2.7.1.137 ATP + 1,2-dibutanoylphosphatidylinositol 4,5-diphosphate - Mus musculus ADP + 1,2-dibutanoylphosphatidylinositol 3,4,5-trisphosphate - ? 379186 2.7.1.137 ATP + 1,2-dioctanoylphosphatidylinositol 4,5-diphosphate - Mus musculus ADP + 1,2-dioctanoylphosphatidylinositol 3,4,5-trisphosphate - ? 379189 2.7.1.137 ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol - Mus musculus ADP + ? - ? 357264 2.7.1.137 ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol - Bos taurus ADP + ? - ? 357264 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Canis lupus familiaris ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Arabidopsis thaliana ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Rickettsia typhi ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Canis lupus familiaris ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate Trypanosoma cruzi ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol substrate from bovine liver Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol phosphorylation of phosphatidylinositol at the 3'-position on the inositol ring Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol phosphorylation of phosphatidylinositol at the 3'-position on the inositol ring Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Rickettsia typhi ATCC VR-144 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate Trypanosoma cruzi CL Brener ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Rickettsia typhi Wilmington ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol - Mus musculus C57BL/6 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.137 ATP + 1-phosphatidylinositol - Gallus gallus ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Cricetulus griseus ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Cavia porcellus ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Drosophila melanogaster ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Drosophila sp. (in: flies) ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Mus musculus ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Homo sapiens ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Rattus norvegicus ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Sus scrofa ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Bos taurus ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Glycine max ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Dictyostelium discoideum ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Caenorhabditis elegans ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Chlamydomonas sp. ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Xenopus sp. ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Saccharomyces cerevisiae ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Candida albicans ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Schizosaccharomyces pombe ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Hortaea werneckii ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Arabidopsis thaliana ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network Homo sapiens ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + 1-phosphatidylinositol - Homo sapiens PI3K-C2alpha ADP + phosphatidylinositol 3-phosphate - ? 357261 2.7.1.137 ATP + Akt1 phosphorylation at Ser473 Rattus norvegicus ADP + Akt1 phosphate - ? 410735 2.7.1.137 ATP + Akt1 phosphorylation at Ser473, a step in PI3K/Akt signaling Rattus norvegicus ADP + Akt1 phosphate - ? 410735 2.7.1.137 ATP + phosphatidylinositol class I enzyme Mammalia ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.137 ATP + phosphatidylinositol class I enzyme, preferred substrate of the class III enzyme Homo sapiens ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate - Rattus norvegicus ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate - Sus scrofa ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate no activity Homo sapiens ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate weak activity Bos taurus ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate class I enzyme, preferred substrate in vivo Mammalia ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate class I enzyme, preferred substrate in vivo, physiologic regulation and mode of action Homo sapiens ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate class I enzyme Mammalia ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4,5-bisphosphate class I enzyme, preferred substrate of the class I enzyme Homo sapiens ADP + phosphatidylinositol 3,4,5-trisphosphate - ? 357263 2.7.1.137 ATP + phosphatidylinositol 4-phosphate - Rattus norvegicus ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate - Sus scrofa ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate - Homo sapiens ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate - Drosophila melanogaster ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate no activity Homo sapiens ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate weak activity Bos taurus ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate class I enzyme Mammalia ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol 4-phosphate class I enzyme, preferred substrate of the class II enzyme Homo sapiens ADP + phosphatidylinositol 3,4-bisphosphate - ? 