2.7.12.2	additional information	-	Schizosaccharomyces pombe	?	-	?	89	
2.7.12.2	additional information	Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state	Schizosaccharomyces pombe	?	-	?	89	
2.7.12.2	additional information	MEKK3 activates SEK and MEK, the known kinases targeting SAPK and ERK respectively	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview	eukaryota	?	-	?	89	
2.7.12.2	additional information	the enzyme performs autophosphorylation	Leishmania mexicana	?	-	?	89	
2.7.12.2	additional information	MEK1/2 are involved in the mitogen-activated protein kinase signaling pathway and in cancer tumorigenesis	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	the enzyme is involved in the mitogen-activated protein kinase signaling pathway	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	the enzyme is involved in the mitogen-activated protein kinase signaling pathway regulating cell dissociation of cancer cells, MEK2 is an invasion-metastasis related factor between highly and weakly invasive cells, occludin acts as antagonist	Mesocricetus auratus	?	-	?	89	
2.7.12.2	additional information	the enzyme is involved in the mitogen-activated protein kinase signaling pathway, pathway induction by neurotrophin stabilizes the axonal growth cone, pathway inhibitor semaphorin 3F induces growth cone collaps in sympathetic neurons and reduction of axonal growth	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview	Mus musculus	?	-	?	89	
2.7.12.2	additional information	the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is linked to the cell cycle machinery, constitutive phosphorylation and activation of the enzyme leads to cell proliferation in choroidal melanoma cells	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	MKK7gamma1 is unable to phosphorylate p38	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway, overview	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	Arabidopsis thaliana mitogen-activated protein kinase kinase MKK1 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. The mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes	Arabidopsis thaliana	?	-	?	89	
2.7.12.2	additional information	Arabidopsis thaliana mitogen-activated protein kinase kinase MKK2 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. mkk2 single mutants appear morphologically normal, the mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes	Arabidopsis thaliana	?	-	?	89	
2.7.12.2	additional information	lithium protection of phencyclidine-induced neurotoxicity and cell death in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways, overview	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	MAP kinase kinase 1 is regulated by salt and drought stresses, differential expression, overview	Oryza sativa	?	-	?	89	
2.7.12.2	additional information	MAP kinase kinase 10-2 is regulated only by cold stress, differential expression, overview	Oryza sativa	?	-	?	89	
2.7.12.2	additional information	MAP kinase kinase 6 is strongly regulated by cold and salt stresses, differential expression, overview	Oryza sativa	?	-	?	89	
2.7.12.2	additional information	MAP kinase kinases 4 is strongly regulated by cold and salt stresses, differential expression, overview	Oryza sativa	?	-	?	89	
2.7.12.2	additional information	mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma it is required for growth of fibrosarcoma-derived xenografts, to maintain tumor blood flow, and for vascularization of fibrosarcoma-derived xenografts, and MKK signaling is required for the release of proangiogenic factors from other sarcoma-derived cell lines, overview	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	MKK3 positively regulates PR gene expression and plays a role in defense against Pst DC3000. MKK3 is an upstream activator of the group C MAPKs MPK1, MPK2, MPK7, and MPK14, overview	Arabidopsis thaliana	?	-	?	89	
