2.3.1.48 2 acetyl-CoA + histone H4 - Pisum sativum 2 CoA + diacetylhistone H4 mono-, di- and triacetylated products ? 320934 2.3.1.48 2 acetyl-CoA + histone H4 enzyme form B Zea mays 2 CoA + diacetylhistone H4 mono- and diacetylated products ? 320934 2.3.1.48 2 acetyl-CoA + histone H4 enzyme form B Zea mays Cuzco 2 CoA + diacetylhistone H4 mono- and diacetylated products ? 320934 2.3.1.48 3 acetyl-CoA + histone H4 enzyme form B Pisum sativum 3 CoA + triacetylhistone H4 mono-, di- and triacetylated products ? 320935 2.3.1.48 3-azidopropionyl-CoA + [histone peptide H3-20]-L-lysine - Homo sapiens CoA + [histone peptide H3-20]-N6-3-azidopropionyl-L-lysine - ? 454991 2.3.1.48 3-azidopropionyl-CoA + [histone peptide H3-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H3-20]-N6-3-azidopropionyl-L-lysine - ? 454991 2.3.1.48 3-azidopropionyl-CoA + [histone peptide H4-20]-L-lysine - Homo sapiens CoA + [histone peptide H4-20]-N6-3-azidopropionyl-L-lysine - ? 454992 2.3.1.48 3-azidopropionyl-CoA + [histone peptide H4-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H4-20]-N6-3-azidopropionyl-L-lysine - ? 454992 2.3.1.48 4 acetyl-CoA + histone H4 - Saccharomyces cerevisiae 4 CoA + tetraacetylhistone H4 NuA4 randomly acetylates free and nucleosomal H4, with a small preference for lysines 5, 8, and 12 over 16 ? 419282 2.3.1.48 4-pentynoyl-CoA + [histone peptide H3-20]-L-lysine - Homo sapiens CoA + [histone peptide H3-20]-N6-4-pentynoyl-L-lysine - ? 455071 2.3.1.48 4-pentynoyl-CoA + [histone peptide H3-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H3-20]-N6-4-pentynoyl-L-lysine - ? 455071 2.3.1.48 4-pentynoyl-CoA + [histone peptide H4-20]-L-lysine - Homo sapiens CoA + [histone peptide H4-20]-N6-4-pentynoyl-L-lysine - ? 455072 2.3.1.48 4-pentynoyl-CoA + [histone peptide H4-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H4-20]-N6-4-pentynoyl-L-lysine - ? 455072 2.3.1.48 5-hexynoyl-CoA + [histone peptide H3-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H3-20]-N6-5-hexynoyl-L-lysine - ? 455108 2.3.1.48 5-hexynoyl-CoA + [histone peptide H3-20]-L-lysine very low activity with 5-hexynoyl-CoA Homo sapiens CoA + [histone peptide H3-20]-N6-5-hexynoyl-L-lysine - ? 455108 2.3.1.48 5-hexynoyl-CoA + [histone peptide H4-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H4-20]-N6-5-hexynoyl-L-lysine - ? 455109 2.3.1.48 5-hexynoyl-CoA + [histone peptide H4-20]-L-lysine very low activity with 5-hexynoyl-CoA Homo sapiens CoA + [histone peptide H4-20]-N6-5-hexynoyl-L-lysine - ? 455109 2.3.1.48 6-heptynoyl-CoA + [histone peptide H3-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H3-20]-N6-6-heptynoyl-L-lysine - ? 455117 2.3.1.48 6-heptynoyl-CoA + [histone peptide H3-20]-L-lysine very low activity with 6-heptynoyl-CoA Homo sapiens CoA + [histone peptide H3-20]-N6-6-heptynoyl-L-lysine - ? 455117 2.3.1.48 6-heptynoyl-CoA + [histone peptide H4-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H4-20]-N6-6-heptynoyl-L-lysine - ? 455118 2.3.1.48 6-heptynoyl-CoA + [histone peptide H4-20]-L-lysine very low activity with 6-heptynoyl-CoA Homo sapiens CoA + [histone peptide H4-20]-N6-6-heptynoyl-L-lysine - ? 455118 2.3.1.48 acetyl-CoA + 1,4-butanediamine enzyme form A and B, low activity Rattus norvegicus ? - ? 320945 2.3.1.48 acetyl-CoA + 1,4-butanediamine i.e. putrescine Rattus norvegicus ? - ? 320945 2.3.1.48 acetyl-CoA + 1,5-pentanediamine enzyme form A and B, low activity Rattus norvegicus ? - ? 320946 2.3.1.48 acetyl-CoA + 1,5-pentanediamine i.e. cadaverine Rattus norvegicus ? - ? 320946 2.3.1.48 acetyl-CoA + 1,6-hexanediamine enzyme form A shows low activity , B not Rattus norvegicus ? - ? 320947 2.3.1.48 acetyl-CoA + AVDSVFDTILDALK histone-like protein HBsu peptide Bacillus subtilis CoA + AVDSVFDTILDALKac - ? 455231 2.3.1.48 acetyl-CoA + AVDSVFDTILDALK histone-like protein HBsu peptide Bacillus subtilis 168 CoA + AVDSVFDTILDALKac - ? 455231 2.3.1.48 acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1 - Homo sapiens CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1 - ? 407079 2.3.1.48 acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1 50 mM Tris-HCl, pH 8.0, 30°C Homo sapiens CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1 - ? 407079 2.3.1.48 acetyl-CoA + biotinylated histone H3 (1-21) peptide - Homo sapiens CoA + acetylated biotinylated histone H3 (1-21) peptide - ? 455170 2.3.1.48 acetyl-CoA + c-Myc acetylation by Tip60 increases c-Myc protein stability in transfected H-1299 human lung carcinoma cells Mus musculus CoA + acetylated c-Myc - ? 407080 2.3.1.48 acetyl-CoA + c-Myc acetylation by Tip60 Mus musculus CoA + acetylated c-Myc - ? 407080 2.3.1.48 acetyl-CoA + H3 peptide - Toxoplasma gondii ? - ? 420197 2.3.1.48 acetyl-CoA + histone - Drosophila melanogaster CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Drosophila melanogaster CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Mus musculus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Mus musculus CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens CoA + acetylhistone - ir 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Saccharomyces cerevisiae CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Bos taurus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Pisum sativum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Zea mays CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Arabidopsis thaliana CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Tetrahymena thermophila CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Tetrahymena thermophila CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Tetrahymena sp. CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Betapolyomavirus macacae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens CoA + acetylhistone in the assay the CoA thiolate is detected by the thiol sensitive fluorescent dye 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin ? 320931 2.3.1.48 acetyl-CoA + histone enzyme form B nearly exclusively acetylates histones H4 and H2a Bos taurus CoA + acetylhistone formation of N6-acetyllysine as the only acetylation product ? 320931 2.3.1.48 acetyl-CoA + histone calf thymus and HeLa cell histones Homo sapiens CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone pea histones, enzyme form A and B Pisum sativum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone H2A is a substrate for enzyme form A1 Physarum polycephalum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone free histones Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone chicken erythrocyte histones, enzyme form A and B Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone chicken erythrocyte histones, enzyme form A and B Pisum sativum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone nucleosome-histones, enzyme form A, not enzyme form B Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone f1, enzyme form A Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone f2a1, enzyme form B1 and B2 Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone nucleosome-histones, enzyme form A and B Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Sus scrofa CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Saccharomyces cerevisiae CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Bos taurus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Physarum polycephalum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Artemia nauplii CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone acetylates histones H2A, H3, and H4, but not histone 2B Human Immunodeficiency Virus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone free pea and chicken histones H4, enzyme form B Pisum sativum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone or chymotryptic peptides of histone Bos taurus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone chymostatic peptides of histones Sus scrofa CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone H1 is a better substrate than H3 or H4 Artemia salina CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone H1 poor substrate Rattus norvegicus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone H2B: poor substrate for enzyme form A2 Physarum polycephalum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone acetylation of lysine 5, 8, 12, and 16 of free histone H4 with increasing preference Pisum sativum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone H1 is not acetylated in vivo Homo sapiens CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone Esa1 protein is involved in cell cycle regulation Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone involved in chromatin remodeling and DNA repair Homo sapiens CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone involved in chromatin remodeling and DNA repair Saccharomyces cerevisiae CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Drosophila melanogaster CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Mus musculus CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Homo sapiens CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Saccharomyces cerevisiae CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Arabidopsis thaliana CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Homo sapiens CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Tetrahymena sp. CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone involved in dynamic equilibrium of core histone acetylation Physarum polycephalum CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Homo sapiens CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Tetrahymena sp. CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone most likely involved in acetylation of newly synthesized histones in cytoplasm prior to chromatin assembly Drosophila melanogaster CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone important role of the enzyme for chromatin modulating activity Aspergillus nidulans CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone the bifunctional enzyme NCOAT, nuclear cytoplasmic O-GlcNacase and acetyltransferase, may be regulated to reduce the state of glycosylation of transcriptional activators while increasing the acetylation of histones to allow for concerted activation of eukaryotic gene transcription Mus musculus CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone acetylation on Lys16 by Sas2 Saccharomyces cerevisiae CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens GCN5 CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone histone H1 is not acetylated in vivo Homo sapiens GCN5 CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Homo sapiens GCN5 CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Homo sapiens GCN5 CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens GCN5 CoA + acetylhistone - ir 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens GCN5 CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Homo sapiens GCN5 CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone involved in chromatin remodeling and DNA repair Homo sapiens GCN5 CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Homo sapiens GCN5 CoA + acetylhistone - r 320931 2.3.1.48 acetyl-CoA + histone - Tetrahymena thermophila GCN5 CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone - Zea mays Cuzco CoA + acetylhistone - ? 