2.6.1.B16	(S)-(-)-1-phenyl-ethylamine + 4-nitrobenzaldehyde	complete conversion at pH 8.0 and 37°C	Halomonas elongata	4-nitrobenzylamine + L-alanine	-	?	457412	
2.6.1.B16	(S)-(-)-1-phenyl-ethylamine + cinnamaldehyde	-	Halomonas elongata	cinnamylamine + L-alanine	-	?	457413	
2.6.1.B16	(S)-(-)-1-phenyl-ethylamine + vanillin	-	Halomonas elongata	vanillylamine + L-alanine	-	?	457414	
2.6.1.B16	(S)-1-phenylethylamine + 2-butanone	-	Bacillus anthracis	acetophenone + ?	-	r	457415	
2.6.1.B16	(S)-1-phenylethylamine + 2-heptanone	-	Bacillus anthracis	acetophenone + ?	-	r	457416	
2.6.1.B16	(S)-1-phenylethylamine + 2-oxoglutarate	-	Bacillus anthracis	acetophenone + L-glutamate	-	r	457417	
2.6.1.B16	(S)-1-phenylethylamine + 4-phenyl-2-butanone	-	Bacillus anthracis	acetophenone + ?	-	r	457419	
2.6.1.B16	(S)-1-phenylethylamine + beta-tetralone	-	Bacillus anthracis	acetophenone + ?	-	r	457420	
2.6.1.B16	(S)-1-phenylethylamine + cyclohexanone	-	Bacillus anthracis	acetophenone + ?	-	r	457421	
2.6.1.B16	(S)-1-phenylethylamine + cyclooctanone	-	Bacillus anthracis	acetophenone + ?	-	r	457422	
2.6.1.B16	(S)-1-phenylethylamine + methoxyacetone	-	Bacillus anthracis	acetophenone + ?	-	r	457423	
2.6.1.B16	(S)-1-phenylethylamine + methylpyruvate	-	Bacillus anthracis	acetophenone + methylalanine	-	r	457424	
2.6.1.B16	(S)-1-phenylethylamine + oxaloacetate	-	Bacillus anthracis	acetophenone + L-aspartate	-	r	457425	
2.6.1.B16	(S)-1-phenylethylamine + pyruvate	-	Chromobacterium violaceum	acetophenone + L-alanine	-	r	457044	
2.6.1.B16	(S)-1-phenylethylamine + pyruvate	-	Bacillus anthracis	acetophenone + L-alanine	-	r	457044	
2.6.1.B16	(S)-1-phenylethylamine + pyruvate	mechanism of the conversion of (S)-1-phenylethylamine to acetophenone, overview	Chromobacterium violaceum	acetophenone + L-alanine	-	r	457044	
2.6.1.B16	(S)-1-phenylethylamine + pyruvate	-	Halomonas elongata	L-alanine + acetophenone	-	r	457426	
2.6.1.B16	(S)-1-phenylethylamine + rac-2-methylcyclohexanone	-	Bacillus anthracis	acetophenone + ?	-	r	457427	
2.6.1.B16	(S)-alpha-methylbenzylamine + pyruvate	-	Albidovulum sp.	acetophenone + L-alanine	-	r	386907	
2.6.1.B16	(S)-alpha-methylbenzylamine + pyruvate	-	Albidovulum sp. SLM16	acetophenone + L-alanine	-	r	386907	
2.6.1.B16	2,2-dimethyl-1-phenylpropan-1-one + isopropylamine	the conversion by all active enzyme mutants lays between 22 and 71% with isopropylamine as amine donor, with enantiomeric excess above 99%, low activity	Ruegeria sp. TM1040	(R)-2,2-dimethyl-1-phenylpropan-1-amine + acetone	-	r	457501	
2.6.1.B16	2,2-dimethyl-1-phenylpropan-1-one + L-alanine	the conversion by all active enzyme mutants is complete with L-alanine as amine donor, with enantiomeric excess above 99%	Ruegeria sp. TM1040	(R)-2,2-dimethyl-1-phenylpropan-1-amine + pyruvate	-	r	457502	
2.6.1.B16	2-nitroacetophenone + L-alanine	-	Halomonas elongata	2-nitro-(S)-1-phenylethylamine + pyruvate	-	r	457557	
2.6.1.B16	2-phenylpropionaldehyde + (S)-1-phenylethylamine	67% conversion of 2-phenylpropionaldehyde	Halomonas elongata	2-phenylpropylamine + acetophenone	-	?	436806	
