2.7.11.10 ATP + a protein autophosphorylation at both Ser and Thr Myxococcus xanthus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection Mus musculus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein the expression of pkn1 is developmentally regulated to start immediately before spore formation. The enzyme plays an important role in the onset of proper differentiation Myxococcus xanthus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + a protein phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses Mus musculus ADP + a phosphoprotein - ? 323385 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling Mus musculus ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling Homo sapiens ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl Mus musculus ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl Homo sapiens ADP + phosphorylated Bcl - ? 386259 2.7.11.10 ATP + Bcl Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl Homo sapiens ADP + phosphorylated Bcl10 - ? 387972 2.7.11.10 ATP + Bcl10 negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview Homo sapiens ADP + phosphorylated Bcl10 - ? 386258 2.7.11.10 ATP + GST-IkappaBalpha activity assay Homo sapiens ADP + GST-IkappaBalpha phosphoprotein - ? 408547 2.7.11.10 ATP + IkappaB alpha - Homo sapiens ADP + phosphorylated IkappaB alpha - ? 400182 2.7.11.10 ATP + IkappaB protein the enzyme targets the inhibitory IkappaB protein tightly bound to the transcription factor NF-kappaB for proteasomal degradation and allows the freed NF-kappaB to enter the nucleus where it can be transactivate its target gene, IKKalpha is involved in inflammation in macrophages Mus musculus ADP + phosphorylated IkappaB - ? 386292 2.7.11.10 ATP + IkappaB protein - Homo sapiens ADP + IkappaB phosphoprotein - ? 400183 2.7.11.10 ATP + IkappaBalpha - Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha degradation of IkappaBalpha Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha phosphorylation of IkappaBalpha at Ser32 and Ser36 Mus musculus ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha recombinant GST-fusion substrate Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha phosphorylation at Ser-32 and Ser-36 Homo sapiens ADP + phosphorylated IkappaBalpha - ? 379371 2.7.11.10 ATP + IkappaBalpha - Rattus norvegicus ADP + phosphorylated-IkappaBalpha - ? 400184 2.7.11.10 ATP + IkappaBbeta phosphorylation of IkappaBalpha at Ser19 and Ser23 Mus musculus ADP + phosphorylated IkappaBbeta - ? 388063 2.7.11.10 ATP + interferon regulatory factor 3 - Homo sapiens ADP + phosphorylated interferon regulatory factor 3 - ? 408564 2.7.11.10 ATP + KKKKERLLDDRHDSGLDSMKDEE IKK substrate peptide derived from IkappaBalpha sequence Homo sapiens ADP + phosphorylated-KKKKERLLDDRHDSGLDSMKDEE - ? 400191 2.7.11.10 ATP + NF-kappaB - Homo sapiens ADP + phosphorylated NF-kappaB - ? 379436 2.7.11.10 ATP + NF-kappaB p65 subunit IKKalpha and IKKbeta phosphorylate NF-kappaB p65 subunit at Ser536 Homo sapiens ADP + phosphorylated NF-kappaB p65 subunit - ? 408653 2.7.11.10 ATP + p65/RelA - Homo sapiens ADP + phosphorylated p65/RelA - ? 400270 2.7.11.10 ATP + protein p100 interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p100 - ? 386346 2.7.11.10 ATP + protein p100 required for the interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p100 - ? 386346 2.7.11.10 ATP + protein p165 p65 is part of the IKKepsilon complex with p25, interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p165 - ? 386348 2.7.11.10 ATP + protein p165 required for the interaction with the NF-kappaB complex Mus musculus ADP + phosphorylated protein p165 - ? 386348 2.7.11.10 ATP + STAT1 transcription factor - Homo sapiens ADP + phosphorylated STAT1 transcription factor - ? 408696 2.7.11.10 ATP + [acetylated histone H3 protein] IKKalpha is required for histone function regulation in the nucleus Mus musculus ADP + [acetylated histone H3 phosphoprotein] - ? 378606 2.7.11.10 ATP + [acetylated histone H3 protein] IKKalpha is required for histone function regulation in the nucleus Homo sapiens ADP + [acetylated histone H3 phosphoprotein] - ? 378606 2.7.11.10 ATP + [acetylated histone H3 protein] phosphorylation at Ser10 Mus musculus ADP + [acetylated histone H3 phosphoprotein] - ? 