2.7.11.18 ATP + 20kDa myosin light chain phosphorylation occurs at Ser-19 and Thr-18 Canis lupus familiaris ADP + 20kDa myosin light chain phosphate - ? 411657 2.7.11.18 ATP + BpaKKRAARATSNVFA Bpa is the photoreactive amino acid p-benzoylphenylalanine Oryctolagus cuniculus ADP + ? - ? 357121 2.7.11.18 ATP + Dictyostelium myosin - Dictyostelium discoideum ADP + Dictyostelium myosin phosphate - ? 452325 2.7.11.18 ATP + H-KKRAARATSNVFA-NH2 peptide substrate Homo sapiens ADP + ? - ? 379353 2.7.11.18 ATP + kemptamide - Bos taurus ADP + ? - ? 357117 2.7.11.18 ATP + kemptamide i.e. peptide KKRPQRATSNVFS-NH2, activated enzyme Dictyostelium discoideum ADP + kemptamide phosphate - ? 379376 2.7.11.18 ATP + KKRAARATSNVFA - Oryctolagus cuniculus ADP + ? - ? 357120 2.7.11.18 ATP + light chain myosin II - Mus musculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II - Homo sapiens ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II - Rattus norvegicus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II - Bos taurus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos Danio rerio ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II causes endothelial contraction Bos taurus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease Homo sapiens ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview Oryctolagus cuniculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview Mus musculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events Mus musculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization Oryctolagus cuniculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview Lytechinus pictus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview Homo sapiens ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II phosphorylation at Ser19 Lytechinus pictus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II regulatory myosin chain Oryctolagus cuniculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus Homo sapiens ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus Oryctolagus cuniculus ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II regulatory myosin light chain Homo sapiens ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II the cardiac-specific substrate cardiac-MLCKis phosphorylated by the cardiac-specific isozyme MLC2v Danio rerio ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + light chain myosin II the cardiac-specific substrate MLC2v is phosphorylated by the cardiac-specific isozyme cardiac-MLCK Homo sapiens ADP + phosphorylated light chain myosin II - ? 386307 2.7.11.18 ATP + Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala - Gallus gallus ADP + ? - ? 357116 2.7.11.18 ATP + Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ser - Gallus gallus ADP + ? - ? 357115 2.7.11.18 ATP + myosin - Dictyostelium discoideum ADP + myosin phosphate - ? 452326 2.7.11.18 ATP + myosin II from Dictyostelium discoideum, activated enzyme Dictyostelium discoideum ADP + myosin II phosphate - ? 379426 2.7.11.18 ATP + myosin IIB - Gallus gallus ADP + phosphorylated myosin IIB - ? 386310 2.7.11.18 ATP + myosin light chain - Mammalia ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - eukaryota ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Mus musculus ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Oryctolagus cuniculus ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Gallus gallus ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Rattus norvegicus ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Dictyostelium discoideum ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Homo sapiens ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Bos taurus ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability Homo sapiens ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain the enzyme phosphorylates the 18000 Da Dictyostelium myosin regulatory light chain Dictyostelium discoideum ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview Mus musculus ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain the enzyme phosphorylates the 18000 Da Dictyostelium myosin regulatory light chain Dictyostelium discoideum Ax-3 ADP + phosphorylated myosin light chain - ? 323357 2.7.11.18 ATP + myosin light chain - Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Mus musculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Ovis aries ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Dictyostelium discoideum ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle myosin Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle myosin Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle myosin Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle myosin Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle myosin Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Dictyostelium discoideum ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is protamine Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is protamine Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of cardiac muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are actin and tropomyosin Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain transfers the gamma-phosphate of ATP to a Ser-residue of myosin light chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Ovis aries ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2-A Dictyostelium discoideum ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain ITP, GTP, CTP or UTP cannot replace