357262 2.7.1.137 ATP + phosphatidylinositol-4,5-bisphosphate - Mus musculus ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.137 ATP + phosphatidylinositol-4,5-bisphosphate - Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.137 ATP + phosphatidylinositol-4,5-bisphosphate - Saccharomyces cerevisiae ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.137 ATP + phosphatidylinositol-4,5-bisphosphate class Ia isozyme Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.137 ATP + phosphatidylinositol-4,5-bisphosphate synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.137 ATP + phosphatidylinositol-4,5-bisphosphate from rat liver and bovine erythrocyte and brain, substrate specificities, free or membrane anchored, phosphorylated phosphatidylinositol is poorer substrate than nonphosphorlyated, overview Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.137 ATP + phosphatidylinositol-4-phosphate - Mus musculus ADP + phosphatidylinositol-3,4-bisphosphate - ? 378563 2.7.1.137 ATP + phosphatidylinositol-4-phosphate - Homo sapiens ADP + phosphatidylinositol-3,4-bisphosphate - ? 378563 2.7.1.137 ATP + phosphatidylinositol-4-phosphate - Saccharomyces cerevisiae ADP + phosphatidylinositol-3,4-bisphosphate - ? 378563 2.7.1.137 ATP + phosphatidylinositol-4-phosphate synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility Homo sapiens ADP + phosphatidylinositol-3,4-bisphosphate - ? 378563 2.7.1.137 additional information - Mus musculus ? - ? 89 2.7.1.137 additional information - Homo sapiens ? - ? 89 2.7.1.137 additional information - Rattus norvegicus ? - ? 89 2.7.1.137 additional information TAPP1 and TAPP2 are direct targets of PI3K signaling Homo sapiens ? - ? 89 2.7.1.137 additional information isoform p110b of the catalytic subunit plays a crucial role in cellular activities evoked acutely by insulin Rattus norvegicus ? - ? 89 2.7.1.137 additional information activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity, activation is dependent on the phosphorylation event of p85 Homo sapiens ? - ? 89 2.7.1.137 additional information PI-3-kinase might be involved in the induction of erythroid differentiation, possibly engaging a protein kinase C z as downstream effector Mus musculus ? - ? 89 2.7.1.137 additional information generation of phosphatidyl 3,4,5-triphosphate by phosphatidylinositol 3-kinase is necessary for insulin-induced germinal vesicle breakdown in Xenopus oocytes Xenopus sp. ? - ? 89 2.7.1.137 additional information the enzyme is implicated in the control of breast cancer cell growth by free fatty acids and may provide a link between fat and cancer Homo sapiens ? - ? 89 2.7.1.137 additional information important functional role of phosphatidylinositol 3-kinase in motile responses of HL-60 cells Homo sapiens ? - ? 89 2.7.1.137 additional information PI 3-kinase is the first step of the insulin signaling pathway to be impaired by high-fat feeding Rattus norvegicus ? - ? 89 2.7.1.137 additional information essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes Rattus norvegicus ? - ? 89 2.7.1.137 additional information monocytes respond to LPS with the rapid activation of PI 3-kinase, resulting in transient increases in levels of PtdIns 3,4,5-P3. This process is CD14 dependent and involves the physiological association of PI 3-kinase with activated p53/56lyn Homo sapiens ? - ? 89 2.7.1.137 additional information role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein-coupled receptor systems in human neutrophils Homo sapiens ? - ? 89 2.7.1.137 additional information regulating longevity and diapause Caenorhabditis elegans ? - ? 89 2.7.1.137 additional information PI 3-K pathways is involved in the short-term activation of pyruvate kinase L by insulin in rat hepatocytes Rattus norvegicus ? - ? 89 2.7.1.137 additional information the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters Mus musculus ? - ? 89 2.7.1.137 additional information may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system Mus musculus ? - ? 89 2.7.1.137 additional information enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment Glycine max ? - ? 89 2.7.1.137 additional information phosphatidylinositol 3-kinase-mediated signaling in the immune system Homo sapiens ? - ? 89 2.7.1.137 additional information phosphatidylinositol 3-kinase-mediated signaling in the immune system Mus musculus ? - ? 89 2.7.1.137 additional information phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells Mus musculus ? - ? 89 2.7.1.137 additional information enzyme is involved in formyl peptide-induced stimulation of neutrophils Cavia porcellus ? - ? 89 2.7.1.137 additional information IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase Homo sapiens ? - ? 89 2.7.1.137 additional information enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae Saccharomyces cerevisiae ? - ? 89 2.7.1.137 additional information PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment Glycine max ? - ? 