320931 2.3.1.48 acetyl-CoA + histone H histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway Arabidopsis thaliana CoA + acetylhistone H - ? 375028 2.3.1.48 acetyl-CoA + histone H1 histone H1 is a better substrate than H3 or H4 Artemia salina CoA + acetylhistone H1 - ? 320940 2.3.1.48 acetyl-CoA + histone H1 histone H1 poor substrate Homo sapiens CoA + acetylhistone H1 - ? 320940 2.3.1.48 acetyl-CoA + histone H1 histone H1 poor substrate Rattus norvegicus CoA + acetylhistone H1 - ? 320940 2.3.1.48 acetyl-CoA + histone H1 acetylation of histone H1 only in vitro Homo sapiens CoA + acetylhistone H1 - ? 320940 2.3.1.48 acetyl-CoA + histone H1 histone H1 poor substrate Homo sapiens GCN5 CoA + acetylhistone H1 - ? 320940 2.3.1.48 acetyl-CoA + histone H1 acetylation of histone H1 only in vitro Homo sapiens GCN5 CoA + acetylhistone H1 - ? 320940 2.3.1.48 acetyl-CoA + histone H2A - Mus musculus CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A - Homo sapiens CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A - Saccharomyces cerevisiae CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A - Aspergillus nidulans CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A - Human Immunodeficiency Virus CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A enzyme form B nearly exclusively acetylates histones H4 and H2a Bos taurus CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A histone H2A is a substrate for enzyme form A1 Physarum polycephalum CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A NuA4-like protein acetylates histone H4 and H2A Saccharomyces cerevisiae CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A NuA4-like protein acetylates histone H4 and H2A Tetrahymena thermophila CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A MYST-related histone acetyltransferase complex Tip60 Homo sapiens CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A acetylation at Lys5 by Tip60 Homo sapiens CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A - Mus musculus C57BL/6 CoA + acetylhistone H2A - ? 320938 2.3.1.48 acetyl-CoA + histone H2A - Saccharomyces cerevisiae Nalpha-acetylated-histone H2A + CoA - ? 376144 2.3.1.48 acetyl-CoA + histone H2B - Homo sapiens CoA + acetylhistone H2B - ? 320939 2.3.1.48 acetyl-CoA + histone H2B - Saccharomyces cerevisiae CoA + acetylhistone H2B - ? 320939 2.3.1.48 acetyl-CoA + histone H2B histone H2B: poor substrate for enzyme form A2 Physarum polycephalum CoA + acetylhistone H2B - ? 320939 2.3.1.48 acetyl-CoA + histone H2B histone H2B: preferred substrate of enzyme form A Saccharomyces cerevisiae CoA + acetylhistone H2B - ? 320939 2.3.1.48 acetyl-CoA + histone H2B GNAT-related histone acetyltransferase complexes SAGA, ADA or H2B Saccharomyces cerevisiae CoA + acetylhistone H2B - ? 320939 2.3.1.48 acetyl-CoA + histone H2B GNAT-related histone acetyltransferase complexes STAGA or TFTC Homo sapiens CoA + acetylhistone H2B - ? 320939 2.3.1.48 acetyl-CoA + histone H3 - Gallus gallus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Mammalia CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 - Mus musculus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Aspergillus nidulans CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Vitis vinifera CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Human immunodeficiency virus 1 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Tetrahymena sp. CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Human Immunodeficiency Virus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Toxoplasma gondii CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Arabidopsis thaliana CoA + acetylhistone H3 residues K14, K18, and K23 of H3 are acetylated by domain C1 of isoform Idm1 in vitro ? 320936 2.3.1.48 acetyl-CoA + histone H3 preferred substrate Toxoplasma gondii CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 histone H1 is a better substrate than H3 or H4 Artemia salina CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 PCAF protein Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: specific for Lys14 of histone H3 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Drosophila melanogaster CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Mus musculus CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Homo sapiens CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Saccharomyces cerevisiae CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Arabidopsis thaliana CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 histone H3: preferred substrate Rattus norvegicus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 histone H3: preferred substrate Sus scrofa CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 histone H3: preferred substrate Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 enzyme form B, very low activity Zea mays CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 histone H3 preferred substrate of enzyme form A Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 histone H3 is the preferred substrate of enzyme form A1 and A2 Physarum polycephalum CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 Lys14 of histone H3 and a peptide containing Lys14 thereof are the preferred substrates for Gnc5 and PCAF protein, as well as Gnc5 and PCAF catalytic domain Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 recombinant and native SAS complex acetylates Lys14 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 GNAT-related histone acetyltransferase complexes PCAF, STAGA or TFTC Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 GNAT-related histone acetyltransferase complexes SAGA, ADA or HAT-A2, MYST-related histone acetyltransferase complex NuA3 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 strong preference for free histones relative to chromatin substrate Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation at Lys9 Gallus gallus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation at Lys9 Arabidopsis thaliana CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys14 by tGCN5 in the consensus sequence QTARKSTGGK14APRKLASK Tetrahymena thermophila CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys56 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys56 Candida albicans CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 CBP binds and acetylates histones at neural promoters, and regulates Corpus Callosum development. CBP binds to neuronal and glial promoters and globally promotes histone acetylation in the embryonic cortex, e.g. the beta-actin promoter, overview Mus musculus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview Mus musculus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 regulation, detailed overview. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an NF-kappaB-signaling code and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner, overview Mammalia CoA + acetylhistone H3 - r 320936 2.3.1.48 acetyl-CoA + histone H3 Rtt109 association with distinct histone chaperones directs substrate selection between N-terminal lysines, H3K9, H3K23, and those within the histone fold domain, H3K56 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56. RTT109 has functions in addition to maintaining genome stability Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation at Lys14 of histone H3 Arabidopsis thaliana CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys14 by tGCN5 in the consensus sequence QTARKSTGGK14APRKLASK. Phe125 and Phe164 interact with the substrate, but are not directly involved in the acetylation reaction, while residues Glu122, Val123 and Tyr160 are critical for catalysis Tetrahymena thermophila CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys9 and Lys14 Mus musculus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys9 and Lys14 by PCAF. PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 Rtt109 association with distinct histone chaperones directs substrate selection between N-terminal lysines, H3K9, H3K23, and those within the histone fold domain, H3K56. The sequence G-K-X-P within histone H3, which includes the primary Gcn5 substrate K14, makes several key contacts within the active site that are conserved with other GNAT members Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 substrate is a H3 peptide Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 the sequence G-K-X-P within histone H3 makes several key contacts within the active site that are conserved in GNAT members including p/CAF Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 the sequence G-K-X-P within histone H3, which includes the primary Gcn5 substrate K14, makes several key contacts within the active site that are conserved in GNAT members Tetrahymena sp. CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation at Lys18 Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation at Lys18 Saccharomyces cerevisiae CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys23 Homo sapiens CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys9, Lys14, Lys18, Lys23, Lys27, Lys36, and Lys37 Drosophila melanogaster CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation at Lys4 and Lys9 Human immunodeficiency virus 1 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys56 Saccharomyces cerevisiae BY4705 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 PCAF protein Homo sapiens GCN5 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Tetrahymena sp. GCN5 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 the sequence G-K-X-P within histone H3, which includes the primary Gcn5 substrate K14, makes several key contacts within the active site that are conserved in GNAT members Tetrahymena sp. GCN5 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 - Toxoplasma gondii ME49 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 preferred substrate Toxoplasma gondii ME49 CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 enzyme form B, very low activity Zea mays Cuzco CoA + acetylhistone H3 - ? 320936 2.3.1.48 acetyl-CoA + histone H3 preferred substrate, the N-terminal substrate region plays an importsant role in enhanced affinity of the Gcn5/PCAF proteins for histone H3 Tetrahymena sp. peptide CoA + acetylhistone H3 peptide - ? 376146 2.3.1.48 acetyl-CoA + histone H3 - Toxoplasma gondii CoA + acetyl-histone H3 - ? 434587 2.3.1.48 acetyl-CoA + histone H3 - Toxoplasma gondii ATCC 50611 CoA + acetyl-histone H3 - ? 