2.6.1.B16	2-phenylpropionaldehyde + (S)-1-phenylethylamine	67% conversion of 2-phenylpropionaldehyde	Halomonas elongata DSM 2581	2-phenylpropylamine + acetophenone	-	?	436806	
2.6.1.B16	3-nitroacetophenone + L-alanine	-	Halomonas elongata	3-nitro-(S)-1-phenylethylamine + pyruvate	-	r	457616	
2.6.1.B16	4-nitroacetophenone + L-alanine	-	Halomonas elongata	4-nitro-(S)-1-phenylethylamine + pyruvate	-	r	457634	
2.6.1.B16	benzaldehyde + ortho-xylylenediamine	95% conversion of benzaldehyde	Halomonas elongata	benzylamine + ?	conversion rate 90-95%	?	437205	
2.6.1.B16	benzaldehyde + ortho-xylylenediamine	95% conversion of benzaldehyde	Halomonas elongata DSM 2581	benzylamine + ?	conversion rate 90-95%	?	437205	
2.6.1.B16	beta-alanine + pyruvate	high activity	Bacillus anthracis	4-hydroxybutyrate + L-alanine	-	r	457826	
2.6.1.B16	cinnamaldehyde + (S)-1-phenylethylamine	56% conversion of cinnamaldehyde	Halomonas elongata	(2E)-3-phenylprop-2-en-1-amine + acetophenone	-	?	437281	
2.6.1.B16	cinnamaldehyde + (S)-1-phenylethylamine	56% conversion of cinnamaldehyde	Halomonas elongata DSM 2581	(2E)-3-phenylprop-2-en-1-amine + acetophenone	-	?	437281	
2.6.1.B16	isopropylamine + 4-phenylbutan-2-one	high activity, two half reaction steps, overview	uncultured bacterium	acetone + (S)-4-phenyl-2-butanamine	-	r	458055	
2.6.1.B16	L-alanine + glyoxylate	41% conversion of alanine, 97% conversion of glyoxylate	Halomonas elongata	pyruvate + glycine	-	?	353466	
2.6.1.B16	L-alanine + glyoxylate	41% conversion of alanine, 97% conversion of glyoxylate	Halomonas elongata DSM 2581	pyruvate + glycine	-	?	353466	
2.6.1.B16	additional information	application of the amine transaminase (ATA) for stereoselective amination of prochiral ketones represents an environmentally benign and economically attractive alternative to transition metal catalyzed asymmetric synthesis, overview	Chromobacterium violaceum	?	-	-	89	
2.6.1.B16	additional information	engineered ATAs perform asymmetric synthesis of the respective R-amine with high conversions by using either alanine or isopropylamine as amine donor. Asymmetric synthesis of (R)-2,2-dimethyl-1-phenylpropan-1-amine by amino group transfer to 2,2-dimethyl-1-phenylpropan-1-one catalyzed by ATAs. Isopropylamine or alanine serve as the amine donors. Analysis of specific activities of Rsp-ATA mutant variants towards rac-amine 2,2-dimethyl-1-phenylpropan-1-amine. Enzyme-ligand interaction analysis, overview	Ruegeria sp. TM1040	?	-	-	89	
2.6.1.B16	additional information	substrate specificity of Ban-TA, overview. Even though enzyme Ban-TA shows a relatively narrow amine substrate scope within the tested substrates, it accepts 2-propylamine, which is a prerequisite for industrial asymmetric amine synthesis. Structural information imply that the so-called dual substrate recognition of chemically different substrates (i.e. amines and amino acids) differs from that in formerly known enzymes. It lacks the normally conserved flipping arginine, which enables dual substrate recognition by its side chain flexibility in other omega-amino acid:pyruvate transaminases. Molecular dynamics studies suggest that another arginine (R162) binds omega-amino acids in Ban-TA, but no side chain movements are required for amine and amino acid binding	Bacillus anthracis	?	-	-	89	