89 2.7.1.137 additional information insulin stimulation of fatty acid synthase promoter is mediated by the PI 3-kinase pathway Mus musculus ? - ? 89 2.7.1.137 additional information plays a central part in the mediation of insulin-stimulated glucose disposal Homo sapiens ? - ? 89 2.7.1.137 additional information role for Dp110 in growth control during Drosophila development Drosophila melanogaster ? - ? 89 2.7.1.137 additional information insulin signaling in heart involves insulin receptor substrate-1 and insulin receptor substrate-2, activation of phosphatidylinositol 3-kinase Rattus norvegicus ? - ? 89 2.7.1.137 additional information activation of PI3K is a critical component of the anti-Ig-initiated signaling cascade that leads to growth inhibition of human B lymphoma cells Homo sapiens ? - ? 89 2.7.1.137 additional information signaling pathways for phosphoinositolglycan-peptide and insulin to glucose transport and metabolism converge at the level of PI 3-kinase Rattus norvegicus ? - ? 89 2.7.1.137 additional information the enzyme is essential for protein sorting Saccharomyces cerevisiae ? - ? 89 2.7.1.137 additional information enzyme plays an important role in the signalling of cell growth Bos taurus ? - ? 89 2.7.1.137 additional information enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs Mus musculus ? - ? 89 2.7.1.137 additional information enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs Bos taurus ? - ? 89 2.7.1.137 additional information myotubularin, a phosphatase deficient in myotubular myopathy, may decrease PI3P levels by down-regulating PI3K activity and by directly degrading PI3P Homo sapiens ? - ? 89 2.7.1.137 additional information PI 3-kinase activity is a necessary step in the regulation of bone resorption Gallus gallus ? - ? 89 2.7.1.137 additional information PI 3-kinase activity is a necessary step in the regulation of bone resorption Bos taurus ? - ? 89 2.7.1.137 additional information PI 3-kinase activity appears to be an important component of ovariectomy-stimulated bone loss in rats Rattus norvegicus ? - ? 89 2.7.1.137 additional information insulin and dexamethasone regulate phosphatidylinositol 3-kinase in Fao hepatoma cells Rattus norvegicus ? - ? 89 2.7.1.137 additional information enzyme plays an important role in the signaling of cell growth Bos taurus ? - ? 89 2.7.1.137 additional information insulin-stimulated IRS-1 association with PI 3-kinase is decreased to 84% in the liver and to 84% in the muscle in the fructose-fed group compared to controls Rattus norvegicus ? - ? 89 2.7.1.137 additional information lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase Xenopus sp. ? - ? 89 2.7.1.137 additional information differential regulation of insulin receptor substrate-1 and insulin receptor substrate-2 and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic mouse Mus musculus ? - ? 89 2.7.1.137 additional information the level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase Cricetulus griseus ? - ? 89 2.7.1.137 additional information insulin activates ATP-sensitive K+ channels in pancreatic B-cells through a phosphatidylinositol 3-kinase-dependent pathway Mus musculus ? - ? 89 2.7.1.137 additional information reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes Mus musculus ? - ? 89 2.7.1.137 additional information essential for normal cell growth and vacuole morphology Schizosaccharomyces pombe ? - ? 89 2.7.1.137 additional information mitogenic signal transduction pathway mediated by P13K is dependent upon the enzymatic activity of the p110 alpha subunit of P13K Homo sapiens ? - ? 89 2.7.1.137 additional information enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes Homo sapiens ? - ? 89 2.7.1.137 additional information class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity Homo sapiens ? - ? 89 2.7.1.137 additional information in both the liver and muscle of high salt-fed rats, intracellular insulin signaling leading to PI 3-kinase activation is enhanced and insulin action is attenuated Rattus norvegicus ? - ? 89 2.7.1.137 additional information enzyme could be involved in stimulated glucose transport in muscle Mus musculus ? - ? 89 2.7.1.137 additional information receptor linked enzyme may generate a second-messenger signal Bos taurus ? - ? 89 2.7.1.137 additional information enzyme is involved in the signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli Homo sapiens ? - ? 89 2.7.1.137 additional information multiple defects of PI 3-kinase activation, involving both the p85a and the p85b adaptor subunits, may contribute to cardiac insulin resistance Rattus norvegicus ? - ? 89 2.7.1.137 additional information the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, e.g. in cell survival, vesicle trafficking, cytoskeletal reorganization, and chemotaxis, the enzymeis involved in diverse signalling pathways, detailed schematic overview Mammalia ? - ? 89 2.7.1.137 additional information the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, the enzyme is involved in many cellular responses important in pathogenesis of disease Homo sapiens ? - ? 