434587 2.3.1.48 acetyl-CoA + histone H3 N-terminal tail 50 mM Tris-HCl, pH 8.0, 30°C Homo sapiens CoA + acetylated histone H3 N-terminal tail - ? 408280 2.3.1.48 acetyl-CoA + histone H3 peptide Lys14 of histone H3 and a peptide containing Lys14 thereof are the preferred substrates for Gnc5 and PCAF protein, as well as Gnc5 and PCAF catalytic domain Homo sapiens CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide Lys14 of histone H3 and a peptide containing Lys14 thereof are the preferred substrates for Gnc5 and PCAF protein, as well as Gnc5 and PCAF catalytic domain Saccharomyces cerevisiae CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptides H3p19, H3p27, H3p11 are substrates for the catalytic domain of Gcn5 and PCAF Homo sapiens CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptides H3p19, H3p27, H3p11 are substrates for the catalytic domain of Gcn5 and PCAF Saccharomyces cerevisiae CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptides H3p19, H3p27, H3p11 are substrates for the catalytic domain of Gcn5 and PCAF Tetrahymena thermophila CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptide H3p20 Homo sapiens CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptide H3p20 Saccharomyces cerevisiae CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptide H3p20 Tetrahymena thermophila CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptides H3p19, H3p27, H3p11 are substrates for the catalytic domain of Gcn5 and PCAF Homo sapiens GCN5 CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptide H3p20 Homo sapiens GCN5 CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptides H3p19, H3p27, H3p11 are substrates for the catalytic domain of Gcn5 and PCAF Tetrahymena thermophila GCN5 CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide peptide H3p20 Tetrahymena thermophila GCN5 CoA + acetylhistone H3 peptide - ? 320937 2.3.1.48 acetyl-CoA + histone H3 peptide residues 1-21 of human histone H3 Homo sapiens CoA + actylhistone H3 - ? 420200 2.3.1.48 acetyl-CoA + histone H3 tail peptide H3 peptide substrate, amino acid sequence ARTKQTARKSTGGKAPRKQL Saccharomyces cerevisiae CoA + acetylhistone H3 peptide - ? 420201 2.3.1.48 acetyl-CoA + histone H3-peptide - Homo sapiens CoA + acetylhistone H3-peptide - ? 451955 2.3.1.48 acetyl-CoA + histone H3-peptide - Saccharomyces cerevisiae CoA + acetylhistone H3-peptide - ? 451955 2.3.1.48 acetyl-CoA + histone H3-peptide - Homo sapiens CoA + acetylhistone H3 -peptide - ? 453926 2.3.1.48 acetyl-CoA + histone H3-peptide - Saccharomyces cerevisiae CoA + acetylhistone H3 -peptide - ? 453926 2.3.1.48 acetyl-CoA + histone H3-peptide - Homo sapiens GCN5 CoA + acetylhistone H3 -peptide - ? 453926 2.3.1.48 acetyl-CoA + histone H3-peptide p19 - Homo sapiens CoA + acetylhistone H3-peptide p19 - ? 451953 2.3.1.48 acetyl-CoA + histone H3-peptide p19 - Homo sapiens CoA + acetylhistone H3 -peptide p19 - ? 453925 2.3.1.48 acetyl-CoA + histone H3-peptide p20 - Homo sapiens CoA + acetylhistone H3 -peptide p20 - ? 453927 2.3.1.48 acetyl-CoA + histone H3-peptide p20 - Homo sapiens GCN5 CoA + acetylhistone H3 -peptide p20 - ? 453927 2.3.1.48 acetyl-CoA + histone H3-peptide p27 - Homo sapiens CoA + acetylhistone H3 -peptide p27 - ? 451954 2.3.1.48 acetyl-CoA + histone H4 - Gallus gallus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Aspergillus nidulans CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Plasmodium falciparum CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Tetrahymena thermophila CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Tetrahymena thermophila CoA + acetylhistone H4 - r 320933 2.3.1.48 acetyl-CoA + histone H4 - Human Immunodeficiency Virus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Plasmodium falciparum CoA + acetylhistone H4 acetylates histone H4 in vitro at K5, K8, K12 and K16 ? 320933 2.3.1.48 acetyl-CoA + histone H4 highly specific for Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 highly specific for Pisum sativum CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B nearly exclusively acetylates histones H4 and H2a Bos taurus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Drosophila melanogaster CoA + acetylhistone H4 - r 320933 2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Homo sapiens CoA + acetylhistone H4 - r 320933 2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Saccharomyces cerevisiae CoA + acetylhistone H4 - r 320933 2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Arabidopsis thaliana CoA + acetylhistone H4 - r 320933 2.3.1.48 acetyl-CoA + histone H4 NuA4-like protein acetylates histone H4 and H2A Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 NuA4-like protein acetylates histone H4 and H2A Tetrahymena thermophila CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 SAS complex, native and recombinant, acetylates Lys16 Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 histone H4: all of the acetate groups are introduced within the NH2-terminal amino acids 4 to 17 Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B has a marked specificity for histone H4 Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B Pisum sativum CoA + acetylhistone H4 mono-, di- and triacetylated products ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B Zea mays CoA + acetylhistone H4 mono- and diacetylated products ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B is specific for histone H4 Rattus norvegicus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B is specific for histone H4 Physarum polycephalum CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 histone H4 is a poor substrate Rattus norvegicus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 PCAF protein Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 histone H4 is the preferred substrate Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 histone H4 is the preferred substrate Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation of histone H4 by NuA4 is required for the cellular resistance to spindle stress. The NuA4 histone acetyltransferase subunit Yaf9, is required for the cellular response to spindle stress in yeast Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 exclusively acetylates of Lys16 of histone H4, the enzyme is required for bulk of H4 lysine 16 acetylation in vivo, role of SAS complex in antagonizing the speading of Sir proteins at silent loci in Saccharomyces cerevisiae Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 RmtA is specific for histone H4 with Arg3 as the methylation site. Methylation of histone H4 by recombinant RmtA affects the acetylation by p300/CBP, supporting aninterrelation of histone methylation and acetylation in transcriptional regulation. Important role of the enzyme for chromatin modulating activity Aspergillus nidulans CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 specific acetylation of Lys16, reversible acetylation of histones play an important role in regulation of chromatin structure and function. HMOF has a role in DNA damage responseduring cell cycle progression Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 the level of HAT-B-dependent acK12H4 may be very low under normal growth condition Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetyltion of Lys16, acetylates free histones and weakly acetylates nucleosomes Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 MYST-related histone acetyltransferase complex NuA4 or SAS(SAS-I) Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 MYST-related histone acetyltransferase complex Tip60, GNAT-related histone acetyltransferase complex PCAF Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 RmtA is specific for histone H4 with Arg3 as the methylation site Aspergillus nidulans CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 specifically acetylates Lys12, and to a lesser extent Lys5 of free, non-chromatin-bound histone H4 Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 both Lys12 and Lys5 of soluble, non-chromatin-bound histone H4 are in vivo targets of acetylation for the yeast HAT-B enzyme. Lys12/Lys5-acetylated histone H4 is bound to the HAT-B complex in the soluble cell fraction. Exchange of Lys for Arg at position 12 of histone H4 do not interfere with histone H4 association with the complex, but prevented acetylation on Lys5 by the HAT-B enzyme, in vivo as well as in vitro Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview Mus musculus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 Hat1 is a primary enzyme for di-acetylating cytosolic histone H4 at Lys5 and Lys12 in the cytosol Gallus gallus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 HBO1 is an H4-specific histone acetylase, and is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is essential for DNA licensing of replication origins, where it controls H4 acetylation at the origins. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 HBO1 regulates global histone H4 acetylation Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 Mof is required for sex chromosome dosage compensation acting in the MSL complex, which also contains Msl1-3, Mle, and RNA, to acetylate H4K16 and to increase gene transcription from the single male X chromosome Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 Mof is solely responsible for H4K16 acetylation in mouse blastocysts. Tip60 plays essential roles in cell cycle progression in vitro Mus musculus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on Lys16, while NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on Lys5 and Lys8 Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 MYST1 specificity to Lys16 of histone H4 is not absolute, because in experiments in vitro the protein is also able to acetylate histones H3 and H2A, whereas in vivo only modification of histone H4 is specific. Acetylation at Lys16 by MYST1 is essential for chromatin remodeling and is used for regulation of gene expression in eukaryotes. The nucleosome is a disc-shaped octamer consisting of two heterotetramers formed by histones H3/H4 and histones H2A and H2B. All human autosomes are susceptible to histone H4 acetylation by Lys16 residue and acetyltransferase MYST1 Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys16 Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys16 Mus musculus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys16 by MYST1 Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys16 by MYST1 Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 activity with synthetic histone H4 tail peptide substrate of p300 that shows different degrees of autoacetylation, overview. Tyr1467 appears to serve as a general acid protonating the departing coenzyme A sulfur Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 full-length histone H4 is acetylated 2000fold faster than histone tail peptides Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 