378606 2.7.11.10 ATP + [acetylated histone H3 protein] phosphorylation at Ser10 Homo sapiens ADP + [acetylated histone H3 phosphoprotein] - ? 378606 2.7.11.10 ATP + [biotinylated IkappaBa peptide] i.e. biotin-Gly-Leu-Lys-Lys-Glu-Arg-Leu-Leu-Asp-Asp-Arg-His-Asp-Ser32-Gly-Leu-Asp-Ser36-Met-Lys-Asp-Glu-Glu Homo sapiens ADP + [biotinylated IkappaBa phosphopeptide] - ? 423047 2.7.11.10 ATP + [DELTANp73alpha protein] phosphorylation at Ser422 by IKKbeta, IKKbeta is inactive with S422A mutant substrate. DELTANp73alpha i a dominant negative inhibitor of p53 and p73 Homo sapiens ADP + [DELTANp73alpha phosphoprotein] - ? 423048 2.7.11.10 ATP + [GST-IkappaB protein] - Homo sapiens ADP + [GST-IkappaB phosphoprotein] - ? 378620 2.7.11.10 ATP + [GST-IkappaBalpha protein] - Homo sapiens ADP + [GST-IkappaBalpha phosphoprotein] - ? 378621 2.7.11.10 ATP + [GST-IkappaBalpha1-54 protein] - Mus musculus ADP + [GST-IkappaBalpha1-54 phosphoprotein] - ? 379531 2.7.11.10 ATP + [GST-IkappaBalpha1-54 protein] - Homo sapiens ADP + [GST-IkappaBalpha1-54 phosphoprotein] - ? 379531 2.7.11.10 ATP + [GST-IkappaBalpha1-54 protein] recombinant substrate derived from mouse IkappaBalpha Toxoplasma gondii ADP + [GST-IkappaBalpha1-54 phosphoprotein] - ? 379531 2.7.11.10 ATP + [GST-IkappaBbeta protein] - Mus musculus ADP + [GST-IkappaBbeta phosphoprotein] - ? 379532 2.7.11.10 ATP + [histone H3 protein] - Homo sapiens ADP + [histone H3 phosphoprotein] - ? 378622 2.7.11.10 ATP + [histone H3 protein] histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression Mus musculus ADP + [histone H3 phosphoprotein] - ? 378622 2.7.11.10 ATP + [histone H3 protein] histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression Homo sapiens ADP + [histone H3 phosphoprotein] - ? 378622 2.7.11.10 ATP + [histone H3 protein] phosphorylation at Ser10 by IKK-alpha Mus musculus ADP + [histone H3 phosphoprotein] - ? 378622 2.7.11.10 ATP + [IFN regulatory factor 3 protein (380-427)] the truncated mutant is a good substrate Mus musculus ADP + [IFN regulatory factor 3 phosphoprotein (380-427)] - ? 423049 2.7.11.10 ATP + [IFN regulatory factor 3 protein] IRF3 activation is triggered by IKKepsilon/TBK1-mediated phosphorylation on Ser396 Mus musculus ADP + [IFN regulatory factor 3 phosphoprotein] - ? 421899 2.7.11.10 ATP + [IFN regulatory factor 3 protein] phosphorylation on Ser396, and phosphorylation of Ser402/404/405 cluster in the C-terminal regulatory domain of IRF3 in vitro Mus musculus ADP + [IFN regulatory factor 3 phosphoprotein] - ? 421899 2.7.11.10 ATP + [IkappaB protein] - Mus musculus ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] - Homo sapiens ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] - Rattus norvegicus ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] - Canis lupus familiaris ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] - Toxoplasma gondii ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] inhibition and degradation of IkappaB, an inhibitor of NF-kappaB retaining it in the cytoplasm, phosphorylation of IkappaB marks the protein for ubiquitination followed by degradation, activated NF-kappaB is translocated to the nucleus initiating signalling pathways, regulation mechanism, overview Mus musculus ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] inhibitor substrate is bound to NF-kappaB Mus musculus ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex Toxoplasma gondii ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] phosphorylation of IkappaB results in its proteolytic degradation Mus musculus ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] required for activation of NF-kappaB resulting in activation of signalling pathways Mus musculus ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] signalling step of IKK bound to NFkappaB for subsequent ubiquitination of IkappaB and proteolytic degradation Homo sapiens ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] the enzyme is also active with a peptide derived from IkappaB protein spanning Ser32 and Ser36 which are phosphorylated Homo sapiens ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] the IkappaBalpha subunit of NF-kappaB is phosphorylated at serine residues 32 and 36 Homo sapiens ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaB protein] phosphorylation at Ser32 and Ser36 catalyzed by IkappaBalpha kinase Homo sapiens ADP + [IkappaB phosphoprotein] - ? 