1.1.79 additional information Lip3 substrate specificity, overview Malassezia globosa CBS 7966 ? - ? 89 3.1.1.79 additional information Lip3 substrate specificity, overview Malassezia globosa ATCC MYA-4612 ? - ? 89 3.1.1.79 additional information LIPY may be responsible for the utilization of stored triglycerides during dormancy and reactivation of the pathogen Mycobacterium tuberculosis Mycobacterium tuberculosis ? - ? 89 3.1.1.79 4-nitrophenyl caprate + H2O low activity uncultured organism 4-nitrophenol + caprate - ? 364083 3.1.1.79 4-nitrophenyl caprylate + H2O low activity uncultured organism 4-nitrophenol + caprylate - ? 363889 3.1.1.79 4-nitrophenyl laurate + H2O low activity uncultured organism 4-nitrophenol + laurate - ? 363891 3.1.1.79 4-nitrophenyl myristate + H2O low activity uncultured organism 4-nitrophenol + myristate - ? 364082 3.1.1.79 4-nitrophenyl palmitate + H2O low activity uncultured organism 4-nitrophenol + palmitate - ? 363890 3.1.1.79 additional information no activity of enzyme Lip1 with tristearin, trilinolein, and tripalmitoylglycerol. Lip1 substrate specificity, overview Malassezia globosa ? - ? 89 3.1.1.79 additional information no activity of enzyme Lip1 with tristearin, trilinolein, and tripalmitoylglycerol. Lip1 substrate specificity, overview Malassezia globosa CBS 7966 ? - ? 89 3.1.1.79 additional information no activity of enzyme Lip1 with tristearin, trilinolein, and tripalmitoylglycerol. Lip1 substrate specificity, overview Malassezia globosa ATCC MYA-4612 ? - ? 89 3.1.1.79 additional information no activity with chain length exceeding C6 Bjerkandera adusta ? - ? 89 3.1.1.79 additional information no activity with dipalmitin, MDL2 substrate specificity, overview Malassezia globosa ? - ? 89 3.1.1.79 additional information no activity with dipalmitin, MDL2 substrate specificity, overview Malassezia globosa CBS 7966 ? - ? 89 3.1.1.79 additional information no activity with dipalmitin, MDL2 substrate specificity, overview Malassezia globosa ATCC MYA-4612 ? - ? 89 3.1.1.79 dilinolein + H2O over 50% conversion Malassezia globosa monolineoylglycerol + linoleate - ? 447462 3.1.1.79 dilinolein + H2O over 50% conversion Malassezia globosa CBS 7966 monolineoylglycerol + linoleate - ? 447462 3.1.1.79 dilinolein + H2O over 50% conversion Malassezia globosa ATCC MYA-4612 monolineoylglycerol + linoleate - ? 447462 3.1.1.79 dipalmitolein + H2O over 50% conversion Malassezia globosa monopalmitoleoylglycerol + palmitoleate - ? 447472 3.1.1.79 dipalmitolein + H2O over 50% conversion Malassezia globosa CBS 7966 monopalmitoleoylglycerol + palmitoleate - ? 447472 3.1.1.79 dipalmitolein + H2O over 50% conversion Malassezia globosa ATCC MYA-4612 monopalmitoleoylglycerol + palmitoleate - ? 447472 3.1.1.79 distearin + H2O over 50% conversion Malassezia globosa monostearoylglycerol + stearate - ? 447475 3.1.1.79 distearin + H2O over 50% conversion Malassezia globosa CBS 7966 monostearoylglycerol + stearate - ? 447475 3.1.1.79 distearin + H2O over 50% conversion Malassezia globosa ATCC MYA-4612 monostearoylglycerol + stearate - ? 447475 3.1.1.79 cholesteryl ester + H2O overexpression of HSL increases the supply of free cholesterol as a ligand for liver X receptor, thereby stimulates the expression of ABCA1 gene in macrophages Mus musculus cholesterol + a carboxylate - ? 370891 3.1.1.79 1-myristoyl-2-oleoyl-3-palmitoyl glycerol + H2O racemic substrate Halalkalibacterium halodurans myristate + oleate + palmitate + ? - ? 446564 3.1.1.79 additional information rate-limiting enzyme in lipolysis Rattus norvegicus ? - ? 89 3.1.1.79 lipid emulsion + H2O recombinant HSL, the release of fatty acids is only slightly affected by their degree of unsaturation Homo sapiens fatty acids fatty acids ranging in chain length from 12 to 24 carbon atoms and in unsaturation from 0 to 6 double bonds ? 373715 3.1.1.79 lipid emulsion + H2O recombinant HSL, the release of fatty acids is only slightly affected by their degree of unsaturation Rattus norvegicus fatty acids fatty acids ranging in chain length from 12 to 24 carbon atoms and in unsaturation from 0 to 6 double bonds ? 