recombinant ATAC2 has a weak HAT activity directed to histone H4 Mus musculus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 recombinant ATAC2 has a weak HAT activity directed to histone H4 Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 recombinant Hbo1 can acetylate nucleosomal histone H4 in vitro, with a preference for Lys5 and Lys12, mapping of acetylation sites, overview Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 substrate is a H4 peptide Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 substrate is H4 peptide Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 substrates are synthetic N-terminal H4 peptides. The HAT-B complex acetylates only Lys12, recombinant Hat1 is able to modify Lys12 and Lys5. Exchange of Lys for Arg at position 12 of histone H4 does not interfere with histone H4 association with the complex, but prevents acetylation on Lys5 by the HAT-B enzyme, in vivo as well as in vitro Saccharomyces cerevisiae CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys14 Gallus gallus CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation at Lys14 Arabidopsis thaliana CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation of Lys16 Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation of Lys16 Homo sapiens CoA + acetylhistone H4 in the assay the CoA thiolate is detected by the thiol sensitive fluorescent dye 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation of Lys5, Lys8, Lys12, and Lys16 Drosophila melanogaster CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 the enzyme PCAF acetylates histone H4 at lysine 8 Homo sapiens CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 histone H4 is the preferred substrate Homo sapiens GCN5 CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 PCAF protein Homo sapiens GCN5 CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 - Tetrahymena thermophila GCN5 CoA + acetylhistone H4 - ? 320933 2.3.1.48 acetyl-CoA + histone H4 enzyme form B Zea mays Cuzco CoA + acetylhistone H4 mono- and diacetylated products ? 320933 2.3.1.48 acetyl-CoA + histone H4 acetylation of N-terminal Ser Saccharomyces cerevisiae Nalpha-acetylated-histone H4 + CoA - ? 376147 2.3.1.48 acetyl-CoA + histone H4 - Saccharomyces cerevisiae peptide CoA + acetylhistone H4 peptide - ? 376148 2.3.1.48 acetyl-CoA + histone H4 specific acetylation of Lys16 Homo sapiens peptide CoA + acetylhistone H4 peptide - ? 376148 2.3.1.48 acetyl-CoA + histone H4 peptide residues 1-20 of histone H4 Homo sapiens CoA + acetylpeptide of histone H4 - ? 420203 2.3.1.48 acetyl-CoA + histone H4 peptide residues 2-24 of human histone H4 Homo sapiens CoA + actylhistone H4 - ? 420204 2.3.1.48 acetyl-CoA + histone H4 peptide a synthetic peptide corresponding to the first 20 amino acids of the histone H4 N-terminus Homo sapiens CoA + acetylhistone H4 peptide - ? 435247 2.3.1.48 acetyl-CoA + N-terminal L-lysyl-[beta-catenin] - Homo sapiens CoA + H+ + N-terminal Nalpha-acetyl-lysyl-[beta-catenin] - ir 454257 2.3.1.48 acetyl-CoA + N-terminal L-lysyl-[Hsp70] - Homo sapiens CoA + H+ + N-terminal Nalpha-acetyl-L-lysyl-[Hsp70] - ir 454258 2.3.1.48 acetyl-CoA + N-terminal L-lysyl-[Hsp70] acetylation of residue K77 Homo sapiens CoA + H+ + N-terminal Nalpha-acetyl-L-lysyl-[Hsp70] - ir 454258 2.3.1.48 acetyl-CoA + NF-kB p65 acetylation of the subunit at Lys310 by p300 or PCAF Mammalia CoA + acetyl-NF-kB p65 - ? 408291 2.3.1.48 acetyl-CoA + non-histone chromatin high-mobility group protein or chymotryptic peptides of Bos taurus CoA + acetylated non-histone chromatin high-mobility group protein - ? 320932 2.3.1.48 acetyl-CoA + p50 protein acetylation of p50 by p300 independent of shear stress Homo sapiens CoA + acetyl-p50 protein - ? 407093 2.3.1.48 acetyl-CoA + p50 protein acetylation of histones H4 at the site of SSRE within the eNOS promoter Homo sapiens CoA + acetyl-p50 protein - ? 407093 2.3.1.48 acetyl-CoA + p53 p53 protein-acetylation of the Lys120 residue Homo sapiens CoA + acetyl-p53 - ? 407094 2.3.1.48 acetyl-CoA + p53 p53 protein-acetylation of the Lys120 residue is carried out by acetyltransferases MYST1 and TIP60 to approximately equal extent Homo sapiens CoA + acetyl-p53 - ? 407094 2.3.1.48 acetyl-CoA + p65 protein acetylation of p65 by p300 during translocation into the nuclei in response to shear stress Homo sapiens CoA + acetyl-p65 protein - ? 407095 2.3.1.48 acetyl-CoA + p65 protein acetylation of histones H3 at the site of SSRE within the eNOS promoter Homo sapiens CoA + acetyl-p65 protein - ? 407095 2.3.1.48 acetyl-CoA + peptide H4-20 histone H4-derived peptide substrate Human immunodeficiency virus 1 CoA + acetylpeptide H4-20 - ? 435269 2.3.1.48 acetyl-CoA + poly-L-lysine enzyme form A, not enzyme form B1 and B2 Rattus norvegicus CoA + N6-acetyllysine - ? 320944 2.3.1.48 acetyl-CoA + protamine sulfate enzyme form A, not enzyme form B Saccharomyces cerevisiae ? - ? 320943 2.3.1.48 acetyl-CoA + protamine sulfate enzyme form A, not enzyme form B Pisum sativum ? - ? 320943 2.3.1.48 acetyl-CoA + protein p53 - Homo sapiens CoA + acetylprotein p53 - r 320948 2.3.1.48 acetyl-CoA + protein p53 - Homo sapiens CoA + acetylprotein p53 - ? 320948 2.3.1.48 acetyl-CoA + protein p53 substrate is a DNA-binding transcription activator and a tumor suppressor Homo sapiens CoA + acetylprotein p53 - ? 320948 2.3.1.48 acetyl-CoA + protein p53 peptide of p53 is a substrate for PCAF catalytic domain Homo sapiens CoA + acetylprotein p53 - ? 320948 2.3.1.48 acetyl-CoA + putrescine - Acinetobacter baumannii ? - ? 455225 2.3.1.48 acetyl-CoA + SGRGKGGKGLGKGGAKRHRK - Homo sapiens CoA + SGRGKGGKGLGKGGAKRHR(acK) - ? 455228 2.3.1.48 acetyl-CoA + spermidine - Rattus norvegicus ? - ? 320942 2.3.1.48 acetyl-CoA + spermidine - Bos taurus ? - ? 320942 2.3.1.48 acetyl-CoA + spermidine - Acinetobacter baumannii ? - ? 320942 2.3.1.48 acetyl-CoA + spermidine enzyme form B, not enzyme form A Pisum sativum ? - ? 320942 2.3.1.48 acetyl-CoA + spermine - Rattus norvegicus ? - ? 320941 2.3.1.48 acetyl-CoA + spermine - Bos taurus ? - ? 320941 2.3.1.48 acetyl-CoA + spermine - Acinetobacter baumannii ? - ? 320941 2.3.1.48 acetyl-CoA + spermine enzyme form A inactive, enzyme form B active Pisum sativum ? - ? 320941 2.3.1.48 acetyl-CoA + transcription factor TFIIE substrate is a basal transcription factor Homo sapiens CoA + acetylated transcription factor TFIIE - ? 320949 2.3.1.48 acetyl-CoA + transcription factor TFIIF substrate is a basal transcription factor Homo sapiens CoA + acetylated transcription factor TFIIF - ? 320950 2.3.1.48 acetyl-CoA + VPAFKPGK histone-like protein HBsu peptide Bacillus subtilis CoA + VPAFKPGKac - ? 455243 2.3.1.48 acetyl-CoA + [alpha-tubulin]-L-lysine - Saccharomyces cerevisiae CoA + [alpha-tubulin]-N6-acetyl-L-lysine - ? 419325 2.3.1.48 acetyl-CoA + [alpha-tubulin]-L-lysine - Saccharomyces cerevisiae D273-10B/A1 CoA + [alpha-tubulin]-N6-acetyl-L-lysine - ? 419325 2.3.1.48 acetyl-CoA + [alpha-tubulin]-L-lysine - Saccharomyces cerevisiae W303-1A CoA + [alpha-tubulin]-N6-acetyl-L-lysine - ? 419325 2.3.1.48 acetyl-CoA + [alpha-tubulin]-L-lysine40 - Homo sapiens CoA + [alpha-tubulin]-N6-acetyl-L-lysine40 - ? 435224 2.3.1.48 acetyl-CoA + [alpha-tubulin]-L-lysine40 KAT2A acetylates Lys40 of TUBA Homo sapiens CoA + [alpha-tubulin]-N6-acetyl-L-lysine40 - ? 435224 2.3.1.48 acetyl-CoA + [ATM]-L-lysine - Homo sapiens CoA + [ATM]-N6-acetyl-L-lysine - ? 454265 2.3.1.48 acetyl-CoA + [ATM]-L-lysine - Drosophila melanogaster CoA + [ATM]-N6-acetyl-L-lysine - ? 454265 2.3.1.48 acetyl-CoA + [AuA]-L-lysine125 lysine residues at positions 75 and 125 of aurora kinase A (AuA) are acetylated by ARD1, mutational analysis with AUA mutant substrates, overview Homo sapiens CoA + [AuA]-N6-acetyl-L-lysine125 - ? 454266 2.3.1.48 acetyl-CoA + [AuA]-L-lysine75 lysine residues at positions 75 and 125 of aurora kinase A (AuA) are acetylated by ARD1, mutational analysis with AUA mutant substrates, overview Homo sapiens CoA + [AuA]-N6-acetyl-L-lysine75 - ? 454267 2.3.1.48 acetyl-CoA + [beta-catenin]-L-lysine - Homo sapiens CoA + [beta-catenin]-N6-acetyl-L-lysine - ? 454268 2.3.1.48 acetyl-CoA + [c-myc]-L-lysine - Homo sapiens CoA + [c-myc]-N6-acetyl-L-lysine - ? 454270 2.3.1.48 acetyl-CoA + [c-myc]-L-lysine - Drosophila melanogaster CoA + [c-myc]-N6-acetyl-L-lysine - ? 454270 2.3.1.48 acetyl-CoA + [CDC6]-L-lysine - Homo sapiens CoA + [CDC6]-N6-acetyl-L-lysine - ? 454271 2.3.1.48 acetyl-CoA + [CDC6]-L-lysine14 - Homo sapiens CoA + [CDC6]-N6-acetyl-L-lysine14 - ? 455232 2.3.1.48 acetyl-CoA + [CDC6]-L-lysine14 - Mus musculus CoA + [CDC6]-N6-acetyl-L-lysine14 - ? 455232 2.3.1.48 acetyl-CoA + [connexin 43]-L-lysine - Homo sapiens CoA + [connexin 43]-N6-acetyl-L-lysine - ? 454272 2.3.1.48 acetyl-CoA + [DNMT1]-L-lysine - Homo sapiens CoA + [DNMT1]-N6-acetyl-L-lysine - ? 454273 2.3.1.48 acetyl-CoA + [DNMT1]-L-lysine - Drosophila melanogaster CoA + [DNMT1]-N6-acetyl-L-lysine - ? 454273 2.3.1.48 acetyl-CoA + [E2F1]-L-lysine - Homo sapiens CoA + [E2F1]-N6-acetyl-L-lysine - ? 454274 2.3.1.48 acetyl-CoA + [E2F1]-L-lysine - Drosophila melanogaster CoA + [E2F1]-N6-acetyl-L-lysine - ? 454274 2.3.1.48 acetyl-CoA + [EGR2]-L-lysine - Mus musculus CoA + [EGR2]-N6-acetyl-L-lysine - ? 454275 2.3.1.48 acetyl-CoA + [EGR2]-L-lysine - Mus musculus C57BL/6 CoA + [EGR2]-N6-acetyl-L-lysine - ? 454275 2.3.1.48 acetyl-CoA + [Foxo1]-L-lysine - Homo sapiens CoA + [Foxo1]-N6-acetyl-L-lysine - ? 454276 2.3.1.48 acetyl-CoA + [Geminin]-L-lysine14 - Homo sapiens CoA + [Geminin]-N6-acetyl-L-lysine14 - ? 455234 2.3.1.48 acetyl-CoA + [Geminin]-L-lysine14 - Mus musculus CoA + [Geminin]-N6-acetyl-L-lysine14 - ? 455234 2.3.1.48 acetyl-CoA + [HBsu]-L-lysine essential histone-like protein HBsu contains seven acetylation sites in vivo, mutational analysis using mutants hbsK86Q, hbsK41Q, hbsK3Q, hbsK41R, and hbsK37R Bacillus subtilis CoA + [HBsu]-N6-acetyl-L-lysine - ? 454277 2.3.1.48 acetyl-CoA + [HBsu]-L-lysine histone-like protein HBsu Bacillus subtilis CoA + [HBsu]-N6-acetyl-L-lysine - ? 454277 2.3.1.48 acetyl-CoA + [HBsu]-L-lysine essential histone-like protein HBsu contains seven acetylation sites in vivo, mutational analysis using mutants hbsK86Q, hbsK41Q, hbsK3Q, hbsK41R, and hbsK37R Bacillus subtilis 168 CoA + [HBsu]-N6-acetyl-L-lysine - ? 454277 2.3.1.48 acetyl-CoA + [HBsu]-L-lysine histone-like protein HBsu Bacillus subtilis 168 CoA + [HBsu]-N6-acetyl-L-lysine - ? 454277 2.3.1.48 acetyl-CoA + [histone H2A]-L-lysine5 - Homo sapiens CoA + [histone H2A]-N6-acetyl-L-lysine5 - ir 454278 2.3.1.48 acetyl-CoA + [histone H2A]-L-lysine5 - Homo sapiens CoA + [histone H2A]-N6-acetyl-L-lysine5 - ? 454278 2.3.1.48 acetyl-CoA + [histone H2B]-L-lysine - Homo sapiens CoA + [histone H2B]-N6-acetyl-L-lysine - ? 454281 2.3.1.48 acetyl-CoA + [histone H2B]-L-lysine12 - Homo sapiens CoA + [histone H2B]-N6-acetyl-L-lysine12 - ? 