2.7.10.2 AEEEIYGEFEAKKKK + ATP - Gallus gallus ? + ADP - ? 323287 2.7.10.2 ATP + a protein - eukaryota ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein - Saccharomyces cerevisiae ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein autophosphorylation Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein autophosphorylation Arabidopsis thaliana ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein phosphorylates tyrosine, serine and threonine Arabidopsis thaliana ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein serine-threonine kinase Mus musculus ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein enzyme plays an important role in spermatogenesis Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein enzyme is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein ILK is involved in agonist stimulated, Pi(3)K-dependent, PKB/AKT activation. ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3 Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein the enzyme controls shoot and floral meristem size Arabidopsis thaliana ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein enzyme contributes to signal transduction Arabidopsis thaliana ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein TESK1 has a specific function in spermatogenesis Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein TESK1 has a specific function in spermatogenesis Rattus norvegicus ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein it is likely that LIMK is involved in developmental or oncogenic processes through interactions with these LIM-containing proteins Gallus gallus ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions Rattus norvegicus ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein role for this kinase in spermatogenesis Mus musculus ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein proximal mediators of IL-1 signaling Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein apoptosis-inducing kinase Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein NF-kappaB-activating and cell death-inducing kinase Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein enzyme functions as an intermediary in TNFalpha-induced apoptosis Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein enzyme is required in early larval development Drosophila melanogaster ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein enzyme plays a critical role in cell growth and development Homo sapiens ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a protein PhK phosphorylates e.g. the protein substrate GPb, v-Fps phosphorylates e.g. the peptide substrate EAEIYEAEI, Csk phosphorylates e.g. the substrate poly-Glu4-Tyr eukaryota ADP + a phosphoprotein - ? 323385 2.7.10.2 ATP + a [homeodomain-interacting protein kinase 2]-L-tyrosine - Homo sapiens ADP + a [homeodomain-interacting protein kinase 2]-L-tyrosine phosphate - ? 436308 2.7.10.2 ATP + a [peptide]-L-tyrosine - Homo sapiens ADP + a [peptide]-L-tyrosine phosphate - ? 379245 2.7.10.2 ATP + a [protein]-L-tyrosine - Gallus gallus ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine - Mus musculus ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine - Homo sapiens ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine - Rattus norvegicus ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine - Oncorhynchus mykiss ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine - Rous sarcoma virus ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter Homo sapiens ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine enzymes of the Tec tyrosine kinase family phosphorylate themselves or other family members Homo sapiens ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [protein]-L-tyrosine substrate docking-site and binding structure of Src involving R279, R281, and R283 Homo sapiens ADP + a [protein]-L-tyrosine phosphate - ? 378448 2.7.10.2 ATP + a [Tyr-2 peptide]-L-tyrosine - Homo sapiens ADP + a [Tyr-2 peptide]-L-tyrosine phosphate - ? 437083 2.7.10.2 ATP + A-kinase anchor protein 8 - Homo sapiens ? - ? 400066 2.7.10.2 ATP + Abl Abl is an important substrate for Src signalling in normal cells Homo sapiens ADP + phospho-L-tyrosinyl-Abl - ? 386246 2.7.10.2 ATP + Abl Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview Mus musculus ADP + phospho-L-tyrosinyl-Abl - ? 386246 2.7.10.2 ATP + Abl Abl is a substrate of Src Homo sapiens ADP + phospho-L-tyrosinyl-Abl - ? 386246 2.7.10.2 ATP + Abl Abl is a substrate of Src, phosphorylation on Tyr245 and Tyr412 Mus musculus ADP + phospho-L-tyrosinyl-Abl - ? 386246 2.7.10.2 ATP + Akt tyrosine kinase - Mus musculus ADP + phosphotyrosinyl-Akt - ? 386249 2.7.10.2 ATP + Akt tyrosine kinase tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview Mus musculus ADP + phosphotyrosinyl-Akt - ? 386249 2.7.10.2 ATP + arsenate resistance protein ARS2 - Homo sapiens ? - ? 400080 2.7.10.2 ATP + ataxin 2 related protein - Homo sapiens ? - ? 400081 2.7.10.2 ATP + Bad protein substrate of Akt Mus musculus ADP + phosphotyrosinyl Bad protein - ? 386256 2.7.10.2 ATP + Bad protein substrate of Akt Homo sapiens ADP + phosphotyrosinyl Bad protein - ? 386256 2.7.10.2 ATP + Bcl-2-associated transcription factor 1 - Homo sapiens ? - ? 400086 2.7.10.2 ATP + beta 1-integrin cytoplasmic domain peptide - Homo sapiens ADP + ? - ? 323440 2.7.10.2 ATP + beta-catenin - Mus musculus ADP + phospho-tyrosinyl-beta-catenin - ? 386260 2.7.10.2 ATP + beta-catenin - Homo sapiens ADP + phospho-tyrosinyl-beta-catenin - ? 386260 2.7.10.2 ATP + beta-catenin - Rattus norvegicus ADP + phospho-tyrosinyl-beta-catenin - ? 386260 2.7.10.2 ATP + biotin-GGEAIYAAPFKK-amide a peptide with the preferred c-Abl substrate sequence carrying an Nterminal biotin Homo sapiens ADP + phosphorylated biotin-GGEAIYAAPFKK-amide - ? 387980 2.7.10.2 ATP + c-Src - Homo sapiens ? - ? 400095 2.7.10.2 ATP + calponin 3 - Homo sapiens ? - ? 400097 2.7.10.2 ATP + Cas protein - Mus musculus ADP + phospho-tyrosinyl-Cas protein - ? 386266 2.7.10.2 ATP + Cas protein - Homo sapiens ADP + phospho-tyrosinyl-Cas protein - ? 386266 2.7.10.2 ATP + Cas protein - Rattus norvegicus ADP + phospho-tyrosinyl-Cas protein - ? 386266 2.7.10.2 ATP + casein serine/threonine kinase activity, and no tyrosine kinase activity Arabidopsis thaliana ADP + phosphocasein - ? 323362 2.7.10.2 ATP + Cbp murine Csk binding protein, Cbp, amino acids 74-474, substrate used in kinase activity assay Mus musculus ? + ADP - ? 400102 2.7.10.2 ATP + cdc2 - Drosophila melanogaster ADP + phosphorylated cdc2 - ? 323374 2.7.10.2 ATP + cdc2 phosphorylated exclusively on Y15 Xenopus laevis ADP + phosphorylated cdc2 - ? 323374 2.7.10.2 ATP + cdc2 the Cdc2-inhibitory kinase is required for preventing premature activation of the mitotic program. Maternally provided Dwee1 is sufficient for regulating Cdc2 during embryogenesis Drosophila melanogaster ADP + phosphorylated cdc2 - ? 323374 2.7.10.2 ATP + cdc2(6-20) peptide i.e. KVEKIGEGTYGVVYK, substrate of Src family kinases Homo sapiens ? - ? 387984 2.7.10.2 ATP + chromosome 20 open reading frame 77 - Homo sapiens ? - ? 400108 2.7.10.2 ATP + cleavage and polyadenylation specific factor 5 - Homo sapiens ? - ? 400113 2.7.10.2 ATP + cofilin phosphorylation specifically at Ser-3 Rattus norvegicus ADP + phosphorylated cofilin - ? 323447 2.7.10.2 ATP + cofilin phosphorylation specifically at Ser-3 Homo sapiens ADP + phosphorylated cofilin - ? 323447 2.7.10.2 ATP + cortactin - Mus musculus ADP + phospho-tyrosinyl-cortactin - ? 386270 2.7.10.2 ATP + cortactin - Homo sapiens ADP + phospho-tyrosinyl-cortactin - ? 386270 2.7.10.2 ATP + cortactin - Rattus norvegicus ADP + phospho-tyrosinyl-cortactin - ? 386270 2.7.10.2 ATP + cortactin - Homo sapiens ? - ? 400119 2.7.10.2 ATP + cyclin-associated cyclin-dependent kinase phosphorylated on Y15 Homo sapiens ADP + phosphorylated cyclin-associated cyclin-dependent kinase - ? 353170 2.7.10.2 ATP + cyclin-associated cyclin-dependent kinase Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15 Homo sapiens ADP + phosphorylated cyclin-associated cyclin-dependent kinase - ? 353170 2.7.10.2 ATP + EAIYAAPFAKKKG - Monosiga brevicollis ADP + EAI-pY-AAPFAKKKG - ? 437123 2.7.10.2 ATP + EEEEY - Homo sapiens ADP + EEEE(phospho)Y - ? 388036 2.7.10.2 ATP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G Y7 Sox-based substrate, kinetic assay Homo sapiens ADP + EEEEYIQ[dP]-8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline-G phosphate - ? 400136 2.7.10.2 ATP + EEEPQYEEIPI + - Sulfurisphaera tokodaii ADP + EEEPQpYEEIPI - ? 425958 2.7.10.2 ATP + enolase serine/threonine kinase activity, and no tyrosine kinase activity Arabidopsis thaliana ADP + ? - ? 323444 2.7.10.2 ATP + epidermal growth factor receptor the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability Homo sapiens ADP + phospho-L-tyrosinyl-epidermal growth factor receptor - ? 386276 2.7.10.2 ATP + epidermal growth factor receptor activated Abl phosphorylates the EGFR primarily on Tyr1173, no activity with the Tyr1173 mutant substrate Homo sapiens ADP + phospho-L-tyrosinyl-epidermal growth factor receptor - ? 386276 2.7.10.2 ATP + EQEDEPEGDYFEWLE - Homo sapiens ADP + EQEDEPEGDpYFEWLE - ? 