2.4.1.41 2 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1a sequence APPAHGVTSAPDTRPAPGC Biomphalaria glabrata 2 UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1a - ? 436114 2.4.1.41 2 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1a' sequence AHGVTSAPDTR Biomphalaria glabrata 2 UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1a' - ? 436113 2.4.1.41 5 UDP-N-acetyl-alpha-D-galactosamine + beta1-adrenergic receptor - Homo sapiens 5 UDP + (N-acetyl-alpha-D-galactosaminyl)5-beta1-adrenergic receptor - ? 455073 2.4.1.41 5 UDP-N-acetyl-D-galactosamine + DSTTPAPTTK mucin derived substrate Homo sapiens 5 UDP + N-acetyl-D-galactosaminylated DSTTPAPTTK - ? 398525 2.4.1.41 5 UDP-N-acetyl-D-galactosamine + DSTTPAPTTK mucin derived substrate, acceptor substrate Homo sapiens 5 UDP + N-acetyl-D-galactosaminylated DSTTPAPTTK - ? 398525 2.4.1.41 additional information - Mus musculus ? - ? 89 2.4.1.41 additional information GalNAc-T7: no activity with non-glycosylated peptides and GalNAc-glycosylated Muc1 substrate Homo sapiens ? - ? 89 2.4.1.41 additional information not: lacto-N-fucopentaose I, ceramide dihexosides, ceramide trihexosides, globoside Rattus norvegicus ? - ? 89 2.4.1.41 additional information contains a lectin-like repeat sequence at the C-terminus, role of GalNAc-T1 lectin domain, which is involved in glycosylation of substrates with multiple acceptor sites Rattus norvegicus ? - ? 89 2.4.1.41 additional information different substrate specificities before and after Muc2 affinity chromatography of enzyme Homo sapiens ? - ? 89 2.4.1.41 additional information different substrate specificities before and after Muc2 affinity chromatography of enzyme Sus scrofa ? - ? 89 2.4.1.41 additional information different substrate specificities before and after Muc2 affinity chromatography of enzyme Ovis sp. ? - ? 89 2.4.1.41 additional information 519-amino acid putative catalytic region Drosophila melanogaster ? - ? 89 2.4.1.41 additional information multiple enzyme isoforms Mus musculus ? - ? 89 2.4.1.41 additional information multiple enzyme isoforms Homo sapiens ? - ? 89 2.4.1.41 additional information multiple enzyme isoforms Rattus norvegicus ? - ? 89 2.4.1.41 additional information not: UDP-glucuronate, UDP-xylose, GDP-mannose, GDP-fucose, intact mucins, desialylated mucins, glycolipid acceptors, including globoside and ceramide hexosides, no transfer of GalNAc to terminal sugar residues in oligosaccharide chains Sus scrofa ? - ? 89 2.4.1.41 additional information 14 distinct isoforms different with regard to their expression and specificity, but overlaps also occur, ppGalNAc-T14 forms together with ppGalNAc-T2 a subfamily of ppGalNAc-T gene family Homo sapiens ? - ? 89 2.4.1.41 additional information ppGaNTase-T6: no activity with unglycosylated peptides Rattus norvegicus ? - ? 89 2.4.1.41 additional information all known rGalNAc-Ts are characterized by a putative lectin domain in their C-terminal regions Homo sapiens ? - ? 89 2.4.1.41 additional information 9 isoforms, ppGaNTase-T9 contains a 480-amino acid conserved region and shows no activity with non-glycosylated peptides Rattus norvegicus ? - ? 89 2.4.1.41 additional information not: UDP-Glc Bos taurus ? - ? 89 2.4.1.41 additional information not: bovine cytochrome c Bos taurus ? - ? 89 2.4.1.41 additional information GalNAc-T9 contains a 485-amino acid putative catalytic region, GalNAc-T1, -T2, -T4 and -T8 belongs to the housekeeping enzymes with ubiquitous expression, GalNAc-T3, -T5, -T6, -T7 and -T9 belongs to the tissue-specific enzymes Homo sapiens ? - ? 89 2.4.1.41 additional information existence of multiple enzyme activities, differentially expressed in different organs, at least 2 distinct enzyme specificities Homo sapiens ? - ? 89 2.4.1.41 additional information existence of multiple enzyme activities, differentially expressed in different organs, at least 2 distinct enzyme specificities Rattus norvegicus ? - ? 89 2.4.1.41 additional information enzyme structure, GT1 motif, DXD motif, Gal/GalNAc-T motif Mus musculus ? - ? 89 2.4.1.41 additional information at least 11 human ppGalNAc-Ts Homo sapiens ? - ? 89 2.4.1.41 additional information not: UDP-GlcNAc Homo sapiens ? - ? 89 2.4.1.41 additional information not: UDP-GlcNAc Sus scrofa ? - ? 89 2.4.1.41 additional information not: UDP-GlcNAc Bos taurus ? - ? 89 2.4.1.41 additional information not: UDP-Gal Sus scrofa ? - ? 89 2.4.1.41 additional information not: UDP-Gal Bos taurus ? - ? 89 2.4.1.41 additional information not: alphaS1-casein, alphaS2-casein, beta-casein, alpha-lactalbumin, beta-lactoglobulin, bovine serum albumin Bos taurus ? - ? 89 2.4.1.41 additional information amino acid sequences of seven GalNAc-transferases Homo sapiens ? - ? 89 2.4.1.41 additional information involved in development, necessary for viability Drosophila melanogaster ? - ? 89 2.4.1.41 additional information pp-GalNAc-T13 is specifically expressed in neurons and synthesizes Tn antigen Homo sapiens ? - ? 89 2.4.1.41 additional information MUC1-2GalNAc, MUC2-6GalNAc, OSM fragments, hCG-beta are not substrates for GalNAc-T11 Homo sapiens ? - ? 89 2.4.1.41 additional information MUC1b' and hCG-beta are no substrates for GalNAc-T1 Homo sapiens ? - ? 89 2.4.1.41 additional information UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase catalyzes the first step in the mucin-type O-glycan biosynthesis pathway by transferring GalNAc to Ser or Thr residues in a protein from the sugar donor UDP-GalNAc Mus musculus ? - ? 89 2.4.1.41 additional information UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases transfer GalNAc from UDP-GalNAc to the Ser and Thr residues of polypeptide acceptors, and initiate and regulate mucin-type O-glycosylation Homo sapiens ? - ? 89 2.4.1.41 additional information UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases transfer GalNAc from UDP-GalNAc to the Ser and Thr residues of polypeptide acceptors, and initiate and regulate mucin-type O-glycosylation Bos taurus ? - ? 89 2.4.1.41 additional information most active with partially glycosylated MUC5AC (by a combination of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 and UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2) Homo sapiens ? - ? 89 2.4.1.41 additional information no activity observed with substrate peptides of other UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases Homo sapiens ? - ? 89 2.4.1.41 additional information no activity toward classical substrates Homo sapiens ? - ? 89 2.4.1.41 additional information no activity with 2'-deoxy-alpha-D-galactosamine or 2'-oxymethyl-alpha-D-galactosamine Homo sapiens ? - ? 89 2.4.1.41 additional information almost no activity with polypeptides biotin-EA2-7, biotin-MUC5AC, and no activity with polypeptide MUC5AC-biotin Cryptosporidium parvum ? - ? 89 2.4.1.41 additional information almost no activity with polypeptides biotin-EA2-7, biotin-MUC5AC, and no activity with polypeptide MUC5AC-biotin Cryptosporidium hominis ? - ? 89 2.4.1.41 additional information almost no activity with polypeptides biotin-EA2-7, biotin-MUC5AC, and no activity with polypeptide MUC5AC-biotin Cryptosporidium muris ? - ? 89 2.4.1.41 additional information no activity with UDP-alpha-D-galactose, UDP-N-acetyl-alpha-D-glucoamine, GDP-fucose, UDP-xylose, UDP-glucuronic acid and CMP-neuraminic acid Biomphalaria glabrata ? - ? 89 2.4.1.41 additional information enzyme exhibits a strong preference for UDP-GalNAc over other nucleotide sugar donors, with no activity against UDP-Gal, and 40% activity of that seen toward UDP-GalNAc toward UDP-GlcNAc Cryptosporidium parvum ? - - 89 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Ac-Asn-Leu-Thr-Pro-Pro-Pro - Bos taurus ? - ? 452102 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Ac-Pro-Thr-Thr-Thr - Bos taurus ? - ? 452100 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Ac-Pro-Thr-Thr-Thr-Pro-Ile-Ser-Thr-NH2 - Bos taurus ? - ? 452101 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Ac-Thr-Pro-Pro-Pro - Bos taurus ? - ? 452103 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Arg-Thr-Pro-Pro-Pro - Bos taurus ? - ? 452104 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Asp-Ala-Ala-Ser-Ala-Ala-Pro-Leu - Sus scrofa ? - ? 452109 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + deglycosylated human trachea mucin - Sus scrofa ? - ? 452125 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + deglycosylated swine trachea mucin - Sus scrofa ? - ? 452126 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + EA2 peptide - Drosophila melanogaster ? - ? 452117 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Gln-Ala-Ala-Gly-Thr-Ser-Gly-Ala-Gly-Pro-Gly - Sus scrofa ? - ? 452110 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Gly-Val-Val-Pro-Thr-Val-Val-Pro-Gly - Rattus norvegicus ? - ? 452118 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + human mucin Muc2 peptide - Homo sapiens ? - ? 452116 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Muc7 peptide - Homo sapiens ? - ? 452120 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Ala-Ser-Thr-Ser-Ala-Pro-Gly - Bos taurus ? - ? 452108 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Asp-Ala-Ala-Ser-Ala-Ala-Pro-Leu-Arg - Sus scrofa ? - ? 452111 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Asp-Ala-Ala-Ser-Ala-Ala-Pro-Leu-Arg - Bos taurus ? - ? 452111 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Asp-Ala-Ala-Thr-Ala-Ala-Pro-Leu - Rattus norvegicus ? - ? 452119 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Asp-Ala-Ser-Ser-Ser-Ala-Pro-Leu-Arg - Sus scrofa ? - ? 