2.7.10.1	ATP + a protein	-	Mammalia	ADP + a phosphoprotein	-	?	323385	
2.7.10.1	ATP + a protein	-	eukaryota	ADP + a phosphoprotein	-	?	323385	
2.7.10.1	ATP + a [macrophage-stimulating protein]-L-tyrosine	-	Homo sapiens	ADP + a [macrophage-stimulating protein]-L-tyrosine phosphate	-	?	436309	
2.7.10.1	ATP + a [protein]-L-tyrosine	-	Drosophila melanogaster	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	-	Mus musculus	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	-	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	-	Rattus norvegicus	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	-	Xenopus laevis	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	-	Meriones unguiculatus	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	FLT-3 is involved in signal transduction, mechanisms	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	phosphorylation of downstream signalling proteins	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	regulation mechanisms and ligand binding, ligand binding induces a conformational change, overview	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	stem cell factor and Kit receptor are essential playing important roles in e.g. gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase, regulation mechanism, overview	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility	Mus musculus	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	stem cell factor and Kit receptor are essential playing important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis, complete absence is lethal, enzyme deficiencies lead to defects in white and red blood cell production, to hypopigmentation, and to sterility, Kit receptor signaling regulation by autophosphorylation and dephosphorylation via a phosphatase	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	substrate binding and active structure	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + a [protein]-L-tyrosine	substrates are membrane and cytosolic proteins	Rattus norvegicus	ADP + a [protein]-L-tyrosine phosphate	-	?	378448	
2.7.10.1	ATP + Ac-DYFE-6-chloro-W-NHMe	substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner	Homo sapiens	ADP + Ac-DYpFE-6-chloro-W-NHMe	-	?	422868	
2.7.10.1	ATP + Ac-DYFGW-NHMe	substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner	Homo sapiens	ADP + Ac-DYpFGW-NHMe	-	?	422869	
2.7.10.1	ATP + cortactin-L-tyrosine	-	Mus musculus	ADP + cortactin-L-tyrosine phosphate	-	?	407130	
2.7.10.1	ATP + G protein-coupled receptor kinase-2	GRK2 activation also increases GRK2 degradation and downregulation, independent of Gbetagamma subunits and phosphoinositide 3-kinase	Homo sapiens	ADP + phosphorylated G protein-coupled receptor kinase-2	-	?	378511	
2.7.10.1	ATP + G protein-coupled receptor kinase-2	activates GRK2 by tyrosine phosphorylation at Y13, Y86, and Y92, the wild-type PDGFRbeta is 60fold more active with GRK2 than PDGFRbeta mutant Y857F, independent of Gbetagamma subunits and phosphoinositide 3-kinase	Homo sapiens	ADP + phosphorylated G protein-coupled receptor kinase-2	-	?	378511	
2.7.10.1	ATP + insulin receptor substrate 1-L-tyrosine	-	Mus musculus	ADP + insulin receptor substrate 1-L-tyrosine phosphate	tyrosine phosphorylation of insulin receptor substrate-1 by insulin receptor is decreased when insulin receptor substrate-1 is contained in high-molecular mass complexes prepared from 3T3-L1 adipocytes treated with tumor necrosis factor-alpha. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases	?	379372	
2.7.10.1	ATP + insulin receptor substrate 1-L-tyrosine	peptide derived from the regulatory domain of insulin receptor	Homo sapiens	ADP + insulin receptor substrate 1-L-tyrosine phosphate	-	?	379372	
2.7.10.1	ATP + insulin receptor substrate 2-L-tyrosine	-	Rattus norvegicus	ADP + insulin receptor substrate 2-L-tyrosine phosphate	tyrosine phosphorylation of insulin receptor substrate-2 by insulin-like growth factor IGF-I receptor is increased when insulin receptor substrate-2 is contained in high-molecular-mass complexes prepared from FRTL-5 thyrocytes treated with dibutyryl cAMP. Cytokine/hormone-induced formation of high-molecular mass complexes modulates availability of insulin receptor substrates to receptor tyrosine kinases	?	422950	
2.7.10.1	ATP + KKHTDDGYMPMSPGVA	commercial peptide substrate	Homo sapiens	ADP + KKHTDDGY-phosphate-MPMSPGVA	-	?	379381	
2.7.10.1	ATP + KKSRGDYMTMQIG	commercial peptide substrate	Homo sapiens	ADP + KKSRGDY-phosphate-MTMQIG	-	?	379383	
2.7.10.1	ATP + NAEYLRV	-	Homo sapiens	ADP + NAE-phospho-Y-LRV	-	?	437157	
2.7.10.1	ATP + p130Cas-L-tyrosine	-	Mus musculus	ADP + p130Cas-L-tyrosine phosphate	-	?	407154	
2.7.10.1	ATP + paxillin-L-tyrosine	-	Mus musculus	ADP + paxillin-L-tyrosine phosphate	-	?	407156	
