2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Mus musculus ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Homo sapiens ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Rattus norvegicus ATP + citrate + CoA - r 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Aspergillus nidulans ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Aspergillus niger ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Arabidopsis thaliana ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Yarrowia lipolytica ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Lipomyces starkeyi ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Rhodotorula toruloides ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Hydrogenobacter thermophilus ATP + citrate + CoA - r 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Phaffia rhodozyma ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Aspergillus niger ATCC 1015 ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Phaffia rhodozyma NRRL Y-10922 ATP + citrate + CoA - ? 321844 2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate - Hydrogenobacter thermophilus TK-6 / IAM 12695 ATP + citrate + CoA - r 321844 2.3.3.8 ATP + citrate + CoA - Gallus gallus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Chlorobium limicola ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - r 321845 2.3.3.8 ATP + citrate + CoA - Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Sus scrofa ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Bos taurus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Oryctolagus cuniculus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Aspergillus nidulans ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Spinacia oleracea ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Pisum sativum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Nicotiana tabacum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Brassica napus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Arabidopsis sp. ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Rhodotorula toruloides ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Columba livia ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Fusarium graminearum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Chlorobaculum tepidum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Talaromyces trachyspermus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ir 321845 2.3.3.8 ATP + citrate + CoA - Cunninghamella sp. ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Mus musculus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for ATP Lipomyces starkeyi ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for ATP Ricinus communis ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for ATP Rhodotorula toruloides ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA cleaves citrate with inversion of configuration Gallus gallus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the synthase activity is less than 0.5% of the ATP:citrate lyase activity Hydrogenobacter thermophilus ADP + phosphate + acetyl-CoA + oxaloacetate - r 321845 2.3.3.8 ATP + citrate + CoA specific for CoA Ricinus communis ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the first step of the reaction is reversible Chlorobium limicola ADP + phosphate + acetyl-CoA + oxaloacetate - ir 321845 2.3.3.8 ATP + citrate + CoA specific for citrate Gallus gallus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for citrate Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for citrate Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - r 321845 2.3.3.8 ATP + citrate + CoA the cytosolic enzyme may provide acetyl-coenzyme A for the mevalonate pathway or fatty acid elongation Spinacia oleracea ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the cytosolic enzyme may provide acetyl-coenzyme A for the mevalonate pathway or fatty acid elongation Pisum sativum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the cytosolic enzyme may provide acetyl-coenzyme A for the mevalonate pathway or fatty acid elongation Nicotiana tabacum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the cytosolic enzyme may provide acetyl-coenzyme A for the mevalonate pathway or fatty acid elongation Brassica napus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA enzyme is induced by starvation-refeeding regimen Columba livia ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the plastidic enzyme is proposed to function for the supply of acetyl-coenzyme A for lipid biosynthesis de novo Spinacia oleracea ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the plastidic enzyme is proposed to function for the supply of acetyl-coenzyme A for lipid biosynthesis de novo Brassica napus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA enzyme regulates both the direction and carbon flux of the carbon dioxide-fixing reductive tricarboxylic acid cycle Chlorobium limicola ADP + phosphate + acetyl-CoA + oxaloacetate - ir 321845 2.3.3.8 ATP + citrate + CoA the enzyme is regulated by the carbon source present in the medium Aspergillus nidulans ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA enzyme generates cytosolic acetyl-CoA Arabidopsis sp. ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA possibly plays a role in providing acetyl-CoA for lipid biosynthesis Ricinus communis ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme is engaged in the transport of acetyl groups from mitochondria to cytosol. On the metabolic pathway from carbohydrate to lipid it is the first enzyme which is exclusively biosynthetic Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA key enzyme of CO2 fixation by reductive tricarboxylic acid Chlorobaculum tepidum ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA one of the key enzymes of lipogenesis Gallus gallus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA one of the key enzymes of lipogenesis Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA one of the key enzymes of lipogenesis Columba livia ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme catalyzes the first cytoplasmic step in the synthesis of long-chain fatty acids in mammalian tissues Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme is responsible for production of cytoplasmic acetyl-CoA for lipogenesis Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA key enzyme for lipid accumulation Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA acetyl-CoA is produced in mitochondria, but it cannot cross the mitochondrial membranes to the cytosol. Instead, citrate is exported from mitochondria. In the cytosol, ATP-citrate lyase (ACLY; EC 2.3.3.8) catalyses the reaction to produce acetyl-CoA and oxaloacetate from citrate and ATP Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA ATP citrate lyase is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA essential enzyme for generating acetyl-CoA, a key metabolite for the first step in fatty acid synthesis and for histone acetylation. Regulation of the enzyme activity is a potentially important point of control for cell cycle regulation in the myeloid lineage Mus musculus ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme catalyzes the formation of cytosolic acetyl CoA, the starting material for de novo lipid and cholesterol biosynthesis Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme links carbohydrate and lipid metabolism Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme links glycolysis to lipid metabolism Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the enzyme synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Fusarium graminearum GZ3639 ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for ATP Lipomyces starkeyi CBS 1809 ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Aspergillus nidulans R21 ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Cunninghamella sp. 2A1 ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA - Aspergillus nidulans 54 ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA specific for ATP Rhodotorula toruloides CBS 13 ADP + phosphate + acetyl-CoA + oxaloacetate - ? 321845 2.3.3.8 ATP + citrate + CoA the synthase activity is less than 0.5% of the ATP:citrate lyase activity Hydrogenobacter thermophilus TK-6 / IAM 12695 ADP + phosphate + acetyl-CoA + oxaloacetate - r 321845 2.3.3.8 ATP + citrate + CoA - Mus musculus acetyl-CoA + oxaloacetate + ADP + phosphate - ir 419355 2.3.3.8 ATP + citrate + CoA - Homo sapiens acetyl-CoA + oxaloacetate + ADP + phosphate - ir 419355 2.3.3.8 citrate + CoA + ATP - Homo sapiens acetyl-CoA + oxaloacetate + ADP + phosphate - ? 408871 2.3.3.8 dATP + citrate + CoA - Hydrogenobacter thermophilus dADP + phosphate + acetyl-CoA + oxaloacetate - ? 321846 2.3.3.8 dATP + citrate + CoA 40% of the activity with ATP Chlorobium limicola dADP + phosphate + acetyl-CoA + oxaloacetate - ? 321846 2.3.3.8 dATP + citrate + CoA - Hydrogenobacter thermophilus TK-6 / IAM 12695 dADP + phosphate + acetyl-CoA + oxaloacetate - ? 321846 2.3.3.8 GTP + citrate + CoA - Hydrogenobacter thermophilus GDP + phosphate + acetyl-CoA + oxaloacetate - ? 321848 2.3.3.8 GTP + citrate + CoA - Hydrogenobacter thermophilus TK-6 / IAM 12695 GDP + phosphate + acetyl-CoA + oxaloacetate - ? 321848 2.3.3.8 additional information enzyme is a nonredundant source of cytosolic acetyl-CoA Arabidopsis thaliana ? - ? 89 2.3.3.8 additional information dATP may substitute for ATP, no substrate: malate, isocitrate, succinate, acetate Chlorobium limicola ? - ? 89 2.3.3.8 additional information only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein Aspergillus niger ? - ? 89 2.3.3.8 additional information only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein Aspergillus niger ATCC 1015 ? - ? 89 2.3.3.8 N6-etheno-adenosine triphosphate + citrate + CoA - Talaromyces trachyspermus N6-etheno-adenosine diphosphate + phosphate + acetyl-CoA + oxaloacetate - ? 321847