452112 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Asp-Val-Val-Ser-Val-Val-Pro-Leu-Arg - Sus scrofa ? - ? 452113 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Pro-Thr-Ala-Pro-Pro-Pro - Bos taurus ? - ? 452105 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + SDC106 peptide - Homo sapiens ? - ? 452121 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + SDC155 peptide - Homo sapiens ? - ? 452122 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + SDC165 peptide - Homo sapiens ? - ? 452123 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + SDC284 peptide - Homo sapiens ? - ? 452124 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Val-Leu-Gly-Ala-Thr-Ala-Val - Sus scrofa ? - ? 452114 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Val-Leu-Gly-Thr-Ala-Ala-Val - Sus scrofa ? - ? 452115 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Val-Leu-Gly-Thr-Thr-Ala-Val - Sus scrofa ? - ? 452106 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Val-Lys-Thr-Glu-Ala-Thr-Thr-Phe-Ile - Sus scrofa ? - ? 452107 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro - Sus scrofa ? - ? 452099 2.4.1.41 erythropoietin T + UDP-Gal - Homo sapiens erythropoietin T-nGalNAc + UDP - ? 397121 2.4.1.41 erythropoietin T + UDP-Gal also catalysed by mutants GalTNAc-T2-D458H and GalTNAc-T2-D541A Homo sapiens erythropoietin T-nGalNAc + UDP - ? 397121 2.4.1.41 UDP-GalNAc + GAGA(X)3T(X)3AGAGK - Drosophila melanogaster GAGA(X)3(GalNAc)T(X)3AGAGK + UDP - ? 398490 2.4.1.41 UDP-GalNAc + GAGA(X)5T(X)5AGAGK transferase activity relatively insensitive to the nature of amino acids 4 and 5 residues away from site of glycosylation, high correlation between peptide preferences of PGANT5 and mammalian orthologue ppGalNAc T1 with r(square) = 0.67, the hydrophobic residue proline is preferred at the -1, +1, and +3 positions, the hydrophobic residues valine and tyrosin are moderately preferred at the -1 and +3 positions, the hydrophobic residue methionine is disfavoured at the -1 position, low hydrophilic preference at the -1 position, strong glutamate/aspartate preference at the +1 position, higher preference of glutamate at +1 and +2 positions than mammalian orthologue ppGalNAc T1 Drosophila melanogaster GAGA(X)5(GalNAc)T(X)5AGAGK + UDP - ? 398492 2.4.1.41 UDP-GalNAc + GAGA(X)5T(X)5AGAGK transferase activity relatively insensitive to the nature of amino acids 4 and 5 residues away from site of glycosylation, very high correlation between peptide preferences of PGANT2 and mammalian orthologue ppGalNAc T2 with r(square) = 0.92 Drosophila melanogaster GAGA(X)5(GalNAc)T(X)5AGAGK + UDP - ? 398492 2.4.1.41 UDP-GalNAc + GAGA(X)nT(X)nAGAGK library of unmodified peptides, with randomized residue at position X and n=3 or n=5 Drosophila melanogaster GAGA(X)n(GalNAc)T(X)nAGAGK + UDP - ? 398494 2.4.1.41 UDP-GalNAc + GAGA(X)nT(X)nAGAGK library of unmodified peptides, with randomized residue at position X and n=3 or n=5, random peptide preferences are not significantly altered by increased peptide substrate length n=5 compared to n=3 or the proximity of flanking Gly and Ala residues to the site of glycosylation, major peptide substrate preference determinants are the 2 to 3 residues flanking the site of glycosylation Bos taurus GAGA(X)n(GalNAc)T(X)nAGAGK + UDP - ? 398494 2.4.1.41 UDP-GalNAc + GAGA(X)nT(X)nAGAGK library of unmodified peptides, with randomized residue at position X and n=3 or n=5, random peptide preferences are not significantly altered by increased peptide substrate length n=5 compared to n=3 or the proximity of flanking Gly and Ala residues to the site of glycosylation, major peptide substrate preference determinants are the 2 to 3 residues flanking the site of glycosylation Homo sapiens GAGA(X)n(GalNAc)T(X)nAGAGK + UDP - ? 398494 2.4.1.41 UDP-alpha-GalNAc + polypeptide - Drosophila melanogaster GalNAc-alpha-polypeptide + UDP major mucin-type O-glycan in embryonic tracheal system along the apical region and luman of the tracheal tubes O-glycan, detectable by lectins Jacalin, soybean agglutinin and Vicia villosa agglutinin ? 397215 2.4.1.41 UDP-GalNAc + polypeptide - Xenopus laevis GalNAc-alpha-polypeptide + UDP glycosylation at Thr or Ser ? 398498 2.4.1.41 UDP-GalNAc + EA2 - Mus musculus GalNAc-EA2 + UDP - ? 398489 2.4.1.41 UDP-GalNAc + EA2 ternary complex of ppGalNAcT-2 in crystal structure PDB: 2FFU, UDP-GalNAc binding results in the closed confirmation of loop B which stabilises loop A by binding of loop A (N102) to loop B (R362), EA2 peptide binds in an extended confirmation Homo sapiens GalNAc-EA2 + UDP binary complex of UDP and ppGalNAcT-2 in crystal structure PDB: 2FFV ? 398489 2.4.1.41 MUC5AC glycopeptides + UDP-GalNAc hT2: site preference of glycosylation depends on location of pre-existing GalNAc and is mediated by its lectin domain which directs glycosylation 10 residues N- or C-terminal to an extant GalNAc residue and aids site selection only when potential site is N-terminal to an extant GalNAc residue not C-terminal, Thr-9 is no preferred site of glycosylation, hT10: must recognize existing GalNAc residues via its catalytic domain which directs selection to the glycosylation site immediately N-terminal to the present GalNAc, Homo sapiens GalNAc-MUC5AC + UDP - ? 397794 2.4.1.41 UDP-GalNAc + PRFODSSSKAPPPLPSPSRLPG - Mus musculus GalNAc-PRFODSSSKAPPPLPSPSRLPG + UDP - ? 398500 2.4.1.41 UDP-GalNAc + selectin - Mus musculus GalNAc-selectin + UDP reduced expression of cell surface E- and P-selectins (fourfold and fivefold) and L-selectins on immune cells of ppGalNAcT-1 deficient mice ? 398501 2.4.1.41 MUC5AC-3,13 + UDP-GalNAc hT2, not catalysed by hT2CD and hT2CD-hT10LD Homo sapiens GalNAc-Ser-5-MUC5AC-3,13 + UDP preferred site by hT2 ? 397801 2.4.1.41 MUC5AC-13 + UDP-GalNAc hT10, hT10CD, hT10CD-hT2LD Homo sapiens GalNAc-Thr12-MUC5AC-13 + UDP - ? 397795 2.4.1.41 MUC5AC-3 + UDP-GalNAc hT2: no initial burst phase during catalysis, substrate binding through its catalytic domain, hT10: transfer of only single GalNAc residues Homo sapiens GalNAc-Thr13-MUC5AC-3 + UDP hT2: preferred site for glycosylation, mediated by enhanced product release through lectin domain, hT10: predominant product ? 397798 2.4.1.41 MUC5AC-3,13 + UDP-GalNAc hT10, hT10CD, hT10CD-hT2LD Homo sapiens GalNAc-Thr2,12-MUC5AC-3,13 + UDP - ? 397802 2.4.1.41 MUC5AC-3 + UDP-GalNAc hT10CD, hT10CD-hT2LD, hT10: catalysis faster than for MUCAC-9 Homo sapiens GalNAc-Thr2-MUC5AC + UDP - ? 397799 2.4.1.41 MUC5AC-9 + UDP-GalNAc not catalysed by hT10CD and hT10CD-hT2LD, hT10: catalysis slower than for MUC5AC-3 Homo sapiens GalNAc-Thr2-MUC5AC-9 + UDP preferred site of glycosylation by hT10 ? 397803 2.4.1.41 MUC5AC-13 + UDP-GalNAc hT2: substrate binding through its catalytic domain, hT10: transfer of only single GalNAc residues Homo sapiens GalNAc-Thr3-MUC5AC-13 + UDP predominant product of hT2 and hT10 ? 397796 2.4.1.41 MUC5AC + UDP-GalNAc hT2CD, hT2: glycosylation site selection driven by and substrate binding through its catalytic domain, hT10: not catalysed by hT10 because hT10 does not recognize naked peptides Homo sapiens GalNAc-Thr9-MUC5AC + UDP preferred site for glycosylation by hT2 and hT2CD compared to Thr-3, Thr-10 and Thr-13 ? 397793 2.4.1.41 MUC5AC-13 + UDP-GalNAc hT2, hT2CD: no initial burst phase during catalysis Homo sapiens GalNAc-Thr9-MUC5AC-13 + UDP not preferred by hT2, preferred by hT2CD ? 397797 2.4.1.41 MUC5AC-3 + UDP-GalNAc hT2, hT2CD Homo sapiens GalNAc-Thr9-MUC5AC-3 + UDP not preferred by hT2, hT2CD: preferred site for glycosylation, lack of lectin domain in hT2CD results in rate-limiting product release ? 397800 2.4.1.41 hCG-beta + UDP-Gal - Homo sapiens hCG-beta-nGalNAc + UDP - ? 397408 2.4.1.41 IgA hinge + UDP-Gal - Homo sapiens IgA hinge-nGal + UDP - ? 397455 2.4.1.41 IgA hinge + UDP-GalNAc - Homo sapiens IgA hinge-nGalNAc + UDP - ? 397454 2.4.1.41 IgA hinge + UDP-GalNAc GalTNAc-T11 incorporates only two GalNAc residues into IgA hinge peptide Homo sapiens IgA hinge-nGalNAc + UDP - ? 397454 2.4.1.41 IgA hinge + UDP-GalNAc mutant GalNAc-T2-D458H incorporates 1-2 fewer GalNAc residues than wild-type Homo sapiens IgA hinge-nGalNAc + UDP - ? 397454 2.4.1.41 IgA hinge-4GalNAc + UDP-GalNAc - Homo sapiens IgA hinge-nGalNAc + UDP - ? 397456 2.4.1.41 MUC1 + UDP-GalNAc - Homo sapiens MUC1-nGalNAc + UDP - ? 397787 2.4.1.41 MUC1 + UDP-GalNAc GalNAc-T4 lectin domain does not exhibit selective specificities for peptide sequences, or the density or pattern of GalNAc glycosylation, GalNAc-T4 lectin domain mediates GalNAc-glycopeptide substrate specificity Homo sapiens MUC1-nGalNAc + UDP - ? 397787 2.4.1.41 MUC1 + UDP-GalNAc mutant GalNAc-T2-D458H incorporates 1-2 fewer GalNAc residues than wild-type, GalNAc-T2 lectin domain does not exhibit selective specificities for peptide sequences, or the density or pattern of GalNAc glycosylation Homo sapiens MUC1-nGalNAc + UDP - ? 397787 2.4.1.41 MUC1-2GalNAc + UDP-GalNAc - Homo sapiens MUC1-nGalNAc + UDP - ? 397788 2.4.1.41 MUC1a' + UDP-GalNAc - Homo sapiens MUC1a'-nGalNAc + UDP - ? 397789 2.4.1.41 MUC1b' + UDP-GalNAc - Homo sapiens MUC1b'-nGalNAc + UDP - ? 397790 2.4.1.41 MUC2 + UDP-GalNAc - Homo sapiens MUC2-nGalNAc + UDP - ? 397791 2.4.1.41 MUC2-6GalNAc + UDP-GalNAc - Homo sapiens MUC2-nGalNAc + UDP - ? 397792 2.4.1.41 MUC7 + UDP-GalNAc - Homo sapiens MUC7-nGalNAc + UDP - ? 397804 2.4.1.41 OSM fragment + UDP-Gal - Homo sapiens OSM fragment-nGalNAc + UDP - ? 398021 2.4.1.41 UDP-GalNAc + HGVTSAPDTRPAPGSTAPPA - Homo sapiens UDP + ? - ? 421650 2.4.1.41 UDP-GalNAc + PTTTPISTTTMVTPTPTPTC - Homo sapiens UDP + ? - ? 