2.7.1.134 ATP + 1D-myo-inositol 1,4,6-trisphosphate - Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate - ? 459208 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Bos taurus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Hordeum vulgare ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Oryza sativa ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Commelina communis ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Oryza sativa Japonica Group ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate enzyme has both inositol-3,4,5,6-tetrakisphosphate 1-kinase and inositol-1,3,4-trisphosphate 5/6 kinase activity, 2 times higher activity than with inositol-1,3,4-trisphosphate, no activity with inositol-1,4-bisphosphate, inositol-1,4,5-trisphosphate, inositol-1,3,4,5-tetrakisphosphate, inositol-1,3,4,6-tetrakisphosphate or inositol-1,3,4,5,6-pentakisphosphate Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate no activity with D-myo-inositol 1,3,4,5-tetrakisphosphate Mus musculus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate no activity with D-myo-inositol 1,3,4,5-tetrakisphosphate Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate i.e. L-myo-inositol 1,4,5,6-tetrakisphosphate, phosphorylation site: L-3 or D-1 substitution position Mus musculus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate i.e. L-myo-inositol 1,4,5,6-tetrakisphosphate, phosphorylation site: L-3 or D-1 substitution position Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate enzyme has 1-kinase and 1-phosphatase activity as well as phosphomutase activity Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - r 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate no activity with inositol-1,3,4,5-tetrakisphosphate Glycine max ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate involved in synthesis of higher phosphorylated inositol phosphates Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate enzyme ITPK1 has robust enantiospecific hydroxykinase activity against Ins(3,4,5,6)P4 Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Rattus norvegicus Sprague-Dawley ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate involved in synthesis of higher phosphorylated inositol phosphates Rattus norvegicus Sprague-Dawley ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate - Arabidopsis thaliana Col-0 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate - ? 357223 2.7.1.134 ATP + 1D-myo-inositol 3,4,6-trisphosphate - Arabidopsis thaliana ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate - ? 459210 2.7.1.134 ATP + D-myo-inositol 1,3,4-triphosphate - Homo sapiens ? - ? 388018 2.7.1.134 ATP + myo-inositol-1,3,4,6-tetrakisphosphate - Homo sapiens ADP + myo-inositol-1,3,4,5-tetrakisphosphate - r 357228 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Bos taurus ADP + myo-inositol-1,3,4,6-tetrakisphosphate - ? 357224 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Glycine max ADP + myo-inositol-1,3,4,6-tetrakisphosphate minor product ? 357224 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate enzyme has both inositol-1,3,4-trisphosphate 5-kinase and inositol-1,3,4-trisphosphate 6-kinase activity Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate 5:1 ratio of inositol-tetrakis-1,3,4,6-phosphate and inositol-1,2,4,5-tetrakisphosphate ? 357224 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Bos taurus ADP + myo-inositol-1,3,4,5-tetrakisphosphate - ? 357225 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Homo sapiens ADP + myo-inositol-1,3,4,5-tetrakisphosphate - ? 357225 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Homo sapiens ADP + myo-inositol-1,3,4,5-tetrakisphosphate - r 357225 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Glycine max ADP + myo-inositol-1,3,4,5-tetrakisphosphate major product ir 357225 2.7.1.134 ATP + myo-inositol-1,3,4-trisphosphate - Glycine max ADP + myo-inositol-1,2,3,4-tetrakisphosphate minor product ? 357226 2.7.1.134 ATP + myo-inositol-3,4,6-trisphosphate - Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate - ? 357229 2.7.1.134 ATP + myo-inositol-3,4,6-trisphosphate - Homo sapiens ADP + myo-inositol-1,3,4,6-tetrakisphosphate - r 357229 2.7.1.134 additional information Ipk kinase plays a significant role in the inositol phosphate interacting network in plants Hordeum vulgare ? - ? 89 2.7.1.134 additional information Ipk kinase plays a significant role in the inositol phosphate interacting network in plants Oryza sativa ? - ? 89 2.7.1.134 additional information phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide. Intersubstrate phosphate transfer explains how competing substrates are able to stimulate each others’ catalysis by ITPK1 Homo sapiens ? - ? 89 2.7.1.134 additional information no detectable 2-kinase activity Hordeum vulgare ? - ? 89 2.7.1.134 additional information no detectable 2-kinase activity Oryza sativa ? - ? 89 2.7.1.134 additional information the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate Arabidopsis thaliana ? - ? 89 2.7.1.134 additional information substrate docking calculations, substrate specificity of Arabidopsis thaliana ITPK1, overview. Lack of Ins(1,4,5,6)P4/Ins(3,4,5,6) P4 product for Ins(1,4,6)P3 or Ins(3,4,6)P3 substrates. Consistent with the phosphorylation of the enantiomeric pair Ins(1,4,5,6)P4/Ins (3,4,5,6)P4, ITPK1 shows phosphorylation of Ins(1,4,6)P3 at the 3-position and Ins(3,4,6)P3 at the 1-position. ITPK1 has robust enantiospecific hydroxykinase activity against Ins(3,4,5,6)P4. With inositol tris/tetrakisphosphate kinase 1 (ITPK1, EC 2.7.1.134) and inositol pentakisphosphate 2-kinase (IPK1, EC 2.7.1.158) combined at a 1:20 ATP:ADP ratio, InsP6 is converted via Ins(1,3,4,5,6)P5 to Ins(3,4,5,6) P4 and/or Ins(1,4,5,6)P4 with concomitant generation of ATP Arabidopsis thaliana ? - - 89 2.7.1.134 additional information the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate Arabidopsis thaliana Col-0 ? - ? 89