2.7.10.1	ATP + phosphatidylinositol 3-kinase	binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase	Homo sapiens	ADP + phosphorylated phosphatidylinositol 3-kinase	-	?	323293	
2.7.10.1	ATP + phosphoinositide-dependent kinase-1-L-tyrosine	insulin-like growth factor-1 receptor directly interacts with and activates phosphoinositide-dependent kinase-1	Homo sapiens	ADP + phosphoinositide-dependent kinase-1-L-tyrosine phosphate	-	?	408676	
2.7.10.1	ATP + phospholipase C gamma	-	Homo sapiens	ADP + phosphorylated phospholipase C gamma	-	?	323294	
2.7.10.1	ATP + phospholipase C gamma	growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo	Homo sapiens	ADP + phosphorylated phospholipase C gamma	-	?	323294	
2.7.10.1	ATP + phospholipase C gamma-L-tyrosine	-	Mus musculus	ADP + phospholipase C gamma-L-tyrosine phosphate	-	?	407157	
2.7.10.1	ATP + poly(Glu-Ala-Tyr)	-	Homo sapiens	ADP + poly(Glu-Ala-Tyr)-L-tyrosine phosphate	-	?	379458	
2.7.10.1	ATP + poly(Glu:Tyr)	-	Escherichia coli	ADP + phosphorylated poly(Glu:Tyr)	-	?	323284	
2.7.10.1	ATP + poly(Glu:Tyr)	-	Homo sapiens	ADP + poly(Glu:Tyr) phosphate	-	?	386338	
2.7.10.1	ATP + poly-(Glu-Tyr)	-	Rattus norvegicus	ADP + poly-(Glu-Tyr) phosphate	Tyr-phosphate	?	379461	
2.7.10.1	ATP + poly-Ala-Glu-Lys-Tyr	substrate used for c-Met	Homo sapiens	ADP * poly-Ala-L-Glu-L-Lys-L-tyrosine phosphate	-	?	437167	
2.7.10.1	ATP + poly-Glu-Tyr	substrate used for EGFR	Homo sapiens	ADP + poly-L-Glu-L-tyrosine phosphate	-	?	437168	
2.7.10.1	ATP + protein	autophosphorylation	Gallus gallus	ADP + protein tyrosine phosphate	-	?	323298	
2.7.10.1	ATP + protein	Y602 is a major site of in vitro autophosphorylation in Sek, Y596 is phosphorylated to a lower stoichiometry	Mus musculus	ADP + protein tyrosine phosphate	-	?	323298	
2.7.10.1	ATP + protein	intrinsic autophosphorylation activity	Mus musculus	ADP + protein tyrosine phosphate	-	?	323298	
2.7.10.1	ATP + protein tyrosine	autophosphorylation	Homo sapiens	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	autophosphorylation	Mesocricetus auratus	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	autophosphorylation	Rattus norvegicus	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	protein kinase activity with specificity for tyrosine residues	Homo sapiens	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase	Homo sapiens	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	specific for tyrosine	Homo sapiens	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	insulin stimulates sequential autophosphorylation of Tyr1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation	Mus musculus	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	IRS-1 and IRS-2 proteins serve as substrates	Mus musculus	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	phospholipase C-gamma 1 is directly phosphorylated by TrkB	Rattus norvegicus	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	major sites of autophosphorylation are in the region containing Tyr670, Tyr674, and Tyr675	Rattus norvegicus	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + protein tyrosine	autophosphorylated on tyrosine and also mediated tyrosine phosphorylation of casein	Homo sapiens	ADP + protein tyrosine phosphate	-	?	323281	
2.7.10.1	ATP + tyrosine-protein kinase Etp	-	Escherichia coli	ADP + phosphotyrosine-protein kinase Etp	-	?	323283	
2.7.10.1	ATP + tyrosine-protein kinase Wcz	autophosphorylation	Escherichia coli	ADP + phosphotyrosine-protein kinase Wcz	-	?	323282	
2.7.10.1	ATP + tyrosine-protein kinase Wcz	autophosphorylation	Acinetobacter johnsonii	ADP + phosphotyrosine-protein kinase Wcz	-	?	323282	
2.7.10.1	ATP + tyrosine-protein kinase Wcz	The C-terminal domain alone can undergo autophosphorylation and thus appears to harbor the protein-tyrosine kinase activity. By contrast, the N-terminal domain is not phosphorylated when incubated either alone or in the presence of the C-domain, and does not influence the extent of phosphorylation of the C-domain. The C-domain contains six different sites of phosphorylation. Among these, five are located at the C-terminal end of the molecule in the form of a tyrosine cluster Tyr708, Tyr710, Tyr711, Tyr713, and Tyr715, and one site is located upstream, at Tyr569. The Tyr569 residue can autophosphorylate through an intramolecular process, whereas the tyrosine cluster cannot. The phosphorylation of Tyr569 results in an increased protein kinase activity of Wzc, which can, in turn, phosphorylate the five terminal tyrosines through an intermolecular process. It is concluded that protein Wzc autophosphorylates by using a cooperative two-step mechanism that involves both intraphosphorylation and interphosphorylation	Escherichia coli	ADP + phosphotyrosine-protein kinase Wcz	-	?	323282	