2.7.12.2	additional information	pro-oncogenic role of mitogen-activated protein kinase kinase 4 in cancer, overview	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	pro-oncogenic role of mitogen-activated protein kinase kinase 4 in cancer, overview. MKK4 is also involved in the immune system and development of B- and T-cells, as well as in cardiac hypertrophy, overview	Mus musculus	?	-	?	89	
2.7.12.2	additional information	regulation and differential expression, overview	Oryza sativa	?	-	?	89	
2.7.12.2	additional information	role of mitogen-activated protein kinase kinase 4 in cancer, overview. MKK4 is also involved in the immune system and development of B- and T-cells, as well as in cardiac hypertrophy, overview	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	the MEKK-1 is involved in stress-induced cell death of insulin-producing cells and essential in JNK activation, overview	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators involving signaling through IkappaB kinase complex 2, IKB, nuclear factor kappaB, extracellular signal-regulated kinase, mitogen-activated protein kinase kinase, p38, and phosphatidylinositol 3-kinase, and Akt1/2. MEK, p38, and IKK inhibitors block TNF-alpha-induced IL-8, IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not, overview	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	MKK signaling is required for cell proliferation and for cytokine release in vitro	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	substrate binding via the D-domain of the MKK	Drosophila melanogaster	?	-	?	89	
2.7.12.2	additional information	substrate binding via the D-domain of the MKK	Rattus norvegicus	?	-	?	89	
2.7.12.2	additional information	substrate binding via the D-domain of the MKK	Xenopus laevis	?	-	?	89	
2.7.12.2	additional information	substrate binding via the D-domain of the MKK	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	substrate binding via the D-domain of the MKK	Mus musculus	?	-	?	89	
2.7.12.2	additional information	GhMKK3 interacts with GhMPK7, a typical C group MAPK member, and GhPIP1 potein. GhMPK7 is phosphorylated by GhMKK3 in protoplasts	Gossypium hirsutum	?	-	?	89	
2.7.12.2	additional information	MKK4 phosphorylates JNK on Tyr, while MKK7 phosphorylates Thr, and MKK4 and MKK7 together cause dual phosphorylation of JNK thus, optimal activation	Mus musculus	?	-	?	89	
2.7.12.2	additional information	protein-protein docking of MAPKK and MAPK	Oryza sativa Indica Group	?	-	?	89	
2.7.12.2	additional information	development of a continuous spectrophotometric assay for mitogen-activated protein kinase kinases. The assay relies on the measurement of phosphoprotein product generated in the first step of the MAPK kinase reaction. Dephosphorylation of the phosphoprotein is coupled to a MAPK phosphatase, MKP3, to generate phosphate, which is then used as the substrate of purine nucleoside phosphorylase to catalyze the N-glycosidic cleavage of 2-amino 6-mercapto 7-methyl purine ribonucleoside. Of the reaction products ribose 1-phosphate and 2-amino 6-mercapto 7-methylpurine, the latter has a high absorbance at 360 nm relative to the nucleoside and, hence, provides a spectrophotometric signal that can be continuously followed. In the presence of excess phosphatase, the phosphorylated protein substrate molecules undergo dephosphorylation almost immediately after their formation. The steady-state use of the resultant inorganic phosphate is a reflection of the constant initial velocity of the exchange reaction. Method development and evaluation, overview	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	development of a continuous spectrophotometric assay for mitogen-activated protein kinase kinases. The assay relies on the measurement of phosphoprotein product generated in the