408509 2.7.10.2 ATP + eukaryotic translation initiation factor 3, subunit 4 - Homo sapiens ? - ? 400141 2.7.10.2 ATP + ewing sarcoma breakpoint region 1 - Homo sapiens ? - ? 400143 2.7.10.2 ATP + ezrin - Mus musculus ADP + phospho-tyrosinyl-ezrin - ? 386278 2.7.10.2 ATP + ezrin - Homo sapiens ADP + phospho-tyrosinyl-ezrin - ? 386278 2.7.10.2 ATP + ezrin - Rattus norvegicus ADP + phospho-tyrosinyl-ezrin - ? 386278 2.7.10.2 ATP + F peptide i.e. biotin-Aca-AAAEEIFGEI-NH2 Homo sapiens ADP + phospho-L-tyrosinyl-F peptide - ? 388041 2.7.10.2 ATP + FAK - Mus musculus ADP + phospho-tyrosinyl-FAK - ? 386280 2.7.10.2 ATP + FAK - Homo sapiens ADP + phospho-tyrosinyl-FAK - ? 386280 2.7.10.2 ATP + FAK - Rattus norvegicus ADP + phospho-tyrosinyl-FAK - ? 386280 2.7.10.2 ATP + FUS interacting protein (serine/arginine rich) 1 - Homo sapiens ? - ? 400148 2.7.10.2 ATP + FUS/TLS oncogene - Homo sapiens ? - ? 400149 2.7.10.2 ATP + FUSE binding protein - Homo sapiens ? - ? 400151 2.7.10.2 ATP + FUSE binding protein 2 - Homo sapiens ? - ? 400150 2.7.10.2 ATP + GAPEVIYATPGAKKK consensus substrate Homo sapiens ADP + GAPEVI-phosphotyrosinyl-ATPGAKKK - ? 422931 2.7.10.2 ATP + GGEAIYAAPFKK kinase assay using biotinylated model substrate peptide Homo sapiens ADP + GGEAIYAAPFKK phosphate - ? 400156 2.7.10.2 ATP + glycogen synthase kinase 3beta substrate of Akt Mus musculus ADP + phosphotyrosinyl glycogen synthase kinase 3beta - ? 386287 2.7.10.2 ATP + glycogen synthase kinase 3beta substrate of Akt Homo sapiens ADP + phosphotyrosinyl glycogen synthase kinase 3beta - ? 386287 2.7.10.2 ATP + heterogeneous nuclear ribonucleoprotein A3 - Homo sapiens ? - ? 400166 2.7.10.2 ATP + heterogeneous nuclear ribonucleoprotein AB - Homo sapiens ? - ? 400167 2.7.10.2 ATP + heterogeneous nuclear ribonucleoprotein D-like - Homo sapiens ? - ? 400168 2.7.10.2 ATP + heterogeneous nuclear ribonucleoprotein K - Homo sapiens ? - ? 400169 2.7.10.2 ATP + histone serine/threonine-specific kinase activity Homo sapiens ADP + phosphorylated histone - ? 323446 2.7.10.2 ATP + homeobox prox 1 - Homo sapiens ? - ? 400175 2.7.10.2 ATP + IkappaBalpha-L-tyrosine p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation, molecular mechanism, physiological role Homo sapiens ADP + IkappaBalpha-L-tyrosine phosphate - ? 378524 2.7.10.2 ATP + IkappaBalpha-L-tyrosine Lck interacts via its SH2 domain with tyrosine-phosphorylated IkappaBalpha Homo sapiens ADP + IkappaBalpha-L-tyrosine phosphate - ? 378524 2.7.10.2 ATP + KVEKIGEGTYGVVYK synthetic peptide substrate Homo sapiens ADP + ? - ? 379384 2.7.10.2 ATP + KVEKIGEGTYGVVYK substrate peptide used in kinase activity assay, derived from p34cdc2 Mus musculus ? + ADP - ? 400193 2.7.10.2 ATP + lysozyme-L-tyrosine substrate of Src, low activity with Csk or Chk Homo sapiens ADP + lysozyme-L-tyrosine phosphate - ? 379413 2.7.10.2 ATP + myelin basic protein serine/threonine kinase activity Homo sapiens ADP + phosphorylated myelin basic protein - ? 323343 2.7.10.2 ATP + myelin basic protein serine/threonine-specific kinase activity Homo sapiens ADP + phosphorylated myelin basic protein - ? 323343 2.7.10.2 ATP + myelin basic protein - Homo sapiens ADP + ? - ? 323438 2.7.10.2 ATP + myosin light chain serine/threonine kinase activity, and no tyrosine kinase activity Arabidopsis thaliana ADP + ? - ? 323443 2.7.10.2 ATP + NaV1.2 channel Y66 and Y1893, which are in consensus sequences appropriate for binding to the Fyn SH2 domain after phosphorylation, are both required for optimal binding and regulation by Fyn. Y730, which is located near the SH3-binding motif in LI-II, and Y1497 and Y1498 in the inactivation gate in LIII-IV, are also required for optimal regulation, but phosphorylation of these sites likely promotes fast inactivation Homo sapiens ADP + phospho-L-tyrosinyl-NaV1.2 channel - ? 386315 2.7.10.2 ATP + NEFA-interacting nuclear protein - Homo sapiens ? - ? 400253 2.7.10.2 ATP + NICE-4 - Homo sapiens ? - ? 400255 2.7.10.2 ATP + P1 peptide i.e. biotin-Aca-AAAEEIpYGEI-NH2 Homo sapiens ADP + phospho-L-tyrosinyl-P1 peptide - ? 388121 2.7.10.2 ATP + p120 protein - Mus musculus ADP + phospho-tyrosinyl-p120 protein - ? 386322 2.7.10.2 ATP + p120 protein - Homo sapiens ADP + phospho-tyrosinyl-p120 protein - ? 386322 2.7.10.2 ATP + p120 protein - Rattus norvegicus ADP + phospho-tyrosinyl-p120 protein - ? 386322 2.7.10.2 ATP + p190 GTPase - Mus musculus ADP + phospho-tyrosinyl-p190 GTPase - ? 386323 2.7.10.2 ATP + p190 GTPase - Homo sapiens ADP + phospho-tyrosinyl-p190 GTPase - ? 386323 2.7.10.2 ATP + p190 GTPase - Rattus norvegicus ADP + phospho-tyrosinyl-p190 GTPase - ? 386323 2.7.10.2 ATP + p32-L-tyrosine - Sus scrofa ADP + p32-L-tyrosine phosphate - ? 378557 2.7.10.2 ATP + p32-L-tyrosine p32 is a sperm protein Sus scrofa ADP + p32-L-tyrosine phosphate - ? 378557 2.7.10.2 ATP + p34cdc2 phosphorylated exclusively on Y15 Homo sapiens ADP + phosphorylated p34cdc2 - ? 353172 2.7.10.2 ATP + p34cdc2 Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15 Homo sapiens ADP + phosphorylated p34cdc2 - ? 353172 2.7.10.2 ATP + PAK1 Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1 Homo sapiens ADP + phospho-L-tyrosinyl-PAK1 - ? 386326 2.7.10.2 ATP + PAK1 a serine-threonine kinase, phosphorylation at Y153, Y201, and Y285 activates PAK1, no activation of PAK1 mutants Y153F,Y201F,Y285F, mutational analysis of phosphorylation sites,overview Homo sapiens ADP + phospho-L-tyrosinyl-PAK1 - ? 386326 2.7.10.2 ATP + paxillin - Mus musculus ADP + phospho-tyrosinyl-Shc paxillin - ? 386328 2.7.10.2 ATP + paxillin - Homo sapiens ADP + phospho-tyrosinyl-Shc paxillin - ? 386328 2.7.10.2 ATP + paxillin - Rattus norvegicus ADP + phospho-tyrosinyl-Shc paxillin - ? 386328 2.7.10.2 ATP + peptide PTKs phosphorylate substrates in a sequence-specific manner, relatively short peptide sequences determine selectivity, substrate specificity analysis using 144 different peptides, overview Danio rerio ADP + phospho-L-tyrosinyl-peptide - ? 388128 2.7.10.2 ATP + PIKE-A i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview Homo sapiens ADP + phosphotyrosinyl-PIKE-A - ? 386334 2.7.10.2 ATP + PIKE-A i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation at Y682 and Y774 by fyn, the kinase domain of activated fyn binds to the ArfGAP domain of PIKE-A, reduced activity with Y682F and with Y774F mutant PIKE-A, no activity with Y682F/Y774F mutant PIKE-A Homo sapiens ADP + phosphotyrosinyl-PIKE-A - ? 386334 2.7.10.2 ATP + plakoglobin - Mus musculus ADP + phospho-tyrosinyl-plakoglobin - ? 386335 2.7.10.2 ATP + plakoglobin - Homo sapiens ADP + phospho-tyrosinyl-plakoglobin - ? 386335 2.7.10.2 ATP + plakoglobin - Rattus norvegicus ADP + phospho-tyrosinyl-plakoglobin - ? 386335 2.7.10.2 ATP + poly(Glu,Tyr) substrate used in the tyrosine kinase asssay Homo sapiens ? + ADP - ? 400279 2.7.10.2 ATP + poly(Glu-Tyr) substrate used in the activity assay Homo sapiens ? + ADP - ? 400278 2.7.10.2 ATP + poly(Glu4-Tyr) - Homo sapiens ADP + poly(Glu4-Tyr)-L-tyrosine phosphate - ? 379459 2.7.10.2 ATP + poly(Glu4-Tyr) artificial substrate Homo sapiens ADP + poly(Glu4-Tyr)-L-tyrosine phosphate - ? 379459 2.7.10.2 ATP + poly-(Tyr-Glu) tyrosine kinase substrate, phosphoryated by Swe1p, Mps1p, Ime2p, and Hrr25p, but not by Ste7p, Rad53p, or Mck1p Saccharomyces cerevisiae ADP + phospho-poly-(Tyr-Glu) - ? 379462 2.7.10.2 ATP + proteasome activator subunit 3 - Homo sapiens ? - ? 400284 2.7.10.2 ATP + protein CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus Homo sapiens ADP + protein tyrosine phosphate - ? 323298 2.7.10.2 ATP + protein phosphorylates the regulatory C-terminal tyrosine residue present on cytoplasmic tyrosine kinases of the Src family Gallus gallus ADP + protein tyrosine phosphate - ? 323298 2.7.10.2 ATP + protein CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus. By regulating the activity of these kinases, CSK may play an important role in cell growth and development Homo sapiens ? - ? 370397 2.7.10.2 ATP + protein tyrosine protein kinase activity with specificity for tyrosine residues Homo sapiens ADP + protein tyrosine phosphate - ? 323281 2.7.10.2 ATP + protein tyrosine specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain, specifically phosphorylates a negative regulatory site of p60c-src Rattus norvegicus ADP + protein tyrosine phosphate - ? 323281 2.7.10.2 ATP + protein tyrosine p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R Homo sapiens ADP + protein tyrosine phosphate - ? 323281 2.7.10.2 ATP + protein tyrosine kinase Yes Csk inactivates the enzyme substrate Homo sapiens ADP + phospho-L-tyrosinyl Yes - ? 386353 2.7.10.2 ATP + RasGAP SH3-domain binding protein - Homo sapiens ? - ? 400290 2.7.10.2 ATP + recombinant GST/beta3 integrin cytoplasmic tail peptide - Homo sapiens ADP + ? - ? 323439 2.7.10.2 ATP + Rho protein - Mus musculus ADP + phospho-tyrosinyl-Rho protein - ? 386356 2.7.10.2 ATP + Rho protein - Homo sapiens ADP + phospho-tyrosinyl-Rho protein - ? 386356 2.7.10.2 ATP + Rho protein - Rattus norvegicus ADP + phospho-tyrosinyl-Rho protein - ? 386356 2.7.10.2 ATP + RNA binding motif protein 10 - Homo sapiens ? - ? 