2.7.10.1	ATP + tyrosine-protein kinase Wcz	autophosphorylation at several tyrosine residues	Acinetobacter johnsonii	ADP + phosphotyrosine-protein kinase Wcz	-	?	323282	
2.7.10.1	ATP + tyrosine-protein kinase Wcz	efficient autophosphorylation in presence of ATP	Escherichia coli	ADP + phosphotyrosine-protein kinase Wcz	-	?	323282	
2.7.10.1	ATP + tyrosine-protein kinase Wcz	presence of at least five isoforms, all phosphorylated exclusively at tyrosine supports the concept that autophosphorylation occurs at multiple sites within the protein	Acinetobacter johnsonii	ADP + phosphotyrosine-protein kinase Wcz	-	?	323282	
2.7.10.1	ATP + VPEYINQ	-	Homo sapiens	ADP + VPE-phosphoY-INQ	-	?	437179	
2.7.10.1	ATP + YFEW	tetrapeptide identified by substrate profiling	Homo sapiens	ADP + YpFEW	-	?	423043	
2.7.10.1	ATP + [beta-catenin]-Tyr142	isoforms FGFR2, FGFR3, EGFR and TRKA directly phosphorylate beta-catenin at Tyr142, which increases cytoplasmic beta-catenin concentration via release of beta-catenin from membranous cadherin complexes	Homo sapiens	ADP + [beta-catenin]-Tyr142 phosphate	-	?	421896	
2.7.10.1	ATP + [endothelial growth-factor]-L-tyrosine	EGFR tyrosine kinase	Homo sapiens	ADP + [endothelial growth-factor]-L-tyrosine phosphate	-	?	378612	
2.7.10.1	ATP + [flagellin]-L-tyrosine	-	Pseudomonas aeruginosa	ADP + [flagellin]-L-tyrosine phosphate	-	?	379528	
2.7.10.1	ATP + [gastrin]-L-tyrosine	-	Homo sapiens	ADP + [gastrin]-L-tyrosine phosphate	-	?	437180	
2.7.10.1	ATP + [minigastrin]-L-tyrosine	-	Homo sapiens	ADP + [minigastrin]-L-tyrosine phosphate	-	?	437181	
2.7.10.1	ATP + [poly-(Glu,Tyr)1:4]	synthetic substrate	Homo sapiens	ADP + [poly-(Glu,Tyr)1:4]-tyrosine phosphate	-	?	379537	
2.7.10.1	ATP + [vascular endothelial growth-factor-1]-L-tyrosine	VEGFR-1 tyrosine kinase	Homo sapiens	ADP + [vascular endothelial growth-factor-1]-L-tyrosine phosphate	-	?	378641	
2.7.10.1	additional information	-	Mus musculus	?	-	?	89	
2.7.10.1	additional information	-	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	autophosphorylation	Branchiostoma lanceolatum	?	-	?	89	
2.7.10.1	additional information	autophosphorylation	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	no phosphorylation of synthetic substrates such as poly(Glu80 Tyr20) or angiotensin II	Acinetobacter johnsonii	?	-	?	89	
2.7.10.1	additional information	generalized function of the Zek1 receptor in neuronal cell ontogeny	Danio rerio	?	-	?	89	
2.7.10.1	additional information	N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells	Avian erythroblastosis virus	?	-	?	89	
2.7.10.1	additional information	functions in neural and epithelial morphogenesis	Caenorhabditis elegans	?	-	?	89	
2.7.10.1	additional information	alternative splicing of the FGFR2 gene in the region encoding the carboxyl-terminal half of the third immunoglobulin domain determines the ligand specificity of this group of receptors	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	enzyme is involved in signal transduction	Escherichia coli	?	-	?	89	
2.7.10.1	additional information	possible involvement of the enzyme in cell recognition and bacterial pathogenicity	Acinetobacter johnsonii	?	-	?	89	
2.7.10.1	additional information	involved in exopolysaccharide production and virulence	Escherichia coli	?	-	?	89	
2.7.10.1	additional information	phosphotyrosine-protein phosphatase Wzb is able to dephosphorylate previously autophosphorylated Wzc. Reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria	Escherichia coli	?	-	?	89	
2.7.10.1	additional information	phosphorylation of Wzc, as regulated by Wzb, is directly connected with the production of a particular capsular polysaccharide, colanic acid. Thus, when Wzc is phosphorylated on tyrosine, no colanic acid is synthesised by bacteria, but when dephosphorylated by Wzb, colanic acid is produced	Escherichia coli	?	-	?	89	
2.7.10.1	additional information	enzyme is involved in the production of the extracellular polysaccharide colanic acid	Escherichia coli	?	-	?	89	
2.7.10.1	additional information	Sek-1, perhaps with other Eph-related receptors, is required for interactions that regulate the segmental identity or movement of cells	Xenopus laevis	?	-	?	89	
2.7.10.1	additional information	tyrosine kinase may play an important function in the developing mouse	Mus musculus	?	-	?	89	
2.7.10.1	additional information	important role in the formation of neuronal structures and possibly other morphogenic processes	Mus musculus	?	-	?	89	
2.7.10.1	additional information	important role in neurogenesis	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	the neurotrophic receptor may function during early stages of neural development	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	may play an important role in the generation of the mammalian nervous system	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	Dnrk may play an important role in neural development during Drosophila embryogenesis	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	Pag may play a role in the differentiation of cranial neural crest and other tissues	Xenopus laevis	?	-	?	89	
