2.1.1.158	additional information	enzyme expression and activity during caffeine biosynthesis in fruits, overview	Coffea canephora	?	-	?	89	
2.1.1.158	additional information	enzyme expression and activity during caffeine biosynthesis in fruits, overview	Coffea arabica	?	-	?	89	
2.1.1.158	additional information	substrate specificity of the recombinant His-tagged enzyme, no activity with xanthosine 5'-phosphate, theobromine, or 7-methylxanthosine	Coffea arabica	?	-	?	89	
2.1.1.158	additional information	7-methylxanthosine synthase shows the most critical substrate specifi city of the three types of N-methyltransferases in Coffea species	Coffea sp.	?	-	?	89	
2.1.1.158	additional information	both xanthosine and its monoanionic form with N3 deprotonated are used as the substrates for the methylation. While the methyl group can be transferred to the monoanionic form of xanthosine with a reasonable free energy barrier (about 17 kcal/mol), this is not the case for the neutral xanthosine (barrier is about 31 kcal/mol). The hydrogen bonding and hydrophobic interactions involving the monoanionic form closely represent the corresponding interactions in the crystal structure, which seems not to be the case for the reactant complex involving the neutral xanthosine	Coffea canephora	?	-	-	89	
2.1.1.158	additional information	enzyme expression and activity during caffeine biosynthesis in fruits, overview	Coffea canephora CCS1	?	-	?	89	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Camellia sinensis	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Coffea sp.	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Coffea canephora	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Coffea canephora	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	first step in caffeine biosynthesis	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	first step in caffeine biosynthesis pathway from xanthosine	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	first step in caffeine biosynthesis pathway from xanthosine	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	first step in caffeine biosynthesis pathway from xanthosine, reduction of the second enzyme of the pathway, 7-methylxanthine methyltransferase, EC 2.1.1.159, leads to reduced XMT1 expression	Coffea canephora	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	first step in caffeine biosynthesis pathway from xanthosine, reduction of the second enzyme of the pathway, 7-methylxanthine methyltransferase, EC 2.1.1.159, leads to reduced XMT1 expression	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	in vivo feeding experiments with radio-labeled substrate, product determination, overview	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	step of the caffeine biosynthesis, caffeine accumulation in seeds	Coffea canephora	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	step of the caffeine biosynthesis, caffeine accumulation in seeds	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	the enzyme is part of a caffeine biosynthetic pathway which includes a recycling of adenosine released from S-adenosyl-L-methionine in form of xanthosine monophosphate, overview	Camellia sinensis	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	specific methylation at N-7 position	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	ir	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	the enzyme is specific for xanthosine	Coffea arabica	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	-	Coffea canephora CCS1	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364	
2.1.1.158	S-adenosyl-L-methionine + xanthosine	step of the caffeine biosynthesis, caffeine accumulation in seeds	Coffea canephora CCS1	S-adenosyl-L-homocysteine + 7-methylxanthosine	-	?	383364