2.1.1.20 additional information all-trans-retinoic acid and dexamethasone independently induce GNMT in liver, no effect on enzyme from pancreas Rattus norvegicus ? - ? 89 2.1.1.20 additional information interaction of benzo(a)pyrene with the enzyme may contribute to carcinogenesis Homo sapiens ? - ? 89 2.1.1.20 additional information major folate binding protein Mus musculus ? - ? 89 2.1.1.20 additional information major folate binding protein Homo sapiens ? - ? 89 2.1.1.20 additional information major folate binding protein Rattus norvegicus ? - ? 89 2.1.1.20 additional information major folate binding protein, interacts with environmental carcinogens such as benzo(a)pyrene Homo sapiens ? - ? 89 2.1.1.20 additional information major folate binding protein, involved in the regulation of the expression of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, binds benzo(a)pyrene and prevents DNA-adduct formation Mus musculus ? - ? 89 2.1.1.20 additional information GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 Mus musculus ? - ? 89 2.1.1.20 additional information a mammalian target of rapamycin (mTOR) inhibitor (DEP domain containing MTOR-interacting protein [DEPDC6/DEPTOR]) is identified as a GNMT-binding protein by using yeast two-hybrid screening. The C-terminal half of GNMT interacts with the PSD-95/Dlg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR Homo sapiens ? - ? 89 2.1.1.20 additional information kinetic isotope effects at the transferred methyl group implicate a compaction effect that is conferred by the protein structure Rattus norvegicus ? - - 89 2.1.1.20 S-adenosyl-L-methionine + glycine - Mus musculus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine - Homo sapiens S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine - Rattus norvegicus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine - Oryctolagus cuniculus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine strict specificity for glycine as methyl acceptor Rattus norvegicus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine strict specificity for glycine as methyl acceptor Oryctolagus cuniculus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine regulates the ratio of S-adenosylmethionine to S-adenosylhomocysteine Rattus norvegicus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine the enzyme regulates the methyl group supply for S-adenosylmethionine-dependent transmethylation reactions. All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats Rattus norvegicus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a „Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs Mus musculus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a „Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs Homo sapiens S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine mechanism: the bound S-adenosyl-L-methionine is firmly connected to protein and a „Gly pocket" is created near the bound S-adenosyl-L-methionine. The second substrate Gly binds to Arg175 and is brought into the Gly pocket. Five hydrogen bonds connect the Gly in the proximity of the bound S-adenosyl-L-methionine and orient the lone pair orbital on the amino nitrogen of Gly towards the donor methyl group of S-adenosyl-L-methionine. Thermal motion of the enzyme leads to a collision of the N and C(E) so that a SN2 methyltransfer reaction occurs Rattus norvegicus S-adenosyl-L-homocysteine + sarcosine - ? 319640 2.1.1.20 S-adenosyl-L-methionine + glycine - Mus musculus S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Sus scrofa S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Oryctolagus cuniculus S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Danio rerio S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine - Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio Mus musculus S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine - ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine Mus musculus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens Mus musculus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA-methylation, key role in the one-carbon metabolism pathway Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682 2.1.1.20 S-adenosyl-L-methionine + glycine key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, control of the methylating potential of the cell Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine N-methylglycine = sarcosine ? 386682