89 2.7.1.137 additional information the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview Rattus norvegicus ? - ? 89 2.7.1.137 additional information the enzyme is involved in cytokin-stimulated cell migration Homo sapiens ? - ? 89 2.7.1.137 additional information the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview Mus musculus ? - ? 89 2.7.1.137 additional information the lipid-lowering effect of leptin on livers from lean rats is mediated by the enzyme, diet-induced obesity abolishes the effect of leptin on the enzyme and the lipid level and causes leptin resistance Rattus norvegicus ? - ? 89 2.7.1.137 additional information phosphoinositide quantification via labeled and/or tagged ligands binding to the pleckstrin homology PH domain of the enzyme in competition with phosphoinositides, overview Mus musculus ? - ? 89 2.7.1.137 additional information the enzyme interacts with other proteins and substrates via the pleckstrin homology PH domain Homo sapiens ? - ? 89 2.7.1.137 additional information the enzyme interacts with other proteins and substrates via the pleckstrin homology PH domain, class I isozyme subgroups Ia and Ib are divided due to their mode of action and structure Mammalia ? - ? 89 2.7.1.137 additional information the enzyme shows both lipid and protein kinase activity Mus musculus ? - ? 89 2.7.1.137 additional information interaction between Beclin and hVps34 PI 3-kinase is essential for engagement of hVps34 in the process of macroautophagy, but is dispensable for the normal function of hVps34 in endocytic trafficking or lysosomal enzyme sorting Homo sapiens ? - ? 89 2.7.1.137 additional information leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression Mus musculus ? - ? 89 2.7.1.137 additional information PI3-kinase-dependent activation of diacylglycerol kinase and production of phosphatidic acid in caveolae/rafts in response to norepinephrine but not endothelin-1 Rattus norvegicus ? - ? 89 2.7.1.137 additional information two populations of p27 use different kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation Oryctolagus cuniculus ? - ? 89 2.7.1.137 additional information type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3 Mus musculus ? - ? 89 2.7.1.137 additional information AMP-activated protein kinase, activated by energy depletion, inhibits cell survival by binding to and phosphorylating insulin receptor substrate-1 at Ser-794. Phosphorylation of insulin receptor substrate-1 at this site inhibits phosphatidylinositol 3-kinase/Akt signaling, suppresses the mitochondrial membrane potential, and promotes apoptosis Homo sapiens ? - ? 89 2.7.1.137 additional information anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway Homo sapiens ? - ? 89 2.7.1.137 additional information HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway Rattus norvegicus ? - ? 89 2.7.1.137 additional information Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism Homo sapiens ? - ? 89 2.7.1.137 additional information IGF-I regulates the expression of FLIP in FRTL cells by activating the PI3K/NF-kB cascade Homo sapiens ? - ? 89 2.7.1.137 additional information IL-2-induced PI3K activation limits IL-17RA gene expression. Blockade of the PI3K pathway but not p70S6K leads to up-regulation of IL-17RA Homo sapiens ? - ? 89 2.7.1.137 additional information lutein inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways Mus musculus ? - ? 89 2.7.1.137 additional information mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism Homo sapiens ? - ? 89 2.7.1.137 additional information nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb Rattus norvegicus ? - ? 89 2.7.1.137 additional information overexpression of mkrn2 completely abrogates constitutively active PI3K- and Akt-induced, but not dominant negative glycogen synthase kinase-3beta-induced, neural cell adhesion molecule expression, indicating that mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta. Important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development Xenopus sp. ? - ? 89 2.7.1.137 additional information PI 3-kinase signaling in proliferating cells regulates a novel program of gene expression, which is distinct from that induced by growth factor stimulation of quiescent cells. The expression program controlled by continuous PI 3-kinase signaling in proliferating cells is enriched in genes that regulate cell survival and is mediated in large part by FOXO and RelB transcription factors Homo sapiens ? - ? 89 2.7.1.137 additional information raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene Mus musculus ? - ? 89 2.7.1.137 additional information the phosphatidylinositol 3-kinase/Akt signaling pathway is required for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes Homo sapiens ? - ? 89 2.7.1.137 additional information two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation Oryctolagus cuniculus ? - ? 