400297 2.7.10.2 ATP + RNA binding motif protein 4B - Homo sapiens ? - ? 400298 2.7.10.2 ATP + S1 peptide i.e. biotin-Aca-AAAEEIYGEI-NH2 Homo sapiens ADP + phospho-L-tyrosinyl-S1 peptide - ? 388144 2.7.10.2 ATP + Shc protein - Mus musculus ADP + phospho-tyrosinyl-Shc protein - ? 386360 2.7.10.2 ATP + Shc protein - Homo sapiens ADP + phospho-tyrosinyl-Shc protein - ? 386360 2.7.10.2 ATP + Shc protein - Rattus norvegicus ADP + phospho-tyrosinyl-Shc protein - ? 386360 2.7.10.2 ATP + signal transducer and activator of transcription - Drosophila melanogaster ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription - ? 408690 2.7.10.2 ATP + signal transducer and activator of transcription - Homo sapiens ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription - ? 408690 2.7.10.2 ATP + similar to zinc finger CCCH-type domain-containing protein 6 - Homo sapiens ? - ? 400307 2.7.10.2 ATP + splicing factor proline/glutamine-rich - Homo sapiens ? - ? 400314 2.7.10.2 ATP + splicing factor, arginine/serine-rich9 - Homo sapiens ? - ? 400315 2.7.10.2 ATP + Src wild-type Src and catalytically inactive mutant Src K295M, terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site, Glu510 of Src interacts with Arg283 of Csk in Csk-Src recognition, activity with Src fragments, overview Homo sapiens ADP + phospho-L-tyrosinyl Src family kinase - ? 388148 2.7.10.2 ATP + Src family kinase substrate of the protein kinases CSK and CHK, which specifically phosphorylate a tyrosine residue at the C-terminus forming intramolecular bonds to the SH2 domain and inhibiting the Src family kinase, overview Homo sapiens ? - ? 386365 2.7.10.2 ATP + Src family kinase terminal Src kinase Csk specifically phosphorylates Src family kinases on a C-terminal Tyr residue, which down-regulates their activities, identification of the docking determinants in Src recognized by the Csk substrate-docking site Homo sapiens ADP + phospho-L-tyrosinyl Src family kinase - ? 386366 2.7.10.2 ATP + Src protein MATK can phosphorylate the carboxyl-terminal conserved tyrosine of the Src protein Homo sapiens ADP + Src protein phosphate - ? 370396 2.7.10.2 ATP + STAT3 - Mus musculus ADP + phospho-tyrosinyl-STAT3 - ? 386368 2.7.10.2 ATP + STAT3 - Homo sapiens ADP + phospho-tyrosinyl-STAT3 - ? 386368 2.7.10.2 ATP + STAT3 - Rattus norvegicus ADP + phospho-tyrosinyl-STAT3 - ? 386368 2.7.10.2 ATP + STAT3 - Homo sapiens ADP + phospho-L-tyrosinyl-STAT3 - ? 408697 2.7.10.2 ATP + Tc10/Cdc42 GTPase-activating protein physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth Homo sapiens ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein - ? 386370 2.7.10.2 ATP + Tc10/Cdc42 GTPase-activating protein physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, phosphorylation mainly at Tyr406, no activity with TCGAP Y406F mutant, recombinant substrate from mouse and human, overview Homo sapiens ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein - ? 386370 2.7.10.2 ATP + thyroid hormone receptor associated protein 3 - Homo sapiens ? - ? 400326 2.7.10.2 ATP + TRK-fused gene - Homo sapiens ? - ? 400333 2.7.10.2 ATP + Tyr267 of Vav1 - Homo sapiens ADP + phosphorylated Tyr267 of Vav1 isoform c-Abl kinase probably regulates the activity of Rho guanine exchange factor Vav1 by direct phosphorylation at Tyr267 in the Dbl homology domain. The C-terminal SH3-SH2-SH3 domain and proline-rich region of Vav1 are required for its interaction with c-Abl kinase ? 423035 2.7.10.2 ATP + zinc finger, CCHC domain containing protein 8 - Homo sapiens ? - ? 400512 2.7.10.2 ATP + [Abi1]-L-tyrosine c-Abl phosphorylates Y213 of Abi1 Homo sapiens ADP + [Abi1]-L-tyrosine phosphate - ? 399998 2.7.10.2 ATP + [actin-stabilizing adapter protein HS1]-L-tyrosine c-Abl binds to phospho-HS1 via its SH2 domains and is required for full tyrosine phosphorylation of HS1 during T-cell activation Homo sapiens ADP + [actin-stabilizing adapter protein HS1]-L-tyrosine phosphate - ? 399999 2.7.10.2 ATP + [androgen receptor]-L-tyrosine - Homo sapiens ADP + [androgen receptor]-L-tyrosine phosphate - ? 436392 2.7.10.2 ATP + [aryl hydrocarbon receptor]-L-tyrosine Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316 Homo sapiens ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate - ? 378607 2.7.10.2 ATP + [aryl hydrocarbon receptor]-L-tyrosine in vivo assay utilizing Hep-G2 cells or H4IIE cells expressing AhR and Src kinase Homo sapiens ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate - ? 378607 2.7.10.2 ATP + [c-Cbl]-L-tyrosine proto-oncogenic PTK protein substrate Homo sapiens ADP + [c-Cbl]-L-tyrosine phosphate - ? 378608 2.7.10.2 ATP + [c-Cbl]-L-tyrosine activity and phosphorylation patterns of Syk, Fyn, and Abl with recombinant wild-type and mutant Y700F, Y731F, and Y774F c-Cbl proteins, phosphorylation site preferences are determined by interaction of the enzymes' SH2 domain with the substrate via p85, a phosphatidylinositol 3-kinase, overview Homo sapiens ADP + [c-Cbl]-L-tyrosine phosphate - ? 378608 2.7.10.2 ATP + [carrier protein-intein-CAEEEIYGEFEA]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CAEEEIYGEFEA derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CAEEEIYGEFEA]-L-tyrosine phosphate - ? 379519 2.7.10.2 ATP + [carrier protein-intein-CIGEGKYGVVYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGKYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGKYGVVYK]-L-tyrosine phosphate - ? 379520 2.7.10.2 ATP + [carrier protein-intein-CIGEGTFGVVYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTFGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGTFGVVYK]-L-tyrosine phosphate - ? 379521 2.7.10.2 ATP + [carrier protein-intein-CIGEGTpYGVVYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTpYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGTpYGVVYK]-L-tyrosine phosphate - ? 379522 2.7.10.2 ATP + [carrier protein-intein-CIGEGTYFVVYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYFVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGTYFVVYK]-L-tyrosine phosphate - ? 379523 2.7.10.2 ATP + [carrier protein-intein-CIGEGTYGVEYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVEYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGTYGVEYK]-L-tyrosine phosphate - ? 379524 2.7.10.2 ATP + [carrier protein-intein-CIGEGTYGVVFK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVVFK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGTYGVVFK]-L-tyrosine phosphate - ? 379525 2.7.10.2 ATP + [carrier protein-intein-CIGEGTYGVVYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGEGTYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGEGTYGVVYK]-L-tyrosine phosphate - ? 379526 2.7.10.2 ATP + [carrier protein-intein-CIGKGTYGVVYK]-L-tyrosine substrate is synthesized by fusing a 27 kDa carrier protein to intein which is linked to the peptide CIGKGTYGVVYK derived from human cyclin-dependent kinase harboring a phosphorylation site for Src kinase Homo sapiens ADP + [carrier protein-intein-CIGKGTYGVVYK]-L-tyrosine phosphate - ? 379527 2.7.10.2 ATP + [disabled-1 adaptor protein]-L-tyrosine - Mus musculus ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate - ? 378609 2.7.10.2 ATP + [disabled-1 adaptor protein]-L-tyrosine activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview Mus musculus ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate - ? 378609 2.7.10.2 ATP + [disabled-1 adaptor protein]-L-tyrosine - Mus musculus C57BL6J/129Sv ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate - ? 378609 2.7.10.2 ATP + [disabled-1 adaptor protein]-L-tyrosine activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview Mus musculus C57BL6J/129Sv ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate - ? 378609 2.7.10.2 ATP + [estrogen receptor alpha]-L-tyrosine - Homo sapiens ADP + [estrogen receptor alpha]-L-tyrosine phosphate estrogen receptor alpha associates with c-Abl nonreceptor tyrosine kinase. The direct interaction is mediated by two PXXP motifs of estrogen receptor alpha and the c-Abl SH3 domain. Estrogen receptor alpha can be phosphorylated on residues Y52 and Y219. Phosphorylation by c-Abl stabilizes estrogen recptor alpha, resulting in enhanced estrogen receptor alpha transcriptional activity and increased expression of endogenous target genes. Phosphorylation at the Y219 site affects DNA binding and dimerization by estrogen receptor alpha. c-Abl kinase activity is required for regulation of the estrogen receptor alpha function, and a Y52F/Y219F mutant estrogen receptor leads to reduced breast cancer cell growth and invasion ? 421898 2.7.10.2 ATP + [estrogen receptor alpha]-L-tyrosine - Homo sapiens ADP + [estrogen receptor alpha]-L-tyrosine phosphate estrogen receptor alpha associates with c-Abl nonreceptor tyrosine kinase. The direct interaction is mediated by two PXXP motifs of estrogen receptor alpha and the c-Abl SH3 domain. Estrogen receptor alpha can be phosphorylated on residues Y52 and Y219. Phosphorylation by c-Abl stabilizes estrogen receptor alpha, resulting in enhanced estrogen receptor alpha transcriptional activity and increased expression of endogenous target genes. Phosphorylation at the Y219 site affects DNA binding and dimerization by estrogen receptor alpha ? 