373715 3.1.1.79 additional information sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol Mus musculus ? - ? 89 3.1.1.79 trioctanoylglycerol + H2O SsoNDELTA shows 1.7fold lower activity than SsoNDELTAlong with glyceryl trioctanoate as substrate Saccharolobus solfataricus ? - ? 393713 3.1.1.79 trioleoylglycerol + H2O SsoNDELTA shows 10fold higher activity than SsoNDELTAlong with glyceryl trioleate as substrate Saccharolobus solfataricus ? - ? 393715 3.1.1.79 p-nitrophenyl-dodecanoate + H2O SsoNDELTA shows 4.4fold lower activity than SsoNDELTAlong with p-nitrophenyl-dodecanoate as substrate Saccharolobus solfataricus p-nitrophenol + dodecanoate - ? 393132 3.1.1.79 tridecanoylglycerol + H2O SsoNDELTA shows 4.7fold higher activity than SsoNDELTAlong with glyceryl tridecanoate as substrate Saccharolobus solfataricus ? - ? 393707 3.1.1.79 trihexanoylglycerol + H2O SsoNDELTA shows 4fold lower activity than SsoNDELTAlong with glyceryl trihexanoate as substrate Saccharolobus solfataricus ? - ? 393709 3.1.1.79 tributyrylglycerol + H2O SsoNDELTA shows 6old lower activity than SsoNDELTAlong with glyceryl tributyrate as substrate Saccharolobus solfataricus ? - ? 73187 3.1.1.79 p-nitrophenyl hexanoate + H2O SsoNDELTAlong, is 15fold more active with the substrate p-nitrophenyl hexanoate than SsoNDELTA Saccharolobus solfataricus p-nitrophenol + hexanoate - ? 74072 3.1.1.79 trioleoylglycerol + H2O suspended in glycerol/phospholipid, 30-50% of a gum-based substrate suspension Sus scrofa dioleoylglycerol + oleate - ? 371199 3.1.1.79 additional information the enzyme a substrate preference for the diacylglycerols originating from triacylglycerols. The ee% of 1,2-sn-diolein over 2,3-sn-diolein increases with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol. The ee% of 1,2-sn-diolein reaches a maximum value of 36% at 42% hydrolysis Homo sapiens ? - ? 89 3.1.1.79 additional information the enzyme catalyses the hydrolysis of myocellular triacylglycerol, which is a potential energy source diuring exercise Homo sapiens ? - ? 89 3.1.1.79 additional information the enzyme is involved in the hormone regulated release of fatty acids and glycerol from adipocyte lipid stores Homo sapiens ? - ? 89 3.1.1.79 additional information the enzyme shows broad substrate specificity, with a strong preference towards short-chain esters, e.g. 4-nitrophenyyl acetateand 4-nitrophenyyl butyrate, little activity is observed towards long-chain esters such as 4-nitrophenyl dodecanoate uncultured bacterium ? - ? 89 3.1.1.79 additional information the purified enzyme Est06 exhibits high affinity for acyl esters with short-chain fatty acids, and shows optimum activity with p-nitrophenyl valerate uncultured organism ? - ? 89 3.1.1.79 trioleoylglycerol + H2O the type of dietary fat has no effect on kinetic properties of hormone-sensitive lipase Rattus norvegicus dioleoylglycerol + oleate - ? 371199 3.1.1.79 p-nitrophenyl acetate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 385491 3.1.1.79 p-nitrophenyl butyrate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 74070 3.1.1.79 p-nitrophenyl caproate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 401585 3.1.1.79 p-nitrophenyl caprylate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 401584 3.1.1.79 p-nitrophenyl decanoate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 401586 3.1.1.79 p-nitrophenyl palmitate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 401590 3.1.1.79 p-nitrophenyl stearate + H2O using various p-nitrophenyl esters as substrates. Enzyme efficiently hydrolyzes p-nitrophenyl acetate (75%), p-nitrophenyl butyrate (100%), p-nitrophenyl carproate (55%) and p-nitrophenyl caprylate (50%), a lower level of hydrolysis is observed for p-nitrophenyl decanoate (25%), p-nitrophenyl palmitate (2%) and p-nitrophenyl stearate (2%) uncultured bacterium ? - ? 401596