2.7.8.29 1,2-diacylphosphatidylethanolamine + L-serine the substrate is 6times better utilized than phosphatidylethanolamine plasmalogen Mus musculus ? - ? 422241 2.7.8.29 L-1-phosphatidylethanolamine + L-serine - Mus musculus L-1-phosphatidylserine + ethanolamine - ? 418734 2.7.8.29 L-1-phosphatidylethanolamine + L-serine - Cricetulus griseus L-1-phosphatidylserine + ethanolamine - ? 418734 2.7.8.29 L-1-phosphatidylethanolamine + L-serine - Homo sapiens L-1-phosphatidylserine + ethanolamine - ? 418734 2.7.8.29 additional information no substrate: phosphatidylcholine Homo sapiens ? - ? 89 2.7.8.29 additional information the enzyme synthesizes docosahexaenoic acid-phosphatidylserine much more efficiently than phosphatidylserine containing either 18:1 or 20:4 at the sn-2 position. Although no sn-1 fatty acyl preference is noted, phosphatidylserine synthase 2 exhibits significant preference toward docosahexaenoic acid compared with 18:1 or 20:4 at the sn-2 position Mus musculus ? - ? 89 2.7.8.29 additional information isozyme PSS1 shows a 2fold higher preference for sn-1 18:0 compared with 16:0 when the sn-2 position contains 18:1 Mus musculus ? - ? 89 2.7.8.29 additional information the recombinant FLAG-tagged enzyme is also active with phosphatidylethanolamine plasmalogen, [C18(plasm),22:6-PS], which is six times less effective as a substrate than the corresponding ester-linked phosphatidylethanolamine species, the isozyme is active with oleic acid (OA; 18:1n-9), DHA (DHA; 22:6n-3), or arachidonic acid esters. Compounds analysis by mass spectroscopy. A carbonyl group next to the glycerol backbone in the substrate-binding pocket substantially increases the catalytic activity of PSS2. Isozyme PSS2 shows a 10fold preference for sn-1 18:0, when 22:6 is esterified at the sn-2 position. Synthesis of 18:0,22:6-PS is most efficient compared with 18:0,18:1-PS and with 18:0,20:4-PS. Substrate specificity and acyl chain preference of isozyme PS2, overview Mus musculus ? - ? 89 2.7.8.29 phosphatidylethanolamine plasmalogen + L-serine - Mus musculus ? - ? 423950 2.7.8.29 L-1-phosphatidylcholine + L-serine isozyme PSS1 Mus musculus L-1-phosphatidylserine + choline - r 438367 2.7.8.29 L-1-phosphatidylcholine + L-serine isozyme PSS1 Homo sapiens L-1-phosphatidylserine + choline - r 438367 2.7.8.29 L-1-phosphatidylethanolamine + L-serine isozyme PSS2 Mus musculus L-1-phosphatidylserine + ethanolamine - r 418734 2.7.8.29 L-1-phosphatidylethanolamine + L-serine isozyme PSS2 Homo sapiens L-1-phosphatidylserine + ethanolamine - r 418734