2.7.10.1	additional information	receptor may play a role in the regulation of beta-cell mass	Mus musculus	?	-	?	89	
2.7.10.1	additional information	role for DDR2 in critical events during wound repair	Mus musculus	?	-	?	89	
2.7.10.1	additional information	essential for migration of tracheal and specific midline glial cells	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	required for cartilage and growth plate development	Mus musculus	?	-	?	89	
2.7.10.1	additional information	receptor of neuregulin	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	may play a role in the development or function of the central nervous system	Xenopus laevis	?	-	?	89	
2.7.10.1	additional information	may play a role in cell-cell interactions involved in retinotectal projections and differentiation of the central nervous system	Coturnix japonica	?	-	?	89	
2.7.10.1	additional information	required for directed tracheal cell extension	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	part of a novel signal transduction cascade involved in learning and memory	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	involved in cell-cell interactions	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	essential for the pathfinding ability of expressing neurons, participates in a mechanism required for muscle attachment site selection	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	expression of neuregulins and their putative receptor ErbB3, is induced during Wallerian degeneration	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	transformation of fibroblasts and transformation of erythroid cells	Avian erythroblastosis virus	?	-	?	89	
2.7.10.1	additional information	the erB oncogene efficiently transforms erythroblasts	Avian erythroblastosis virus	?	-	?	89	
2.7.10.1	additional information	plays an important role in cell growth control	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	implicated in the control of cell growth and differentiation	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	enzyme functions as the cell surface receptor for the macrophage colony stimulating factor	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	cell-surface receptor for an as-yet-unknown ligand	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the proto-oncogene c-kit is involved in signal transduction	Mus musculus	?	-	?	89	
2.7.10.1	additional information	receptor for an as yet unidentified growth factor	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	functions as a cell surface receptor for an as yet unidentified ligand	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas	Mus musculus	?	-	?	89	
2.7.10.1	additional information	Elk tyrosine kinase may be involved in cell-cell interactions in the nervous system	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	piebaldism results from mutations of the KIT proto-oncogene, which encodes the cellular receptor transmembrane tyrosine kinase for mast/stem cell growth factor	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	Ltk is expressed at a very low level in only a few cell lines and tissues and may be the receptor for a pre-B lymphocyte growth or differentiation factor	Mus musculus	?	-	?	89	
2.7.10.1	additional information	activity of inr gene appears to be required in the embryonic epidermis and nervous system among others, since development of the cuticle, as well as the peripheral and central nervous systems are affected by inr mutations	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	mutations in the fibroblast growth factor receptor-1 gene, which maps to 8p, cause one form of familial Pfeiffer syndrome. A C to G transversion in exon 5, predicting a proline to arginine substitution in the putative extracellular domain, is identified in all affected members of five unrelated PS families but not in any unaffected individuals	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	determination of anterior and posterior terminal structures of Drosophila embryos requires activation of two genes encoding putative protein kinases, torso and D-raf	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	Jackson-Weiss syndrome and Crouzon syndrome are allelic with mutations in fibroblast growth factor receptor 2	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	enzyme is required for normal eye development	Drosophila virilis	?	-	?	89	
2.7.10.1	additional information	IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	IR-related protein is a receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family	Cavia porcellus	?	-	?	89	