454279 2.3.1.48 acetyl-CoA + [histone H2B]-L-lysine15 - Homo sapiens CoA + [histone H2B]-N6-acetyl-L-lysine15 - ? 454280 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine - ? 454288 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine - Mus musculus CoA + [histone H3]-N6-acetyl-L-lysine - ? 454288 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine - Saccharomyces cerevisiae CoA + [histone H3]-N6-acetyl-L-lysine - ? 454288 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine - Drosophila melanogaster CoA + [histone H3]-N6-acetyl-L-lysine - ? 454288 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H3]-N6-acetyl-L-lysine - ? 454288 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine13 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine13 - ir 455235 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine14 - ir 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Arabidopsis thaliana CoA + [histone H3]-N6-acetyl-L-lysine14 - ? 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine14 - ? 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Plasmodium falciparum CoA + [histone H3]-N6-acetyl-L-lysine14 - ? 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Mus musculus CoA + [histone H3]-N6-acetyl-L-lysine14 - ? 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Saccharomyces cerevisiae CoA + [histone H3]-N6-acetyl-L-lysine14 - ? 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine14 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H3]-N6-acetyl-L-lysine14 - ? 454282 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine18 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine18 - ir 454283 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine18 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine18 - ? 454283 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine20 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine20 - ? 454284 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine23 - Saccharomyces cerevisiae CoA + [histone H3]-N6-acetyl-L-lysine23 - ? 454285 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine23 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H3]-N6-acetyl-L-lysine23 - ? 454285 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine27 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine27 - ir 455236 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine27 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine27 - ? 455236 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine56 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine56 - ir 454286 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine56 - Saccharomyces cerevisiae CoA + [histone H3]-N6-acetyl-L-lysine56 - ? 454286 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine56 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H3]-N6-acetyl-L-lysine56 - ? 454286 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine79 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine79 - ir 455237 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine9 - ir 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Arabidopsis thaliana CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Saccharomyces cerevisiae CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Plasmodium falciparum CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Toxoplasma gondii CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Ictidomys tridecemlineatus CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H3]-L-lysine9 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H3]-N6-acetyl-L-lysine9 - ? 454287 2.3.1.48 acetyl-CoA + [histone H4]-L-lysin16 - Mus musculus CoA + [histone H4]-N6-acetyl-L-lysine16 - ? 454289 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine - Saccharomyces cerevisiae CoA + [histone H4]-N6-acetyl-L-lysine - ? 454296 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine - ? 454296 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine - Mus musculus CoA + [histone H4]-N6-acetyl-L-lysine - ? 454296 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine - Drosophila melanogaster CoA + [histone H4]-N6-acetyl-L-lysine - ? 454296 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine - Saccharomyces cerevisiae BY4741 CoA + [histone H4]-N6-acetyl-L-lysine - ? 454296 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H4]-N6-acetyl-L-lysine - ? 454296 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine12 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine12 - ir 454290 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine12 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine12 - ? 454290 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine12 - Saccharomyces cerevisiae CoA + [histone H4]-N6-acetyl-L-lysine12 - ? 454290 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine12 - Drosophila melanogaster CoA + [histone H4]-N6-acetyl-L-lysine12 - ? 454290 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine12 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H4]-N6-acetyl-L-lysine12 - ? 454290 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine16 - ir 454292 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine16 - ? 454292 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 - Drosophila melanogaster CoA + [histone H4]-N6-acetyl-L-lysine16 - ? 454292 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 - Mus musculus CoA + [histone H4]-N6-acetyl-L-lysine16 - ? 454292 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 main substrate Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine16 - ? 454292 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine16 main substrate Drosophila melanogaster CoA + [histone H4]-N6-acetyl-L-lysine16 - ? 454292 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine5 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine5 - ir 454293 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine5 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine5 - ? 454293 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine5 - Saccharomyces cerevisiae CoA + [histone H4]-N6-acetyl-L-lysine5 - ? 454293 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine5 - Drosophila melanogaster CoA + [histone H4]-N6-acetyl-L-lysine5 - ? 454293 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine5 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H4]-N6-acetyl-L-lysine5 - ? 454293 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine8 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine8 - ir 454295 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine8 - Homo sapiens CoA + [histone H4]-N6-acetyl-L-lysine8 - ? 454295 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine8 - Saccharomyces cerevisiae CoA + [histone H4]-N6-acetyl-L-lysine8 - ? 454295 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine8 - Drosophila melanogaster CoA + [histone H4]-N6-acetyl-L-lysine8 - ? 454295 2.3.1.48 acetyl-CoA + [histone H4]-L-lysine8 - Saccharomyces cerevisiae ATCC 204508 CoA + [histone H4]-N6-acetyl-L-lysine8 - ? 454295 2.3.1.48 acetyl-CoA + [histone peptide H3-20]-L-lysine - Homo sapiens CoA + [histone peptide H3-20]-N6-acetyl-L-lysine - ? 455238 2.3.1.48 acetyl-CoA + [histone peptide H3-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H3-20]-N6-acetyl-L-lysine - ? 455238 2.3.1.48 acetyl-CoA + [histone peptide H4-20]-L-lysine - Homo sapiens CoA + [histone peptide H4-20]-N6-acetyl-L-lysine - ? 455239 2.3.1.48 acetyl-CoA + [histone peptide H4-20]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [histone peptide H4-20]-N6-acetyl-L-lysine - ? 455239 2.3.1.48 acetyl-CoA + [Hsp70]-L-lysine difference in the acetylation of Hsp70 with or without rhARD1 can be observed at low ratio of enzyme: substrate up to 1:25 but not at that of higher ratio over 1:25. The enzyme targets Lys77 of Hsp70, the hARD1/NAA10-mediated catalysis of Hsp70 is abolished with K77R mutation in Hsp70 Homo sapiens CoA + [Hsp70]-N6-acetyl-L-lysine - ? 455240 2.3.1.48 acetyl-CoA + [MCM2]-L-lysine14 - Homo sapiens CoA + [MCM2]-N6-acetyl-L-lysine14 - ? 455241 2.3.1.48 acetyl-CoA + [MCM2]-L-lysine14 - Mus musculus CoA + [MCM2]-N6-acetyl-L-lysine14 - ? 455241 2.3.1.48 acetyl-CoA + [NFkappaB]-L-lysine - Homo sapiens CoA + [NFkappaB]-N6-acetyl-L-lysine - ? 454297 2.3.1.48 acetyl-CoA + [ORC2]-L-lysine14 - Homo sapiens CoA + [ORC2]-N6-acetyl-L-lysine14 - ? 455242 2.3.1.48 acetyl-CoA + [ORC2]-L-lysine14 - Mus musculus CoA + [ORC2]-N6-acetyl-L-lysine14 - ? 455242 2.3.1.48 acetyl-CoA + [p27]-L-lysine - Homo sapiens CoA + [p27]-N6-acetyl-L-lysine - ? 454298 2.3.1.48 acetyl-CoA + [p53]-L-lysine - Homo sapiens CoA + [p53]-N6-acetyl-L-lysine - ? 454300 2.3.1.48 acetyl-CoA + [p53]-L-lysine - Drosophila melanogaster CoA + [p53]-N6-acetyl-L-lysine - ? 454300 2.3.1.48 acetyl-CoA + [p53]-L-lysine120 - Homo sapiens CoA + [p53]-N6-acetyl-L-lysine120 - ? 454299 2.3.1.48 acetyl-CoA + [p53]-L-lysine120 - Drosophila melanogaster CoA + [p53]-N6-acetyl-L-lysine120 - ? 454299 2.3.1.48 acetyl-CoA + [PGC-1alpha]-L-lysine - Homo sapiens CoA + [PGC-1alpha]-N6-acetyl-L-lysine - ? 454301 2.3.1.48 acetyl-CoA + [PGC-1]-L-lysine - Homo sapiens CoA + [PGC-1]-N6-acetyl-L-lysine - ? 454302 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Homo sapiens CoA + [protein]-N6-acetyl-L-lysine - ir 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Saccharomyces cerevisiae CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Homo sapiens CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Mus musculus CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Bacillus subtilis CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Toxoplasma gondii CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Ictidomys tridecemlineatus CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine endogenous GCN5 and EGR2 in iNKT cells Mus musculus CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine substrate of wild-type enzyme GCN5 and enzyme mutant T612G Homo sapiens CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa ATCC 15692 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Bacillus subtilis 168 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Saccharomyces cerevisiae BY4741 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa 1C CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa PRS 101 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Saccharomyces cerevisiae D273-10B/A1 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa DSM 22644 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa CIP 104116 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa LMG 12228 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Mus musculus C57BL/6 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine endogenous GCN5 and EGR2 in iNKT cells Mus musculus C57BL/6 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Pseudomonas aeruginosa JCM 14847 CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [protein]-L-lysine - Saccharomyces cerevisiae W303-1A CoA + [protein]-N6-acetyl-L-lysine - ? 