2.7.3.2 ADP + phosphocreatine - Gallus gallus ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Homo sapiens ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Homo sapiens ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine - Rattus norvegicus ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Rattus norvegicus ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine - Bos taurus ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine - Oryctolagus cuniculus ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Torpedo marmorata ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine - Tethya aurantium ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Chaetopterus variopedatus ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Clupea harengus ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Ginglymostoma cirratum ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine - Rhamdia quelen ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Rhamdia quelen ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine - Mus musculus ATP + creatine - r 358150 2.7.3.2 ADP + phosphocreatine synergistic substrate binding, mitochondrial isoform sMiCK Physeter catodon ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine synergistic substrate binding, muscle-type isoform MCK Physeter catodon ATP + creatine - ? 358150 2.7.3.2 ADP + phosphocreatine - Rattus norvegicus Wistar ATP + creatine - ? 358150 2.7.3.2 alpha-(RP)-borano-ADP + phosphocreatine the SP-ADPalphaB isomer is a 70fold better substrate for creatine kinase than the RP isomer Oryctolagus cuniculus alpha-(RP)-borano-ATP + creatine - ? 396380 2.7.3.2 alpha-(SP)-borano-ADP + phosphocreatine the SP-ADPalphaB isomer is a 70fold better substrate for creatine kinase than the RP isomer Oryctolagus cuniculus alpha-(SP)-borano-ATP + creatine - ? 396381 2.7.3.2 ATP + creatine - Gallus gallus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Gallus gallus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Mammalia ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Mus musculus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Homo sapiens ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Homo sapiens ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Rattus norvegicus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Rattus norvegicus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Sus scrofa ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Sus scrofa ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Bos taurus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Bos taurus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Oryctolagus cuniculus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Oryctolagus cuniculus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Canis lupus familiaris ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Canis lupus familiaris ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Equus caballus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Pagrus major ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Scomber japonicus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Cyprinus carpio ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Columba livia ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Scyliorhinus canicula ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Strongylocentrotus purpuratus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Strongylocentrotus purpuratus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Urocitellus richardsonii ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Clupea harengus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Chaenocephalus aceratus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Lepomis cyanellus ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine - Danio rerio ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Gallus gallus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Rattus norvegicus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Sus scrofa ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Bos taurus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Oryctolagus cuniculus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Torpedo marmorata ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Papio anubis ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- trout ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Discopyge tschudii ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Ginglymostoma cirratum ADP + creatine phosphate - ? 358130 2.7.3.2 ATP + creatine ATP required as MgATP2- Homo sapiens ADP + creatine phosphate in the reverse direction ADP can be replaced by IDP with 18% efficiency, ADP cannot be replaced by GDP, CDP, UDP, dTDP r 358130 2.7.3.2 ATP + creatine creatine cannot be replaced by creatinine Oryctolagus cuniculus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine Mg-complexes of ATP and ADP are the true substrates for the mitochondrial enzymes Rattus norvegicus ADP + creatine phosphate - r 358130 2.7.3.2 ATP + creatine - Mus musculus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Mus musculus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Homo sapiens ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Homo sapiens ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Rattus