2.1.1.33 additional information no substrates: tRNALeu/CAG, tRNALeu/GAG, and tRNASec(p)/UCA Pseudomonas aeruginosa ? - - 89 2.1.1.33 additional information no substrates: tRNALeu/CAG, tRNALeu/GAG, and tRNASec(p)/UCA Pseudomonas aeruginosa UCBPP-PA14 ? - - 89 2.1.1.33 additional information not as methyl group acceptors: methyl-deficient DNA from E. coli, polyadenylic acid, polycytidylic acid, polyuridylic acid, polyinosinic acid, copolymers of adenylic acid and uridylic acid and of guanylic acid and cytidylic acid, tobacco mosaic viral RNA, turnip yellow mosaic viral RNA, RNA from bacteriophage f2, CMP, AMP, UMP, GMP, rRNA Escherichia coli additional information - ? 1440 2.1.1.33 additional information complex of 2 proteins Trm8 and Trm82 is required for efficient m7G-methyltransferase activity in vitro and in vivo, but Trm82 is not an absolute requirement for activity in vitro, Trm8 may be the catalytically active subunit Saccharomyces cerevisiae additional information - ? 1440 2.1.1.33 additional information methyl group transfer at the polynucleotide level of tRNA, two m7G tRNA-methyltransferases with different specificities for the extra arm unpaired G in different tRNA species Escherichia coli additional information - ? 1440 2.1.1.33 additional information proteins METTL1 and WDR4 are required for m7G-methyltransferase activity Homo sapiens additional information - ? 1440 2.1.1.33 additional information methyl group transfer at the polynucleotide level of tRNA, two m7G tRNA-methyltransferases with different specificities for the extra arm unpaired G in different tRNA species Escherichia coli MRE 600 additional information - ? 1440 2.1.1.33 S-adenosyl-L-methionine + guanine46 in methyl deficient tRNA from E. coli - Escherichia coli ? - ? 451819 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAAla/UGC - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAla/UGC - ? 456503 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAAla/UGC - Pseudomonas aeruginosa UCBPP-PA14 S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAla/UGC - ? 456503 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/ACG - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/ACG - ? 456504 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/ACG - Pseudomonas aeruginosa UCBPP-PA14 S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/ACG - ? 456504 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/CCG - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCG - ? 456505 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/CCG - Pseudomonas aeruginosa UCBPP-PA14 S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCG - ? 456505 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/CCU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCU - ? 456506 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/CCU - Pseudomonas aeruginosa UCBPP-PA14 S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCU - ? 456506 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAArg/UCU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/UCU - ? 456507 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAAsn/GUU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAsn/GUU - ? 456508 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAAsp/GUC - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAsp/GUC - ? 456509 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAGly/GCC - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAGly/GCC - ? 456510 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAHis/GUG - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAHis/GUG - ? 456511 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAIle/GAU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAIle/GAU - ? 456512 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNALys/UUU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNALys/UUU - ? 456513 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAThr/CGU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAThr/CGU - ? 456514 2.1.1.33 S-adenosyl-L-methionine + guanine46 in RNAVal/GAC - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAVal/GAC - ? 456515 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA - Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA - Thermus thermophilus S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA - Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA - Aquifex aeolicus S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA - Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: methyl-deficient tRNA from E. coli Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: methyl-deficient tRNA from E. coli Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ir 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: methyl-deficient tRNA from E. coli Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA highly specific for tRNA and S-adenosyl-L-methionine, cannot be replaced by methionine plus ATP, formaldehyde plus tetrahydrofolic acid, methylcobalamin and methyltetrahydrofolic acid Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ir 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptors: tRNACys, tRNATrp, tRNAPro, tRNAMet, tRNAMet-i and 2 of each tRNAPhe, tRNAVal and tRNALys, methylation at G46 in the extra loop Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptors: methyl-deficient bulk tRNA from E. coli K12met-rel-, tRNAfMet from Bacillus subtilis, formation of 0.8 mol N7-methylguanine residues per mol Bacillus subtilis tRNA, enzyme recognizes and methylates specifically the extra arm unpaired methyl-deficient guanylate residue Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: yeast pre-tRNAPhe Homo sapiens S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: yeast pre-tRNAPhe Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA extend of methylation is directly proportional to the amount of tRNA added, 0.19% of nucleotide residues are methylated Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ir 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: yeast tRNA1Ala, methylates G located in the extra loop at position 46 from the 5’ end of tRNA1Ala Phaseolus vulgaris S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: yeast tRNA1Ala, methylates G located in the extra loop at position 46 from the 5’ end of tRNA1Ala Parthenocissus tricuspidata S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: undermethylated tRNA Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: undermethylated tRNA from Salmonella typhimurium CS 14, NH2- and COOH-group of S-adenosyl-L-methionine as well as the length of hydrocarbon chain connecting them to the aromatic ring of adenosine, chirality at the alpha-C atom and NH2-group of adenosine are important for substrate binding to enzyme Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA tRNA modifying enzyme Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA specific enzyme involved in the maturation of tRNA Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA complex of 2 proteins Trm8 and Trm82 is required for efficient m7G-methyltransferase activity in vitro and in vivo, tRNA site G46 is methylated in vivo Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptor: methyl-deficient tRNA from E. coli Saccharomyces cerevisiae D84 S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNA methyl group acceptors: methyl-deficient bulk tRNA from E. coli K12met-rel-, tRNAfMet from Bacillus subtilis, formation of 0.8 mol N7-methylguanine residues per mol Bacillus subtilis tRNA, enzyme recognizes and methylates specifically the extra arm unpaired methyl-deficient guanylate residue Escherichia coli MRE 600 S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA - ? 289650 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAAla/GGC - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAAla/GGC - ? 456516 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAMet/CAU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAMet/CAU - ? 456517 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAPhe substrate tRNAPhe of Saccharomyces cerevisiae Aquifex aeolicus S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPhe - ? 456519 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAPhe/GAA - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPhe/GAA - ? 456518 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAPro/CGG - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPro/CGG - ? 456520 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAPro/GGG - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPro/GGG - ? 456521 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAPro/UGG - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPro/UGG - ? 456522 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAThr/GGU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAThr/GGU - ? 456523 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAThr/UGU - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAThr/UGU - ? 456524 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNATrp/CCA - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNATrp/CCA - ? 456525 2.1.1.33 S-adenosyl-L-methionine + guanine46 in tRNAVal/UAC - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAVal/UAC - ? 456526 2.1.1.33 S-adenosyl-L-methionine + guanine46 in undermethylated tRNA - Salmonella enterica subsp. enterica serovar Typhimurium ? - ? 451820