454303 2.3.1.48 acetyl-CoA + [PTEN]-L-lysine acetylation of the oncosuppressor protein PTEN on two lysine residues (Lys125 and Lys128) Homo sapiens CoA + [PTEN]-N6-acetyl-L-lysine - ? 454304 2.3.1.48 acetyl-CoA + [STAT3]-L-lysine - Homo sapiens CoA + [STAT3]-N6-acetyl-L-lysine - ? 454306 2.3.1.48 acetyl-CoA + [TIP5]-L-lysine - Homo sapiens CoA + [TIP5]-N6-acetyl-L-lysine - ? 454307 2.3.1.48 acetyl-CoA + [TIP5]-L-lysine - Drosophila melanogaster CoA + [TIP5]-N6-acetyl-L-lysine - ? 454307 2.3.1.48 acetyl-CoA + [TRRAP]-L-lysine - Homo sapiens CoA + [TRRAP]-N6-acetyl-L-lysine - ? 454308 2.3.1.48 acetyl-CoA + [TRRAP]-L-lysine - Drosophila melanogaster CoA + [TRRAP]-N6-acetyl-L-lysine - ? 454308 2.3.1.48 activated RNA polymerase II transcriptional coactivator p15 + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 420234 2.3.1.48 alpha-tubulin + acetyl-CoA - Homo sapiens acetyl-alpha-tubulin + CoA - ? 387853 2.3.1.48 alpha-tubulin + acetyl-CoA - Saccharomyces cerevisiae acetyl-alpha-tubulin + CoA - ? 387853 2.3.1.48 androgen receptor + acetyl-CoA receptor signaling in prostate cancer cells is augmented by the androgen receptor coactivator p300, which transactivates and acetylates the androgen receptor in the presence of 100 nM dihydrotestosterone, involvement of p300 in neuropeptide activation of androgen receptor signaling, overview Homo sapiens acetylated androgen receptor + CoA - ? 386230 2.3.1.48 androgen receptor + acetyl-CoA the KLKK motif of androgen receptor protein is both necessary and sufficient for acetylation by p300 in the presence of 100 nM dihydrotestosterone Homo sapiens acetylated androgen receptor + CoA - ? 386230 2.3.1.48 ATM kinase + acetyl-CoA ATM protein kinase regulates the cell’s response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair, suppression of Tip60 blocks the activation of ATM’s kinase activity, ATM autophosphorylation e.g. at Ser1981, and prevents the ATM-dependent phosphorylation of p53 and chk2, inactivation of Tip60 sensitizes cells to ionizing radiation, overview Homo sapiens acetylated ATM kinase + CoA - ? 386237 2.3.1.48 ATM kinase + acetyl-CoA the ataxia telangiectasia mutant, i.e. ATM, protein kinase, ATM forms a stable complex with Tip60 through the conserved, highly required FATC domain of ATM, the interaction between ATM and Tip60 is not regulated in response to DNA damage, but is specifically induced by DNA damage, overview, mutations in the FATC domain that abolish the interaction between ATM and Tip60 Homo sapiens acetylated ATM kinase + CoA - ? 386237 2.3.1.48 H4 peptide + acetyl-CoA - Homo sapiens ? - ? 420763 2.3.1.48 H4 peptide + acetyl-CoA - Saccharomyces cerevisiae ? - ? 420763 2.3.1.48 histone + acetyl-CoA - Homo sapiens acetyl-histone + CoA - ? 386502 2.3.1.48 histone + acetyl-CoA - Arabidopsis thaliana acetyl-histone + CoA - ? 386502 2.3.1.48 histone + acetyl-CoA - Saccharomyces cerevisiae acetyl-histone + CoA - ? 386502 2.3.1.48 histone + acetyl-CoA histone acetylation is an important posttranslational modification correlated with gene activation, the HAC1 is involved in the regulation of flowering time via repression of flowering locus C, the enzyme participates in many physiological processes, including proliferation, differentiation, and apoptosis Arabidopsis thaliana acetyl-histone + CoA - ? 386502 2.3.1.48 histone + acetyl-CoA key enzyme in post-translational modification of histones associated with transcriptionally active genes Saccharomyces cerevisiae acetyl-histone + CoA - ? 386502 2.3.1.48 histone + acetyl-CoA phosphorylation of p300 at Ser1834 by the kinase Akt is essential for its histone acetyltransferase and transcriptional activity Homo sapiens acetyl-histone + CoA - ? 386502 2.3.1.48 histone + acetyl-CoA histones from the Hela cell core Homo sapiens acetyl-histone + CoA - ? 386502 2.3.1.48 histone + propionyl-CoA - Saccharomyces cerevisiae propionyl-histone + CoA - ? 388892 2.3.1.48 histone H2A + acetyl-CoA acetylation of the tail of the histone, the enzyme is organized in the NuA4 subcomplex acting on the nucleosome, overview Saccharomyces cerevisiae acetyl-histone H2A + CoA - ? 388893 2.3.1.48 histone H2B + acetyl-CoA acetylation of the tail of the histone, the enzyme is organized in the catalytic Ada2/Ada3/Gcn5 subcomplex of SAGA acting on the nucleosome, overview Saccharomyces cerevisiae acetyl-histone H2B + CoA - ? 388895 2.3.1.48 histone H3 + acetyl-CoA - Homo sapiens acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA - Saccharomyces cerevisiae acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA regulation Rattus norvegicus acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA acetylation of Lys9, and Lys14 Drosophila melanogaster acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA acetylation of Lys9, and Lys14 Homo sapiens acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview Rattus norvegicus acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA acetylation at Lys9 Rattus norvegicus acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA acetylation at Lys9 and Lys14 Rattus norvegicus acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 + acetyl-CoA acetylation of the tail of the histone, the enzyme is organized in the catalytic Ada2/Ada3/Gcn5 subcomplex of SAGA acting on the nucleosome, overview Saccharomyces cerevisiae acetyl-histone H3 + CoA - ? 386505 2.3.1.48 histone H3 tail peptide + acetyl-CoA - Saccharomyces cerevisiae acetyl-histone H3 tail peptide + CoA - ? 388897 2.3.1.48 histone H3.2 + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 420776 2.3.1.48 histone H4 + acetyl-CoA - Mus musculus acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA - Homo sapiens acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA - Schizosaccharomyces pombe acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA - Saccharomyces cerevisiae acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation Drosophila melanogaster acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA acetylation at Lys5 and Lys12, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail Schizosaccharomyces pombe acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA acetylation at Lys8, NCOAT has the ability to directly associate with both an acetylated and unacetylated histone H4 tail in vitro without tequiring acetyl-lysine contacts, binding and interaction mechanism, overview Mus musculus acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA acetylation of Lys5, Lys8, and Lys12 Drosophila melanogaster acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA acetylation of Lys5, Lys8, and Lys12 Homo sapiens acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 + acetyl-CoA acetylation of the tail of the histone, the enzyme is organized in the NuA4 subcomplex acting on the nucleosome, overview Saccharomyces cerevisiae acetyl-histone H4 + CoA - ? 386506 2.3.1.48 histone H4 N-terminal peptide + acetyl-CoA N-terminal peptide of histone H4 of different length and sequence, prepared in HeLa cell extract, overview, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail, substituting glutamine for lysine at Lys8 and Lys16 dramatically reduces the ability of yHat1p to acetylate the H4 tail peptide, phosphorylation of Ser1 also reduces the acetylation of H4 peptides Schizosaccharomyces pombe acetyl-histone H4 N-terminal peptide + CoA - ? 388898 2.3.1.48 isoform 1 of DNA polymerase zeta catalytic subunit + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 420806 2.3.1.48 isoform 1 of transcription factor BTF3 + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 420807 2.3.1.48 isoform 2 of protein SET + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 420808 2.3.1.48 isoform long of antigen KI-67 + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 420809 2.3.1.48 additional information diaminodipropylamine and 1,3-propanediamine are no substrates Rattus norvegicus ? - ? 89 2.3.1.48 additional information HeLa nucleosome or core histones are no substrate for recombinant SAS complex Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information protamine, bovine serum albumin, and ubiquitin are no substrates Bos taurus ? - ? 89 2.3.1.48 additional information for acetylation activity of Sas2, Sas4 is absolutely required, while Sas5 stimulate Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information Gcn5 is a coactivator of transcription Drosophila melanogaster ? - ? 89 2.3.1.48 additional information Gcn5 is a coactivator of transcription Mus musculus ? - ? 89 2.3.1.48 additional information Gcn5 is a coactivator of transcription Homo sapiens ? - ? 89 2.3.1.48 additional information Gcn5 is a coactivator of transcription Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information Gcn5 is a coactivator of transcription Arabidopsis thaliana ? - ? 89 2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Drosophila melanogaster ? - ? 89 2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Mus musculus ? - ? 89 2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Homo sapiens ? - ? 89 2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Arabidopsis thaliana ? - ? 89 2.3.1.48 additional information enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors Homo sapiens ? - ? 89 2.3.1.48 additional information enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information MOZ and MORF genes are rearranged by chromosome abnormalities associated with several types of leukemia Homo sapiens ? - ? 89 2.3.1.48 additional information MYST-related histone acetyltransferase complex NuA4: required for cell growth, required for p53-dependent transcription activation in yeast, presumably through its Yng2 subunit, homolog of the tumor suppressor ING1. GNAT-related histone acetyltransferase complex SAGA can stimulate Gal4-VP16 activation in a manner dependent on HAT activity. D´SAGA can be recruited by several yeast activators. SAGA is targeted to promoter regions proximal to the activator binding site. Once targeted, SAGA acetylates histone h3 in the vicinity of the promoter. Targeted acetylation by SAGA stabilizes its binding and that of a targeted SWI/SNF chromatin-remodeling complex. SAGA is required for both activation of the yeast ARG1 promoter by Gcn4 activator and repression by the ArgR/Mcm1 repressor complex Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information MYST-related histone acetyltransferase complex Tip60 also acts as a transcriptional coactivator in several systems including class I nuclear hormone receptors, NF-kappaB and at the superoxide dismutase gene. Tip 60 has been implicated in Alzheimer disease because it stimulates transcription when asociated with the cleaved cytoplasmic tail fragment of the amyloid-beta precursor protein Homo sapiens ? - ? 