ATP Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of non-muscle myosin Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not specific for 22 kDa and 15 kDa light chain Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Ovis aries ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is casein Dictyostelium discoideum ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are 15 kDa and 22 kDa light-chain or heavy-chain fractions of myosin from white skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-residues in smooth and skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of adrenal medullary myosin Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2 b Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone 2 b Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is troponin Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone H1 Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for 18 kDa light chain Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for 18 kDa light chain Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for 18 kDa light chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain highly specific for 18 kDa light chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 18.5 kDa Dictyostelium or 19 kDa skeletal muscle light chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is synapsin Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is synapsin Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 1 mol phosphate per mol light chain in skeletal muscle Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 1 mol phosphate per mol light chain in skeletal muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 1 mol phosphate per mol light chain in skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 1 mol phosphate per mol light chain in skeletal muscle Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase kinase Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is molluscan adductor myosin Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Limulus sp. ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myelin basic protein, glycogen synthase, tubulin, microtubule-associated protein 2, kemptide and peptide pp60src Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not 16 kDa light chain Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not 16 kDa light chain Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain not 16 kDa light chain Dictyostelium discoideum ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone V-S Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone V-S Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone V-S Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone V-S Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of Ml3-myosin rabbit muscle Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Sus scrofa ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Ovis aries ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Dictyostelium discoideum ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrate is histone III-S from thymus Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain kinase from skeletal muscle with broader specificity than smooth muscle kinase Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in myosin phosphorylation and enzyme secretion Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain obligatory step in development of active tension in smooth muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Meleagris gallopavo ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Cavia porcellus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in muscle contractility and motility of non-muscle cells Canis lupus familiaris ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain involved in regulation of actin-myosin contractile activity in adrenal medulla Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain event in initiation of smooth-muscle contraction Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain event in initiation of smooth-muscle contraction Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain event in initiation of smooth-muscle contraction Oryctolagus cuniculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain inhibition of actin-myosin ineraction Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain phosphorylation at Ser19 Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction Ovis aries ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain MLCK plays a crucial role in the cell migration and tumor metastasis Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics Mus musculus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics Homo sapiens ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain the enzyme has effects on the actin-myosin interaction in vitro, binding of full-length and fragmented enzyme, overview. The Asp-Phe-Arg-X-X-Leu motif plays a major role in the binding of MLCK to myofibrils. Regulation of actin–myosin interaction by MLCK through its non-kinase activity, overview Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain the enzyme has effects on the actin-myosin interaction in vitro, regulation of actin-myosin interaction by MLCK through its non-kinase activity, overview Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 20 kDa regulatory light chain of smooth muscle Gallus gallus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 20 kDa regulatory light chain of smooth muscle Bos taurus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain myosin light chain is phosphorylated at Thr 18 and Ser 19 by myosin light chain kinase Rattus norvegicus ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Dictyostelium discoideum Ax-3 ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain no substrates are myosin heavy chain and phosvitin Dictyostelium discoideum Ax-3 ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain - Mus musculus C57BL/6 ADP + myosin light chain phosphate - ? 