first step of the MAPK kinase reaction. Dephosphorylation of the phosphoprotein is coupled to a MAPK phosphatase, MKP5, to generate phosphate, which is then used as the substrate of purine nucleoside phosphorylase to catalyze the N-glycosidic cleavage of 2-amino 6-mercapto 7-methyl purine ribonucleoside. Of the reaction products ribose 1-phosphate and 2-amino 6-mercapto 7-methylpurine, the latter has a high absorbance at 360 nm relative to the nucleoside and, hence, provides a spectrophotometric signal that can be continuously followed. In the presence of excess phosphatase, the phosphorylated protein substrate molecules undergo dephosphorylation almost immediately after their formation. The steady-state use of the resultant inorganic phosphate is a reflection of the constant initial velocity of the exchange reaction. Method development and evaluation, overview	Homo sapiens	?	-	?	89	
2.7.12.2	additional information	interaction of ZmMKK1 and ZmMEKK1, a MAP kinase kinase kinase, in vitro	Zea mays	?	-	?	89	
2.7.12.2	additional information	the enzyme displays both serine/threonine and tyrosine kinase activities in autophosphorylation reactions as well as in phosphorylation of the exogenous myelin basic protein substrate. Ability of Pfnek3 to autophosphorylate on both the serine/threonine and the tyrosine residues. The dual-specificity activity of the kinase is distinctly influenced by the type of divalent cation present	Plasmodium falciparum	?	-	?	89	
2.7.12.2	additional information	MKK3 positively regulates PR gene expression and plays a role in defense against Pst DC3000. MKK3 is an upstream activator of the group C MAPKs MPK1, MPK2, MPK7, and MPK14, overview	Arabidopsis thaliana Col-0	?	-	?	89	
2.7.12.2	ATP + MAP kinase ERK1	-	Caenorhabditis elegans	ADP + ?	-	?	323433	
2.7.12.2	ATP + p38	-	Homo sapiens	ADP + ?	-	?	323430	
2.7.12.2	ATP + p38 MAP kinase	phosphorylates and activates p38 MAP kinase	Homo sapiens	ADP + ?	-	?	323425	
2.7.12.2	ATP + p38/MPK2 kinase	phosphorylates and specifically activates the p38/MPK2 subgroup of the mitogen-activated protein kinase superfamily	Homo sapiens	ADP + ?	-	?	323429	
2.7.12.2	ATP + p42 MAP kinase	-	Rattus norvegicus	ADP + ?	-	?	323431	
2.7.12.2	ATP + a protein	-	eukaryota	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + a protein	-	Saccharomyces cerevisiae	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + a protein	-	Arabidopsis thaliana	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + a protein	-	Verticillium dahliae	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + a protein	-	Homo sapiens	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + a protein	MKK1 phosphorylates and activates the MAP kinases ERK1 and ERK2	eukaryota	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + a protein	-	Verticillium dahliae XS11	ADP + a phosphoprotein	-	?	323385	
2.7.12.2	ATP + JNK	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer, physiologic effects, overview	Homo sapiens	ADP + JNK phosphate	-	?	394764	
2.7.12.2	ATP + JNK	substrate of MKK4 and MKK7 in a synergistic manner	Homo sapiens	ADP + JNK phosphate	-	?	394764	
2.7.12.2	ATP + p38	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer, physiologic effects, overview	Homo sapiens	ADP + p38 phosphate	-	?	394771	
2.7.12.2	ATP + p38	substrate of MKK7	Homo sapiens	ADP + p38 phosphate	-	?	394771	
2.7.12.2	ATP + JNK	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer acting as a metastasis suppressor, overview	Mus musculus	ADP + phopsho-JNK	-	?	394765	
2.7.12.2	ATP + myelin basic protein	-	Arabidopsis thaliana	ADP + phoshorylated myelin basic protein	-	?	439194	
2.7.12.2	ATP + MyoD	phosphorylation at Tyr156, activated MEK1 associates with MyoD	Homo sapiens	ADP + phospharylated MyoD	-	?	438237	