378623 2.7.11.10 ATP + [IkappaBalpha protein] - Homo sapiens ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBalpha protein] enzyme is involved in activation of pro-inflammation signalling Homo sapiens ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBalpha protein] parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB through phosphorylation of host IkappaBalpha at Ser32 and Ser36 in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex Toxoplasma gondii ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBalpha protein] IKKbeta-dependent phosphorylation and subsequent ubiquitin-dependent proteolytic degradation of IKKalpha, the 2 subunits have opposing function in NF-kappaB metabolism, overview Mus musculus ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBalpha protein] phosphorylation at Ser32 and Ser36 Mus musculus ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBalpha protein] phosphorylation at Ser32 and Ser36 Homo sapiens ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBalpha protein] phosphorylation on Ser32 and Ser36 Mus musculus ADP + [IkappaBalpha phosphoprotein] - ? 378624 2.7.11.10 ATP + [IkappaBbeta protein] - Homo sapiens ADP + [IkappaBbeta phosphoprotein] - ? 378625 2.7.11.10 ATP + [IkappaBbeta protein] phosphorylation at Ser19 and Ser23 Mus musculus ADP + [IkappaBbeta phosphoprotein] - ? 378625 2.7.11.10 ATP + [IkappaBbeta protein] phosphorylation at Ser19 and Ser23 Homo sapiens ADP + [IkappaBbeta phosphoprotein] - ? 378625 2.7.11.10 ATP + [IRF3 protein] phosphorylation at Ser396 by IKK-related IKKepsilon and TBK1 kinase Mus musculus ADP + [IRF3 phosphoprotein] - ? 421900 2.7.11.10 ATP + [leucine-rich repeat kinase 2 protein] catalyzed reaction of canonical IKKalpha and IKKbeta and IKK-related IKKepsilon and TBK1 kinase Mus musculus ADP + [leucine-rich repeat kinase 2 phosphoprotein] - ? 421901 2.7.11.10 ATP + [leucine-rich repeat kinase 2 protein] phosphorylation of LRRK2 at Ser910 and Ser935 by IKKalpha and IKKbeta Mus musculus ADP + [leucine-rich repeat kinase 2 phosphoprotein] - ? 421901 2.7.11.10 ATP + [MYPT1] the enzyme phosphorylates MYPT1 at Thr853 Rattus norvegicus ADP + [MYPT1 phosphoprotein] - ? 458579 2.7.11.10 ATP + [NFkappaB subunit p56] - Homo sapiens ADP + [NFkappaB subunit p56]phosphate - ? 378632 2.7.11.10 ATP + [NFkappaB subunit p56] phosphorylation at serine residues, especially at S536, in the cytoplasm prior to NFkappaB p56 translocation to the nucleus Homo sapiens ADP + [NFkappaB subunit p56]phosphate - ? 378632 2.7.11.10 ATP + [optineurin protein] phosphorylation at Ser177 by IKK-related IKKepsilon and TBK1 kinase Mus musculus ADP + [optineurin phosphoprotein] - ? 421904 2.7.11.10 ATP + [p73 protein] IKKalpha in the nucleus Homo sapiens ADP + [p73 phosphoprotein] - ? 421905 2.7.11.10 ATP + [RelA/p65 protein] - Mus musculus ADP + [RelA/p65 phosphoprotein] - ? 378634 2.7.11.10 ATP + [RelA/p65 protein] phosphorylation on Ser536 of the transactivation domain, dependent on lipopolysaccharide-induction, but not on Akt or p65 Mus musculus ADP + [RelA/p65 phosphoprotein] - ? 378634 2.7.11.10 ATP + [S386A IFN regulatory factor 3 protein] the mutant substrate is equally phosphorylated as the wild-type IRF3 Mus musculus ADP + [S386A IFN regulatory factor 3 phosphoprotein] - ? 423051 2.7.11.10 ATP + [S396A IFN regulatory factor 3 protein] the mutant substrate is equally phosphorylated as the wild-type IRF3 Mus musculus ADP + [S396A IFN regulatory factor 3 phosphoprotein] - ? 423052 2.7.11.10 ATP + [S402A/S404A/S405A IFN regulatory factor 3 protein] low activity with the IRF3 mutant Mus musculus ADP + [S402A/S404A/S405A IFN regulatory factor 3 phosphoprotein] - ? 423053 2.7.11.10 additional information activation of heterodimeric nuclear transcription factor NFkappaB is an essential step in inflammation, e.g. resulting in osteoarthritis, ulcerative colitis, asthma, and Crohn's disease, signalling step for phosphorylation, subsequent ubiquitination and proteolytic degradation of IkappaB, NFkappaB remains free after the reaction and is translocated to the nucleus, NFkappaB activation is also involved in development of diseases like cancer, gut ischemia-reperfusion, diabetes, or in transplant rejections, overview Homo sapiens ? - ? 