357118 2.7.11.18 ATP + myosin light chain 2 - Mus musculus ADP + myosin light chain 2 phosphate - ? 394768 2.7.11.18 ATP + myosin light chain 2 MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview Mus musculus ADP + myosin light chain 2 phosphate - ? 394768 2.7.11.18 ATP + myosin regulatory light chain - Oryctolagus cuniculus ? - ? 357122 2.7.11.18 ATP + myosin regulatory light chain - Mus musculus ADP + myosin regulatory light chain phosphate - ? 357191 2.7.11.18 ATP + myosin regulatory light chain - Rattus norvegicus ADP + myosin regulatory light chain phosphate - ? 357191 2.7.11.18 ATP + myosin regulatory light chain - Mus musculus ADP + phosphorylated myosin regulatory light chain - ? 394769 2.7.11.18 ATP + myosin-II regulatory light chain - Bos taurus ADP + myosin-II regulatory light chain phosphate - ? 411679 2.7.11.18 ATP + obscurin - Mus musculus ADP + obscurin phosphate - ? 394770 2.7.11.18 ATP + obscurin - Homo sapiens ADP + obscurin phosphate - ? 394770 2.7.11.18 ATP + obscurin - Rattus norvegicus ADP + obscurin phosphate - ? 394770 2.7.11.18 ATP + protein intramolecular autophosphorylation activates the enzyme Dictyostelium discoideum ADP + phosphoprotein - ? 323335 2.7.11.18 ATP + protein intramolecular autophosphorylation activates the enzyme Dictyostelium discoideum Ax-3 ADP + phosphoprotein - ? 323335 2.7.11.18 ATP + telokin telokin may modulate enzyme activity in vivo Gallus gallus ADP + ? - ? 357119 2.7.11.18 ATP + TRPC5 channel Ca2+/calmodulin-dependent myosin light chain kinase is essential for activation of plasma membrane TRPC5 channels, responsible for Ca2+ influx, from Drosophila melanogaster expressed in HEK-293 cells, phosphorylation sites are Ser698, Ser775, and Thr700, mutational analysis Homo sapiens ADP + phosphorylated TRPC5 channel - ? 388156 2.7.11.18 ATP + [myosin II light chain] from Dictyostelium discoideum, activated enzyme Dictyostelium discoideum ADP + [myosin II lihght chain] phosphate - ? 379536 2.7.11.18 ATP + [myosin II regulatory light chain] - Homo sapiens ADP + [myosin II regulatory light chain] phosphate - ? 378628 2.7.11.18 ATP + [myosin II regulatory light chain] involved in many cellular cytoskeletal functions Homo sapiens ADP + [myosin II regulatory light chain] phosphate - ? 378628 2.7.11.18 ATP + [myosin light chain 2a] - Homo sapiens ADP + [myosin light chain 2a] phosphate - ? 378629 2.7.11.18 ATP + [myosin light chain 2a] MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae Homo sapiens ADP + [myosin light chain 2a] phosphate - ? 378629 2.7.11.18 ATP + [myosin light chain] - Mus musculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] - Homo sapiens ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] - Bos taurus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] - Oryctolagus cuniculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] - Gallus gallus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] activation of the enzyme is a key regulatory step in the modulation of endothelial permeability, central to parthogenesis of inflammatory lung disease is disruption of the endothelial barrier function Homo sapiens ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] enzyme is regulating cytoskeletal rearrangement and cell motility Homo sapiens ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] the endothelial isozyme is a mutifunctional contractile effector involved in vascular barrier regulation, leukocyte diapedesis, apoptosis, and angiogenesis Homo sapiens ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] the multifunctional regulatory enzyme stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain, kinetics, overview Bos taurus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] the non-muscle myosin light chain kinase is involved in regulation of hepatic functions in response to intra- and extracellular signals Oryctolagus cuniculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] activated phosphorylated enzyme Homo sapiens ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] myyosin II Rattus norvegicus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] non-muscle myosin II Gallus gallus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] non-muscle myosin II and preferred substrate smooth muscle myosin II Gallus gallus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] non-muscle myosin II and preferred substrate smooth muscle myosin II Mus musculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] phosphorylation levels of MLC2v in the apex of the hearts. The MLC2v phosphorylation in strain C57BL/6N is significantly lower than that in C57BL/6J mice Mus musculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] smooth muscle myosin Rattus norvegicus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] smooth muscle myosin II Homo sapiens ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] MLC2 Mus musculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] myosin II Rattus