89 2.3.1.48 additional information Tip60 plays a role in the control of cell-related events Homo sapiens ? - ? 89 2.3.1.48 additional information no acetylation of adrenocorticotropin or a H3 peptide Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information acetylation of proteins by the enzyme plays a critical role in the regulation of gene expression Homo sapiens ? - ? 89 2.3.1.48 additional information androgen Src kinase and PKCd kinase are involved in the regulation of p300 HAT activity via bombesin, overview Homo sapiens ? - ? 89 2.3.1.48 additional information deregulated HAT activity plays a role in the development of a range of cancers Homo sapiens ? - ? 89 2.3.1.48 additional information the enzyme is involved in Sp1 activation of the cyclin D1 promoter, TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G1-to-S-phase progression, regulation, overview Homo sapiens ? - ? 89 2.3.1.48 additional information the enzyme modulates gene expression in liver nuclei in an epigenetic manner at high blood alcohol levels, no alteratins of MAP kinase levels, overview Rattus norvegicus ? - ? 89 2.3.1.48 additional information the enzyme plays a role in chromatin structure and gene expression regulation as a catalytic component of multiprotein complexes, some of which also contain Ada2-type transcriptional coactivators Drosophila melanogaster ? - ? 89 2.3.1.48 additional information the histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein Homo sapiens ? - ? 89 2.3.1.48 additional information in absence of acceptor substrate the enzyme performs autoacetylation, identification of 13 autoacetylation sites and mechanism, autoacetylation catalyzed by p300 HAT is about 1000-fold more efficient than p300/CREB-binding protein-associated factor-mediated acetylation of catalytically defective p300 HAT, overview Homo sapiens ? - ? 89 2.3.1.48 additional information in the absence of histone acceptor, slow rates of enzyme autoacetylation and of CoA formation occur Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information substrate specificity and order of acetylation of histone H4 by Hat1, overview Schizosaccharomyces pombe ? - ? 89 2.3.1.48 additional information the nuclear cytoplasmic O-GlcNAcase and acetyltransferase, NCOAT, is a bifunctional enzyme with both glycoside hydrolase and alkyltransferase activity and contains a zinc finger-like motif responsible for substrate recognition, via making contacts with the histone tails within nucleosomes, essential for activity, overview Mus musculus ? - ? 89 2.3.1.48 additional information MOZ specifically interacts and associates with transcription factors such as AML1, PU.1, p53, Runx2 and NF-kappaB, functioning as their transcriptional coactivator and cooperatively activating target gene transcription Mus musculus ? - ? 89 2.3.1.48 additional information a homologue of Moz, zMoz, occurs in zebrafish to perform a potential Moz function in the trunk region Danio rerio ? - ? 89 2.3.1.48 additional information affects the inflorescence meristem and stamen development in Arabidopsis thaliana Arabidopsis thaliana ? - ? 89 2.3.1.48 additional information ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism Mus musculus ? - ? 89 2.3.1.48 additional information ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism Homo sapiens ? - ? 89 2.3.1.48 additional information besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity Homo sapiens ? - ? 89 2.3.1.48 additional information Esa1 is the catalytic subunit of at least two multiprotein complexes, NuA4 and Piccolo NuA4, picNuA4 Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information HATs perform a conserved mechanism of acetyl-transfer, where the lysine-containing substrate directly attacks enzyme-bound acetyl-CoA. The ability of HATs to form distinct multi-subunit complexes provide a means to regulate HAT activity by altering substrate specificity, targeting to specific loci, enhancing acetyltransferase activity, restricting access of non-target proteins, and coordinating the multiple enzyme activities of the complex Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information HBO1 histone acetylase is involved in DNA replication licensing and associates with replication origins, located within the HPRT1 coding sequence, specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor geminin Homo sapiens ? - ? 89 2.3.1.48 additional information HBO1 occurs as a component of a multiprotein complex with histone H3 and H4 acetyltransferase activity in 293 cells. The mammalian complex corresponding to the yeast NuA4 complex contains the MYST HAT Tip60 Homo sapiens ? - ? 89 2.3.1.48 additional information HBO1, Sas2 and Sas3 are involved in transcriptional repression enhancing Sir1-mediated epigenetic gene silencing. NuA3 and NuA4 complexes contain the MYST HATs Sas3 and Esa1, respectively. Sas2 histone acetylation of H4K16 opposed by Sir2 deacetylation of H4K16 at the euchromatin/heterochromatin interface maintains the boundary between regions of transcriptionally active and silent telomeric chromatin. Esa1 plays a role in maintaining the integrity of the DNA, rather than open chromatin structure and high-level transcriptional activity Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information histone acetylation and deacetylation is an epigenetic mechanism in volved in regulation of mIRNA production. GCN5 has a general repressive effect on microRNAs, miRNAs, and it targets a subset of MIRNA genes, GCN5 is required for acetylation of histone H3 lysine 14 at these loci, overview Arabidopsis thaliana ? - ? 89 2.3.1.48 additional information histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview Gallus gallus ? - ? 89 2.3.1.48 additional information in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22 Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information in response to DNA damage, Tip60 acetylates ATM, a DNA damage related kinase, allowing for phosphorylation of Chk2 and p53 by ATM. HATs perform a conserved mechanism of acetyl-transfer, where the lysine-containing substrate directly attacks enzyme-bound acetyl-CoA. The ability of HATs to form distinct multi-subunit complexes provide a means to regulate HAT activity by altering substrate specificity, targeting to specific loci, enhancing acetyltransferase activity, restricting access of non-target proteins, and coordinating the multiple enzyme activities of the complex Homo sapiens ? - ? 89 2.3.1.48 additional information increase in eNOS mRNA, caused by shear stress, is completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA Homo sapiens ? - ? 89 2.3.1.48 additional information mechanistically, p300 acts as a transcriptional coactivator through the direct interaction with a diverse set of transcription factors and RNA polymerase II transcription machinery Homo sapiens ? - ? 89 2.3.1.48 additional information Mst1 interacts with a number of proteins involved in chromosome integrity and centromere function, including the methyltransferase Skb1, the recombination mediator Rad22, Sc Rad52, the chromatin assembly factor Hip1, Sc Hir1, and the Msc1 protein related to a family of histone demethylases, detailed interaction analysis, overview Schizosaccharomyces pombe ? - ? 89 2.3.1.48 additional information MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. Interactions between MSL1 and MYST1 within the MSL complex in Drosophila melanogaster, the compensasome includes proteins MSL1, MSL2, MSL3, MLE, MOF, a histone acetyltransferase homologous to MYST1, JIL1, and two non-coding RNA: roX1 and roX2, structure and function of the compensasome, detailed overview. Cell interactome fragments including protein homologs of hampin and MYST1, overview Drosophila melanogaster ? - ? 89 2.3.1.48 additional information MYST1 is a part of multiprotein complexes that accomplish functions of male X chromosome activation and thereby functions of dosage compensation in Drosophila and, in mammals, global acetylation of histone H4 K16. Functional links between MYST1 and proteins ATM and p53. MYST1 interacts with WDR5. Cell interactome fragments including protein homologs of hampin and MYST1, overview Homo sapiens ? - ? 89 2.3.1.48 additional information PCAF is present in USF1/PRMT1 complexes Mus musculus ? - ? 89 2.3.1.48 additional information Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information soluble histone H4 Hat1-dependently acetylated on Lys12 is present in cells arrested at all cell cycle stages, G1, S, G2/M and also G0. Histone H3 seems to be no substrate for the HAT-B complex Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required Mus musculus ? - ? 89 2.3.1.48 additional information the mammalian complex corresponding to the yeast NuA4 complex contains the MYST HAT Tip60. Myc recruits the Tip60 complex to the chromatin in Rat1 wild-type cells, but not in Rat1 Myc mutant cells. Hbo1 appears to function predominantly in transcriptional repression Mus musculus ? - ? 89 2.3.1.48 additional information Tip60 is part of the evolutionarily conserved NuA4 complex Homo sapiens ? - ? 89 2.3.1.48 additional information Tip60, in complex with homologues of the mammalian Tip60 complex, exhibits functional redundancy with two other groups of genes, known as synthetic multivulva A and B genes, synMUV. Therefore, the genes encoding proteins of the Tip60 complex are termed class C synMUV genes. SynMUV A and B counteract EGF to Ras to MAPK signaling and the Tip60 complex is a chromatin-modifying complex Caenorhabditis elegans ? - ? 89 2.3.1.48 additional information Gcn5 and p300 appear to be constituitive HATs that do not require helper proteins to exhibit full catalytic activity. Esa1 and Rtt109 represent low-activity HATs that are stimulated by regulatory helper proteins, Yng2-Epl1 and Vps75/Asf1, respectively. p300/CBP exhibits the broadest protein specificity, p300 prefers histone acetylation sites with a positive charge in the -3 or +4 position. Ability of some HATs to utilize longer chain acyl-CoA, i.e. propionyl-CoA Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information Gcn5 appears to be constituitive HAT that does not require helper proteins to exhibit full catalytic activity Tetrahymena sp. ? - ? 89 2.3.1.48 additional information HBO1 interacts both with transcriptional activator proteins and with MCM2 and ORC1 Homo sapiens ? - ? 89 2.3.1.48 additional information MYST1 specificity to Lys16 of histone H4 is not absolute, because in experiments in vitro the protein is also able to acetylate histones H3 and H2A, whereas in vivo only modification of histone H4 is specific Homo sapiens ? - ? 89 2.3.1.48 additional information no activity with histones H3, H2A and H2B by recombinant MOF in HeLa nucleosomes Homo sapiens ? - ? 