89 2.7.1.137 additional information PI3K family plays a prominent role in various inflammatory cells by controlling cell growth, differentiation, survival, proliferation, migration, and mediator production (such as cytokines) through its downstream components Homo sapiens ? - ? 89 2.7.1.137 additional information activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta Mus musculus ? - ? 89 2.7.1.137 additional information activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia Rattus norvegicus ? - ? 89 2.7.1.137 additional information class III PI3K Vps34p is associated with Vsp15 Homo sapiens ? - ? 89 2.7.1.137 additional information effects of the specific PI3K inhibitor LY294002 on Kv1.5 channels, wild-type and mutant, are independent of the effects on PI3K activity, overview Homo sapiens ? - ? 89 2.7.1.137 additional information PI3K inhibits recombinantly expressed rat excitatory amino acid transporter 4 in oocytes, which is inhibited by the specific PI3K inhibitor wortmannin Xenopus laevis ? - ? 89 2.7.1.137 additional information PI3K is implicated in the phosphorylation of ERK and CaMKII in spinal neurons, and of NR2B subunits of the NMDA receptor, as well as in the increased synthesis of c-Fos and the trafficking of AMPA-R GluR1 subunit, all after formalin injection Rattus norvegicus ? - ? 89 2.7.1.137 additional information PI3K signaling, overview Mus musculus ? - ? 89 2.7.1.137 additional information PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, peptide N24. This interaction is critical for cell proliferation and cell cycle progression Homo sapiens ? - ? 89 2.7.1.137 additional information the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt Homo sapiens ? - ? 89 2.7.1.137 additional information the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt Canis lupus familiaris ? - ? 89 2.7.1.137 additional information Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy Homo sapiens ? - ? 89 2.7.1.137 additional information a p110alpha/beta-subunit binds to a p85 regulatory subunit, and this heterodimer is recruited to the membrane through the association with phosphotyrosyl proteins, leading to production of phosphatidylinositol 3,4,5-triphosphate, PIP3, followed by activation of downstream signal pathway(s) Rattus norvegicus ? - ? 89 2.7.1.137 additional information PI3-kinase activity is not required for starvation-induced Atg14 puncta formation Homo sapiens ? - ? 89 2.7.1.137 additional information PI3K binds PD1 peptide, a 12-residue proline-rich peptide HSKRPLPPLPSL, and PD1R peptide, at the SH3 domain with type I ligand orientation of the bound peptide with an extended conformation where the central portion forms a left-handed type II polyproline, PPII, helix. The residue at anchor position P-3 is a tyrosine Homo sapiens ? - ? 89 2.7.1.137 additional information the enzyme also catalyzes the reactions of EC 2.7.1.68, 1-phosphatidylinositol-4-phosphate 5-kinase, and EC 2.7.1.67, 1-phosphatidylinositol 4-kinase Homo sapiens ? - ? 89 2.7.1.137 additional information PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo Arabidopsis thaliana ? - ? 89 2.7.1.137 additional information wild-type Risk1 binds preferentially to PIs (i.e., phosphatidylinositol [PI], phosphatidylinositol 4-phosphate [PI(4)P], phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], and phosphatidylserine [PS]) over other lipids such as phosphatidylethanolamine (PE), phosphatidylcholine (PC), diacylglycerol (DAG), cholesterol, or sphingomyelin. Class III PI3Ks convert PI to phosphatidylinositol 3-phosphate [PI(3)P] Rickettsia typhi ? - - 89 2.7.1.137 additional information nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb Rattus norvegicus Sprague-Dawley ? - ? 89 2.7.1.137 additional information wild-type Risk1 binds preferentially to PIs (i.e., phosphatidylinositol [PI], phosphatidylinositol 4-phosphate [PI(4)P], phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], and phosphatidylserine [PS]) over other lipids such as phosphatidylethanolamine (PE), phosphatidylcholine (PC), diacylglycerol (DAG), cholesterol, or sphingomyelin. Class III PI3Ks convert PI to phosphatidylinositol 3-phosphate [PI(3)P] Rickettsia typhi ATCC VR-144 ? - - 89 2.7.1.137 additional information wild-type Risk1 binds preferentially to PIs (i.e., phosphatidylinositol [PI], phosphatidylinositol 4-phosphate [PI(4)P], phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], and phosphatidylserine [PS]) over other lipids such as phosphatidylethanolamine (PE), phosphatidylcholine (PC), diacylglycerol (DAG), cholesterol, or sphingomyelin. Class III PI3Ks convert PI to phosphatidylinositol 3-phosphate [PI(3)P] Rickettsia typhi Wilmington ? - - 89 2.7.1.137 additional information PI3K signaling, overview Mus musculus C57BL/6 ? - ? 89 2.7.1.137 additional information HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway Rattus norvegicus Wistar ? - ? 89 2.7.1.137 additional information class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity Homo sapiens PI3K-C2alpha ? - ? 89 2.7.1.137 phosphatidylinositol-4,5-bisphosphate + ATP involved in signalling pathways leading to mitosis and differentiation Rattus norvegicus ? - ? 370512