2.3.1.221	7 malonyl-CoA + acetyl-[acyl-carrier protein]	-	422704	
2.3.1.221	7 malonyl-CoA + hexanoyl-[acyl-carrier protein]	-	421824	
2.3.1.221	7 malonyl-CoA + hexanoyl-[acyl-carrier protein]	ACP-bound intermediates and major products of the reaction, overview	421824	
2.3.1.221	additional information	processivity of polyketide extension and substrate specificity, overview. The enzyme shows activity against hexanoyl- and acetyl-, but not malonyl-CoA. Rapid loading of extension units onto the carrier domain facilitates efficient chain extension in a manner kinetically favorable to ultimate product formation. Essential roles of the product template and thioesterase domains for cyclization and product release, editing role for the thioesterase domain	89