1.7.1.7 dGMP + NADPH + H+ dGMP is a poor substrate Homo sapiens dIMP + NH3 + NADP+ - r 462431 1.7.1.7 dIMP + NH3 + NADP+ dIMP is a poor substrate Homo sapiens dGMP + NADPH + H+ - r 462446 1.7.1.7 GMP + NADPH + H+ - Trypanosoma brucei IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Homo sapiens IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Homo sapiens IMP + NH3 + NADP+ - r 440260 1.7.1.7 GMP + NADPH + H+ - Trypanosoma brucei brucei IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Leishmania major IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Trypanosoma congolense IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ reductive deamination of GMP, the back conversion of IMP to GMP is highly unfavorable Leishmania major IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Trypanosoma brucei ILTat IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Trypanosoma congolense IL3000 IMP + NH3 + NADP+ - ? 440260 1.7.1.7 GMP + NADPH + H+ - Trypanosoma brucei brucei 927/4 GUTat10.1 IMP + NH3 + NADP+ - ? 440260 1.7.1.7 IMP + NH3 + NADP+ - Homo sapiens GMP + NADPH + H+ - r 461622 1.7.1.7 additional information enzyme nucleotide bindng analysis, nucleotide binding alters the quarternary structure of the enzyme, overview Leishmania major ? - ? 89 1.7.1.7 NADPH + guanosine 5'-phosphate - Salmonella enterica subsp. enterica serovar Typhimurium NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Salmonella enterica subsp. enterica serovar Typhimurium NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Bacillus subtilis NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Escherichia coli NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Homo sapiens NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Homo sapiens NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Bos taurus NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Klebsiella aerogenes NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Leishmania donovani NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Mycoplasma mycoides NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Artemia salina NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Rattus norvegicus NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate - Escherichia coli NADP+ + inosine 5'-phosphate + NH3 GMP and IMP binding are thermodynamically favorable processes. Protonation and hydride transfer steps take place in the same transition state. Product release does not contribute to the rate-limiting step of the reaction ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate less than 10% of the NADPH rate: thionicotinamide-NADPH, deamino-NADPH, 3-acetylpyrimidine-NADPH Homo sapiens NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate arabinosylGMP, 2'-dGMP and 8-azaGMP are reductively deaminated to their corresponding IMP analog at rates 1-2% the rate with GMP Homo sapiens NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate specific for GMP Salmonella enterica subsp. enterica serovar Typhimurium NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate specific for GMP Escherichia coli NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate specific for GMP Klebsiella aerogenes NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate the rate of the reverse reaction is 6% of the forward reaction Artemia salina NADP+ + inosine 5'-phosphate + NH3 - r 260152 1.7.1.7 NADPH + guanosine 5'-phosphate enzyme may play a role in brown fat response Rattus norvegicus NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate enzyme is involved in interconversion of purine ribonucleotides Salmonella enterica subsp. enterica serovar Typhimurium NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate involved in salvage pathway of purine synthesis Bacillus subtilis NADP+ + inosine 5'-phosphate + NH3 - ? 260152 1.7.1.7 NADPH + guanosine 5'-phosphate essential for the salvage pathway of purine ribonucleotide biosynthesis Homo sapiens NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + guanosine 5'-phosphate important for the maintenance of the intracellular adenine guanine balance, possible role in the regulation of differentiation of leukemia cells Homo sapiens NADP+ + inosine 5'-phosphate + NH3 - ir 260152 1.7.1.7 NADPH + H+ + guanosine 5'-phosphate - Escherichia coli NADP+ + inosine 5'-phosphate + NH3 - ? 426828