norvegicus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] phosphorylation of myosin on Ser19 of the regulatory light chain. Non-muscle myosin II regulatory light chain and preferred substrate smooth muscle myosin II regulatory light chain Gallus gallus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] phosphorylation of Thr-18/Ser-19 on the regulatory light chain of myosin II Mus musculus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] smooth muscle myosin regulatory light chain phosphorylation at Ser19 Gallus gallus ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] phosphorylation levels of MLC2v in the apex of the hearts. The MLC2v phosphorylation in strain C57BL/6N is significantly lower than that in C57BL/6J mice Mus musculus C57BL/6N/C57BL/6J ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] MLC2 Mus musculus C57BL/6N/C57BL/6J ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] - Mus musculus CF-1 ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [myosin light chain] smooth muscle myosin Rattus norvegicus Wistar ADP + [myosin light chain] phosphate - ? 378630 2.7.11.18 ATP + [non-muscle heavy meromyosin IIB] - Gallus gallus ADP + [non-muscle heavy meromyosin IIB] phosphate - ? 439226 2.7.11.18 ATP + [non-muscle regulatory light chain] - Gallus gallus ADP + [non-muscle regulatory light chain] phosphate - ? 439227 2.7.11.18 ATP + [rabbit white skeletal muscle myosin P-light chain] - Oryctolagus cuniculus ADP + [rabbit white skeletal muscle myosin P-light chain] phosphate - ? 452324 2.7.11.18 ATP + [smooth muscle heavy meromyosin] - Gallus gallus ADP + [smooth muscle heavy meromyosin] phosphate - ? 439228 2.7.11.18 ATP + [smooth muscle regulatory light chain] - Gallus gallus ADP + [smooth muscle regulatory light chain] phosphate - ? 439229 2.7.11.18 ATP + [ventricular isoform of myosin regulatory light chain MLC2v] - Homo sapiens ADP + [ventricular isoform of myosin regulatory light chain MLC2v] phosphate - ? 458584 2.7.11.18 additional information substrate specificity eukaryota ? - ? 89 2.7.11.18 additional information the enzyme possesses ATPase activity Bos taurus ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Gallus gallus ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Cavia porcellus ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Homo sapiens ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Rattus norvegicus ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Bos taurus ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Canis lupus familiaris ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Dictyostelium discoideum ? - ? 89 2.7.11.18 additional information no intramolecular autophosphorylation in the absence of acceptor substrate Sus scrofa ? - ? 89 2.7.11.18 additional information no intramolecular autophosphorylation in the absence of acceptor substrate Limulus sp. ? - ? 89 2.7.11.18 additional information the differentiation-dependent enzyme splice variant MLCK1 regulates epithelial tight junction permeability, the endothelial isozyme is responsible for Na+-glucose cotransport-induced tight junction regulation Homo sapiens ? - ? 89 2.7.11.18 additional information the enzyme activity is cell cycle regulated with a decrease in activity during mitosis due to phosphorylation, inhibition of enzyme phosphorylation during mitosis leads to microtubule defects, overview Homo sapiens ? - ? 89 2.7.11.18 additional information the enzyme interacts with macrophage migration inhibition factor MIF in endothelium which may be important for the regulation of both non-muscle cytoskeletal dynamics as well as pathobiological vascular events involving the enzyme Homo sapiens ? - ? 89 2.7.11.18 additional information the enzyme is a potential cytoskeleton integrator through its unique N-terminal domain, the enzyme binds tubulin and actin, and is involved in microtubule/microfilament association Gallus gallus ? - ? 89 2.7.11.18 additional information the enzyme is involved, probably via microfilament assembly, in sperm chromatin-induced cortical reorganization during oocyte maturation to a polarized egg Mus musculus ? - ? 89 2.7.11.18 additional information the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner Homo sapiens ? - ? 89 2.7.11.18 additional information the enzyme plays an important role in TNFalpha-dependent induction of NFkappaB activity, mechanism Homo sapiens ? - ? 89 2.7.11.18 additional information substrate specificity and binding structure, the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ? - ? 89 2.7.11.18 additional information Human T cell leukemia virus 1-infected lymphocytes can cause a breakdown of the blood-brain barrier inducing an increase in paracellular endothelial permeability and transcellular migration, this disruption is associated with tight junction disorganization between endothelial cells and altered tight junction proteinexpression involving the enzyme MLCK, enzyme inhibition prevents the changes in endothelial cells, overview Homo sapiens ? - ? 89 2.7.11.18 additional information increased MLCK activity accompanies increases in MLC expression, overview Homo sapiens ? - ? 89 2.7.11.18 additional information infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview Bos taurus ? - ? 89 2.7.11.18 additional information inhibition of MLCK results in spherical cells and marked impairment of adhesion and migration of fibrosarcoma cells, overview Homo sapiens ? - ? 