421898 2.7.10.2 ATP + [FAK]-L-tyrosine - Danio rerio ADP + [FAK]-L-tyrosine phosphate - ? 378613 2.7.10.2 ATP + [FAK]-L-tyrosine activation of FAK during epiboly and gastrulation by dynamic phosphorylation at Tyr861 Danio rerio ADP + [FAK]-L-tyrosine phosphate - ? 378613 2.7.10.2 ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2 Homo sapiens ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate - ? 378615 2.7.10.2 ATP + [fibroblast growth factor receptor FGFR2]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain Homo sapiens ADP + [fibroblast growth factor receptor FGFR2]-L-tyrosine phosphate - ? 378615 2.7.10.2 ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain, activation is antagonized by tyrosine phosphatase Shp2 Homo sapiens ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate - ? 378616 2.7.10.2 ATP + [fibroblast growth factor receptor FGFR3]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2, interaction via the FGFR juxtamembrane and the Pyk2 kinase domain Homo sapiens ADP + [fibroblast growth factor receptor FGFR3]-L-tyrosine phosphate - ? 378616 2.7.10.2 ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine substrate HCN4, tyrosine 531 is phosphorylated Mus musculus ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate - ? 400001 2.7.10.2 ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine substrate HCN4, tyrosine 531 is phosphorylated Homo sapiens ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate - ? 400001 2.7.10.2 ATP + [kdSrc kinase]-L-tyrosine i.e. kinase-defective chicken Src mutant K295M Homo sapiens ADP + [kdSrc kinase]-L-tyrosine phosphate - ? 379533 2.7.10.2 ATP + [kdSrc kinase]-L-tyrosine i.e. kinase-defective Src, substrate of Chk and Csk, inactivation mechanism of Src, overview Homo sapiens ADP + [kdSrc kinase]-L-tyrosine phosphate - ? 379533 2.7.10.2 ATP + [kinase Btk29]-L-tyrosine - Drosophila melanogaster ADP + [kinase Btk29]-L-tyrosine phosphate - ? 436399 2.7.10.2 ATP + [P-110]-L-tyrosine - Homo sapiens ADP + [P-110]-L-tyrosine phosphate - ? 378633 2.7.10.2 ATP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine - Homo sapiens ADP + [p110 catalytic subunit of PI 3-kinase]-L-tyrosine phosphate - ? 436402 2.7.10.2 ATP + [p21Cip1]-L-tyrosine - Homo sapiens ADP + [p21Cip1]-L-tyrosine phosphate - ? 436403 2.7.10.2 ATP + [p27Kip1]-L-tyrosine - Homo sapiens ADP + [p27Kip1]-L-tyrosine phosphate - ? 436404 2.7.10.2 ATP + [p57Kip2]-L-tyrosine - Homo sapiens ADP + [p57Kip2]-L-tyrosine phosphate - ? 436405 2.7.10.2 ATP + [parkin]-Tyr143 - Homo sapiens ADP + [parkin]-phospho-Tyr143 nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, which encodes a ubiquitin E3 ligase, related to autosomal recessive Parkinson disease. Phosphorylation inhibits parkin's ubiquitin E3 ligase activity and protective function ? 421906 2.7.10.2 ATP + [protein kinase C zeta]-L-tyrosine - Rattus norvegicus ADP + [protein kinase C zeta]-L-tyrosine phosphate Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation ? 421907 2.7.10.2 ATP + [protein]-L-tyrosine - Mammalia ADP + [protein]-L-tyrosine phosphate - ? 398745 2.7.10.2 ATP + [protein]-L-tyrosine - Mus musculus ADP + [protein]-L-tyrosine phosphate - ? 398745 2.7.10.2 ATP + [protein]-L-tyrosine - Homo sapiens ADP + [protein]-L-tyrosine phosphate - ? 398745 2.7.10.2 ATP + [protein]-L-tyrosine - Rattus norvegicus ADP + [protein]-L-tyrosine phosphate - ? 398745 2.7.10.2 ATP + [protein]-L-tyrosine - Escherichia coli ADP + [protein]-L-tyrosine phosphate - ? 398745 2.7.10.2 ATP + [protein]-L-tyrosine - Bos taurus ADP + [protein]-L-tyrosine phosphate - ? 398745 2.7.10.2 ATP + [ring canal protein]-L-tyrosine - Drosophila melanogaster ADP + [ring canal protein]-L-tyrosine phosphate - ? 436408 2.7.10.2 ATP + [Runx1]-L-tyrosine - Homo sapiens ADP + [Runx1]-L-tyrosine phosphate - ? 458583 2.7.10.2 ATP + [Runx1]-L-tyrosine the enzyme phosphorylates transcription factor Runx1 and regulates Runx1-mediated megakaryocyte maturation Homo sapiens ADP + [Runx1]-L-tyrosine phosphate - ? 458583 2.7.10.2 ATP + [Sam68]-L-tyrosine - Homo sapiens ADP + [Sam68]-L-tyrosine phosphate - ? 400005 2.7.10.2 ATP + [Sam68]-L-tyrosine SRMS regulates the phosphorylation of Sam68 in an EGF-dependent manner in MDA-MB 231 cells Homo sapiens ADP + [Sam68]-L-tyrosine phosphate - ? 400005 2.7.10.2 ATP + [Sam68]-L-tyrosine the enzyme (SRMS) regulates the phosphorylation of Sam68 in an EGF-dependent manner in MDA-MB 231 cells Homo sapiens ADP + [Sam68]-L-tyrosine phosphate - ? 400005 2.7.10.2 ATP + [Sam68]-L-tyrosine phosphoproteomics analysis identifies novel candidate substrates of the enzyme (SRMS) Homo sapiens ADP + [Sam68]-L-tyrosine phosphate - ? 400005 2.7.10.2 ATP + [Signal Transducer and Activation of Transcription (STAT) protein]-L-tyrosine - Homo sapiens ADP + [Signal Transducer and Activation of Transcription (STAT) protein]-L-tyrosine phosphate - ? 459489 2.7.10.2 ATP + [Src-family protein tyrosine kinase]-L-tyrosine i.e. SFK, substrate of protein tyrosine kinases Csk and Chk, phosphorylation at the regulatory tyrosine leading to inhibition of the SFK Homo sapiens ADP + [Src-family protein tyrosine kinase]-L-tyrosine phosphate - ? 378635 2.7.10.2 ATP + [Stat5B]-L-tyrosine activation by non-receptor tyrosine kinase Pyk2 Homo sapiens ADP + [Stat5B]-L-tyrosine phosphate - ? 378636 2.7.10.2 ATP + [transmembrane adaptor protein LAT]-L-tyrosine substrate of ZAP-70 Homo sapiens ADP + [transmembrane adaptor protein LAT]-L-tyrosine phosphate - ? 378639 2.7.10.2 ATP + [tubulin]-L-tyrosine highly active with c-Fes, which also catalyzes tubulin polymerization in vitro Homo sapiens ADP + [tubulin]-L-tyrosine phosphate - ? 379539 2.7.10.2 ATP + [vimentin]-L-tyrosine - Homo sapiens ADP + [vimentin]-L-tyrosine phosphate - ? 459490 2.7.10.2 ATP + [ZAP-70]-L-tyrosine substrate of Lck, Fyn, and c-Abl, leads to ZAP-70 activation, mechanism Homo sapiens ADP + [ZAP-70]-L-tyrosine phosphate - ? 378642 2.7.10.2 ATP + [ZAP-70]-L-tyrosine substrate of Lck, Fyn, and c-Abl Homo sapiens ADP + [ZAP-70]-L-tyrosine phosphate - ? 378642 2.7.10.2 ATP + [[Lys19]Cdc2-(6-20) peptide]-L-tyrosine i.e. KVEKIGEGTYGVVKK Homo sapiens ? - ? 437183 2.7.10.2 denatured enolase + ATP - Gallus gallus phosphorylated denatured enolase + ADP - ? 323288 2.7.10.2 gelsolin + ATP phosphorylation by PYK2 increases the binding of gelsolin to phosphoatidylinositol lipids and actin polymerization at the fibroblastic cell periphery Homo sapiens phospho-tyrosinyl gelsolin + ADP - ? 386476 2.7.10.2 gelsolin + ATP phosphorylation by PYK2 Homo sapiens phospho-tyrosinyl gelsolin + ADP - ? 386476 2.7.10.2 additional information - Homo sapiens ? - ? 89 2.7.10.2 additional information - Drosophila melanogaster ? - ? 89 2.7.10.2 additional information JAK2 plays a central role in non-protein tyrosine kinase receptor signaling pathways Homo sapiens ? - ? 89 2.7.10.2 additional information catalytic domain Src including the C-terminal tail autophosphorylates and efficiently phosphorylates substrate peptides and proteins. Autophosphorylation occurs by an intermolecular mechanism Gallus gallus ? - ? 89 2.7.10.2 additional information p60src, the transforming protein of Rous sarcoma virus, is a protein kinase that has a strict specificity for Tyr. The phosphorylation of cellular proteins by p60src results in transformation Gallus gallus ? - ? 89 2.7.10.2 additional information interaction of the Fyn SH3 domain with the p85 subunit of PI3-kinase Homo sapiens ? - ? 89 2.7.10.2 additional information in vitro autophosphorylation activity at tyrosine residues Drosophila melanogaster ? - ? 89 2.7.10.2 additional information transforms NIH 3T3 cells Gallus gallus ? - ? 89 2.7.10.2 additional information all isoforms of the activin receptor type II bind inhibin A with low affinity Mus musculus ? - ? 89 2.7.10.2 additional information p40mos binds ATP analog p-fluorosulfonylbenzoyladenosine and exhibits ATPase activity Moloney murine sarcoma virus ? - ? 89 2.7.10.2 additional information the bone morphogenetic protein receptor binds bone morphogenetic protein 2 and bone morphogenetic protein 4 Mus musculus ? - ? 89 2.7.10.2 additional information activates NF-kappaB Mus musculus ? - ? 89 2.7.10.2 additional information activates NF-kappaB Homo sapiens ? - ? 89 2.7.10.2 additional information PTK6 may function as an intracellular signal transducer in specific tissues Homo sapiens ? - ? 89 2.7.10.2 additional information role for JAK3 in hematopoiesis and T- and B-cell development Mus musculus ? - ? 89 2.7.10.2 additional information transcriptionally induced in normal T cells by interleukin 2 stimulation, roles in T cell proliferation and differentiation Homo sapiens ? - ? 89 2.7.10.2 additional information involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells Mus musculus ? - ? 89 2.7.10.2 additional information JAK3 kinase is associated with terminal differentiation of hematopoietic cells Mus musculus ? - ? 89 2.7.10.2 additional information sensitizes mammary epithelial cells to epidermal growth factor Homo sapiens ? - ? 89 2.7.10.2 additional information required maternally for the establishment of the normal array of embryonic segments Drosophila melanogaster ? - ? 