2.6.1.B16	additional information	substrate specificity of wild-type and mutant enzymes, overview. No activity of mutant F84G with (S)-1-phenylethylamine. Analysis of activity of the enzymes with ortho-, meta-, and para-substituted derivatives of fluoroacetophenone, trifluoroacetophenone, methoxyacetophenone, methylacetophenone, nitrobenzaldehyde, fluorobenzaldehyde, trifluorobenzaldehyde, methoxybenzaldehyde, methylbenzaldehyde, and of benzaldehyde, docking study	Halomonas elongata	?	-	-	89	
2.6.1.B16	additional information	the enzyme has a clear preference for (S)-(+)-alpha-methylbenzylamine and (S)-(+)-1-methyl-3-phenylpropylamine, having the highest activity toward the former (100% relative activity). The enzyme also shows moderate activity toward aliphatic amino substrates isopropylamine and (S)-(+)-sec-butylamine, with approximately 20% and 40% of relative activity, respectively. The lowest activities (below 10% relative activity) are found when (S)-(+)-1,2,3,4-tetrahydro-1-naphtylamine and (S)-1-phenylbutylamine are used as amino donors	Albidovulum sp.	?	-	-	89	
2.6.1.B16	additional information	vanillylamine is a valuable building block for the synthesis of natural products, such as capsaicinoids	Halomonas elongata	?	-	-	89	
2.6.1.B16	additional information	the enzyme has a clear preference for (S)-(+)-alpha-methylbenzylamine and (S)-(+)-1-methyl-3-phenylpropylamine, having the highest activity toward the former (100% relative activity). The enzyme also shows moderate activity toward aliphatic amino substrates isopropylamine and (S)-(+)-sec-butylamine, with approximately 20% and 40% of relative activity, respectively. The lowest activities (below 10% relative activity) are found when (S)-(+)-1,2,3,4-tetrahydro-1-naphtylamine and (S)-1-phenylbutylamine are used as amino donors	Albidovulum sp. SLM16	?	-	-	89	
2.6.1.B16	propanal + (S)-1-phenylethylamine	55% conversion of propanal	Halomonas elongata	propylamine + acetophenone	-	?	437838	
2.6.1.B16	pyruvate + (S)-1-phenylethylamine	-	Albidovulum sp.	L-alanine + acetophenone	-	?	437857	
2.6.1.B16	pyruvate + (S)-1-phenylethylamine	97% conversion of (S)-1-phenylethylamine, less than 5% conversion of (R)-1-phenylethylamine	Halomonas elongata	L-alanine + acetophenone	-	?	437857	
2.6.1.B16	pyruvate + (S)-1-phenylethylamine	-	Albidovulum sp. SLM16	L-alanine + acetophenone	-	?	437857	
2.6.1.B16	pyruvate + benzylamine	64% conversion of isopropylamine	Halomonas elongata	L-alanine + benzaldehyde	-	?	437858	
2.6.1.B16	pyruvate + glycine	97% conversion of pyruvate	Halomonas elongata	L-alanine + glyoxylate	-	?	353482	
2.6.1.B16	pyruvate + glycine	97% conversion of pyruvate	Halomonas elongata DSM 2581	L-alanine + glyoxylate	-	?	353482	
2.6.1.B16	pyruvate + isopropylamine	41% conversion of isopropylamine	Halomonas elongata	L-alanine + acetone	-	?	437859	
2.6.1.B16	pyruvate + L-serine	19% conversion of serine	Halomonas elongata	L-alanine + 3-hydroxy-2-oxopropanoate	-	?	437860	
2.6.1.B16	rac-2,2-dimethyl-1-phenylpropan-1-amine + pyruvate	-	Ruegeria sp. TM1040	2,2-dimethyl-1-phenylpropan-1-one + L-alanine	-	r	458196