421651 2.4.1.41 UDP-GalNAc + VLTTTATTPTA - Homo sapiens UDP + ? - ? 421652 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + (glycosylated GTTPSPVPTTSTTSAP) natural-type (alpha-GalNAc-O-Thr) and unnatural-type (beta-GalNAc-O-Thr, alpha-Fuc-O-Thr and beta-GlcNAc-O-Thr) glycosylated Homo sapiens UDP + ? - ? 421654 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Ac-CIRIQRGPGRAFVTIGKIGNMR - Homo sapiens UDP + ? - ? 421655 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM - Homo sapiens UDP + ? - ? 421656 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + AHGVTSAPDTR - Homo sapiens UDP + ? - ? 421657 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GAGAEAPTPAPAGAGK - Homo sapiens UDP + ? - ? 421658 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTAKPTTLKPTE - Homo sapiens UDP + ? - ? 421659 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP - Homo sapiens UDP + ? - ? 421660 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP - Homo sapiens UDP + ? - ? 421664 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP - Homo sapiens UDP + ? - ? 421667 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + PDTRPAPGSTAPPAC - Homo sapiens UDP + ? - ? 421671 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + PSTPPTPSPSTPPTPSPS - Homo sapiens UDP + ? - ? 421672 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + PTTDSTTPAPTTK - Homo sapiens UDP + ? - ? 421673 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + SPTTSTPISSTPQPTS - Homo sapiens UDP + ? - ? 421674 2.4.1.41 UDP-N-acetyl-D-galactosamine + AHGVVTSAPDTR i.e. Muc1, 3% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ? - ? 378178 2.4.1.41 UDP-N-acetyl-D-galactosamine + AHGVVTSAPDTR i.e. Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ? - ? 378178 2.4.1.41 UDP-N-acetyl-D-galactosamine + ANTPSFPTATSPAPPI i.e. Muc13, about 25% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ? - ? 378180 2.4.1.41 UDP-N-acetyl-D-galactosamine + ANTPSFPTATSPAPPI i.e. Muc13, about 50% of the activity with Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ? - ? 378180 2.4.1.41 UDP-N-acetyl-D-galactosamine + AWIPTPPPIPG - Drosophila sp. (in: flies) UDP + ? - ? 378181 2.4.1.41 UDP-N-acetyl-D-galactosamine + deglycosylated ovine submaxillary mucin - Echinococcus granulosus UDP + ? - ? 378182 2.4.1.41 UDP-N-acetyl-D-galactosamine + GAGPGTXASSVGVTGAPGSG low activity Sus scrofa UDP + ? - ? 378185 2.4.1.41 UDP-N-acetyl-D-galactosamine + GKPRPYSPRPTSHPRPIRV i.e. drosocin, low activity, enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378198 2.4.1.41 UDP-N-acetyl-D-galactosamine + GSPAGDVGAPAVDSGASQAAG low activity Sus scrofa UDP + ? - ? 378199 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTG - Drosophila sp. (in: flies) UDP + ? - ? 378200 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTS-(O-GalNAc)T-SAP - Rattus norvegicus UDP + ? - ? 378201 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTS-(O-GalNAc)T-SAP - Toxoplasma gondii UDP + ? - ? 378201 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTS-(O-GalNAc)T-SAP 23% of the activity with P-(O-GalNAc)T-TDSTTPAPTTK Mus musculus UDP + ? - ? 378201 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAk i.e. Muc5AC, about 55% of the activity with Muc1a, pp-GalNAc-T15 shows significantly less catalytic activity than pp-GalNAc-T2,T15 transferrs up to seven GalNAcs to the Muc5AC peptide, while T2 transferrs up to five GalNAcs, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ? - ? 378202 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAk i.e. Muc5AC, pp-GalNAc-T15 shows significantly less catalytic activity than pp-GalNAc-T2,T15 transferrs up to seven GalNAcs to the Muc5AC peptide, while T2 transferrs up to five GalNAcs Homo sapiens UDP + ? - ? 378202 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP 0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP Toxoplasma gondii UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP 73% of the activity with P-(O-GalNAc)T-TDSTTPAPTTK Mus musculus UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP i.e. MUC5AC Drosophila melanogaster UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP i.e. MUC5AC, enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP i.e. MUC5AC, low activity enzyme form PGANT6 Drosophila melanogaster UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP i.e. MUC5AC, low activity, enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAP i.e. MUC5AC, very low activity, enzyme form PGANT3 Drosophila melanogaster UDP + ? - ? 378203 2.4.1.41 UDP-N-acetyl-D-galactosamine + HGVTSAPDTRP i.e. Muc1 Echinococcus granulosus UDP + ? - ? 378204 2.4.1.41 UDP-N-acetyl-D-galactosamine + HGVTSAPDTRP i.e. Muc1 Fasciola hepatica UDP + ? - ? 378204 2.4.1.41 UDP-N-acetyl-D-galactosamine + HGVTSAPDTRP i.e. Muc1 Toxocara canis UDP + ? - ? 378204 2.4.1.41 UDP-N-acetyl-D-galactosamine + ITTTTTPLPTG - Drosophila sp. (in: flies) UDP + ? - ? 378205 2.4.1.41 UDP-N-acetyl-D-galactosamine + LGEPLGLAPSSSP low activity Sus scrofa UDP + ? - ? 378206 2.4.1.41 UDP-N-acetyl-D-galactosamine + LPPVTTTPAPG - Drosophila sp. (in: flies) UDP + ? - ? 378207 2.4.1.41 UDP-N-acetyl-D-galactosamine + MPTAGTPPPIG - Drosophila sp. (in: flies) UDP + ? - ? 378208 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC4AC-13 enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378209 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 enzyme form PGANT6 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 enzyme form PGANT7 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 high activity, enzyme form PGANT5 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 PGANT1 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3 very low activity, enzyme form PGANT3 Drosophila melanogaster UDP + ? - ? 378211 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13 enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378210 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13 high activity, enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378210 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13 high activity, enzyme form PGANT5 Drosophila melanogaster UDP + ? - ? 378210 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13 high activity, enzyme form PGANT7 Drosophila melanogaster UDP + ? - ? 378210 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13 low activity, enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378210 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AC-3/13 preferred substrate, enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378210 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13 enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378212 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13 enzyme form PGANT6 Drosophila melanogaster UDP + ? - ? 378212 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13 enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378212 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13 high activity, enzyme form PGANT5 Drosophila melanogaster UDP + ? - ? 378212 2.4.1.41 UDP-N-acetyl-D-galactosamine + mucin MUC5AX-13 low activity, enzyme form PGANT7 Drosophila melanogaster UDP + ? - ? 378212 2.4.1.41 UDP-N-acetyl-D-galactosamine + P-(O-GalNAc)T-TDSTTPAPTTK - Mus musculus UDP + ? - ? 378214 2.4.1.41 UDP-N-acetyl-D-galactosamine + P-(O-GalNAc)T-TDSTTPAPTTK 0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP Toxoplasma gondii UDP + ? - ? 378214 2.4.1.41 UDP-N-acetyl-D-galactosamine + PADVTTAAPGG - Drosophila sp. (in: flies) UDP + ? - ? 378215 2.4.1.41 UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC i.e. MUC1b Drosophila melanogaster UDP + ? - ? 378216 2.4.1.41 UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC i.e. MUC1b, enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378216 2.4.1.41 UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC i.e. MUC1b, low activity, enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378216 2.4.1.41 UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC i.e. MUC1b, low activity, enzyme form PGANT6 Drosophila melanogaster UDP + ? - ? 378216 2.4.1.41 UDP-N-acetyl-D-galactosamine + PDTRPAPGSTAPPAC i.e. MUC1b, low activity, enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378216 2.4.1.41 UDP-N-acetyl-D-galactosamine + PGGDSSSYQPG - Drosophila sp. (in: flies) UDP + ? - ? 378217 2.4.1.41 UDP-N-acetyl-D-galactosamine + PGLPPTTPAVTTTATP - Sus scrofa UDP + ? - ? 378218 2.4.1.41 UDP-N-acetyl-D-galactosamine + PITTTTTVTPG - Drosophila sp. (in: flies) UDP + ? - ? 378219 2.4.1.41 UDP-N-acetyl-D-galactosamine + PPAHGVTSAPG - Drosophila sp. (in: flies) UDP + ? - ? 378220 2.4.1.41 UDP-N-acetyl-D-galactosamine + PPETTAAPPTG - Drosophila sp. (in: flies) UDP + ? - ? 378221 2.4.1.41 UDP-N-acetyl-D-galactosamine + PPVVPFTPLPG - Drosophila sp. (in: flies) UDP + ? - ? 378222 2.4.1.41 UDP-N-acetyl-D-galactosamine + PSPPITTTTTG - Drosophila sp. (in: flies) UDP + ? - ? 378223 2.4.1.41 UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS i.e. IgAh Drosophila melanogaster UDP + ? - ? 378224 2.4.1.41 UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS i.e. IgAh, low activity, enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378224 2.4.1.41 UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS i.e. IgAh, low activity, enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378224 2.4.1.41 UDP-N-acetyl-D-galactosamine + PSTPPTPSPSTPPTPSPS i.e. IgAh, very low activity, enzyme form PGANT3 Drosophila melanogaster UDP + ? - ? 