89 2.7.10.2 additional information plays important roles in cell adhesion, functions downstream of integrins, enzyme is involved in integrin-mediated cell adhesion signaling Drosophila melanogaster ? - ? 89 2.7.10.2 additional information is likely to participate in a variety of integrin-extracellular-matrix-dependent signaling events during morphogenesis Xenopus laevis ? - ? 89 2.7.10.2 additional information the enzyme transduces signals initiated by integrin engagement and G protein-coupled receptors. Several splice isoforms of FAK are preferentially expressed in rat brain, some of which have an increased autophosphorylation activity Mus musculus ? - ? 89 2.7.10.2 additional information activation of FadK may be an important early step in intracellular signal transduction pathways triggered in response to cell interactions with the extracellular matrix Mus musculus ? - ? 89 2.7.10.2 additional information participate in signalling pathways activated in response to cell interaction, role for FAK in gastrulation Xenopus laevis ? - ? 89 2.7.10.2 additional information oncogene v-fps induces fibrosarcomas in birds Avian sarcoma virus ? - ? 89 2.7.10.2 additional information associated with breast cancer and osteoporosis Rous sarcoma virus ? - ? 89 2.7.10.2 additional information mutations in the gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS phenotype of armadillo mutations, consistent with these proteins functioning co-operatively at adherens junctions in both the CNS and the epidermis Drosophila melanogaster ? - ? 89 2.7.10.2 additional information enzyme plays a critical role in a variety of signal transduction pathways Gallus gallus ? - ? 89 2.7.10.2 additional information lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes Mus musculus ? - ? 89 2.7.10.2 additional information enzyme is implicated in neoplastic transformation Mus musculus ? - ? 89 2.7.10.2 additional information enzyme is involved in pathway for signaling through glycosyl-phosphatidylinositol (GPI)-anchored membrane proteins Mus musculus ? - ? 89 2.7.10.2 additional information involved in signal transduction by association with a number of membrane receptors Homo sapiens ? - ? 89 2.7.10.2 additional information elevated levels of p56tck can contribute to the malignant properties of LSTRA cells Mus musculus ? - ? 89 2.7.10.2 additional information p56lck can positively regulate T-cell functions and it mediates at least some of the effects of CD4 and CD8 on T-cell activation Mus musculus ? - ? 89 2.7.10.2 additional information p56lck participates in lymphocyte-specific signal transduction pathways. Disturbances in lck expression may contribute to the pathogenesis of some human neoplastic diseases Mus musculus ? - ? 89 2.7.10.2 additional information yes gene product is likely to play an important role in oogenesis or early development Xenopus laevis ? - ? 89 2.7.10.2 additional information enzyme may serve specialized functions in hemopoietic cells, it is possible that damage to HCK may contribute to the pathogenesis of some human leukemias Homo sapiens ? - ? 89 2.7.10.2 additional information Hck is involved in a number of cell signal transduction pathways, frequently in pathways associated with immune response Homo sapiens ? - ? 89 2.7.10.2 additional information participates in signal transduction events regulating the growth, differentiation and function of phagocytes Homo sapiens ? - ? 89 2.7.10.2 additional information it may be involved in key regulatory processes Homo sapiens ? - ? 89 2.7.10.2 additional information may be specifically involved in the cell growth of hepatocytes or in the step of hepatocarcinogenesis Mus musculus ? - ? 89 2.7.10.2 additional information may interact with the intracellular domain of cell surface receptors Mus musculus ? - ? 89 2.7.10.2 additional information participates in the signalling pathways of a broad range of cytokines Mus musculus ? - ? 89 2.7.10.2 additional information enzyme is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells Mus musculus ? - ? 89 2.7.10.2 additional information possible function during secondary steps of tumor progression Xiphophorus hellerii ? - ? 89 2.7.10.2 additional information directly implicated in the pathogenesis of X-linked agammaglobulinaemia Mus musculus ? - ? 89 2.7.10.2 additional information specifically phosphorylates Tyr527 of p60c-src from neonatal rat brain. Specifically phosphorylates a negative regulatory site of p60c-src Rattus norvegicus ? - ? 89 2.7.10.2 additional information deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia Mus musculus ? - ? 89 2.7.10.2 additional information p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R. Tyk2 protein functions as part of a receptor complex to initiate intracellular signaling in response to type I interferons Homo sapiens ? - ? 89 2.7.10.2 additional information CSK is involved in regulation of src family kinases Rattus norvegicus ? - ? 89 2.7.10.2 additional information ZAP-70 that associates with T cell antigen receptor zeta chain and undergoes tyrosine phosphorylation following TCR stimulation Homo sapiens ? - ? 89 2.7.10.2 additional information tandem ZAP-70 SH2 domains bind phosphorylated, but not nonphosphorylated, T cell antigen receptor zeta cyt. The NH2-terminal ZAP-70 SH2 domain also binds to T cell antigen receptor zeta cyt but with 100-fold lower affinity. No binding is observed with the COOH-terminal ZAP-70 SH2 domain. Similar studies demonstrate that the ZAP-70 tandem SH2 domain can bind a T cell antigen receptor zeta 3 TAM peptide in which both tyrosine residues are phosphorylated: Little or no binding is observed with peptides phosphorylated at only one tyrosine residue, or a nonphosphorylated peptide. Binding of the tandem SH2 domains to the other two TCR zeta TAM peptides and to a CD3 epsilon TAM peptide is also observed. All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70. The affinity of these peptides for the tandem SH2 construct demonstrates a hierarchy of TAM zeta 1, TAM zeta 2, TAM epsilon, TAM zeta 3 Homo sapiens ? - ? 89 2.7.10.2 additional information perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Syk-deficient radiation chimaeras fail to accumulate mature B cells, Syk-deficient mice show impaired development of thymocytes using the V gamma 3 variable region gene, Syk is not required for signalling through the IL-2 and G-CSF receptors Mus musculus ? - ? 89 2.7.10.2 additional information mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency Homo sapiens ? - ? 89 2.7.10.2 additional information Rlk has potential functions in intrathymic T cell development and mature T cell signaling Mus musculus ? - ? 89 2.7.10.2 additional information JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: persistence of genetically and biochemically defective autologous B cells, associated with reconstitution of cellular and humoral immunity, suggests that integrity of the gammac-JAK3 signalling pathway is not strictly required for immunoglobulin production Homo sapiens ? - ? 89 2.7.10.2 additional information JAK3 deficiency in humans results in autosomal recessive T-B+ severe combined immunodeficiency disease Homo sapiens ? - ? 89 2.7.10.2 additional information HYL plays a significant role in the signal transduction of hematopoietic cells Homo sapiens ? - ? 89 2.7.10.2 additional information enzyme plays a pivotal role in cell signal transduction Homo sapiens ? - ? 89 2.7.10.2 additional information Ntk may play an inhibitory role in the control of T-cell proliferation Mus musculus ? - ? 89 2.7.10.2 additional information may play an important role in thymopoiesis, role in controlling cellular growth and differentiation Homo sapiens ? - ? 89 2.7.10.2 additional information role for JAK1 kinase in the differentiation or function of a subset of CNS neurons Mus musculus ? - ? 89 2.7.10.2 additional information effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells Homo sapiens ? - ? 89 2.7.10.2 additional information autosomal recessive form of severe combined immunodeficiency disease in which ZAP-70 is absent as a result of mutations in the ZAP-70 gene. This absence is associated with defects in TCR signal transduction. Integral role in T cell activation and differentiation Homo sapiens ? - ? 89 2.7.10.2 additional information may play a role in the growth and differentiation of hematopoietic cells Homo sapiens ? - ? 89 2.7.10.2 additional information may have a role in human cancer Homo sapiens ? - ? 89 2.7.10.2 additional information Batk may function as a brain-specific regulator of kinases involved in the development and maintenance of the nervous system Rattus norvegicus ? - ? 89 2.7.10.2 additional information JAK3 splice isoforms are functional in JAK3 signaling and may enrich the complexity of the intracellular response functional in IL-2 or cytokine signaling Homo sapiens ? - ? 89 2.7.10.2 additional information activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity Mus musculus ? - ? 