89 2.3.1.48 additional information p/CAF and p300 appear to be constitutive HATs that do not require helper proteins to exhibit full catalytic activity Homo sapiens ? - ? 89 2.3.1.48 additional information p300 performs autoacetylation, overview Homo sapiens ? - ? 89 2.3.1.48 additional information isoform GCN5 is not the enzyme responsible for histone acetylation at cold-regulated genes COR promoters during cold acclimation Arabidopsis thaliana ? - ? 89 2.3.1.48 additional information assembly of the enzyme into male-specific lethal, MSL, or non-specific lethal, NSL, complexes controls its substrate specificity. Although MSL-associated enzyme acetylates nucleosomal histone H4 almost exclusively on lysine 16, NSL-associated enzyme exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on lysines 5 and 8 Homo sapiens ? - ? 89 2.3.1.48 additional information Glu187 and Glu276 could act as the general catalytic base and together with Asp277 have a cumulative effect on deprotonation of the ?-amino group of substrate Lys12 of the histone H4 peptide, which could be mediated by water molecules Homo sapiens ? - ? 89 2.3.1.48 additional information histone chaperone Vps75 acts as activiating subunit. The rate-determining step of the activated complex is the transfer of the acetyl group from acetyl-CoA to the acceptor lysine residue. Vps75 stimulates catalysis more than 250fold, not by contributing a catalytic base, but by stabilizing the catalytically active conformation of enzyme Rtt109 Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information protein participates in var gene activation Plasmodium falciparum ? - ? 89 2.3.1.48 additional information removal of lysine residues does not substantially affect the ability of NuA4 histone actyltransferase complex to acetylate remaining sites, and insertion of an additional lysine into the substrate histone H4 tail leads to rapid quintuple-acetylation. Conversion of the native histone H2A tail to an H4-like sequence results in enhanced multi-site acetylation. NuA4's site selectivity is dictated by accessibility on the nucleosome surface, the relative proximity from the histone fold domain, and a preference for intervening glycine residues with a minimal (n + 2) spacing between lysines Saccharomyces cerevisiae ? - ? 89 2.3.1.48 additional information Brahma is a target of enzyme Kat6B Homo sapiens ? - ? 89 2.3.1.48 additional information enzyme GCN5b interacts with AP2-domain proteins, apicomplexan plant-like transcription factors, as well as a core complex that includes the co-activator ADA2-A, TFIID subunits, LEO1 polymerase-associated factor (Paf1) subunit, and RRM proteins Toxoplasma gondii ? - ? 89 2.3.1.48 additional information enzyme p300 can directly interact with myocardin, and consequently induce the acetylation of myocardin and nucleosomal histones surrounding SRF-binding sites. Acetylation of both histone and myocardin by p300 Homo sapiens ? - ? 89 2.3.1.48 additional information GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters Homo sapiens ? - ? 89 2.3.1.48 additional information GCN5 directly targets HSFA3 and UVH6 and affects their H3K9 and H3K14 acetylation levels Arabidopsis thaliana ? - ? 89 2.3.1.48 additional information NuA4 targets histone and nonhistone proteins Saccharomyces cerevisiae ? - - 89 2.3.1.48 additional information HBO1 exerts significant acetyltransferase activity on proteins such as ORC2, MCM2, CDC6, and Geminin in in vitro assays Homo sapiens ? - - 89 2.3.1.48 additional information HBO1 exerts significant acetyltransferase activity on proteins such as ORC2, MCM2, CDC6, and Geminin in in vitro assays Mus musculus ? - - 89 2.3.1.48 additional information high-resolution mass spectrometry investigations identifies 1750 proteins as substrates of the posttranslational modification of acetylation, overview Saccharomyces cerevisiae ? - - 89 2.3.1.48 additional information high-resolution mass spectrometry investigations identifies 1750 proteins as substrates of the posttranslational modification of acetylation, overview. Both human Gcn5 and PCAF have H3 and H2B as main substrates, showing the highest in vitro affinity for H3K14 Homo sapiens ? - - 89 2.3.1.48 additional information high-resolution mass spectrometry investigations identifies 1750 proteins as substrates of the posttranslational modification of acetylation, overview. Hpa3 also acts as D-amino-acid N-acetyltransferase, EC 2.3.1.36 Saccharomyces cerevisiae ? - - 89 2.3.1.48 additional information lysine acetyltransferase (KAT) activity of recombinant human ARD1/NAA10, overview. Arrest defective 1 (ARD1) is the only enzyme known so far to exhibit both N-terminal acetyltransferase (NAT) and N-terminal lysine acetyltransferase (KAT) activities. Only the monomeric rhARD1/NAA10 form, but not the oligomeric form, can acetylate lysine residues of substrate proteins. rhARD1/NAA10-mediated Hsp70 acetylation increased in a time-dependent manner Homo sapiens ? - - 89 2.3.1.48 additional information Nut1 is a mediator of RNA polymerase II transcription subunit 5, that also has histone acetylase activity Saccharomyces cerevisiae ? - - 89 2.3.1.48 additional information quantification of HBsu acetylation by parallel reaction monitoring-tandem mass spectrometry Bacillus subtilis ? - - 89 2.3.1.48 additional information recombinant hARD1/NAA10 exhibits KAT activity, which disappears soon in vitro due to enzyme oligomerization, which results in the loss of KAT activity. While oligomeric recombinant hARD1/NAA10 loses its ability for lysine acetylation, its monomeric form clearly exhibits lysine acetylation activity in vitro. Assay optimization, under optimal conditions, hARD1/NAA10 retains its KAT activity, overview Homo sapiens ? - - 89 2.3.1.48 additional information Rtt109 has a low catalytic efficiency in isolation, but it is much more active when associated with the histone chaperones Asf1 and Vps75. The two chaperones also determine substrate specificity, with the preferred substrate being H3K56 when Rtt109 is associated with Asf1, whereas H3K9 and H3K23 are acetylated when in complex with Vps75 Saccharomyces cerevisiae ? - - 89 2.3.1.48 additional information screening of interacting proteins for substrate identification, testing of more than four hundred proteins, KAT substrate enrichment with biotin-streptavidin pulldown and semiquantitative LC-MS/MS studies, overview. The proteins are either p300- or GCN5-unique or shared by the two KATs. 3-Azidopropionyl CoA (3AZ-CoA) is applied as a bioorthogonal surrogate of acetyl-, propionyl- and butyryl-CoA for KAT substrate identification, method overview. Comparison of the substrate profiles of p300 and GCN5, different acetyl-CoA surrogates and histone peptide H3-20 or H4-20 (the first 20 amino acids from the N-terminus of histone H3 or H4) are used as substrates. 3AZ-CoA is a sensitive and specific probe for both p300 and GCN5-T612G with comparable or even stronger activity than Ac-CoA. Substrate validations Homo sapiens ? - - 89 2.3.1.48 additional information substrate site specificity, overview Homo sapiens ? - - 89 2.3.1.48 additional information TgGCN5b performs autoacetylation. Proteome-wide acetylome analyses of Toxoplasma tachyzoites identifies seven acetylated lysines on TgGCN5b, i.e. K811, K857, K941, K989, K997, K1002, and K1027 Toxoplasma gondii ? - - 89 2.3.1.48 additional information Tip60 preferentially catalyzes acetylation of histone H4 Homo sapiens ? - - 89 2.3.1.48 additional information Rtt109 facilitates error-free replication to prevent CAG/CTG repeat contractions. The Rtt107/Rtt101 complex is recruited to stalled replication forks in an Rtt109-dependent manner Saccharomyces cerevisiae BY4705 ? - ? 89 2.3.1.48 additional information quantification of HBsu acetylation by parallel reaction monitoring-tandem mass spectrometry Bacillus subtilis 168 ? - - 89 2.3.1.48 additional information NuA4 targets histone and nonhistone proteins Saccharomyces cerevisiae BY4741 ? - - 89 2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Homo sapiens GCN5 ? - ? 89 2.3.1.48 additional information enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors Homo sapiens GCN5 ? - ? 89 2.3.1.48 additional information Gcn5 is a coactivator of transcription Homo sapiens GCN5 ? - ? 89 2.3.1.48 additional information specific role of MOZ-driven acetylation in controlling a desirable balance between proliferation and differentiation during hematopoiesis. MOZ also shows activity either as Runx1 coactivator or in the induction of leukemic transformation via transcriptional intermediary factor 2, TIF2, but is not essentially required Mus musculus C57BL/6 ? - ? 89 2.3.1.48 additional information high-resolution mass spectrometry investigations identifies 1750 proteins as substrates of the posttranslational modification of acetylation, overview. Hpa3 also acts as D-amino-acid N-acetyltransferase, EC 2.3.1.36 Saccharomyces cerevisiae ATCC 204508 ? - - 89 2.3.1.48 additional information Nut1 is a mediator of RNA polymerase II transcription subunit 5, that also has histone acetylase activity Saccharomyces cerevisiae ATCC 204508 ? - - 89 2.3.1.48 additional information high-resolution mass spectrometry investigations identifies 1750 proteins as substrates of the posttranslational modification of acetylation, overview Saccharomyces cerevisiae ATCC 204508 ? - - 89 2.3.1.48 additional information Rtt109 has a low catalytic efficiency in isolation, but it is much more active when associated with the histone chaperones Asf1 and Vps75. The two chaperones also determine substrate specificity, with the preferred substrate being H3K56 when Rtt109 is associated with Asf1, whereas H3K9 and H3K23 are acetylated when in complex with Vps75 Saccharomyces cerevisiae ATCC 204508 ? - - 89 2.3.1.48 additional information a homologue of Moz, zMoz, occurs in zebrafish to perform a potential Moz function in the trunk region Danio rerio zMoz ? - ? 89 2.3.1.48 additional information Gcn5 appears to be constituitive HAT that does not require helper proteins to exhibit full catalytic activity Tetrahymena sp. GCN5 ? - ? 89 2.3.1.48 nucleolin + 4-pentynoyl-CoA - Saccharomyces cerevisiae ? - ? 421133 2.3.1.48 piccoloNuA4 peptide + acetyl-CoA the peptide is part of the physiologic enzme complex, overview Saccharomyces cerevisiae acetyl-piccoloNuA4 peptide + CoA - ? 386664 2.3.1.48 piccoloNuA4 peptide + propionyl-CoA - Saccharomyces cerevisiae propionyl-piccoloNuA4 peptide + CoA - ? 389564 2.3.1.48 promyelotic leukemia zinc finger gene + acetyl-CoA - Homo sapiens acetylated promyelotic leukemia zinc finger gene + CoA - ? 386667 2.3.1.48 promyelotic leukemia zinc finger gene + acetyl-CoA i.e. PLZF, a direct and specific substrate of the p300 HAT, no activity with the substrate deletion mutant lacking zinc fingers 6 to 9 Homo sapiens acetylated promyelotic leukemia zinc finger gene + CoA - ? 386667