2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	-	Candidatus Pelagibacter ubique	2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	403406	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	-	Ruegeria pomeroyi DSS-3	2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	403406	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	enzyme exhibits strict substrate specificity for 2-(dimethylsulfonio)propanoate	Candidatus Pelagibacter ubique	2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	403406	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	enzyme exhibits strict substrate specificity for 2-(dimethylsulfonio)propanoate	Ruegeria pomeroyi	2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	403406	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	DmdA catalyzes a redox-neutral methyl transfer reaction to produce 5-methyltetrahydrofolate	Candidatus Pelagibacter ubique	2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	403406	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	enzyme exhibits strict substrate specificity for 2-(dimethylsulfonio)propanoate	Candidatus Pelagibacter ubique HTCC1062	2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	403406	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	-	Candidatus Pelagibacter ubique	2-(methylthio)propanoate + 5-methyltetrahydrofolate	-	r	453913	
2.1.1.269	2-(dimethylsulfonio)propanoate + tetrahydrofolate	-	Candidatus Pelagibacter ubique HTCC1062	2-(methylthio)propanoate + 5-methyltetrahydrofolate	-	r	453913	
2.1.1.269	3-(S,S-dimethylsulfonio)propanoate + tetrahydrofolate	-	uncultured bacterium	3-(methylthio)propanoate + 5-methyltetrahydrofolate	-	?	422512	
2.1.1.269	3-(S,S-dimethylsulfonio)propanoate + tetrahydrofolate	-	Candidatus Pelagibacter ubique	3-(methylthio)propanoate + 5-methyltetrahydrofolate	-	?	422512	
2.1.1.269	3-(S,S-dimethylsulfonio)propanoate + tetrahydrofolate	-	Ruegeria pomeroyi	3-(methylthio)propanoate + 5-methyltetrahydrofolate	-	?	422512	
2.1.1.269	3-(S,S-dimethylsulfonio)propanoate + tetrahydrofolate	-	Candidatus Pelagibacter ubique HTCC1062	3-(methylthio)propanoate + 5-methyltetrahydrofolate	-	?	422512	
2.1.1.269	3-(S,S-dimethylsulfonio)propanoate + tetrahydrofolate	-	uncultured bacterium WN	3-(methylthio)propanoate + 5-methyltetrahydrofolate	-	?	422512	
2.1.1.269	additional information	marine bacterioplankton regulate sulfur flux by converting the precursor dimethylsulfoniopropionate either to dimethylsulfide or to sulfur compounds that are not climatically active	Ruegeria pomeroyi DSS-3	?	-	?	89	
2.1.1.269	additional information	marine bacterioplankton regulate sulfur flux by converting the precursor dimethylsulfoniopropionate either to dimethylsulfide or to sulfur compounds that are not climatically active	Candidatus Pelagibacter ubique	?	-	?	89	
2.1.1.269	additional information	no detectable demethylase activity with glycine betaine, dimethyl glycine, methylmercaptopropionate, methionine, or dimethylsulfonioacetate. Less than 1% activity is found with dimethylsulfoniobutanoate and dimethylsulfoniopentanoate	Candidatus Pelagibacter ubique	?	-	?	89	
2.1.1.269	additional information	no detectable demethylase activity with glycine betaine, dimethyl glycine, methylmercaptopropionate, methionine, or dimethylsulfonioacetate. Less than 1% activity is found with dimethylsulfoniobutanoate and dimethylsulfoniopentanoate	Ruegeria pomeroyi	?	-	?	89	
2.1.1.269	additional information	no substrate: betaine. Reaction does not require ATP or reductive activation by titanium(III)-nitrilotriacetic acid	uncultured bacterium	?	-	?	89	
2.1.1.269	additional information	strict substrate specificity for dimethylsulfoniopropionate. No detectable demethylase activity with glycine betaine, dimethyl glycine, methylmercaptopropionate, methionine, or dimethylsulfonioacetate and less than 1% activity with dimethylsulfoniobutanoate and dimethylsulfoniopentanoate	Ruegeria pomeroyi	?	-	?	89	