89 2.7.11.10 additional information activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection Mus musculus ? - ? 89 2.7.11.10 additional information defective ubiquination of the NF-kappaB essential modifier/IkappaB kinase-gamma complex leads to impaired cellular NFkappaB signalling and hypohidrotic ectodermal dysplasia with immunodeficiency HED-ID Homo sapiens ? - ? 89 2.7.11.10 additional information enzyme is responsible for NFkappaB activation, specific inhibition of IkB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in male Sprague-Dawley rats Homo sapiens ? - ? 89 2.7.11.10 additional information IkappaB kinases are essential key regulators of the NFkappaB pathways in the tooth development acting as stimulators, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKK activates and regulates NFkappaB important in intracellular signalling, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKK activates NF-kappaB through action of TNFalpha playing an important role in subsequent signaling pathways involved in e.g. apoptosis/cell survival, cell proliferation, and inflammation Homo sapiens ? - ? 89 2.7.11.10 additional information IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKK activates TNFalpha-dependent signaling pathways inducing 5-fluoro-2'-deoxyuridine drug resistance in different cell lines, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKK is involved in NF-kappaB activation, IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of NF-kappaB-dependent osteoclast survival preventing TNFalpha-induced cell death, and is required for formation of fully functional bone-resorbing osteoclasts and for inflammation-induced bone loss Mus musculus ? - ? 89 2.7.11.10 additional information IKK is required for activation of NF-kappaB and subsequent signalling pathways Mus musculus ? - ? 89 2.7.11.10 additional information IKK is responsible for activation of NFkappaB, herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells Homo sapiens ? - ? 89 2.7.11.10 additional information IKK is responsible for NF-kappaB activation by inactivating its inhibitor IkappaB, different inflammation stimuli induce distinct IKK activity profiles, molecular mechanism, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKK marks cytoplasmic NFkappaB inhibitors for proteolytic destruction playing a role in regulation of genetic cell cycle programs, IKK regulates nuclear translocation of transcription factor NFkappaB Homo sapiens ? - ? 89 2.7.11.10 additional information IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKKbeta is required for activation of NFkappaB, IKKbeta induces expression of epithelial sodium channel alphabetagamma-ENaC in cell surfaces Mus musculus ? - ? 89 2.7.11.10 additional information IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation Mus musculus ? - ? 89 2.7.11.10 additional information IKKbeta regulates the translocation of NF-kappaB from cytoplasm to nucleus earmarking the transcription factor for polyubiquitination and proteasome-mediated degradation, the cytokine TNFalpha-induced T-loop-phosphorylated IKKbeta becomes monoubiquitinated at Lyk163 proximal to the T-loop, mechanism of post-translational crosstalk, overview Homo sapiens ? - ? 89 2.7.11.10 additional information infection and genome insertion of human cytomegalovirus induces expression of the catalytic subunit IKK2 in the host cell which is required for viral induction of NF-kappaB activation and involved in viral replication and lytic cycle Homo sapiens ? - ? 89 2.7.11.10 additional information parasite Toxoplasma gondii IKKalpha, localized in parasitophorous vacuole membrane, activates the host intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex Mus musculus ? - ? 89 2.7.11.10 additional information subunit IKKbeta controls the activation of NF-kappaB, important in inflammation, IKKalpha plays a role in lyphoid organogenesis and suppresses NF-kappaB activity by accelerating both the turnover of the NFkappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters, inactivation of IKKalpha enhances inflammation and bacterial clearance in mice, overview Mus musculus ? - ? 