89 2.7.10.2 additional information Ctk is involved in the regulation of neural function and differentiation of male germ cells through interactions with members of the Src family kinases Mus musculus ? - ? 89 2.7.10.2 additional information mutations of the Janus family kinase JAK3 are responsible for autosomal recessive severe combined immunodeficiency. Abnormalities in tyrosine phosphorylation of JAK3 in response to interleukin-2 (IL-2) and IL-4 is present in all patients. In one patient carrying a single amino acid change, Glu481Gly, in the JH3 domain of JAK3, a partially conserved IL-2 responses is observed resulting in reduced but detectable levels of JAK3 and STAT5 phosphorylation. A single cysteine to arginine substitution, Cys759Arg, results in high basal levels of constitutive JAK3 tyrosine phosphorylation unresponsive to either downregulation by serum starvation or cytokine-mediated upregulation Homo sapiens ? - ? 89 2.7.10.2 additional information could be responsible for the tyrosine phosphorylation observed in a murine thymic medullary epithelial cell line E-5 following complex formation with thymocytes Mus musculus ? - ? 89 2.7.10.2 additional information appear to play a role in B-cell-IgM and FcERI receptor signaling Rattus norvegicus ? - ? 89 2.7.10.2 additional information functions during reinitiation of meiotic division Xenopus laevis ? - ? 89 2.7.10.2 additional information TGF-beta RII expression is down-regulated in cells treated with exogenous TGF-beta1 Rattus norvegicus ? - ? 89 2.7.10.2 additional information type II receptor isoforma exist which play preferential binding to TGF-beta2 and have their own defined role in debvelopment Mus musculus ? - ? 89 2.7.10.2 additional information the kinase induces progression through the cell cycle for both meiotic and mitotic cells Xenopus laevis ? - ? 89 2.7.10.2 additional information the receptor shares two-hit inactivation mechanism with tumor suppressor genes and mutation of it may occur in the early stage of tumorgenesis Homo sapiens ? - ? 89 2.7.10.2 additional information mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2 Homo sapiens ? - ? 89 2.7.10.2 additional information activin and its receptor play an important role in development Homo sapiens ? - ? 89 2.7.10.2 additional information the activin receptor-like kinase 1 gene is the second locus for the autosomal dominant vascular disease hereditary hemorrhagic telangiectasia Homo sapiens ? - ? 89 2.7.10.2 additional information signal transduction by TGF bet involves the formation of a heteromeric complex of two different serine/threonine kinase receptors Homo sapiens ? - ? 89 2.7.10.2 additional information involved in signal transduction Xenopus laevis ? - ? 89 2.7.10.2 additional information insensitivity to anti-mullerian hormone is due to a mutation in the human anti-mullerian hormone receptor Homo sapiens ? - ? 89 2.7.10.2 additional information transforming growth factor-beta regulates cell cycle progression by a unique signaling mechanism that involves its binding to the type II TGF beta receptor and activation of type I Homo sapiens ? - ? 89 2.7.10.2 additional information the receptor controls dauer larva development Caenorhabditis elegans ? - ? 89 2.7.10.2 additional information importance of the function of activin receptor in the regulatory mechanism for body axis formation Xenopus laevis ? - ? 89 2.7.10.2 additional information enzyme is involved in TGFbeta signaling Caenorhabditis elegans ? - ? 89 2.7.10.2 additional information enzyme can have a protein-protein interaction, through its putative SH3 binding site, with at least two intracellular SH3-containing proteins Bos taurus ? - ? 89 2.7.10.2 additional information enzyme is involved in bone morphogenetic protein signaling Homo sapiens ? - ? 89 2.7.10.2 additional information mullerian inhibiting substance causes regression of the fetal Mullerian duct on binding a heteromeric complex of types I and II cell-surface receptors in the fetal urogenital ridge. The anti-mullerian hormone type II receptor provides specificity for mullerian inhibiting substance Rattus norvegicus ? - ? 89 2.7.10.2 additional information cell-surface receptor required for transduction of environmental signals into an appropriate developmental response, controls dauer larva development Caenorhabditis elegans ? - ? 89 2.7.10.2 additional information mRIP3 uses a novel mechanism to induce death Mus musculus ? - ? 89 2.7.10.2 additional information RIP2 interacts with members of the TNFR-1 signaling complex, including inhibitor of apoptosis protein cIAP1 and with members of the TNFR-associated factor family, specifically TRAF1, TRAF5, and TRAF6, but not with TRAF2, TRAF3, or TRAF4 Homo sapiens ? - ? 89 2.7.10.2 additional information CARDIAK may be involved in NF-kappa B/JNK signaling and in the generation of the proinflammatory cytokine IL-1 beta through activation of caspase-1 Homo sapiens ? - ? 89 2.7.10.2 additional information in a cell cycle the wee1 kinase is phosphorylated at M-phase, phosphorylation occurs in the N-terminal domain resulting in inactivation of the kinase activity. The N-terminal domain, or the entire molecule is extensively phosphorylated by cdc2-cyclin B kinase Mus musculus ? - ? 89 2.7.10.2 additional information blocks cell division when overexpressed in Hela cells Homo sapiens ? - ? 89 2.7.10.2 additional information activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2 Homo sapiens ? - ? 89 2.7.10.2 additional information down-regulation of Wee1-like kinase activity by phosphorylation at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase Xenopus laevis ? - ? 89 2.7.10.2 additional information active c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly, c-Fes colocalization with microtubules in vivo requires the SH2 enzyme domain, implication in the differentiation of vascular, endothelial, myeloid, hematopoietic, and neuronal cells, overview Homo sapiens ? - ? 89 2.7.10.2 additional information ALK-MYH9 performs tyrosine autophosphorylation in vivo, but not in vitro, possible mechanism Homo sapiens ? - ? 89 2.7.10.2 additional information antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases, overview Oryctolagus cuniculus ? - ? 89 2.7.10.2 additional information CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview Mus musculus ? - ? 89 2.7.10.2 additional information enzyme is involved in cell growth, differentiation, and apoptosis Oncorhynchus mykiss ? - ? 89 2.7.10.2 additional information Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors, e.g. CCAAT/enhancer-binding protein-alpha and STAT3, down-regulation of macrophage marker F4/80 Homo sapiens ? - ? 89 2.7.10.2 additional information Fps/Fes and Fer protein-tyrosine kinases play redundant roles in regulating hematopoiesis Mus musculus ? - ? 89 2.7.10.2 additional information Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival Mus musculus ? - ? 89 2.7.10.2 additional information IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein, overview Citrus limon ? - ? 89 2.7.10.2 additional information JAK2 is an important intracellular mediator of cytokine signalling, JAK2 deficiency may lead to hematologic cancers, and a number of immune diseases Homo sapiens ? - ? 89 2.7.10.2 additional information protein kinases and protein phosphatases regulate enzyme activities in the cell, overview eukaryota ? - ? 89 2.7.10.2 additional information protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in cardiac ventricular myocytes Rattus norvegicus ? - ? 89 2.7.10.2 additional information protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, BCR/ABL and several other constitutive protein tyrosine kinases are activated in myeloid malignancies, overview, protein deregulation probable due to fusion gene formation because of chromosomal translocations or as distinct gain-of-function point mutations, autophosphorylation of BCR/ABL kinase at Tyr177 is essential for myeloid leukomogenesis in vivo, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview Homo sapiens ? - ? 89 2.7.10.2 additional information protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview Mus musculus ? - ? 89 2.7.10.2 additional information protein tyrosine kinases play a critical role in the modulation of a wide range of cellular events such as cell division, cell differentiation, and cell metabolism, over-stimulation of PTKs impairs normal cell growth, resulting in oncogenic transformation, regulation of enzyme activity occurs in dynamic oscillatory behaviour, patterns and mechanism, overview Homo sapiens ? - ? 89 2.7.10.2 additional information PTKs are involved in cell signalling Homo sapiens ? - ? 89 2.7.10.2 additional information spleen tyrosine kinase Syk modulates epidermal growth factor receptor EGFR signalling in mammary epithelial cells acting as a negative controle element, regulation of EGFR by activation of the autophosphorylation activity of EGFR, but not of HER2 and HER3, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Src activates an outwardly rectifying chloride current in myocytes being involved in osmotic swelling, enzyme inhibition also inhibits stretch-activated Cl- current, mechanism, overview Oryctolagus cuniculus ? - ? 