378224 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDS-(O-GalNAc)T-TPAPTTK 38.7% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP Rattus norvegicus UDP + ? - ? 378225 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDS-(O-GalNAc)T-TPAPTTK 4.5% of the activity with P-(O-GalNAc)T-TDSTTPAPTTK Mus musculus UDP + ? - ? 378225 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDS-(O-GalNAc)T-TPAPTTK 59.6% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP Toxoplasma gondii UDP + ? - ? 378225 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTT i.e. EA2, about 25% of the activity with Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ? - ? 378227 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTT i.e. EA2, about 35% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ? - ? 378227 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK 0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP Toxoplasma gondii UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK 74% of the activity with P-(O-GalNAc)T-TDSTTPAPTTK Mus musculus UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK enzyme form PGANT3 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK enzyme form ppGaNTase-T1 Rattus norvegicus UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK enzyme form ppGaNTase-T3 Rattus norvegicus UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK enzyme form ppGaNTase-T4 Rattus norvegicus UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK enzyme form ppGaNTase-T5 Rattus norvegicus UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK i.e. EA2, enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK i.e. EA2, enzyme form PGANT6 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK i.e. EA2, enzyme form PGANT8 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK i.e. EA2, glycosylation at threonines 7, 11, and 12, enzyme form PGANT1 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTTK i.e. EA2, high activity, glycosylation at threonines 7, 11, and 12, enzyme form PGANT1 Drosophila melanogaster UDP + ? - ? 378226 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTV i.e. Muc2 Echinococcus granulosus UDP + ? - ? 378229 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTV i.e. Muc2 Fasciola hepatica UDP + ? - ? 378229 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTV i.e. Muc2 Toxocara canis UDP + ? - ? 378229 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTVTPTPTPTGTQT i.e. Muc2, about 35% of the activity with Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ? - ? 378228 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTVTPTPTPTGTQT i.e. Muc2, about 95% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ? - ? 378228 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPSPPITG - Drosophila sp. (in: flies) UDP + ? - ? 378230 2.4.1.41 UDP-N-acetyl-D-galactosamine + SATTPAPPSSG preferred substrate Drosophila sp. (in: flies) UDP + ? - ? 378232 2.4.1.41 UDP-N-acetyl-D-galactosamine + SDAESSGPVPG - Drosophila sp. (in: flies) UDP + ? - ? 378233 2.4.1.41 UDP-N-acetyl-D-galactosamine + SEVTTTLVPAG - Drosophila sp. (in: flies) UDP + ? - ? 378234 2.4.1.41 UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS i.e. rMUC-2, enzyme form PGANT2 Drosophila melanogaster UDP + ? - ? 378235 2.4.1.41 UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS i.e. rMUC-2, enzyme form PGANT4 Drosophila melanogaster UDP + ? - ? 378235 2.4.1.41 UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS i.e. rMUC-2, high activity Drosophila melanogaster UDP + ? - ? 378235 2.4.1.41 UDP-N-acetyl-D-galactosamine + SPTTSTPISSTPQPTS i.e. rMUC-2, low activity. enzyme form PGANT6 Drosophila melanogaster UDP + ? - ? 378235 2.4.1.41 UDP-N-acetyl-D-galactosamine + STPSTPSTPSTPSTP - Bos taurus UDP + ? - ? 378236 2.4.1.41 UDP-N-acetyl-D-galactosamine + SVLVLTTVSVPPSPASAGPSV - Sus scrofa UDP + ? - ? 378237 2.4.1.41 UDP-N-acetyl-D-galactosamine + TSAPGTTPSPG - Drosophila sp. (in: flies) UDP + ? - ? 378238 2.4.1.41 UDP-N-acetyl-D-galactosamine + TTAAPPTPSAG - Drosophila sp. (in: flies) UDP + ? - ? 378239 2.4.1.41 UDP-N-acetyl-D-galactosamine + TTPLPTTTPSG - Drosophila sp. (in: flies) UDP + ? - ? 378240 2.4.1.41 UDP-N-acetyl-D-galactosamine + TTSTTSAPGTG - Drosophila sp. (in: flies) UDP + ? - ? 378241 2.4.1.41 UDP-N-acetyl-D-galactosamine + TTTTTTPKPTG - Drosophila sp. (in: flies) UDP + ? - ? 378242 2.4.1.41 UDP-N-acetyl-D-galactosamine + TTTVTPTPTPG - Drosophila sp. (in: flies) UDP + ? - ? 378243 2.4.1.41 UDP-N-acetyl-D-galactosamine + TVPVTGPTAPALVQSVTPPT - Sus scrofa UDP + ? - ? 378244 2.4.1.41 UDP-N-acetyl-D-galactosamine + VESDRSTTTTQAP 0.3% of the activity with GTTPSPVPTTS-(O-GalNAc)T-TSAP Toxoplasma gondii UDP + ? - ? 378245 2.4.1.41 UDP-N-acetyl-D-galactosamine + VESDRSTTTTQAP 34% of the activity with P-(O-GalNAc)T-TDSTTPAPTTK Mus musculus UDP + ? - ? 378245 2.4.1.41 UDP-N-acetyl-D-galactosamine + VLTTTATTPTA i.e. Muc5B Echinococcus granulosus UDP + ? - ? 378246 2.4.1.41 UDP-N-acetyl-D-galactosamine + VLTTTATTPTA i.e. Muc5B Fasciola hepatica UDP + ? - ? 378246 2.4.1.41 UDP-N-acetyl-D-galactosamine + VLTTTATTPTA i.e. Muc5B Toxocara canis UDP + ? - ? 378246 2.4.1.41 UDP-N-acetyl-D-galactosamine + VPETASSKTATGDSFS - Sus scrofa UDP + ? - ? 378247 2.4.1.41 UDP-GalNAc + Ac-TPPA pH 7.5, 37°C Bos taurus UDP + Ac-(GalNAcalpha1-)TPPA - ? 410496 2.4.1.41 UDP-GalNAc + AQPTPPP pH 7.5, 37°C, 0.2 mM, 100% activity Bos taurus UDP + AQP-(GalNAcalpha1-)TPPP - ? 410497 2.4.1.41 UDP-GalNAc + GAGA(X)3T(X)3AGAGK - Bos taurus UDP + GAGA(X)3(GalNAc)T(X)3AGAGK - ? 398491 2.4.1.41 UDP-GalNAc + GAGA(X)3T(X)3AGAGK - Homo sapiens UDP + GAGA(X)3(GalNAc)T(X)3AGAGK - ? 398491 2.4.1.41 UDP-GalNAc + GAGA(X)5T(X)5AGAGK very high correlation between peptide preferences of ppGalNAc T2 and fly orthologue PGANT2 with r(square) = 0.92 Homo sapiens UDP + GAGA(X)5(GalNAc)T(X)5AGAGK - ? 398493 2.4.1.41 UDP-GalNAc + GAGA(X)5T(X)5AGAGK very high correlation between peptide preferences of ppGalNAc T2 and fly orthologue PGANT2 with r(square) = 0.92, the hydrophobic residue proline is preferred at the -1, +1, and +3 positions, the hydrophobic residues valine and tyrosin are moderately preferred at the -1 and +3 positions, the hydrophobic residue methionine is disfavoured at the -1 position, low hydrophilic preference at the -1 position, strong glutamate/aspartate preference at the +1 position, lower preference of glutamate at +1 and +2 positions than fly orthologue PGANT5 Bos taurus UDP + GAGA(X)5(GalNAc)T(X)5AGAGK - ? 398493 2.4.1.41 UDP-N-acetyl-D-galactosamine + GAGAPGPTPGPAGAGK optimal isozyme ppGalNAc T2 peptide substrate Homo sapiens UDP + GAGAPGP-(N-acetyl-D-galactosaminylT)-PGPAGAGK - ? 410597 2.4.1.41 UDP-galactose + Muc1 peptide synthetic substrate Homo sapiens UDP + galactosyl-Muc1 peptide - ? 322788 2.4.1.41 UDP-galactose + Muc1 peptide 2 of 3 threonine residues on the Muc1 tandem repeat peptides, none of the serine residues, maximum is 2 Mol of GalNAc linked to each 20-residue repeat unit Homo sapiens UDP + galactosyl-Muc1 peptide - ? 322788 2.4.1.41 UDP-galactose + Muc2 peptide peptides derived of Muc2 mucin Homo sapiens UDP + galactosyl-Muc2 peptide - ? 322786 2.4.1.41 UDP-galactose + Muc2 peptide only GalNAc-T2, only with the Muc2 acceptor peptide Homo sapiens UDP + galactosyl-Muc2 peptide - ? 322786 2.4.1.41 UDP-galactose + Muc2 peptide investigation of preferences for distinct threonine residues in the peptide sequences Homo sapiens UDP + galactosyl-Muc2 peptide - ? 322786 2.4.1.41 UDP-galactose + PTTTPITTTTK Muc2 peptide, investigation of preferences for distinct threonine residues in the peptide sequences of isozyme T1 to T4 Homo sapiens UDP + galactosyl-PTTTPITTTTK - ? 322787 2.4.1.41 UDP-galactose + PTTTPITTTTK linked to FITC Homo sapiens UDP + galactosyl-PTTTPITTTTK - ? 322787 2.4.1.41 UDP-GalNAc + apomucin apomucin is a deglycosylated bovine submaxillary mucin, mutants W328Y, W328F, W328A, W316H and W316A are inactive, mutants W316Y and W316F show 40% and 20% activity, respectively, relative to wild-type Rattus norvegicus UDP + GalNAc-mucin - ? 398488 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP - Homo sapiens UDP + GT[GalNAc]TPSPVPTTSTTSAP - ? 421661 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP - Homo sapiens UDP + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP glycosylation at Thr-3 and Thr-13 ? 421662 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP - Homo sapiens UDP + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP - ? 421665 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP - Homo sapiens UDP + GT[GalNAc]TPSPVPTTS[GalNAc]T[GalNAc]TSAP - ? 421668 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTST[GalNAc]TSAP - Homo sapiens UDP + GT[GalNAc]TPSPVPTTS[GalNAc]T[GalNAc]TSAP - ? 421670 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTSTTSAP - Homo sapiens UDP + GT[GalNAc]TP[GalNAc]SPVPTTSTTSAP - ? 421663 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GTTPSPVPTTST[GalNAc]TSAP - Homo sapiens UDP + GT[GalNAc]TP[GalNAc]SPVPTTST[GalNAc]TSAP - ? 421666 2.4.1.41 UDP-GalNAc + GVVPTVVPG GVVPTVVPG is a synthetic peptide with threonine as acceptor site, weaker acceptor substrate for wild-type and truncated version P-T1/delta42 as PPDAATAAPL Rattus norvegicus UDP + GVVP(GalNAc)TVVPG - ? 398497 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + GT[GalNAc]TPSPVPTTSTTSAP - Homo sapiens UDP + G[GalNAc]T[GalNAc]TPSPVPTTST[GalNAc]TSAP - ? 421669 2.4.1.41 UDP-N-((2S)-2-azidopropanoyl)-alpha-D-galactosamine + peptide EA2-biotin i.e. PTTDSTTPAPTTKK-biotin Homo sapiens UDP + N-((2S)-2-azidopropanoyl)-alpha-D-galactosaminyl-peptide EA2-biotin - - 456920 2.4.1.41 UDP-GalNAc + N-acetyl-4-benzoyl-L-Phe-L-Pro-L-Tyr-L-Pro-L-Pro-L-Pro-NH2 pH 7.5, 37°C Bos taurus UDP + N-acetyl-4-benzoyl-L-Phe-L-Pro-L-(GalNAcalpha1-)Tyr-L-Pro-L-Pro-L-Pro-NH2 - ? 