89 2.7.11.18 additional information inhibition of the enzyme retards the growth of mammary cancer cells Mus musculus ? - ? 89 2.7.11.18 additional information inhibition of the enzyme retards the growth of prostate cancer cells Rattus norvegicus ? - ? 89 2.7.11.18 additional information MLCK is probably involved in development of diabetic nephropathy, overview Rattus norvegicus ? - ? 89 2.7.11.18 additional information regulation of the MLCK promoters and gene expression involving myocardin, model, overview Mus musculus ? - ? 89 2.7.11.18 additional information the enzyme binds to thin filaments with high affinity, myofilament binding by Ig-like modules is blocked by disassembling of the filaments, overview Oryctolagus cuniculus ? - ? 89 2.7.11.18 additional information the enzyme is a key regulator of various forms of cell motility involving actin and myosin II Gallus gallus ? - ? 89 2.7.11.18 additional information the enzyme is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons, overview Rattus norvegicus ? - ? 89 2.7.11.18 additional information the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview Rattus norvegicus ? - ? 89 2.7.11.18 additional information the myosin light chain kinase plays a role in the regulation of epithelial cell survival, and in the generation of pro-survival signals in both untransformed and transformed epithelial cells, apoptosis following inhibition of myosin II activation by MLCK is probably meditated through the death receptor pathway, overview Mus musculus ? - ? 89 2.7.11.18 additional information ventricular/cardiac muscle isozyme cardiac-MLCK, which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development, the cardiac MLCK regulates sarcomere assembly in the vertebrate heart, overview Homo sapiens ? - ? 89 2.7.11.18 additional information MLCK in the plasma membrane distribution of TRPC5 channels, overview Homo sapiens ? - ? 89 2.7.11.18 additional information actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview Bos taurus ? - ? 89 2.7.11.18 additional information actin-myosin interaction of smooth muscle could be activated by the non-kinase activity of MLCK, a mechanism that is quite independent of MLC20 phosphorylation, role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, overview. MLCK phosphorylated at Ser828 stimulates the ATPase activity of unphosphorylated myosin more effectively than the control MLCK Gallus gallus ? - ? 89 2.7.11.18 additional information cytochalasin-induced increases in paracellular permeability are also mediated by MLC in Caco-2 monolayers Homo sapiens ? - ? 89 2.7.11.18 additional information MLCK is a substrate of AMP-activated protein kinase, AMPK Mus musculus ? - ? 89 2.7.11.18 additional information MLCK is a substrate of AMP-activated protein kinase, AMPK Gallus gallus ? - ? 89 2.7.11.18 additional information MLCK is a substrate of AMP-activated protein kinase, AMPK Rattus norvegicus ? - ? 89 2.7.11.18 additional information myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice, overview Mus musculus ? - ? 89 2.7.11.18 additional information myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview Homo sapiens ? - ? 89 2.7.11.18 additional information PKA regulates beta2-integrin avidity activation via a MLCK-dependent pathway, overview Homo sapiens ? - ? 89 2.7.11.18 additional information postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview Ovis aries ? - ? 89 2.7.11.18 additional information the enzyme is involved in inflammation response, including apoptosis, vascular permeability, and leukocyte diapedesis. Single nucleotide polymorphisms are involved in the risk of sepsis-related acute lung injury and asthma Homo sapiens ? - ? 89 2.7.11.18 additional information the cardiac-specific isozyme probably performs also autophosphorylation Mus musculus ? - ? 89 2.7.11.18 additional information the enzyme also exerts non-kinase activity on myosin motor and myosin ATPase activities Gallus gallus ? - ? 89 2.7.11.18 additional information the enzyme also exerts non-kinase activity on myosin motor and myosin ATPase activities Bos taurus ? - ? 89 2.7.11.18 additional information 14-3-3 binding of nmMLCK Homo sapiens ? - ? 89 2.7.11.18 additional information non-muscle myosin and smooth muscle myosin are the only known substrates of MLCK in vivo Gallus gallus ? - ? 89 2.7.11.18 additional information MLCK and truncated 1-75 MLCK interaction analysis with actin, overview Homo sapiens ? - ? 89 2.7.11.18 additional information MLCK has a 2fold higher kcat for both smooth muscle myosin II substrates compared with non-muscle myosin IIB substrates, whereas Km values are very similar. Myosin light chain kinase has a 1.6fold and 1.5fold higher specificity (kcat/Km) for smooth versus non-muscle-free regulatory light chain and heavy meromyosin, respectively, suggesting that differences in specificity are dictated by regulatory light chain sequences. Three residues, Glu70, Gly71, and Ser74, are found to be surface exposed in the N-terminal half of the regulatory light chain, consistent with their importance in substrate recognition. Substrate recognition and specificity, overview Gallus gallus ? - ? 89 2.7.11.18 additional information static substrate binding structure of streptavidin-tagged enzyme, overview Gallus gallus ? - ? 89 2.7.11.18 additional information skeletal, gizzard smooth and cardiac enzymes perform intramolecular autophosphorylation in the absence of acceptor substrate Dictyostelium discoideum Ax-3 ? - ? 89