89 2.7.11.10 additional information the IKK complex is responsible for NFkappaB regulation Homo sapiens ? - ? 89 2.7.11.10 additional information the noncanonical IkappaB kinase homologue IKKepsilon, beneath TANK-binding kinase-1 TBK-1, is required for activation of transcription factor NFkappaB and of interferon regulatory factor 3 IRF3, regulation and interaction, overview Homo sapiens ? - ? 89 2.7.11.10 additional information Vav-1 and IKKalpha subunit of IkappaB kinase functionally associate to induce NFkappaB activation in response to CD28 engagement Homo sapiens ? - ? 89 2.7.11.10 additional information TNF-R1-activated IKKbeta phosphorylates IKKgamma and IKKalpha, autophosphorylation patterns involving K163 of IKKbeta, regulation, overview Homo sapiens ? - ? 89 2.7.11.10 additional information activated IKK2 is responsible for induction of leucocyte infiltration in pancreatic acini, the mutant ICC2CA in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitits, the enzyme is involved in the proinflammatory IKK/NF-kappaB pathway, overview Mus musculus ? - ? 89 2.7.11.10 additional information hypoxia alters the cellular pool of IKKalpha and IKKbeta, and activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta, leading to phosphorylation-dependent degradation of IkappaBalpha and liberation of NFkappaB, overview, hypoxia-induced activation of the NFkappaB pathway is independent of HIF-1alpha, prolyl hydroxylase-1 negatively regulates IKKbeta Homo sapiens ? - ? 89 2.7.11.10 additional information IkappaB kinase beta plays a critical role in metallothionein-1 expression and protection against arsenic toxicity, two signaling pathways appear to be important for modulating arsenic toxicity. First, the IKK-NF-kappaB pathway is crucial for maintaining cellular metallothionein-1 levels to counteract reactive oxygen species accumulation, and second, when this pathway fails, excessive reactive oxygen species leads to activation of the MKK4-JNK pathway, resulting in apoptosis Mus musculus ? - ? 89 2.7.11.10 additional information IkappaB kinase beta plays an essential role in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation, T cell receptor signaling to IkappaB kinase/NF-kappaB is controlled by PKCtheta-dependent activation of the Carma1, Bcl10, and Malt1 CBM complex, IKKbeta triggers the CBM complex formation and phosphorylation of Bcl by PMA/ionomycin or CD3/CD28, regulation, overview Mus musculus ? - ? 89 2.7.11.10 additional information IkappaB kinase beta plays an essential role in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation, T cell receptor signaling to IkappaB kinase/NF-kappaB is controlled by PKCtheta-dependent activation of the Carma1, Bcl10, and Malt1 CBM complex, IKKbeta triggers the CBM complex formation and phosphorylation of Bcl by PMA/ionomycin or CD3/CD28, regulation, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9, but IKK-a is dispensable for a cytoplasmic RNA helicase RIG-I-dependent cytosolic pathway-induced production of IFN-alpha in MEF cells, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKK is responsible for activation of NF-kappaB by initiating the degradation of the NF-kappaB inhibitor IkappaB, subunits IKKalpha and IKKgamma/NEMO, not IKKbeta, are required for reovirus-induced NF-kappaB activation and apoptosis, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKK-beta inhibition in vivo leads to reduction of rhinovirus-induced expression of CXCL8, CCL5, and IL-6, the enzyme is important in regulation of the NF-kappaB signaling pathway, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKK-related kinases tank-binding kinase 1 TBK1/IKKi and cullin-based ubiquitin ligases are involved in IFN regulatory factor-3, IRF-3, phosphorylation, activation, and degradation, IRF-3 activation is induced by viral infection, e.g. by HCMV, molecular mechanisms, detailed overview Mus musculus ? - ? 