410499 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + human proteoglycan 4 - Bombyx mori UDP + N-acetyl-alpha-D-galactosaminyl-(human proteoglycan 4) - ? 456924 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + peptide EA2 - Bombyx mori UDP + N-acetyl-alpha-D-galactosaminyl-(peptide EA2) - ? 456927 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + delta-opioid receptor - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-delta-opioid receptor - ? 456929 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + EA2 peptide EA peptide, i.e. PTTDSTTPAPTTK Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-EA2 peptide - ? 456922 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + gp40-derived peptide - Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-gp40-derived peptide - ? 456923 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + mucin-type O-glycoprotein podoplanin - Mus musculus UDP + N-acetyl-alpha-D-galactosaminyl-mucin-type O-glycoprotein podoplanin - ? 456925 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + neuroglycan - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-neuroglycan - ? 436078 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + peptide EA2-biotin i.e. PTTDSTTPAPTTKK-biotin Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-peptide EA2-biotin - - 456926 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide - ? 434884 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide acceptor sites with adjacent proline residues are highly preferred, while other residues cause less pronounced effects. The enzyme clearly prefers threonine over serine in the in vitro assays Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide - ? 434884 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide ActR-IIB - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide ActR-IIB - ? 436079 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide angiopoietin-like 3 - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide angiopoietin-like 3 - ? 436080 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2 sequence biotin-PTTDSTTPAPTTK, second highest activity Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2 - ? 436082 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2 sequence biotin-PTTDSTTPAPTTK, second highest activity Cryptosporidium hominis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2 - ? 436082 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2 sequence biotin-PTTDSTTPAPTTK, second highest activity Cryptosporidium muris UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2 - ? 436082 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2-2 sequence biotin-PTTDSTTPAPTTK Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2-2 - ? 436081 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2-2 sequence biotin-PTTDSTTPAPTTK Cryptosporidium hominis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2-2 - ? 436081 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide biotin-EA2-2 sequence biotin-PTTDSTTPAPTTK Cryptosporidium muris UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide biotin-EA2-2 - ? 436081 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 1 sequence APPAHPGPTPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 1 - ? 436093 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 10 sequence APPAHPGPTIGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 10 - ? 436083 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 11 sequence APPAHPGPTPRPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 11 - ? 436084 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 12 sequence APPAHHGPTPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 12 - ? 436085 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 13 sequence APPAHPVPTPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 13 - ? 436086 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 14 sequence APPAHPGLTPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 14 - ? 436087 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 15 sequence APPAHHVVTERYRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 15 - ? 436088 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 16 sequence APPAHDFVTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 16 - ? 436089 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 17 sequence APPAHDFPTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 17 - ? 436090 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 18 sequence APPAHPFVTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 18 - ? 436091 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 19 sequence APPAHIFVTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 19 - ? 436092 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 2 sequence APPAHPGVTPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 2 - ? 436098 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 20 sequence APPAHVFVTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 20 - ? 436094 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 21 sequence APPAHDGVTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 21 - ? 436095 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 22 sequence APPAHPGPTPAPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 22 - ? 436096 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 23 sequence PSSSPISSSSSVSPSPSPSGSQSK Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 23 - ? 436097 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 3 sequence APPAHPGPTPGYRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 3 - ? 436099 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 4 sequence APPAHPGPTPGHRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 4 - ? 436100 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 5 sequence APPAHPGPTPGHRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 5 - ? 436101 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 6 sequence APPAHPGVTPGYRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 6 - ? 436102 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 7 sequence APPAHPGITPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 7 - ? 436103 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 8 sequence APPAHPGFTPGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 8 - ? 436104 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide CHT 9 sequence APPAHPGPTEGPRPAPG Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide CHT 9 - ? 436105 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2 - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2 - ? 434881 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2 sequence PTTDSTTPAPTTK Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2 - ? 434881 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2-biotin sequence PTTDSTTPAPTTK-biotin Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2-biotin - ? 436106 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2-biotin sequence PTTDSTTPAPTTK-biotin Cryptosporidium hominis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2-biotin - ? 436106 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide EA2-biotin sequence PTTDSTTPAPTTK-biotin Cryptosporidium muris UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide EA2-biotin - ? 436106 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide FGF23 - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide FGF23 - ? 436107 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPIV preferred substrate Bos taurus UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPIV - ? 436109 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPIV preferred substrate for isoforms ppGalNAc T2, T5, T13, T14, and T16 Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPIV - ? 436109 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPIV-C - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPIV-C - ? 436108 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPV - Bos taurus UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPV - ? 436111 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPV preferred substrate for isoforms ppGalNAc T3, T5, T6, T13, and T16 Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPV - ? 436111 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPV-C - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPV-C - ? 436110 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GPV-C - Bos taurus UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GPV-C - ? 436110 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GRA2-biotin highest activity Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GRA2-biotin - ? 436112 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GRA2-biotin highest activity Cryptosporidium hominis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GRA2-biotin - ? 436112 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide GRA2-biotin highest activity Cryptosporidium muris UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide GRA2-biotin - ? 436112 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1 - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1 - ? 434883 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc10 - Mus musculus UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc10 - ? 