2.1.1.179 additional information RmtC in the presence of aminoglycosides impedes methylation at the N5 position of nucleotide C1407 when the N7 position of G1405 is methylated, MALDI mass spectrometry product analysis, mechanism, overview Escherichia coli ? - ? 89 2.1.1.179 additional information RmtC in the presence of aminoglycosides impedes methylation at the N5 position of nucleotide C1407 when the N7 position of G1405 is methylated, MALDI mass spectrometry product analysis, mechanism, overview Escherichia coli BW25113 ? - ? 89 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Escherichia coli S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Micromonospora zionensis S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Micromonospora echinospora S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Proteus mirabilis S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Micromonospora inyonensis S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Streptoalloteichus hindustanus S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Streptomyces kanamyceticus S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Klebsiella pneumoniae S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Serratia marcescens S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Citrobacter freundii S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Micromonospora olivasterospora S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Micromonospora rosea S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Klebsiella pneumoniae BM4686 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Escherichia coli BW25113 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + cytosine1405 in 16S rRNA - Proteus mirabilis ARS68 S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA - ? 419571 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Escherichia coli S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - plasmid pIP1206 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme confers resistance to aminoglycosides like gentamicin and sisomicin by specifically methylating G1405 in bacterial 16S rRNA Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Frankia sp. S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry Frankia sp. S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as guanine1405 by MALDI-ToF mass spectrometry Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation at guanine1405 mediates cellular resistance by blocking aminoglycoside binding by ribosomes plasmid pAT780 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA post-transcriptional methylation of N7-G1405 in 16S rRNA of 30S ribosomal subunits Escherichia coli S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus Proteus mirabilis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC has an MTase activity specific for the bacterial 30S ribosomal subunit consisting of 16S rRNA and several ribosomal proteins, but not for the naked 16S rRNA Proteus mirabilis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the ArmA methylation reaction is specific for the 30S ribosomal subunit. Neither 16S rRNA alone nor the 70S ribosome is a substrate for this reaction under experimental conditions, implicating ribosomal proteins in substrate recognition plasmid pAT780 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins Frankia sp. CcI3 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry Frankia sp. CcI3 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus Proteus mirabilis ARS68 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC has an MTase activity specific for the bacterial 30S ribosomal subunit consisting of 16S rRNA and several ribosomal proteins, but not for the naked 16S rRNA Proteus mirabilis ARS68 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA - ? 407346 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA - ? 432938 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA - ? 432938 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Micromonospora zionensis S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA - ? 432938 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Escherichia coli BW25113 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA - ? 432938 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Pseudomonas aeruginosa BB1285 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA - ? 432938 2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA - Escherichia coli MM294 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA - ? 432938