89 2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Gallus gallus ? - ? 89 2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Src and Src-family protein-tyrosine kinases are proto-oncogenes important in cell morphology, motility, proliferation, and survival, regulation by reversible phosphorylation, overview Rous sarcoma virus ? - ? 89 2.7.10.2 additional information Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview Mus musculus ? - ? 89 2.7.10.2 additional information Src-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells and required for adhesion of interleukin-8, Src PTKs are required for macrophage antigen-1-mediated adhesion, which is inhibited by cytochalasin D and involved F-actin and protein P-110, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Src-family protein tyrosine kinases are proto-oncogenic enzymes controlling mammalian cell growth and proliferation, the enzymes are regulated by activation through autophosphorylation of their kinase domain and by inhibition through phosphorylation of their regulatory tyrosine residue near the C-terminus, mechanism, overview, abberrant SFK activation contributes to cancer development Homo sapiens ? - ? 89 2.7.10.2 additional information Syk kinase is involved in cell motility and activation of phosphatidylinositol 3'-kinase, Syk kinase inhibits the tyrosine phosphorylation of IkappaBalpha and thus inhibits activation of NFkappaB via interaction of IkappaBalpha and phosphatidylinositol 3'-kinase, pathway regulation, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Tec family tyrosine kinases play a central role in hematopoietic cellular signaling Homo sapiens ? - ? 89 2.7.10.2 additional information the enzyme is involved in regulation of sperm capacitation, signal transduction mechanism, capacitation mechanism, overview Sus scrofa ? - ? 89 2.7.10.2 additional information the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has decreasing effect, opposing to receptor protein tyrosine kinase EGFR, on volume-sensitive chloride current in atrial myocytes, overview Homo sapiens ? - ? 89 2.7.10.2 additional information the enzyme plays an important role in the self-renewal and as comitogen in the movement of stem cells out of the haematopoietic stem cell pool into the progeny pool, regulation of bone marrow cell migration Mus musculus ? - ? 89 2.7.10.2 additional information the Fes tyrosine kinase is regulated via its SH2 domain Homo sapiens ? - ? 89 2.7.10.2 additional information the Janus kinase is involved in the JAK-STAT signaling cascade causing inflammatory activity in the brain Homo sapiens ? - ? 89 2.7.10.2 additional information the Src tyrosine kinase regulates and stimulates silica particle formation in epithelium which induces chemokine KIP-2 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview Rattus norvegicus ? - ? 89 2.7.10.2 additional information the Src tyrosine kinase regulates and stimulates silica particle formation in lung epithelium which induces interleukin-8 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview Homo sapiens ? - ? 89 2.7.10.2 additional information the Syk family tyrosine kinase ZAP-70 is required to couple the activated T-cell antigen receptor TCR to downstream signaling pathways, binding of TCR via its SH2 domains, regulation mechanism, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Yes kinase is required during development, overview Danio rerio ? - ? 89 2.7.10.2 additional information c-Fes interacts with soluble unpolymerized tubulin via its N-terminal Fes/CIP4 homology FCH domain Homo sapiens ? - ? 89 2.7.10.2 additional information Csk-substrate interaction requires the SH2 and SH3 enzyme domains Homo sapiens ? - ? 89 2.7.10.2 additional information low tyrosine autophosphorylation activities of chimeric Alk-NPM and ALK-TPM3 Homo sapiens ? - ? 89 2.7.10.2 additional information poor activity on free amino acids, consensus sequence of c-Src is E-EIYE/G-XF, that of v-Fps is E-IYE-XI/V, and that of Csk is IYM-F-F-F, specificity overview eukaryota ? - ? 89 2.7.10.2 additional information Pyk2 performs autophosphorylation at Tyr402, fibroblast growth factor receptors FGFR1 and FGFR4 are no substrates of Pyk2 Homo sapiens ? - ? 89 2.7.10.2 additional information site specificity of tyrosine phosphorylation by Tec family members, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Syk kinase performs autophosphorylation Homo sapiens ? - ? 89 2.7.10.2 additional information Syk performs autophosphorylation Homo sapiens ? - ? 89 2.7.10.2 additional information the activation loop is not essential for enzyme activity Homo sapiens ? - ? 89 2.7.10.2 additional information the BCR/ABL kinase performs tyrosine autophosphorylation, mechanism Mus musculus ? - ? 89 2.7.10.2 additional information the BCR/ABL kinase performs tyrosine autophosphorylation, mechanism Homo sapiens ? - ? 89 2.7.10.2 additional information the Yes kinase performs autophosphorylation Danio rerio ? - ? 89 2.7.10.2 additional information Wee1: substrate specificity eukaryota ? - ? 89 2.7.10.2 additional information a multisite model for Fyn binding and regulation, overview, subtype-selective modulation by tyrosine phosphorylation/dephosphorylation provides a mechanism for differential regulation of sodium channels by neurotrophins and tyrosine phosphorylation in unmyelinated axons and dendrites, where NaV1.2 channels are expressed in brain neurons, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview Mus musculus ? - ? 89 2.7.10.2 additional information Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview Homo sapiens ? - ? 89 2.7.10.2 additional information c-Abl activates p21 transcription via interaction with and regulation of the DNA-binding of p53, c-Abl also recruits p53 to the p21 promoter, overview Homo sapiens ? - ? 89 2.7.10.2 additional information c-Abl is regulated by conformational changes through intramolecular interactions and phosphorylation, overview Homo sapiens ? - ? 89 2.7.10.2 additional information c-Src is a physiologically relevant substrate for Methionine aminopeptidases, whose dysfunction is likely to account for the cell-cycle effects of MetAP inhibitors including bengamide A, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Csk is essential for mouse embryonic development, Csk plays a role in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration, overview, modeling of Csk regulation of focal adhesion turnover Mus musculus ? - ? 89 2.7.10.2 additional information dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors, overview Homo sapiens ? - ? 89 2.7.10.2 additional information enzyme deficiency leads to X-linked agammaglobulinemia, XLA, a humoral primary immunodeficiency in which affected patients have very low levels of peripheral B cells and a profound deficiency of all immunoglobulin isotypes, overview Homo sapiens ? - ? 89 2.7.10.2 additional information enzyme-deficient endothelial cells shows reduced migration, as well as decreased cell proliferation and survival in vivo Mus musculus ? - ? 89 2.7.10.2 additional information Etk is essential for polymyxin resistance, while Wzc is not Escherichia coli K-12 ? - ? 89 2.7.10.2 additional information FAK plays a role in the anoikis phenomenon or anchorage-dependent cell survival, and in angiogenesis and formation of new blood vessels, overview, downstream targets of the FAK and PYK2 are MAP kinases implicated in proliferative processes, PYK2 is an essential linker between G-protein coupled receptor and the MAPK cascade, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Fes is involved in the regulation of cell-cell and cell-matrix interactions mediated by adherens junctions and focal adhesions, the activated form of the kinase can induce cellular transformation, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Fyn tyrosine kinase is involved in actin stress fiber formation in fibroblasts Homo sapiens ? - ? 89 2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Drosophila melanogaster ? - ? 89 2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Mus musculus ? - ? 89 2.7.10.2 additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Homo sapiens ? - ? 89 2.7.10.2 additional information p38 MAP kinase inhibitor SB203580 and protein tyrosine kinase inhibitor tyrphostin 25 combined can be used for inhibition of matrix metalloproteinase-9 expression, overview Homo sapiens ? - ? 89 2.7.10.2 additional information protein-tyrosine kinase Syk plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system, and is required for pathogen engulfment in complement-mediated phagocytosis Homo sapiens ? - ? 89 2.7.10.2 additional information PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview Mus musculus ? - ? 89 2.7.10.2 additional information spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1, neutrophil activation pathways, overview Mus musculus ? - ? 89 2.7.10.2 additional information Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation Mus musculus ? - ? 