2.1.1.269	additional information	strict substrate specificity for dimethylsulfoniopropionate. No detectable demethylase activity with glycine betaine,dimethyl glycine, methylmercaptopropionate, methionine, or dimethylsulfonioacetate and less than 1% activity with dimethylsulfoniobutanoate and dimethylsulfoniopentanoate	Candidatus Pelagibacter ubique	?	-	?	89	
2.1.1.269	additional information	assay metod, overview. The substrate THF and product 5-methyl-THF are labile under aerobic conditions, oxidation of THF is irreversible and results in the release of 4-aminobenzoyl glutamate, essentially breaking the molecule in half. Half-life of THF in solution at pH 7.0 is about 40 min. DTT can stabilize THF in solution	Candidatus Pelagibacter ubique	?	-	-	89	
2.1.1.269	additional information	assay metod, overview. The substrate THF and product 5-methyl-THF are labile under aerobic conditions, oxidation of THF is irreversible and results in the release of 4-aminobenzoyl glutamate, essentially breaking the molecule in half. Half-life of THF in solution at pH 7.0 is about 40 min. DTT can stabilize THF in solution	Ruegeria pomeroyi	?	-	-	89	
2.1.1.269	additional information	no detectable demethylase activity with glycine betaine, dimethyl glycine, methylmercaptopropionate, methionine, or dimethylsulfonioacetate. Less than 1% activity is found with dimethylsulfoniobutanoate and dimethylsulfoniopentanoate	Candidatus Pelagibacter ubique HTCC1062	?	-	?	89	
2.1.1.269	additional information	strict substrate specificity for dimethylsulfoniopropionate. No detectable demethylase activity with glycine betaine,dimethyl glycine, methylmercaptopropionate, methionine, or dimethylsulfonioacetate and less than 1% activity with dimethylsulfoniobutanoate and dimethylsulfoniopentanoate	Candidatus Pelagibacter ubique HTCC1062	?	-	?	89	
2.1.1.269	additional information	assay metod, overview. The substrate THF and product 5-methyl-THF are labile under aerobic conditions, oxidation of THF is irreversible and results in the release of 4-aminobenzoyl glutamate, essentially breaking the molecule in half. Half-life of THF in solution at pH 7.0 is about 40 min. DTT can stabilize THF in solution	Candidatus Pelagibacter ubique HTCC1062	?	-	-	89	
2.1.1.269	additional information	no substrate: betaine. Reaction does not require ATP or reductive activation by titanium(III)-nitrilotriacetic acid	uncultured bacterium WN	?	-	?	89	
2.1.1.269	additional information	assay metod, overview. The substrate THF and product 5-methyl-THF are labile under aerobic conditions, oxidation of THF is irreversible and results in the release of 4-aminobenzoyl glutamate, essentially breaking the molecule in half. Half-life of THF in solution at pH 7.0 is about 40 min. DTT can stabilize THF in solution	Ruegeria pomeroyi DSM 15171	?	-	-	89	
2.1.1.269	additional information	assay metod, overview. The substrate THF and product 5-methyl-THF are labile under aerobic conditions, oxidation of THF is irreversible and results in the release of 4-aminobenzoyl glutamate, essentially breaking the molecule in half. Half-life of THF in solution at pH 7.0 is about 40 min. DTT can stabilize THF in solution	Ruegeria pomeroyi ATCC 700808	?	-	-	89	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Roseobacter sp.	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Sulfitobacter sp.	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Candidatus Pelagibacter ubique	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Ruegeria pomeroyi	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Litoreibacter sp.	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Loktanella sp.	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Octadecabacter sp.	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Ruegeria sp.	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Candidatus Pelagibacter ubique HTCC1062	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Ruegeria pomeroyi DSM 15171	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476	
2.1.1.269	S,S-dimethyl-beta-propiothetin + tetrahydrofolate	-	Ruegeria pomeroyi ATCC 700808	3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate	-	?	454476