89 2.7.11.10 additional information IKKalpha and IKKbeta are distinctly involved in ERK1-dependent, but IkappaBalpha-P65- and p100-p52-independent, upregulation of MUC5AC mucin transcription in case of infection by Streptococcus pneumoniae, MUC5AC mucin induction also requires pneumolysin and TLR4-dependent MyD88-IRAK1-TRAF6 signaling, molecular mechanism, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKKalpha and IKKbeta are distinctly involved in ERK1-dependent, but IkappaBalpha-P65- and p100-p52-independent, upregulation of MUC5AC mucin transcription in case of infection by Streptococcus pneumoniae, MUC5AC mucin induction also requires pneumolysin and TLR4-dependent MyD88-IRAK1-TRAF6 signaling, molecular mechanism, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKKalpha enhances p73-mediated transactivation and pro-apoptotic functions in p53-deficient H1299 cells, stabilization of p73, but not of the antagonist p53, by nuclear IKKalpha mediates cisplatin-induced apoptosis, DNA damage-induced accumulation of both p53 and p73alpha is associated with the up-regulation of IKK-alpha and IKK-gamma, a functional interaction might exist between them in DNA damage-mediated apoptotic pathways Mus musculus ? - ? 89 2.7.11.10 additional information IKKalpha is involved in the noncanonical NF-kappaB activation pathway, and plays an essential role in thymic organogenesis required for the establishment of self-tolerance, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKKalpha is not only a regulator of mammary epithelial proliferation, but is also an important contributor to ErbB2-induced oncogenesis, providing signals that maintain mammary tumor-initiating cells, IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, and is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells, overview Mus musculus ? - ? 89 2.7.11.10 additional information IKKbeta subunit of IKK complex is essential for the activation of NF-kappaB in response to various proinflammatory signals, Cys179 of IkappaB kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines, overview Homo sapiens ? - ? 89 2.7.11.10 additional information IKKepsilon is important in the regulation of the alternative NF-kappaB activation pathway involving p52 and p65, IKKepsilon interacts with p52 and promotes transactivation via p65 Mus musculus ? - ? 89 2.7.11.10 additional information IKKepsilon, i.e. IKKi, is implicated in virus induction of interferon-beta, IFNbeta, and development of immunity, IKKepsilon functions in a redundant role to its ubiquitous counterpart, TBK1, in the activation of IRF3 and IRF7 ex vivo, IKKe determines ISGF3 binding specificity, regulaiton, overview Mus musculus ? - ? 89 2.7.11.10 additional information mechanisms/pathways of activation and derepression of the IKK complex, regulation, detailed overview Mus musculus ? - ? 89 2.7.11.10 additional information the IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories, IKKalpha is involved in the regulation of histone H3 phosphorylation and acetylation at specific gene promoters in hippocampus in the NF-kappaB pathway, inhibition of IKKalpha regulation results in impairments in fear memory reconsolidation, mechanism, overview Rattus norvegicus ? - ? 89 2.7.11.10 additional information IKKalpha interacts with p73 Mus musculus ? - ? 89 2.7.11.10 additional information interaction analysis of IKKepsilon with NF-kappaB complex components/p25/p65 by immunoprecipitation and mass spectrometric analysis, overview Mus musculus ? - ? 89 2.7.11.10 additional information no activity with Rip2 Homo sapiens ? - ? 89 2.7.11.10 additional information the enzyme activity is included in a complex formed of the scaffold protein NF-kappaB essential modulator, i.e. NEMO or IKKgamma, and the Ikkalpha and IKKbeta kinases, overview Mus musculus ? - ? 89 2.7.11.10 additional information activation of NFkappaB by the catalytic subunit IKKbeta is required for signaling via the NFkappaB pathway in acute and systemic inflammation and for tissue protection Mus musculus C57/BL6J ? - ? 89 2.7.11.10 additional information IKKalpha and IKKbeta are distinctly involved in ERK1-dependent, but IkappaBalpha-P65- and p100-p52-independent, upregulation of MUC5AC mucin transcription in case of infection by Streptococcus pneumoniae, MUC5AC mucin induction also requires pneumolysin and TLR4-dependent MyD88-IRAK1-TRAF6 signaling, molecular mechanism, overview Mus musculus BALB/c ? - ? 89