norvegicus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Bos taurus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Bos taurus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Oryctolagus cuniculus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Oryctolagus cuniculus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Lethenteron camtschaticum ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Oncorhynchus mykiss ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Gadus morhua ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Pelodiscus sinensis ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Tetronarce californica ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Tetronarce californica ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Danio rerio ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Chaetopterus variopedatus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Clupea harengus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Hediste diversicolor ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Ginglymostoma cirratum ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Trachemys scripta elegans ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Rhamdia quelen ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Rhamdia quelen ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Dendronephthya gigantea ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Cryptosporidium muris ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Gallus gallus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Cryptosporidium andersoni ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine role in anaerobic metabolism Trachemys scripta ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine regeneration of ATP as primary energy source Mammalia ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine mitochondrial model of CK in energy transport Gallus gallus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine coupled to (Na+,K+)ATPase system Rattus norvegicus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Gallus gallus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Homo sapiens ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Rattus norvegicus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Sus scrofa ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Bos taurus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Oryctolagus cuniculus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Columba livia ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine physiological roles: 1. buffering of ADP/ATP ratio, 2. transport of high-energy phosphates from sites of ATP production to sites of ATP consumption Strongylocentrotus purpuratus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine overview on physiological roles Gallus gallus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine overview on physiological roles Mus musculus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine overview on physiological roles Rattus norvegicus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine overview on physiological roles Oryctolagus cuniculus ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine overview on physiological roles Frog ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine overview on physiological roles Columba livia ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine evolution of enzyme, phylogenetics echinodermata ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine key enzyme in energy homeostasis Homo sapiens ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine key enzyme in energy homeostasis Bos taurus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine key enzyme in energy homeostasis Oryctolagus cuniculus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine key enzyme in energy homeostasis Tetronarce californica ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine key enzyme in energy homeostasis Gallus gallus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine key enzyme of energy homeostasis Rattus norvegicus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine the enzyme is involved in energy homeostasis Chaetopterus variopedatus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine the reaction equilibrium lies towards ATP production Homo sapiens ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine the brain-type cytosolic isoform of creatine kinase, which is found mainly in the brain and retina, is a key enzyme in brain energy metabolism, because high-energy phosphates are transfered through the creatine kinase/phosphocreatine shuttle system Homo sapiens ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine the mitochondrial isozyme MtCK catalyzes the almost complete transphosphorylation of mitochondrial ATP and cytosolic creatine into ADP and phophocreatine. ADP locally generated by MtCK is transferred into the matrix for rephosphorylation and phosphocreatine is released from mitochondria into the cytosol, direct channelling of ATP and ADP between mitochondrial matrix and MtCK via adenine nucleotide transporter Mus musculus ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine the enzyme has a 20fold greater preference for creatine compared to glycocyamine Cryptosporidium muris ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine the enzyme shows a 20fold greater preference for creatine than glycocyamine Cryptosporidium muris ADP + phosphocreatine - ? 