2.7.12.2	ATP + MyoD	phosphorylation at Tyr156 recombinant GST-tagged MyoD substrate. Mutational analysis of phosphorylation sites using MyoD Tyr mutants, overview	Homo sapiens	ADP + phospharylated MyoD	-	?	438237	
2.7.12.2	ATP + ERK	-	Homo sapiens	ADP + phospho-ERK	-	?	394729	
2.7.12.2	ATP + Janus kinase 2	activation	Rattus norvegicus	ADP + phospho-Janus kinase 2	-	?	394763	
2.7.12.2	ATP + JNK	the enzyme is involved in stress-activated MAP kinase pathways and tumorigenesis, overview	Rattus norvegicus	ADP + phospho-JNK	-	?	394766	
2.7.12.2	ATP + JNK	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer acting as a metastasis suppressor, overview	Mus musculus	ADP + phospho-JNK	-	?	394766	
2.7.12.2	ATP + JNK	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer, physiologic effects, overview	Homo sapiens	ADP + phospho-JNK	-	?	394766	
2.7.12.2	ATP + JNK	substrate of MKK4 and MKK7 in a synergistic manner	Rattus norvegicus	ADP + phospho-JNK	-	?	394766	
2.7.12.2	ATP + JNK	substrate of MKK4 and MKK7 in a synergistic manner	Homo sapiens	ADP + phospho-JNK	-	?	394766	
2.7.12.2	ATP + JNK	substrate of MKK4 and MKK7 in a synergistic manner	Mus musculus	ADP + phospho-JNK	-	?	394766	
2.7.12.2	ATP + K52R-[ERK2]	catalytically inactive ERK2 in which lysine-52 is substituted with arginine	Homo sapiens	ADP + phospho-K52R-[ERK2]	-	?	439186	
2.7.12.2	ATP + K53M-[p38alpha]	catalytically inactive p38alpha in which lysine-53 is substituted with methionine	Homo sapiens	ADP + phospho-K53M-[p38alpha]	-	?	439187	
2.7.12.2	ATP + MPK-7	-	Arabidopsis thaliana	ADP + phospho-MPK-7	-	?	394767	
2.7.12.2	ATP + MPK-7	MKK3 interacts with MPK7 in planta	Arabidopsis thaliana	ADP + phospho-MPK-7	-	?	394767	
2.7.12.2	ATP + MPK-7	-	Arabidopsis thaliana Col-0	ADP + phospho-MPK-7	-	?	394767	
2.7.12.2	ATP + MPK-7	MKK3 interacts with MPK7 in planta	Arabidopsis thaliana Col-0	ADP + phospho-MPK-7	-	?	394767	
2.7.12.2	ATP + p38	-	Homo sapiens	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	activation by phosphorylation	Salmo salar	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	signal cascade upstream activation by phosphorylation, sorbitol induced activation of p38 in salmon TO cells does not require MKK6a, b or c	Salmo salar	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	the enzyme is involved in stress-activated MAP kinase pathways and tumorigenesis, overview	Rattus norvegicus	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer acting as a metastasis suppressor, overview	Mus musculus	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	the enzyme is involved in stress-activated MAP kinase pathways, tumorigenesis, and cancer, physiologic effects, overview	Homo sapiens	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	substrate of MKK4	Homo sapiens	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	substrate of MKK4	Mus musculus	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	substrate of MKK4 and MKK7	Rattus norvegicus	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + p38	substrate of MKK7	Mus musculus	ADP + phospho-p38	-	?	394772	
2.7.12.2	ATP + poly-(Tyr-Glu)	tyrosine kinase substrate	Saccharomyces cerevisiae	ADP + phospho-poly-(Tyr-Glu)	-	?	379462	
2.7.12.2	ATP + Red1	substrate of Mek1	Saccharomyces cerevisiae	ADP + phospho-Red1	-	?	379470	
2.7.12.2	ATP + protein	-	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	-	Rattus norvegicus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme undergoes autophosphorylation on Ser, Thr and Tyr	Xenopus laevis	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	tyrosine/threonine kinase	Rattus norvegicus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	phosphorylates kinase-inactive Erk-1 protein primarily on a tyrosine residue and, to a lesser extent, on a threonine	Mus musculus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state	Schizosaccharomyces pombe	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme is involved in independent human MAP-kinase signal transduction pathway	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme plays a key role in initiation of septum formation and cytokinesis in fission yeast, p120cdc7 interacts with the cdc11 protein in the control of septation	Schizosaccharomyces pombe	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme renders the cell resistant to polymyxin B	Saccharomyces cerevisiae	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	possible role for ASK1 in tissue development during embryogenesis as well as cytokine-induced apoptosis	Mus musculus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme is an activator of the c-Jun NH2-terminal kinase, the enzyme is a component of the JNK signal transduction pathway	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	dosage-dependent regulator of mitosis in Schizosaccharomyces pombe	Schizosaccharomyces pombe	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	Spg1p is a key element in controlling the onset of septum formation that acts through the Cdc7p kinase	Schizosaccharomyces pombe	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MKK1 and MKK2 function in a signal transduction pathway involving the protein kinases encoded by PKC1, BCK1, and MPK1. The site of action for MKK1 and MKK2 is between BCK1 and MPK1	Saccharomyces cerevisiae	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme is the major activator for p38	Mus musculus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme is the major activator for p38	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme is involved on MAPK signal transduction pathway	Mus musculus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme is involved on MAPK signal transduction pathway	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	enzyme is involved in the response of haploid yeast cells to peptide mating pheromones	Saccharomyces cerevisiae	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	Hst7 activates the mating pathway even in the absence of upstream signaling components including the Ste7 regulator Ste11, elevates the basal level of the pheromone-inducible FUS1 gene, and amplifies the pseudohyphal growth response in diploid cells	Candida albicans	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	byr1 is an important gene in the sexual differentiation pathway and at least part of ras1 function is to act directly or indirectly through byr1 to modulate protein phosphorylation	Schizosaccharomyces pombe	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme functions in a novel Drosophila MAPK pathway, controlling puckered expression and morphogenetic activity of the dorsal epidermis	Drosophila melanogaster	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MEKK 2 preferentially activates JNK	Mus musculus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MEKK 3 preferentially activates p42/44MAPK	Mus musculus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme is the major activator of RK/p38	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	mek-2 acts between lin-45 raf and sur-1/mpk-1 in a signal transduction pathway used in the control of vulval differentiation and other developmental events	Caenorhabditis elegans	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme is involved in the mitogenic growth factor signal transduction pathway in vertebrates	Gallus gallus	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme is a component of the mkh1 signaling pathway. Mkh1, Skh1 and Spm1 constitute a MAPK cascade in Schizosaccharomyces pombe	Schizosaccharomyces pombe	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MEKK3 regulates the SAPK and the ERK pathway directly	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme is required for locus-dependent and