2.4.1.40 additional information enzyme also catalyzes the transfer of galactose in alpha-linkage to 2'-fucosyllactose, the transfer rate of galactose is much lower than that of N-acetylgalactosamine Homo sapiens ? - ? 89 2.4.1.40 additional information effective acceptor substrates contain a subterminal beta-galactosyl residue substituted at the O-2 position with fucose Homo sapiens ? - ? 89 2.4.1.40 additional information transfers N-acetylgalactosamine from UDP-N-acetylgalactosamine to H-active structures to form A determinants Homo sapiens ? - ? 89 2.4.1.40 additional information the enzyme catalyzes the final step in the enzymatic synthesis of the ABO(H) blood group A antigen, overview Homo sapiens ? - ? 89 2.4.1.40 additional information substrate binding structure by wild-type and mutant GTA, overview Homo sapiens ? - ? 89 2.4.1.40 additional information the enzyme possesses flexible substrate specificity Helicobacter mustelae ? - ? 89 2.4.1.40 additional information galactose is used as an acceptor analogue and UDP as a donor analogue in all soaking trials Homo sapiens ? - ? 89 2.4.1.40 additional information mouse ABO gene-encoded cis-AB transferase contains the GlyGlyAla tripeptide sequence, which is also found in the majority of GBGT1 genes encoding Forssman glycolipid synthase, EC 2.4.1.88. Mouse cis-AB transferase with the GlyGlyAla tripeptide sequence, but not the human cis-AB transferase with the LeuGlyAla, exhibits Forssman glycolipid synthase activity equivalent of mouse GBGT1 gene-encoded Forssman glycolipid synthase Mus musculus ? - - 89 2.4.1.40 UDP-Gal + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3 - Homo sapiens ? - ? 453935 2.4.1.40 UDP-N-acetyl-alpha-D-galactosamine + 2'-fucosyllactose - Rattus norvegicus UDP + N-acetyl-alpha-D-galactosaminyl-(1,3)-[2'-fucosyllactose] - ? 378175 2.4.1.40 UDP-N-acetyl-alpha-D-galactosamine + alpha-Fuc-(1->2)-beta-D-Gal-(CH2)7CH3 - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-Fuc-(1->2)]-beta-D-Gal-(CH2)7CH3 - ? 456921 2.4.1.40 UDP-N-acetyl-alpha-D-galactosamine + alpha-Fuc-(1->2)-beta-D-Gal-(CH2)7CH3 - Homo sapiens UDP + alpha-D-GalNAc-(1->3)-[alpha-Fuc-(1->2)]-beta-D-Gal-(CH2)7CH3 - ? 456930 2.4.1.40 UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-2'-fucosyllactose - ? 322763 2.4.1.40 UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose - Rattus norvegicus UDP + N-acetyl-alpha-D-galactosaminyl-2'-fucosyllactose - ? 322763 2.4.1.40 UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose - Mesocricetus auratus UDP + N-acetyl-alpha-D-galactosaminyl-2'-fucosyllactose - ? 322763 2.4.1.40 UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose - Rattus norvegicus UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-beta-D-glucose - ? 378249 2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R H-antigen disaccharide Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R - ? 375365 2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R H-antigen disaccharide, Leu226 is responsible for substrate specificity for UDP-N-acetyl-D-galactosamine as donor substrate, acceptor substrate binding pocket structure, overview Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R - ? 375365 2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3 41% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 Homo sapiens ? - ? 390033 2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 79% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 Homo sapiens ? - ? 390034 2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 - Homo sapiens UDP + alpha-D-GalNAc-(1,3)-[alpha-(Fucp-(1,2)])-beta-D-Galp-O(CH2)7CH3 - ? 390035 2.4.1.40 UDP-N-acetyl-D-galactosamine + asialo-porcine submaxillary mucin of A-negative blood-type - Sus scrofa UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[asialo-porcine submaxillary mucin of A-negative blood-type] - ? 322771 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose - Homo sapiens UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose - ? 322762 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose - Sus scrofa UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose - ? 322762 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose - Macaca fascicularis UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose - ? 322762 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose - Pan troglodytes UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose - ? 322762 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose - Helicobacter mustelae UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose - ? 407442 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose substrate is the histo-blood H group antigen Homo sapiens UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose product is the histo-blood A group antigen ? 407442 2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose substrate is the histo-blood H group antigen. Arg176 of the enzyme is not important in determining the sugar specificity of enzyme, while Gly235 is influential and Leu266 and Gly268 are crucial in the determination of GalNAc/galactose specificity Homo sapiens UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose product is the histo-blood A group antigen ? 407442 2.4.1.40 UDP-N-acetyl-D-galactosamine + H type 3-Sp-biotin H type 3-Sp-biotin is the preferred substrate Rattus norvegicus UDP + ? - ? 378251 2.4.1.40 UDP-N-acetyl-D-galactosamine + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3 - Homo sapiens UDP + alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3 - ? 322764 2.4.1.40 UDP-N-acetyl-D-galactosamine + lacto-N-fucopentaose I i.e. Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[lacto-N-fucopentaose I] - ? 322770 2.4.1.40 UDP-N-acetyl-D-glucosamine + L-fucosyl-alpha-1,2-beta-glucosyl-O(CH2)7CH3 - Homo sapiens UDP + N-acetyl-alpha-D-glucosaminyl-1,3-[alpha-L-fucosyl-1,2]-beta-D-glucosyl-O(CH2)7CH3 - ? 322765 2.4.1.40 UDP-N-acetylgalactosamine + octyl 3-O-methyl-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside - Homo sapiens UDP + N-acetyl-alpha-D-galactosamine-1,3-[3-O-methyl-alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3 - ? 322766 2.4.1.40 UDP-N-acetylgalactosamine + octyl 4-O-methyl-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[4-O-methyl-alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3 - ? 322767 2.4.1.40 UDP-N-acetylgalactosamine + octyl alpha-L-xylo-hexopyranosyl-(1-2)-beta-D-galactopyranoside - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-xylo-hexopyranosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3 - ? 322768 2.4.1.40 UDP-N-acetylgalactosamine + octyl beta-D-arabinopyranosyl-(1-2)-beta-D-galactopyranoside - Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[beta-D-arabinopyranosyl-1,2-beta-D-galactosyl-O(CH2)7CH3] - ? 322769