456928 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC13 isoform GALNT14 contributes to the glycosylation of peptide MUC13, which is significantly higher in ovarian cancer cells compared with the normal/benign ovary tissues Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC13 - ? 434882 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr1 - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr1 - ? 436115 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr2 - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr2 - ? 436116 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1fr3 - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1fr3 - ? 436117 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc2 best acceptor polypeptide substrate with sequence PTTTPITTTTTVTPTPTPTGTQTK Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc2 - ? 436118 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc2 best substrate with sequence PTTTPITTTTTVTPTPTPTGTQTK Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc2 - ? 436118 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc5Ac - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc5Ac - ? 436120 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc5Ac second best acceptor polypeptide with sequence GTTPSPVPTTSTTSAP Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc5Ac - ? 436120 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc5Ac sequence GTTPSPVPTTSTTSAP Biomphalaria glabrata UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc5Ac - ? 436120 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC5AC-3,13-biotin sequence biotin-GTTPSPVPTTSTTSAP Cryptosporidium parvum UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC5AC-3,13-biotin - ? 436119 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC5AC-3,13-biotin sequence biotin-GTTPSPVPTTSTTSAP Cryptosporidium hominis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC5AC-3,13-biotin - ? 436119 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide MUC5AC-3,13-biotin sequence biotin-GTTPSPVPTTSTTSAP Cryptosporidium muris UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide MUC5AC-3,13-biotin - ? 436119 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide OPSS1 - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide OPSS1 - ? 436121 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide OPSS4 - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide OPSS4 - ? 436122 2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide RNApII - Xenopus laevis UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide RNApII - ? 436123 2.4.1.41 UDP-N-acetyl-D-galactosamine + A1 protein - Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-A1 protein - ? 322777 2.4.1.41 UDP-N-acetyl-D-galactosamine + AcTPPP - Bos taurus UDP + N-acetyl-D-galactosaminyl-AcTPPP - ? 322793 2.4.1.41 UDP-N-acetyl-D-galactosamine + apoantifreeze glycoproteins apoantifreeze glycoprotein of high molecular weight accepts GalNAc much faster than apoantifreeze glycoprotein 8 Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-apoantifreeze glycoproteins - ? 322779 2.4.1.41 UDP-N-acetyl-D-galactosamine + apofetuin lowest rate of transfer Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-apofetuin - ? 322778 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin bovine apomucin Bos taurus UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin enzymatically prepared apomucin accepts GalNAc much faster than chemically prepared apomucin Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin deglycosylated bovine submaxillary mucin Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin deglycosylated bovine submaxillary mucin Sus scrofa UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin deglycosylated bovine submaxillary mucin Bos taurus UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin porcine apomucin Sus scrofa UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin GalNAc-T1 Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin acceptor: apomucin motif encoded by the MUC5AC gene Homo sapiens UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin ovine apomucin Sus scrofa UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin best substrate, poorer substrates: asialo mucin, native mucin Bos taurus UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin deglycosylated Cowper's gland, swine and human trachea mucins Sus scrofa UDP + N-acetyl-D-galactosaminyl-apomucin - ? 322775 2.4.1.41 UDP-N-acetyl-D-galactosamine + fibronectin fibronectin is a physiological substrate for GalNAc-T3 Homo sapiens UDP + N-acetyl-D-galactosaminyl-fibronectin - ? 322789 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide ppGaNTase-T9: acceptors are di- and triglycosylated MUC5AC and mono-glycosylated EA2, obtained by prior action of ppGaNTase-T1, but not the unmodified peptides, formation of a tetra-glycopeptide species from MUC5AC triglycopeptide substrate, ppGaNTase-T7 forms a hexa-glycopeptide species Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide acceptor: MUC5AC-13 glycopeptide Drosophila melanogaster UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide GalNAc-T7: exclusive specificity for partially GalNAc-glycosylated acceptor substrates, GalNAc-glycosylated peptide substrates derived from the tandem repeats of human Muc2 and rat submandibular gland mucin, specificity of GalNAc-T4 Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide rGalNAc-T4 is dependent on the presence of GalNAc on acceptor peptides, activity is triggered by a lectin-like interaction of enzyme with the glycopeptide directed by the putative lectin domain found in the C-terminal region, rGalNAc-T2 activity is enhanced on glycosylated acceptor peptides Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide GalNAc-T1 may also specifically recognize and glycosylate partially glycosylated acceptors Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide ppGaNTase-T6 requires at least 2 intact GalNAc residues in the substrate, acceptor: MUC5AC-glycopeptide, obtained by the action of ppGaNTase-T1 Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide ppGalNAc-T14 can utilize GalNAc transferred peptides as substrates Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide ppGalNAc-T4 and -T7 prefer peptides having GalNAc residues as acceptor substrates Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide acceptors: partially glycosylated versions of a peptide derived from mucin2, pp-GalNAc-T1, -T2, -T3 and -T4 exhibit distinct specificities toward glycopeptides, pathway of incorporation of the second and third GalNAc, isoenzymes may recognize directly GalNAc residues in the vicinity Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide - ? 322774 2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide submaxillary gland enzyme, low activity Sus scrofa UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide - ? 322782 2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide submaxillary gland enzyme, low activity Ovis sp. UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide - ? 322782 2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide HIVIIIBgp120, only GalNAc-T3 Homo sapiens UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide - ? 322782 2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide placenta, but not liver enzyme Homo sapiens UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide - ? 322782 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide placenta enzyme Homo sapiens UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only Ser acceptor sites, with a very low activity Homo sapiens UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only Ser acceptor sites, with a very low activity Sus scrofa UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only Ser acceptor sites, with a very low activity Ovis sp. UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only GalNAc-T2 Homo sapiens UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide submaxillary gland enzyme Sus scrofa UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide submaxillary gland enzyme Ovis sp. UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide - ? 322781 2.4.1.41 UDP-N-acetyl-D-galactosamine + immunoglobulin A1 O-linked glycosylation of the human IgA1 hinge region by ppGalNAc-T2, synthetic IgA hinge peptide: ppGalNAc-T2 shows strongest activity and is able to transfer GalNAc to almost all possible glycosylation sites, other ppGalNAc-Ts show extremely weak activities Homo sapiens UDP + N-acetyl-D-galactosaminyl-immunoglobulin A1 - ? 322785 2.4.1.41 UDP-N-acetyl-D-galactosamine + kappa-casein - Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-kappa-casein - ? 322776 2.4.1.41 UDP-N-acetyl-D-galactosamine + kappa-casein kappa-subcomponent 1, the nonglycosylated kappa-casein, is the best substrate among kappa-casein subcomponents, asialo kappa-casein, agalacto kappa-casein and nature kappa-casein Bos taurus UDP + N-acetyl-D-galactosaminyl-kappa-casein - ? 322776 2.4.1.41 UDP-N-acetyl-D-galactosamine + kappa-casein glycosylation of kappa-casein occurs after casein micelle formation triggered by the accumulation of Ca2+ in vivo Bos taurus UDP + N-acetyl-D-galactosaminyl-kappa-casein - ? 322776 2.4.1.41 UDP-N-acetyl-D-galactosamine + myelin basic protein - Sus scrofa UDP + N-acetyl-D-galactosaminyl-myelin basic protein - ? 322780 2.4.1.41 UDP-N-acetyl-D-galactosamine + myelin basic protein - Bos taurus UDP + N-acetyl-D-galactosaminyl-myelin basic protein - ? 322780 2.4.1.41 UDP-N-acetyl-D-galactosamine + osteopontin preferred substrate of isozyme ppGalNAcT-1, glycosylation pattern, overview Mus musculus UDP + N-acetyl-D-galactosaminyl-osteopontin - ? 