2.1.1.B84	additional information	IpeOMT1 does not catalyze the 7'-O-methylation of 7'-O-demethylcephaeline. IpeOMT1 shows broad substrate specificity towards the intermediates in emetine biosynthesis. IpeOMT1 dominantly catalyzes 6-O-methylation of the 6,7-dihydroxy- and 6-hydroxy-7-methoxyisoquinolines. The regional substrate specificity at the last step of emetine biosynthesis is restricted to 6'-O-methylation	Carapichea ipecacuanha	?	-	?	89	
2.1.1.B84	additional information	the enzyme is also active on 7'-O-demethylcephaeline forming cephaeline, overview	Carapichea ipecacuanha	?	-	?	89	
2.1.1.B84	additional information	substrate specificity of CiOMT2, overview	Carapichea ipecacuanha	?	-	?	89	
2.1.1.B84	S-adenosyl-L-methionine + (R)-norprotosinomenine	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417581	
2.1.1.B84	S-adenosyl-L-methionine + (R,S)-isococlaurine	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417582	
2.1.1.B84	S-adenosyl-L-methionine + (R,S)-isoorientaline	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417583	
2.1.1.B84	S-adenosyl-L-methionine + (R,S)-norcoclaurine	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417584	
2.1.1.B84	S-adenosyl-L-methionine + (R,S)-protosinomenine	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417585	
2.1.1.B84	S-adenosyl-L-methionine + (S)-4'-O-methyllaudanosoline	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417586	
2.1.1.B84	S-adenosyl-L-methionine + (S)-norprotosinomenine	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + ?	-	?	417587	
2.1.1.B84	S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside	-	?	419557	
2.1.1.B84	S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside	the iminium cation, one of the spontaneous reaction products of 6-O-methyl-N-deacetylisoipecoside aglycon, might be an intermediate of emetine biosynthesis	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside	-	?	419557	
2.1.1.B84	S-adenosyl-L-methionine + 7-O-methyl-N-deacetylisoipecoside	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + 6,7-O,O-dimethyl-N-deacetylisoipecoside	-	?	417590	
2.1.1.B84	S-adenosyl-L-methionine + cephaeline	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + emetine	-	?	415744	
2.1.1.B84	S-adenosyl-L-methionine + cephaeline	the enzyme is involved in emetine biosynthesis. It does not catalyze the 7'-O-methylation of 7'-O-demethylcephaeline, the preceding step in the biosynthesis of emetine	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + emetine	-	?	415744	
2.1.1.B84	S-adenosyl-L-methionine + cephaeline	6'-O-methylation	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + emetine	-	?	415744	
2.1.1.B84	S-adenosyl-L-methionine + N-deacetylisoipecoside	-	Carapichea ipecacuanha	S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylipecoside	-	?	417595