2.7.10.1	additional information	FGFR2 mutations in Pfeiffer syndrome	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	trkB may code for a cell surface receptor involved in neurogenesis	Mus musculus	?	-	?	89	
2.7.10.1	additional information	enzyme is involved in glial cell generation	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	sevenless gene determines the fate of a single photoreceptor cell type in the eye of Drosophila	Drosophila melanogaster	?	-	?	89	
2.7.10.1	additional information	malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu which codes for a receptor tyrosine kinase	Xiphophorus maculatus	?	-	?	89	
2.7.10.1	additional information	ephrin type-A receptor 1 may be involved in the neoplastic process of some tumors	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	FGFR-4 binds acidic fibroblast growth factor with high affinity but does not bind basic fibroblast growth factor	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	receptor tyrosine kinase is necessary for the induction of a vulva, survival past the L1 stage, hermaphrodite fertility and for male spicule development	Caenorhabditis elegans	?	-	?	89	
2.7.10.1	additional information	gp145trkC may play an important role in mediating the neurotrophic effects of NT-3	Sus scrofa	?	-	?	89	
2.7.10.1	additional information	tk gene product likely functions as a cell surface receptor for an unidentified cellular growth factor	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	receptors for at least two hematopoietic growth factors: the stem cell factor and the colony-stimulating factor 1	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	may play a role in vascular development and regulation of vascular permeability	Mus musculus	?	-	?	89	
2.7.10.1	additional information	gene plays important role in embryonic development and carcinogenesis of the stomach	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	Flk-1 as a major regulator of vasculogenesis and angiogenesis	Mus musculus	?	-	?	89	
2.7.10.1	additional information	may be involved in tumor progression of epithelial ovarian cancer	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	may be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development	Caenorhabditis elegans	?	-	?	89	
2.7.10.1	additional information	possibility that overexpression of PDGF-alpha receptor in high-metastatic clones may contribute to an increase in the capacity of tumor cells to generate metastases in the lung	Mus musculus	?	-	?	89	
2.7.10.1	additional information	signal transducing receptor for nerve growth factor	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	increased ERBB3 expression may play a role in some human malignancies	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	ectodermally produced PDGF A may act on the mesoderm during gastrulation and mesoderm induction establishes the tissue pattern of ligand and receptor expression	Xenopus laevis	?	-	?	89	
2.7.10.1	additional information	receptor for the inductive signal required for vulval development	Caenorhabditis elegans	?	-	?	89	
2.7.10.1	additional information	enzyme is a receptor for vascular endothelial cell growth factor	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	plays a part in human neurogenesis, DRT gene may play a part in neuroblastoma and SCLC tumorigenesis	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	may play an important role during development and in signal transduction pathways	Gallus gallus	?	-	?	89	
2.7.10.1	additional information	may play an important role during development and in signal transduction pathways	Mus musculus	?	-	?	89	
2.7.10.1	additional information	acts through a conserved Ras/MAP kinase signaling pathway to induce vulval differentiation	Caenorhabditis elegans	?	-	?	89	
2.7.10.1	additional information	element of the complex signaling network involved in the control of cell proliferation and differentiation	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor I receptor cDNA	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	may have a role in tumorigenesis	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	involved in the proliferation of early progenitor/stem cells	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny	Mus musculus	?	-	?	89	
2.7.10.1	additional information	possible role for repulsive B-class Eph receptor/ligand interactions in constraining the orientation of longitudinal axon projections at the ventral midline	Mus musculus	?	-	?	89	
2.7.10.1	additional information	tyro3 may function as a novel neurotrophic factor receptor	Mus musculus	?	-	?	89	
2.7.10.1	additional information	important role in gestational growth and differentiation	Mus musculus	?	-	?	89	