locus-independent steps in the fungal life cycle. Necessary for locus-dependent processes, such as conjugation tube formation, filament formation, and maintenance of filamentous growth, and for locus-independent processes, such as tumor induction and teliospore germination	Ustilago maydis	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	ASK1 may be a key element in the mechanism of stress-induced and cytokine-induced apoptosis	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MEK6 is a member of the p38 kinase cascade and efficiently phosphorylates p38, induces phosphorylation of ATF2 by p38 but does not phosphorylate ATF2 directly	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	the enzyme functions as a direct upstream activator for a presumed MAP kinase homolog in each signal transduction pathway involved in the regulation of cell cycle progression or cellular responses to extracellular signals	Xenopus laevis	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + protein	sequences located in the N-terminus of MEK5 may be important in coupling GTPase signaling molecules to the MEK5 protein kinase cascade	Homo sapiens	ADP + phosphoprotein	-	?	323335	
2.7.12.2	ATP + BcSak1	-	Botrytis cinerea	ADP + phosphorylated BcSak1	-	?	438208	
2.7.12.2	ATP + BcSak1	protei BcSAK1 is the putative downstream component of BOS5	Botrytis cinerea	ADP + phosphorylated BcSak1	-	?	438208	
2.7.12.2	ATP + BcSak1	-	Botrytis cinerea 38B1	ADP + phosphorylated BcSak1	-	?	438208	
2.7.12.2	ATP + BcSak1	protei BcSAK1 is the putative downstream component of BOS5	Botrytis cinerea 38B1	ADP + phosphorylated BcSak1	-	?	438208	
2.7.12.2	ATP + c-Jun N-terminal kinase	JNK activation	Homo sapiens	ADP + phosphorylated c-Jun N-terminal kinase	-	?	438210	
2.7.12.2	ATP + c-Jun N-terminal kinase	JNK activation	Mus musculus	ADP + phosphorylated c-Jun N-terminal kinase	-	?	438210	
2.7.12.2	ATP + casein	-	Lotus japonicus	ADP + phosphorylated casein	-	?	323354	
2.7.12.2	ATP + ERK	ERK phosphorylation by MEK1/2	Homo sapiens	ADP + phosphorylated ERK	-	?	380493	
2.7.12.2	ATP + ERK	phosphorylation by MEK activates ERK, which plays a role in pain induction modulating the A-type currents of potassium channels in neurons, ERK plays a central role in nocireceptive sensitization in the spinal cord	Mus musculus	ADP + phosphorylated ERK	-	?	380493	
2.7.12.2	ATP + ERK	ERK phosphorylation by MEK	Mus musculus	ADP + phosphorylated ERK	-	?	380493	
2.7.12.2	ATP + Erk-1 gene product	phosphorylation primarily on a tyrosine residue and, to a lesser extent, on a threonine	Mus musculus	ADP + phosphorylated Erk-1 gene product	-	?	323426	
2.7.12.2	ATP + ERK1	MEK2 protein stimulates Thr and Tyr phosphorylation on ERK1 and concomitantly activates ERK1 kinase activity more than 100-fold	Homo sapiens	ADP + phosphorylated ERK1	-	?	323427	
2.7.12.2	ATP + ERK1	phosphorylation of extracellular signal-regulated kinase 1	Homo sapiens	ADP + phosphorylated ERK1	-	?	323427	
2.7.12.2	ATP + ERK1/2	-	Homo sapiens	ADP + phosphorylated ERK1/2	-	?	438218	
2.7.12.2	ATP + ERK2	-	Homo sapiens	ADP + phosphorylated ERK2	-	?	438219	
2.7.12.2	ATP + ERK2	phosphorylation of extracellular signal-regulated kinase 2	Homo sapiens	ADP + phosphorylated ERK2	-	?	438219	
2.7.12.2	ATP + ERK2	MEK1 is able to effectively phosphorylate Thr183 and Tyr185 in the activation loop of ERK2	Homo sapiens	ADP + phosphorylated ERK2	-	?	438219	
2.7.12.2	ATP + extracellular regulated kinase 1	-	Sus scrofa	ADP + phosphorylated extracellular regulated kinase 1	-	?	438221	
2.7.12.2	ATP + extracellular regulated kinase 2	-	Sus scrofa	ADP + phosphorylated extracellular regulated kinase 2	-	?	438222	
2.7.12.2	ATP + GhMPK7	-	Gossypium hirsutum	ADP + phosphorylated GhMPK7	-	?	438224	
2.7.12.2	ATP + JNK	-	Homo sapiens	ADP + phosphorylated JNK	-	?	323422	