358162 2.7.3.2 ATP + creatine - Mus musculus R6/2 ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Mus musculus CF-1 ADP + phosphocreatine - r 358162 2.7.3.2 ATP + creatine - Rattus norvegicus Wistar ADP + phosphocreatine - r 358162 2.7.3.2 ATP + cyclocreatine i.e. 1-carboxymethy-2-iminoimidazolidine Oryctolagus cuniculus ADP + phospho-cyclocreatine - ? 379280 2.7.3.2 ATP + cyclocreatine i.e. 1-carboxymethyl-2-iminoimidazolidine Homo sapiens ADP + phospho-cyclocreatine - ? 379280 2.7.3.2 ATP + glycocyamine - Cryptosporidium muris ADP + phosphoglycocyamine - ? 358161 2.7.3.2 ATP + glycocyamine - Cryptosporidium andersoni ADP + phosphoglycocyamine - ? 358161 2.7.3.2 ATP + glycocyamine very low activity Homo sapiens ADP + glycocyamine phosphate - ? 379350 2.7.3.2 ATP + glycocyamine very low activity Oryctolagus cuniculus ADP + glycocyamine phosphate - ? 379350 2.7.3.2 ATP + N-ethylglycocyamine - Homo sapiens ADP + N-ethylglycocyamine phosphate - ? 379429 2.7.3.2 ATP + N-ethylglycocyamine - Oryctolagus cuniculus ADP + N-ethylglycocyamine phosphate - ? 379429 2.7.3.2 dADP + phosphocreatine - Oryctolagus cuniculus ? - ? 423278 2.7.3.2 additional information ATP undergoes substrate channelling between enzyme and myosin ATPase Rattus norvegicus ? - ? 89 2.7.3.2 additional information enzyme inhibition, e.g. by branched chain alpha-amino acids, might contribute to the brain damage maple syrup urine disease MSUD Rattus norvegicus ? - ? 89 2.7.3.2 additional information probable enzyme evolution, overview Homo sapiens ? - ? 89 2.7.3.2 additional information probable enzyme evolution, overview Bos taurus ? - ? 89 2.7.3.2 additional information probable enzyme evolution, overview Oryctolagus cuniculus ? - ? 89 2.7.3.2 additional information probable enzyme evolution, overview Tetronarce californica ? - ? 89 2.7.3.2 additional information probable enzyme evolution, overview Gallus gallus ? - ? 89 2.7.3.2 additional information substrate binding structure, arginine residues R130, R132, R236, R292, and R320 form a nucleotide phosphate bindig pocket, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes Homo sapiens ? - ? 89 2.7.3.2 additional information substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, assay methods, overview, structure-function analysis, substrate specificity of isozymes, the cytosolic isozymes of skeletal muscle shows broad substrate specificity Oryctolagus cuniculus ? - ? 89 2.7.3.2 additional information substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes Bos taurus ? - ? 89 2.7.3.2 additional information substrate binding structure, reaction equilibrium is highly influenced by pH and Mg2+ concentration, substrate specificity of isozymes Gallus gallus ? - ? 89 2.7.3.2 additional information substrate binding structure, substrate binding at both subunits Tetronarce californica ? - ? 89 2.7.3.2 additional information ADP re-cycling accomplished by mitochondrial creatine kinase regulates reactive oxygen species generation, particularly in high glucose concentrations. Key role of enzyme as a preventive antioxidant against oxidative stress Rattus norvegicus ? - ? 89 2.7.3.2 additional information using a yeast two-hybrid screening to search for molecules that interact with NCX1 (sodium-calcium exchanger) it is shown that sarcomeric mitochondrial creatine kinase (sMiCK) interacts with NCX1IL. In addition to sMiCK, cytoplasmic muscle-type CK (CKM) is also able to interact with NCX1 in mammalian cells Homo sapiens ? - ? 89 2.7.3.2 additional information membrane proteins VAMP2/3 and JWA are putative BCK interaction partners. At the plasma membrane, BCK interacts with at least two members of the family of cation-coupled chloride transporters (solute carrier family 12): the K+/Cl- cotransporters 2 (KCC2 or SLC12A5) and 3 (KCC3 or SLC12A6), BCK may be required for maximal phosphorylation efficiency Mus musculus ? - ? 89 2.7.3.2 additional information synaptical vesicle protein VAMP2/3 and membrane protein and JWA are BCK interaction partners, by Y2H assays. VAMP3 interacts with both, wild-type BCK and truncated DELTABCK mutant. The common and characteristic SNARE domain of VAMPs (amino acids 14-74 in VAMP3) is not sufficient for BCK interaction. JWA and VAMP both link BCK to energy-requiring intracellular vesicle transport Rattus norvegicus ? - ? 89 2.7.3.2 additional information the enzyme binds to 1,2-dipalmitoyl-sn-glycero-3-phosphate with the highest affinity (dissociation constant: 0.002 mM) Mus musculus ? - - 89 2.7.3.2 additional information the enzyme binds to 1,2-dipalmitoyl-snglycero-3-phosphate with the highest affinity (dissociation constant 0.002 mM). The enzyme preferentially interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids, but not with polyunsaturated fatty acid-containing phosphatidic acids Mus musculus ? - - 89 2.7.3.2 additional information synaptical vesicle protein VAMP2/3 and membrane protein and JWA are BCK interaction partners, by Y2H assays. VAMP3 interacts with both, wild-type BCK and truncated DELTABCK mutant. The common and characteristic SNARE domain of VAMPs (amino acids 14-74 in VAMP3) is not sufficient for BCK interaction. JWA and VAMP both link BCK to energy-requiring intracellular vesicle transport Rattus norvegicus Wistar ? - ? 89