2.7.10.1	additional information	Srcasm may help promote Src family kinase signaling in cells	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	tyrosine kinase receptor for hepatocyte growth factor	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	increased c-met expression indicates that this gene may participate in the healing process of gastric mucosa after injury	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	enzyme is implicated in control of cell growth	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	NET potentially plays important roles in human neurogenesis	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	ALK plays an important role in the development of the brain	Mus musculus	?	-	?	89	
2.7.10.1	additional information	important role for this kinase in CD2 co-stimulation of T cell responses	Mus musculus	?	-	?	89	
2.7.10.1	additional information	role for the Ron receptor in progression toward malignancy	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	primary function is likely to be in developmental regulation	Mus musculus	?	-	?	89	
2.7.10.1	additional information	distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by loss of ROR2 activity	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	Cek9 plays an active role in embryonic signal transduction pathways	Gallus gallus	?	-	?	89	
2.7.10.1	additional information	role for Tsk in early T-lymphocyte differentiation	Mus musculus	?	-	?	89	
2.7.10.1	additional information	rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase	Mus musculus	?	-	?	89	
2.7.10.1	additional information	ufo may function as a signal transducer between specific cell types of mesodermal origin	Mus musculus	?	-	?	89	
2.7.10.1	additional information	Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons	Gallus gallus	?	-	?	89	
2.7.10.1	additional information	tek receptor tyrosine kinase may be critically involved in the determination and/or maintenance of cells of the endothelial lineage	Mus musculus	?	-	?	89	
2.7.10.1	additional information	itk functions in a signal transduction pathway unique to T lymphocytes	Mus musculus	?	-	?	89	
2.7.10.1	additional information	ron gene product is a specific cell-surface receptor for macrophage-stimulating protein	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	Sky may be involved in cell adhesion processes, particularly in the central nervous system	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	expression of the EGF-R gene in mouse blastocysts is tightly regulated by maternal steroid hormonal status	Mus musculus	?	-	?	89	
2.7.10.1	additional information	Emt/Itk is a protein tyrosine kinase required for T cell Ag receptor TCR-induced activation and development	Mus musculus	?	-	?	89	
2.7.10.1	additional information	mrfms gene products may play a role in the normal and neoplastic growth of muscular cells	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	activating mutations of the fibroblast growth factor receptor 3 cause skeletal dysplasias including achondroplasia, and the neonatal lethal syndromes thanatophoric dysplasia types I and II, the mutations are also involved in cancer development, e.g. in multiple myeloma, bladder carcinoma, and cervical cancer	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview	Bos taurus	?	-	?	89	
2.7.10.1	additional information	antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases, overview	Oryctolagus cuniculus	?	-	?	89	
2.7.10.1	additional information	deoxycholic acid and taurodeoxycholic acid activate insulin receptor kinase and ERBB1 kinase and subsequent ERK1/2 and AKT signaling pathways activation via induction of reactive oxygen species ROS production in mitochondria, ROS activation can be blocked by scavengers N-acetyl cysteine and Trolox, as well as cyclosporine A and bongkrekic acid	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	downregulation of endogenous Syk non-receptor tyrosine protein kinase expression in mammary endothelial cells enhances the ligand-induced activity of the epidermal growth factor receptor, but not of closely related human epidermal growth factor receptors HER2 and HER3, EGFR has a regulatory feedback effect on Syk, enzyme deregulation is associated with pathophysiological disorders such as cancer, regulation in vivo overview	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade	Cryptosporidium parvum	?	-	?	89	
2.7.10.1	additional information	EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade	Neospora caninum	?	-	?	89	
2.7.10.1	additional information	EGF-like peptides bind as ligands to the extracellular domain of host cell EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade	Sarcocystis neurona	?	-	?	89	