2.7.12.2	ATP + JNK	phosphorylation of JNK at the Thr residue located in the activation loop	Mus musculus	ADP + phosphorylated JNK	-	?	323422	
2.7.12.2	ATP + JNK	phosphorylation of JNK at the Tyr residue located in the activation loop	Mus musculus	ADP + phosphorylated JNK	-	?	323422	
2.7.12.2	ATP + JNK1	-	Homo sapiens	ADP + phosphorylated JNK1	-	?	323421	
2.7.12.2	ATP + JNK1	slight phosphorylation, JNK1 may not be the optimal substrate for the isoform	Homo sapiens	ADP + phosphorylated JNK1	-	?	323421	
2.7.12.2	ATP + KIMPK3	-	Arabidopsis thaliana	ADP + phosphorylated KIMPK3	-	?	439188	
2.7.12.2	ATP + KIMPK6	-	Arabidopsis thaliana	ADP + phosphorylated KIMPK6	-	?	439189	
2.7.12.2	ATP + MAP kinase	-	Xenopus laevis	ADP + phosphorylated MAP kinase	-	?	323432	
2.7.12.2	ATP + MAP kinase	the enzyme is involved in the mitogen-activated protein kinase signaling pathway important for e.g. flagellar length control, the enzyme is involved in differentiation of the parasite and is important for virulence and infection of human peritoneal macrophages	Leishmania mexicana	ADP + phosphorylated MAP kinase	-	?	323432	
2.7.12.2	ATP + MAP kinase	docking site for the substrate is located close to the N-terminal Lys4 and consists of 2 basic amino acid residues separated by a spacer of 2-6 variable residues from an L/I/V-X-L/I/V sequence	Leishmania mexicana	ADP + phosphorylated MAP kinase	-	?	323432	
2.7.12.2	ATP + MAP kinase	activation of MAP kinase	Arabidopsis thaliana	ADP + phosphorylated MAP kinase	-	?	323432	
2.7.12.2	ATP + MAP kinase 6	Arabidopsis thaliana MAP kinase MPK6	Lotus japonicus	ADP + phosphorylated Map kinase 6	-	?	439190	
2.7.12.2	ATP + MAPK	-	Rattus norvegicus	ADP + phosphorylated MAPK	-	?	378539	
2.7.12.2	ATP + MAPK	MAPK activation	eukaryota	ADP + phosphorylated MAPK	-	?	378539	
2.7.12.2	ATP + MKK10	-	Zea mays	ADP + phosphorylated MKK10	-	?	459414	
2.7.12.2	ATP + MKK4	-	Homo sapiens	ADP + phosphorylated MKK4	-	?	323434	
2.7.12.2	ATP + MKP3	-	Zea mays	ADP + phosphorylated MKP3	-	?	459415	
2.7.12.2	ATP + MKP7	-	Zea mays	ADP + phosphorylated MKP7	-	?	459416	
2.7.12.2	ATP + myelin basic protein	-	Leishmania mexicana	ADP + phosphorylated myelin basic protein	-	?	323343	
2.7.12.2	ATP + myelin basic protein	Pfnek3 phosphorylates MBP on threonine, but not serine residues	Plasmodium falciparum	ADP + phosphorylated myelin basic protein	-	?	323343	
2.7.12.2	ATP + myelin basic protein kinase	-	Mus musculus	ADP + phosphorylated myelin basic protein kinase	-	?	323428	
2.7.12.2	ATP + p38	-	Homo sapiens	ADP + phosphorylated p38	-	?	391362	
2.7.12.2	ATP + p38alpha	MKK6 phosphorylates p38 MAPK on Thr180 and Tyr182, the sites of phosphorylation that activate p38 MAPK	Homo sapiens	ADP + phosphorylated p38alpha	-	?	438241	
2.7.12.2	ATP + Pfmap2	the enzyme phosphorylates its potential in vivo Pfmap2 substrate largely on Thr290	Plasmodium falciparum	ADP + phosphorylated Pfmap2	-	?	438243	
2.7.12.2	ATP + Smad3	-	Homo sapiens	ADP + phosphorylated Smad3	-	?	380542	
2.7.12.2	ATP + Smad3	mitogen-activated protein kinase kinase-1 regulates SMAD3 expression in epithelial and smooth muscle cells, which is stimulated by TGFbeta-1, SMAD3 is a transcription factor that mediates TGF-?1 signaling and is important in many of the cellular processes that regulate fibrosis and inflammation, overview	Homo sapiens	ADP + phosphorylated Smad3	-	?	380542	
2.7.12.2	ATP + VdHog1	VdHog1 is a mitogen-activated protein kinase, MAPK	Verticillium dahliae	ADP + phosphorylated VdHog1	-	?	438255	
2.7.12.2	ATP + VdHog1	VdHog1 is a mitogen-activated protein kinase, MAPK	Verticillium dahliae XS11	ADP + phosphorylated VdHog1	-	?	438255	
2.7.12.2	ATP + [ERK2 substrate peptide]	MEK1	Mus musculus	ADP + [ERK2 substrate peptide] phosphate	-	?	396558	
2.7.12.2	ATP + [myelin basic protein substrate peptide]	-	Mus musculus	ADP + [myelin basic protein substrate peptide] phosphate	-	?	396561