3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Bos taurus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Oryctolagus cuniculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin the major mammalian enzyme that deacylates the lipopolysaccharides contained in phygocytosed bacteria. The enzymatic deacylation of lipopolysaccharides is an intrinsic, regulated mechanism by which dendritic cells may modulate host response to this potent bacterial agonist Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin Salmonella enterica serovar typhimurium lipopolysaccharide is used as substrate Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 369909 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O - Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 165190 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O - Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 165190 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O - Bos taurus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 165190 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O - Oryctolagus cuniculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 165190 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O smooth LPS deacylated more slowly than rough LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid palmitoleate released more slowly than myristate and laurate, 2-hydroxylaurate released more slowly than laurate ? 165190 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 165190 3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O detoxification of lipopolysaccharide Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid - ? 165190 3.1.1.77 diacylglycerol + H2O in vitro Homo sapiens ? - ? 165193 3.1.1.77 diacylphosphatidylethanolamine + H2O - Homo sapiens ? - ? 452578 3.1.1.77 glycerophospholipid + H2O in vitro Homo sapiens ? - ? 165191 3.1.1.77 lipopolysaccharide + H2O - Mus musculus ? - ? 370677 3.1.1.77 lipopolysaccharide + H2O - Homo sapiens ? - ? 370677 3.1.1.77 lipopolysaccharide + H2O - Oryctolagus cuniculus ? - ? 370677 3.1.1.77 long chain lipopolysaccharide + H2O - Homo sapiens ? - ? 452575 3.1.1.77 lysophospholipid + H2O in vitro Homo sapiens ? - ? 165192 3.1.1.77 medium chain lipopolysaccharide + H2O - Homo sapiens ? - ? 452576 3.1.1.77 additional information different lipids as substrates Homo sapiens ? - ? 89 3.1.1.77 additional information a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis Bos taurus ? - ? 89 3.1.1.77 additional information endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase Homo sapiens ? - ? 89 3.1.1.77 additional information polymorphisms in markers within the acyloxyacyl hydroxylase gene are associated with the risk of asthma and associated quantitative traits (IgE and cytokine levels) among asthmatic subjects and their families in Barbados Homo sapiens ? - ? 89 3.1.1.77 additional information the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide Mus musculus ? - ? 89 3.1.1.77 short chain lipopolysaccharide + H2O - Homo sapiens ? - ? 452577 3.1.1.77 sn-1,2-dipalmitoylglycerol + H2O in vitro Homo sapiens palmitate + glycerol - ? 165195 3.1.1.77 sn-1,2-dipalmitoylphosphatidylcholine + H2O in vitro Homo sapiens palmitate + phosphatidylcholine - ? 165194