407443 2.4.1.41 UDP-N-acetyl-D-galactosamine + osteopontin isozyme ppGalNAc T10 prefers previously glycosylated peptides as substrates, ppGalNAc T10 exhibits a single large preference for Ser/Thr-O-GalNAc at the +1, C-terminal, position relative to the Ser or Thr acceptor site Homo sapiens UDP + N-acetyl-D-galactosaminyl-osteopontin - ? 407443 2.4.1.41 UDP-N-acetyl-D-galactosamine + PHMAQVTVGPGL - Bos taurus UDP + N-acetyl-D-galactosaminyl-PHMAQVTVGPGL - ? 322792 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide - Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide - Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide - Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide - Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide - Caenorhabditis elegans UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide - Toxoplasma gondii UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T14: acceptors are mucin-derived peptides such as Muc2, Muc5AC, Muc7, Muc13 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: synthetic glycopeptides and peptides most of which contain sequences derived from the tandem repeat region of MUC2 mucin Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor: asialo mucin, subcomponents of kappa-casein, asialo kappa-casein, agalacto kappa-casein Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor: deglycosylated bovine submaxillary mucin Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T13: acceptors are mucin peptides, such as Muc1a', Muc5Ac and Muc7, forms a triplet Tn epitope, 3 consecutive GalNAc-Ser/Thr structures, on peptides encoded in syndecan-3, different substrate specificities of ppGalNAc-T1 and -T13 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGaNTase-T1: EA2 peptide acceptor, interdependence of binding of UDP-GalNAc and acceptor substrate, enzyme undergoes a conformational change upon sugar binding, equilibrium between open and closed states may be used as a regulation mechanism of activity Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T1: Asp-144 is the most important site for GalNAc recognition, primarily recognizes the UDP portion of UDP-GalNAc Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide substrate specificities of recombinant ppGalNAc-T1, -T2, -T3, -T4, -T6 and –T9 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide octapeptide Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro is the best substrate, threonine cannot be glycosylated without a carboxyl triprolyl sequence, the alpha-amino acid group of the threonine must be blocked, the nature of the group NH2-terminal to the threonine affects the kinetics of the reaction, one residue can be between the threonine and the triprolyl sequence Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide site-specific O-glycosylation by rGalNAc-T2 and -T4 is controlled by the primary sequence context and the position and structure of previously introduced O-glycans, acceptors: synthetic mucin-type peptides and glycopeptides derived from tandem repeat regions of MUC1, MUC2 and MUC4, minimum peptide length is required, which is larger for glycosylated substrates, concerted and sequential action of rGalNAc-T2 and -T4 fully glycosylates MUC1, but only partially MUC2 and MUC4 tandem repeat peptides Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor specificity Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide rate of incorporation of GalNAc into Thr is significantly greater than into Ser residues, presence of 1-2 GalNAc-Thr moieties in the subtrate reduces enzyme activity, especially when Galbeta1-3GalNAc is present, O-glycosylation depends on both amino acid sequence and prior glycosylation of substrates, enzyme is selective in glycosylating peptides with the Pro-Thr-Thr-Thr-Pro-Ile-Ser-Thr sequence in that the preferred primary site is the third Thr from the N-terminal end Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide L-threonine specifically O-glycosylated in alpha-configuration, Thr-Pro-Pro-Pro-sequence requires a peptide length of five or more for significant acceptor activity Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide broad specificity, acceptors: unglycosylated protein acceptors, synthetic peptides, O-glycosylates threonine about 35times faster than serine, specificity is determined by the amino acids in the acceptor peptide segment and its accessibility, enzymatic active site interacts with an 8-amino acid long segment of the substrate, spanning 3 amino acids preceding and 4 amino acids following the reactive Thr or Ser Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide only UDP-GalNAc serves as sugar donor Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide only UDP-GalNAc serves as sugar donor Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide only UDP-GalNAc serves as sugar donor Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide only UDP-GalNAc serves as sugar donor Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: synthetic peptides Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: synthetic polypeptides with sequences identical or similar to those found in porcine mucin or human erythropoietin, acceptor substrate specificity is dependent on the amino acid sequence adjacent to serine and threonine residues, but it is more sensitive to the sequence adjacent to serine than to threonine Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: bovine submaxillary mucin core protein, myelin basic protein Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylation of the polypeptide, acceptor: porcine stomach mucin Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T1 and -T3: strict specificity for UDP-GalNAc, GalNAc-T2: utilizes UDP-GalNAc and UDP-Gal Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: apomucin, kappa-casein Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: apomucin, kappa-casein Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: ovine and porcine apomucin, porcine mucin-like synthetic peptides Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: A1 protein, apofetuin, apoantifreeze glycoproteins, frequent glycosylation of the abundant serine plus threonine residues of mucins Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: substantial activity only with EA2 peptide, less active with IgAh peptide Drosophila melanogaster UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylating enzyme, acceptors: synthetic peptides in which the Thr-Pro-Pro-Pro sequence is varied Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylating enzyme, acceptors: synthetic peptides in which the Thr-Pro-Pro-Pro sequence is varied Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor: SIV3 peptide Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor: mucin2 derived fluorescein-conjugated peptide Pro-Thr-Thr-Thr-Pro-Leu-Lys, preferential sites of O-glycosylation by pp-GalNAc-T1, -T2, -T3 and -T4, of which each has a unique specificity Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGaNTase-T1: acceptor is MUC5AC peptide, di-glycopeptide contains GalNAc at Thr-3 and -13, tri-glycopeptide an additional one at Ser-5 Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor: human MUC5AC peptide Thr-Thr-Ser-Ala-Pro-Thr-Thr-Ser Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Ovis sp. UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Drosophila melanogaster UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: deglycosylated Cowper's gland, swine and human trachea mucins, tryptic peptides prepared from them, best substrates are fragments of incompletely deglycosylated mucin polypeptide chains Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide specifically transfers N-acetylgalactosamine from UDP-GalNAc to the hydroxyl group of threonine, no transferase activity towards serine-containing peptides, amino acid sequence adjacent to glycosylated Thr residues may influence the rate of glycosylation Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: human mucin Muc1 and Muc2 peptides, human chorionic gonadotropin-beta peptide, HIV-V3 peptides Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: human mucin Muc1 and Muc2 peptides, human chorionic gonadotropin-beta peptide, HIV-V3 peptides Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: human mucin Muc1 and Muc2 peptides, human chorionic gonadotropin-beta peptide, HIV-V3 peptides Ovis sp. UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide 3 GalNAc-transferases: GalNAc-T1, -T2 and -T3 with distinct but partly overlapping specificities, dependent on the primary sequence of the acceptor substrate, acceptors: peptides based on Muc1 tandem repeat, TAP24, Muc2, Muc5AC, erythropoietin, hCG-beta, HIVIIIBgp120, ovine submaxillary mucin fragment, peptide derived from fibronectin, GalNAc-T1, -T2 and -T3 react at different rates with individual sites in the Muc1 repeat Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide diversely regulated ppGaNTase family may play a role in the various processes governing development Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T13: synthesis of O-glycan, specifically the Tn antigen in neurons Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide key role in O-linked glycosylation, catalyzes first step in the assembly Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide key role in O-linked glycosylation, catalyzes first step in the assembly Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T1 glycosylates unmodified polypeptides in vivo Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T7: functions