2.7.10.1	additional information	EGF-like peptides on the surface of coccidial parasites Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum bind as ligands to the extracellular domain of the gerbils' host cells' EGFR leading to an activation of the intracellular tyrosine kinase domain which initiates downstream signaling pathways, e.g. the mitogen-activated protein kinase cascade	Meriones unguiculatus	?	-	?	89	
2.7.10.1	additional information	enzyme regulation via reversible autophosphorylation, binding to plasma membrane of enzyme and enzyme-derived peptides, overview	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	ErbB family enzymes are absolutely required for viability of embryos	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	mutations in the glycine-riche loop of MET can cause papillary renal-cell carcinomas	eukaryota	?	-	?	89	
2.7.10.1	additional information	PDGFRbeta wild-type and mutant Y857F activate c-Src kinase	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	platelet-derived growth factor receptor or epidermal growth factor receptor transactivation via recombinant dopamine D2 receptor is required for activation of extracellular signal-regulated kinases, i.e. ERKs	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview	eukaryota	?	-	?	89	
2.7.10.1	additional information	receptor tyrosine kinases are key regulators of cellular homeostasis, regulation of enzyme signaling by protein tyrosine phosphatase-1B, defects in this regulation result in increased phosphorylation of epidermal growth factor receptor and platelet-derived growth factor which can be compensated by other signaling mechanisms, overview	Mus musculus	?	-	?	89	
2.7.10.1	additional information	the activated, tyrosine-phosphorylated Kit receptor is a docking site for signal transduction molecules containing SH2 domains, diverse proteins bind to the different tyrosine phosphates of the receptor, e.g. the adaptor protein APS, Src family kinases, Shp2 tyrosyl phosphatase, adaptor proteins Grb2 and Grb7, phosphatidylinositol 3-kinase, and the adaptor protein Shc, analysis of interactions, functions, and biological effects, binding of APS leads to Kit degradation, overview	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the enzyme epidermal growth factor receptor tyrosine kinase is involved in signal transduction in cardiac preconditioning, mechanisms, enzyme inhibition is cardioprotective	Rattus norvegicus	?	-	?	89	
2.7.10.1	additional information	the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has increasing effect, opposing to soluble protein kinase Src, on volume-sensitive chloride current in atrial myocytes	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the receptor protein tyrosine kinases are involved in cell signaling processes and signal transduction pathways in regulation of cell growth, differentiation, migration and metabolism by catalyzing protein phosphorylation and dephosphorylation, overview, EGFR tyrosine kinase regulates cell proliferation, IGFR tyrosine kinase regulates cell survival, VEGFR tyrosine kinase regulates tumor angiogenesis, mechanisms, overexpression of receptor protein tyrosine kinases in cancers	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	autophosphorylation of the insulin receptor via its protein tyrosine kinase activity, regulation mechanism	Xenopus laevis	?	-	?	89	
2.7.10.1	additional information	EGFR performs autophosphorylation	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	poor activity on free amino acids, consensus sequence of InRK is YM-MM, and of EGFR E-EEYF	eukaryota	?	-	?	89	
2.7.10.1	additional information	serotonin 5-HT2c receptor signaling is largely independent from receptor tyrosine kinase activity	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	substrate recognition and binding structure, the enzyme depends on basic residues for substrate recognition, substrate specificity determinants in substrates	Mammalia	?	-	?	89	
2.7.10.1	additional information	ErbB1 receptor shows three phosphorylation sites (Y1110, Y1172 and Y1192)	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	protein tyrosine kinases select substrates with a glutamic acid at the P-1 position and a large hydrophobic amino acid at the P+1 position	Homo sapiens	?	-	?	89	
2.7.10.1	additional information	the erB oncogene efficiently transforms erythroblasts	Avian erythroblastosis virus ES4	?	-	?	89	
2.7.10.1	additional information	N-terminal portion of the enzyme is sufficient for the transformation of fibroblasts, one-third of the carboxy-terminal domain has a key role for the transformation of erythroid cells	Avian erythroblastosis virus ES4	?	-	?	89	
2.7.10.1	additional information	transformation of fibroblasts and transformation of erythroid cells	Avian erythroblastosis virus ES4	?	-	?	89	
2.7.10.1	poly(Glu:Tyr) + ATP	-	Pseudomonas aeruginosa	ADP + ?	-	?	380212	
2.7.10.1	poly(Glu:Tyr) + ATP	-	Homo sapiens	ADP + poly(Glu:Tyr) phosphate	-	?	401768