89 2.7.10.2 additional information Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation, Abl/Rac and Abl/ERK5 pathways also operate in human MCF7 and BT549 breast cancer cells, where neoplastic transformation depends on Src-like activities, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview Mus musculus ? - ? 89 2.7.10.2 additional information Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Src PTK plays a role in NF-kappaB activation in epithelial cells, Src PTKs are important in regulation of vascular permeability and acute inflammatory responses, and are essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells, Src PTKs can also regulate the functional activity of these receptors and is involved in cell signaling, biological functions, cellular and molecular mechanisms, overview Rattus norvegicus ? - ? 89 2.7.10.2 additional information Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview Rattus norvegicus ? - ? 89 2.7.10.2 additional information the BCR-ABL tyrosine kinase is inhibited in Philadelphia chromosome-positive chronic myeloid leukemia, CML, overview Homo sapiens ? - ? 89 2.7.10.2 additional information the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity Mus musculus ? - ? 89 2.7.10.2 additional information the enzyme is involved in cytokine signaling Mus musculus ? - ? 89 2.7.10.2 additional information the enzyme tyrosine phosphorylates a wide range of proteins, especially nuclear matrix proteins Homo sapiens ? - ? 89 2.7.10.2 additional information the Src family of protein kinases mediates mitogenic signal transduction, and constitutive activation of the enzymes is associated with tumorigenesis Homo sapiens ? - ? 89 2.7.10.2 additional information the Src protein tyrosine kinase p56Lck plays a critical role in the O2 sensitivity of Kv1.3 channels and in signalling during hypoxia in T lymphocytes, overview Homo sapiens ? - ? 89 2.7.10.2 additional information the Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival, overview Homo sapiens ? - ? 89 2.7.10.2 additional information Toll-like receptors TLR-8 and TLR-9 require activation/phosphorylation by Btk for acting incell signaling, overview, enzyme deficiency is involved in development of male immune disorder X-linked agammaglobulineamia, XLA Homo sapiens ? - ? 89 2.7.10.2 additional information tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor in to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling Rattus norvegicus ? - ? 89 2.7.10.2 additional information tyrosine kinase Fyn determines the specific localization of TrkB brain-derived neurotrophic factor, BDNF, receptor to intracellular lipid rafts in cortical and hippocampal membranes, this process is critically dependent on the tyrosine kinase Fyn, overview, role for lipid rafts in neurotrophin signaling Mus musculus ? - ? 89 2.7.10.2 additional information tyrosine kinase Src is a key enzyme in mammalian signal transduction and an important target for anticancer drug discovery Homo sapiens ? - ? 89 2.7.10.2 additional information tyrosine kinases play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been shown to mediate malignant cell transformation, Brk may play a key role in lymphomagenesis Homo sapiens ? - ? 89 2.7.10.2 additional information Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity Mus musculus ? - ? 89 2.7.10.2 additional information Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity Homo sapiens ? - ? 89 2.7.10.2 additional information Btk can interact with the TIR domains of Toll-like receptors TLR-8 and TLR-9 Homo sapiens ? - ? 89 2.7.10.2 additional information BTK performs autophosphorylation Homo sapiens ? - ? 89 2.7.10.2 additional information Btk performs autophosphorylation on Tyr223 Homo sapiens ? - ? 89 2.7.10.2 additional information c-Abl performs autophosphorylation Homo sapiens ? - ? 89 2.7.10.2 additional information Fak binds interaction partners, e.g. paxillin, talin, and p190RhoGEF, at the FAT domain, i.e. the focal adhesion targeting domain, at the C-terminal domain modulaing the Fak activity, overview Mus musculus ? - ? 89 2.7.10.2 additional information FAk binds interaction partners, e.g. paxillin, talin, and p190RhoGEF, at the FAT domain, i.e. the focal adhesion targeting domain, at the C-terminal domain modulating the Fak activity, overview Homo sapiens ? - ? 89 2.7.10.2 additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Drosophila melanogaster ? - ? 89 2.7.10.2 additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Mus musculus ? - ? 89 2.7.10.2 additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Homo sapiens ? - ? 89 2.7.10.2 additional information Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin Mus musculus ? - ? 89 2.7.10.2 additional information Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin Homo sapiens ? - ? 89 2.7.10.2 additional information Src PTKs phosphorylate substrates in the cytosol or at the inner face of the plasma membrane, e.g. Shc, Rho GTPase-activating protein p190, and transcription factor STAT3, substrates at cell-matrix adhesions, e.g. cytoskeleton-associated proteins such as focal adhesion kinase FAK, Cas, paxillin, ezrin, and cortactin, and substrates at cell-cell adhesions, e.g. junctional proteins such as beta-catenin, p120, and plakoglobin Rattus norvegicus ? - ? 89 2.7.10.2 additional information Syk affects actin dynamics around the C3bi-mediated phagosomes Homo sapiens ? - ? 89 2.7.10.2 additional information the enzyme is activated by phosphorylation, and also performs autophosphorylation Homo sapiens ? - ? 89 2.7.10.2 additional information the enzyme performs autophosphorylation at tyrosine residues Homo sapiens ? - ? 89 2.7.10.2 additional information Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis, Lyn and and its interaction with rafts and TLR2 are involved in the initial stages of Pseudomonas aeruginosa interaction with host cells and invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa, overview Pseudomonas aeruginosa ? - ? 89 2.7.10.2 additional information SH2 domain-based tyrosine kinase assay using biotin ligase modified with a terbium(III) complex. An SH2 domain from lymphocyte-specific tyrosine kinase is genetically fused to a truncated biotin carboxyl carrier protein, and the resulting fusion protein is labeled through biotinylation with biotin protein ligase carrying multiple copies of a luminescent Tb3+ complex. The labeled SH2 fusion proteins are employed to detect a phosphorylated peptide immobilized on the surface of the microtiter plate, where the phosphorylated peptide is produced by phosphorylation to the substrate peptide by Src tyrosine kinase. The assay allows for a reliable determination of the activity of Src kinase lower than 10 ng/mL Sulfurisphaera tokodaii ? - ? 89 2.7.10.2 additional information after platelet stimulation, integrin alphaIIbbeta3 binds to the enzyme's SH3 domain at a site overlapping with its PPII helix binding site Homo sapiens ? - ? 89 2.7.10.2 additional information the Brutons tyrosine kinase is a critical signaling mediator downstream of the B cell Ag receptor, plays a role in regulating TLR-induced cytokine production, and is required for TLR-induced IL-10 production in multiple macrophage populations and in TLR signaling, overview, X-linked agammaglobulinemia is caused by mutations in Btk resulting in multiple defects in B cell development and function, and recurrent bacterial infections, Btk-dependent induction of NFkappaB and AP-1 DNA binding activity Mus musculus C57BL/6 ? - ? 89 2.7.10.2 additional information p40mos binds ATP analog p-fluorosulfonylbenzoyladenosine and exhibits ATPase activity Moloney murine sarcoma virus HT-1 ? - ? 89 2.7.10.2 additional information oncogene v-fps induces fibrosarcomas in birds Avian sarcoma virus PRCII ? - ? 89 2.7.10.2 p130Cas + ATP phosphorylation of the Crk and Nck adaptor protein by Fak Homo sapiens phospho-tyrosinyl p130Cas + ADP - ? 386644 2.7.10.2 paxillin + ATP phosphorylation at Tyr31 and Tyr118 by Fak plays a role in tumor cell motility inhibition Homo sapiens phospho-tyrosinyl paxillin + ADP - ? 386652 2.7.10.2 paxillin + ATP phosphorylation at Tyr31 and Tyr118 by Fak Homo sapiens phospho-tyrosinyl paxillin + ADP - ? 386652 2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Drosophila melanogaster phosphorylated STAT transcription activator protein + ADP - ? 386696 2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Mus musculus phosphorylated STAT transcription activator protein + ADP - ? 386696 2.7.10.2 STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Homo sapiens phosphorylated STAT transcription activator protein + ADP - ? 386696 2.7.10.2 STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Drosophila melanogaster phosphorylated STAT transcription activator protein + ADP - ? 386696 2.7.10.2 STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Mus musculus phosphorylated STAT transcription activator protein + ADP - ? 386696 2.7.10.2 STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Homo sapiens phosphorylated STAT transcription activator protein + ADP - ? 386696 2.7.10.2 Wiskott-Aldrich syndrome protein + ATP i.e. WASP, phosphorylation by Fak Homo sapiens phospho-tyrosinyl Wiskott-Aldrich syndrome protein + ADP - ? 386764