as a follow-up enzyme in the initiation step of O-glycosylation Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide different enzyme activities are involved in the initiation of GalNAc O-glycosylation and these are differentially expressed in cells and organs Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide different enzyme activities are involved in the initiation of GalNAc O-glycosylation and these are differentially expressed in cells and organs Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T14 may be involved in O-glycosylation in kidney Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide catalyzes the first step in biosynthesis of O-linked oligosaccharides in many glycoproteins Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide catalyzes the first step in biosynthesis of O-linked oligosaccharides in many glycoproteins Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide catalyzes the first step in biosynthesis of O-linked oligosaccharides in many glycoproteins Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T9 catalyzes O-glycosylation in brain Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide first step in biosynthesis of O-linked oligosaccharides in submaxillary gland Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide catalyzes in vivo glycosylation of both threonine and serine Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initial step of mucin-type O-glycosylation Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylation by ppGaNTase-Ts of multisite substrates may proceed in a specific hierarchical manner Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylation by ppGaNTase-Ts of multisite substrates may proceed in a specific hierarchical manner Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide post-translational, initial reaction in O-linked oligosaccharide biosynthesis Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide post-translational, initial reaction in O-linked oligosaccharide biosynthesis Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide key role in overall control of O-glycosylation Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide ppGalNAc-T2: initiation of O-glycosylation in the IgA1 hinge region Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide primary step in the production of mucin-type O-linked oligosaccharide groups in glycoproteins Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide primary step in the production of mucin-type O-linked oligosaccharide groups in glycoproteins Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide can participate in the biosynthesis of O-glycosylated parasite proteins exposed at the interface between Echinococcus granulosus and its hosts Echinococcus granulosus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initiates the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine from UDP-GalNAc to Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-alpha-1-O-Ser/Thr) Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide the enzyme is involved in the normal development of the brain through O-glycosylation of proteins in the neurons Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide the enzyme is involved in the normal development of the brain through O-glycosylation of proteins in the neurons Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide glycosylates peptides containing a sequence of XTPXP or TTAAP most efficiently Drosophila sp. (in: flies) UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfers GalNAc to a broad range of substrate peptides, derived from human mucins and O-glycosylated parasite proteins, including acceptors containing only serine or only threonine residues Echinococcus granulosus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Xenopus laevis UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide mucin-type O-linked glycosylation of serine or threonine residues Drosophila melanogaster UDP + N-acetyl-D-galactosaminyl-polypeptide - ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide usage of random peptide substrates, overview. Isozyme substrate specificities, amino acid residue enhancement factors for ppGalNAc T isozymes are obtained from random peptide substrates, detailed overview Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide product analysis by NMR and mass spectrometry ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide usage of random peptide substrates, overview. Isozyme substrate specificity, amino acid residue enhancement factors for the ppGalNAc T isozyme are obtained from random peptide substrates, detailed overview Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide product analysis by NMR and mass spectrometry ? 322773 2.4.1.41 UDP-N-acetyl-D-galactosamine + PPDAATAAPLR i.e. EPO-T peptide Bos taurus UDP + N-acetyl-D-galactosaminyl-PPDAATAAPLR - ? 322791 2.4.1.41 UDP-N-acetyl-D-galactosamine + rhodanese reduced and carboxylmethylated bovine rhodanese, at a lower rate than with myelin basic protein Bos taurus UDP + N-acetyl-D-galactosaminyl-rhodanese - ? 322783 2.4.1.41 UDP-N-acetyl-D-galactosamine + subtilisin reduced and carboxylmethylated bacterial subtilisin, at a lower rate than with myelin basic protein or bovine rhodanese Bos taurus UDP + N-acetyl-D-galactosaminyl-subtilisin - ? 322784 2.4.1.41 UDP-N-acetyl-D-galactosamine + syndecan-3 syndecan-3 may be a natural substrate for GalNAc-T13 Homo sapiens UDP + N-acetyl-D-galactosaminyl-syndecan-3 - ? 322790 2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSA i.e. Muc5Ac peptide, multiple possible binding sites for N-acetyl-D-galactosamine on the peptide Homo sapiens UDP + N-acetyl-D-galactosaminyl-[GTTPSPVPTTSTTSA] - ? 410598 2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-CIRIQRGPGRAFVTIGKIGNMR - Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-CIRIQRGPGRAFVTIGKIGNMR - ? 398520 2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-PFVTHPGYD - Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-PFVTHPGYD - ? 398521 2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM - Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-QATEYEYLDYDFLPETEPPEM - ? 398522 2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-QATEYEYLDYDFLPETEPPEM - ? 398522 2.4.1.41 UDP-N-acetyl-D-galactosamine + AHGVTSAPDTR - Homo sapiens UDP + N-acetyl-D-galactosaminylated AHGVTSAPDTR - ? 398523 2.4.1.41 UDP-N-acetyl-D-galactosamine + CPPTPSATTPAPPSSSAPPETTAA mucin derived substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated CPPTPSATTPAPPSSSAPPETTAA - ? 398524 2.4.1.41 UDP-N-acetyl-D-galactosamine + CPPTPSATTPAPPSSSAPPETTAA mucin derived substrate, acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated CPPTPSATTPAPPSSSAPPETTAA - ? 398524 2.4.1.41 UDP-N-acetyl-D-galactosamine + PRFQDSSSSKAPPPSLPSPSRLPG - Homo sapiens UDP + N-acetyl-D-galactosaminylated PRFQDSSSSKAPPPSLPSPSRLPG - ? 398527 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPISTTTMVTPTPTPTC mucin derived substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated PTTTPISTTTMVTPTPTPTC - ? 398530 2.4.1.41 UDP-N-acetyl-D-galactosamine + QATEYEYLDYDFLPEC - Homo sapiens UDP + N-acetyl-D-galactosaminylated QATEYEYLDYDFLPEC - ? 398531 2.4.1.41 UDP-N-acetyl-D-galactosamine + RPAPGSTAPPA - Homo sapiens UDP + N-acetyl-D-galactosaminylated RPAPGSTAPPA - ? 398532 2.4.1.41 UDP-N-acetyl-D-galactosamine + TAPPAHGVTSAPDTRPAPGSTAPP - Homo sapiens UDP + N-acetyl-D-galactosaminylated TAPPAHGVTSAPDTRPAPGSTAPP - ? 398533 2.4.1.41 UDP-N-acetyl-D-galactosamine + TAPPAHGVTSAPDTRPAPGSTAPP acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated TAPPAHGVTSAPDTRPAPGSTAPP - ? 398533 2.4.1.41 UDP-N-acetyl-D-galactosamine + PRFQDSSSSKAPPPSLPSPSRL - Homo sapiens UDP + N-actetyl-D-galactosaminylated PRFQDSSSSKAPPPSLPSPSRL - ? 398528 2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPISTTMVTPTPTPTC - Homo sapiens UDP + N-actetyl-D-galactosaminylated PTTTPISTTMVTPTPTPTC - ? 398529 2.4.1.41 UDP-N-hex-5-ynoyl-alpha-D-galactosamine + peptide EA2-biotin i.e. PTTDSTTPAPTTKK-biotin Homo sapiens UDP + N-hex-5-ynoyl-alpha-D-galactosaminyl-peptide EA2-biotin - - 456931 2.4.1.41 UDP-GalNAc + PTTTPITTTG pH 7.5, 37°C, 0.2 mM, 26% activity relative to AQPTPPP Bos taurus UDP + P-(GalNAcalpha1-)TTTPITTTG + P-(GalNAcalpha1-)TTTPI-(GalNAcalpha1-)TTTG - ? 410500 2.4.1.41 UDP-GalNAc + PPDAATAAPL PPDAATAAPL is a synthetic peptide with threonine as acceptor site, efficient acceptor substrate for wild-type and truncated version P-T1/delta42 Rattus norvegicus UDP + PPDAA(GalNAc)TAAPL - ? 398499 2.4.1.41 UDP-GalNAc + TPTGTQTPTG pH 7.5, 37°C, 0.2 mM, 8% activity relative to AQPTPPP Bos taurus UDP + TPTG-(GalNAcalpha1-)TQTPTG - ? 410501 2.4.1.41 UDP-GalNAc + TTTVTPTPTG pH 7.5, 37°C, 0.2 mM, 109% activity relative to AQPTPPP Bos taurus UDP + TTTV-(GalNAcalpha1-)TPTPTG + T-(GalNAcalpha1-)TTV-(GalNAcalpha1-)TPTPTG + T-(GalNAcalpha1-)T-(GalNAcalpha1-)TV-(GalNAcalpha1-)TP-(GalNAcalpha1-)TPTG + T-(GalNAcalpha1-)TTV-(GalNAcalpha1-)TP-(GalNAcalpha1-)TP-(GalNAcalpha1-)TG + TT-(GalNAcalpha1-)TV-(GalNAcalpha1-)TPTPTG + ? monoglycosylated product appears after 30 min, higher glycosylated products appear with increasing time of incubation ? 410502 2.4.1.41 UDP-GalNAc + TVTPTPTPTG pH 7.5, 37°C, 0.2 mM, 145% activity relative to AQPTPPP Bos taurus UDP + TVTP-(GalNAcalpha1-)TPTPTG - ? 410503 2.4.1.41 UDP-N-acetyl-D-galactosamine + bone sialoprotein preferred substrate of isozyme ppGalNAcT-1, glycosylation of Thr101, Ser131, Thr199, and Ser214, glycosylation pattern, overview Mus musculus UDP + UDP-N-acetyl-D-galactosaminyl-bone sialoprotein - ? 407441