2.7.2.8 acetyl-CoA + L-glutamate - Xanthomonas campestris coenzyme A + N-acetyl-L-glutamate ancestral bifunctional N-acetylglutamate synthase and kinase ? 387740 2.7.2.8 ATP + N-acetyl-L-glutamate - Escherichia coli ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Saccharomyces cerevisiae ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Arabidopsis thaliana ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Pseudomonas aeruginosa ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium glutamicum ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Thermotoga maritima ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Synechococcus elongatus ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Xanthomonas campestris ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Maricaulis maris ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium crenatum ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Chlamydomonas reinhardtii ADP + N-acetyl-L-glutamate 5-phosphate in presence of hydroxylamine formation of N-acetyl-L-glutamate 5-hydroxamate + ADP + phosphate ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Pseudomonas aeruginosa ADP + N-acetyl-L-glutamate 5-phosphate in presence of hydroxylamine formation of N-acetyl-L-glutamate 5-hydroxamate + ADP + phosphate ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate highly specific for ATP and N-acetyl-L-glutamate Chlamydomonas reinhardtii ADP + N-acetyl-L-glutamate 5-phosphate in presence of hydroxylamine formation of N-acetyl-L-glutamate 5-hydroxamate + ADP + phosphate ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate highly specific for ATP and N-acetyl-L-glutamate Escherichia coli ADP + N-acetyl-L-glutamate 5-phosphate in presence of hydroxylamine formation of N-acetyl-L-glutamate 5-hydroxamate + ADP + phosphate ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate key enzyme in regulation of arginine biosynthesis Chlamydomonas reinhardtii ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate key enzyme in regulation of arginine biosynthesis Escherichia coli ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate enzyme synthesis not repressed by exogenous L-arginine or its precursors Pseudomonas aeruginosa ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate second enzyme of arginine biosynthesis Pseudomonas aeruginosa ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Escherichia coli W2D / ATCC 25542 ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Escherichia coli Wc2 ADP + N-acetyl-L-glutamate 5-phosphate - ? 358119 2.7.2.8 ATP + N-acetyl-L-glutamate - Saccharomyces cerevisiae ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Pisum sativum ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Pseudomonas aeruginosa ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Saccharolobus solfataricus ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Arabidopsis thaliana ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Thermotoga maritima ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Escherichia coli ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Maricaulis maris ADP + N-acetyl-L-glutamyl 5-phosphate - r 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium crenatum ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Xanthomonas campestris ADP + N-acetyl-L-glutamyl 5-phosphate - r 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium crenatum ADP + N-acetyl-L-glutamyl 5-phosphate - r 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium glutamicum ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Zea mays ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate NAGK catalyzes the second step of arginine biosynthesis. In Pseudomonas aeruginosa, this step is rate limiting, and feedback regulated and sigmoidally inhibited by arginine Pseudomonas aeruginosa ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium crenatum SYPA5-5 ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium crenatum SYPA5-5 ADP + N-acetyl-L-glutamyl 5-phosphate - r 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Corynebacterium glutamicum ATCC 13032 ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Maricaulis maris MCS10 ADP + N-acetyl-L-glutamyl 5-phosphate - r 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Xanthomonas campestris 8004 ADP + N-acetyl-L-glutamyl 5-phosphate - r 398785 2.7.2.8 ATP + N-acetyl-L-glutamate - Saccharomyces cerevisiae K901 ADP + N-acetyl-L-glutamyl 5-phosphate - ? 398785 2.7.2.8 ATP + N-carbamoyl-L-glutamate at 33% of the activity with N-acetyl-L-glutamate Pseudomonas aeruginosa ADP + N-carbamoyl-L-glutamate 5-phosphate - ? 358120 2.7.2.8 ATP + N-formyl-L-glutamate at 20% of the activity with N-acetyl-L-glutamate Pseudomonas aeruginosa ADP + N-formyl-L-glutamate 5-phosphate - ? 358121 2.7.2.8 dATP + N-acetyl-L-glutamate as effective as ATP Pseudomonas aeruginosa dADP + N-acetyl-L-glutamate 5-phosphate - ? 358122 2.7.2.8 additional information not: ITP Pseudomonas aeruginosa ? - ? 89 2.7.2.8 additional information not: GTP Chlamydomonas reinhardtii ? - ? 89 2.7.2.8 additional information not: GTP Escherichia coli ? - ? 89 2.7.2.8 additional information not: GTP Pseudomonas aeruginosa ? - ? 89 2.7.2.8 additional information not: N-benzoyl-L-glutamate, L-glutamate, D-glutamate Chlamydomonas reinhardtii ? - ? 89 2.7.2.8 additional information not: N-benzoyl-L-glutamate, L-glutamate, D-glutamate Escherichia coli ? - ? 89 2.7.2.8 additional information N-propionyl-L-glutamate almost inactive Pseudomonas aeruginosa ? - ? 89 2.7.2.8 additional information NAGK strongly interacts with PII protein only in the presence of Mg-ATP, this process is reversed by 2-oxoglutarate Arabidopsis thaliana ? - ? 89 2.7.2.8 additional information NAGK interacts with PII protein Synechococcus elongatus ? - ? 89 2.7.2.8 additional information residues Lys364, Arg394 and Asn399 in xcNAGS/K are involved in binding of L-glutamate Xanthomonas campestris ? - ? 89 2.7.2.8 additional information not: GTP Escherichia coli W2D / ATCC 25542 ? - ? 89 2.7.2.8 additional information not: N-benzoyl-L-glutamate, L-glutamate, D-glutamate Escherichia coli W2D / ATCC 25542 ? - ? 89 2.7.2.8 additional information residues Lys364, Arg394 and Asn399 in xcNAGS/K are involved in binding of L-glutamate Xanthomonas campestris 8004 ? - ? 89