1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Homo sapiens beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Pseudomonas syringae beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola 1448A beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Pseudomonas syringae 1448A beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi 1448A beta-NAD+ + H2O2 - ? 440054 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Homo sapiens beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Pseudomonas syringae beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola 1448A beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Pseudomonas syringae 1448A beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,2-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi 1448A beta-NADP+ + H2O2 - ? 440055 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Homo sapiens beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Pseudomonas syringae beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola 1448A beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Pseudomonas syringae 1448A beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADH + H+ + O2 - Pseudomonas savastanoi 1448A beta-NAD+ + H2O2 - ? 440058 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Homo sapiens beta-NADP+ + H2O2 - ? 440059 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Pseudomonas syringae beta-NADP+ + H2O2 - ? 440059 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi beta-NADP+ + H2O2 - ? 440059 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola beta-NADP+ + H2O2 - ? 440059 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola 1448A beta-NADP+ + H2O2 - ? 440059 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Pseudomonas syringae 1448A beta-NADP+ + H2O2 - ? 440059 1.6.3.5 1,6-dihydro-beta-NADPH + H+ + O2 - Pseudomonas savastanoi 1448A beta-NADP+ + H2O2 - ? 440059 1.6.3.5 2-dihydronicotinamide adenine dinucleotide phosphate + O2 - Pseudomonas savastanoi pv. phaseolicola ? - ? 440665 1.6.3.5 2-dihydronicotinamide riboside + O2 - Pseudomonas savastanoi pv. phaseolicola ? - ? 440666 1.6.3.5 6-dihydronicotinamide adenine dinucleotide phosphate + O2 - Pseudomonas savastanoi pv. phaseolicola ? - ? 440961 1.6.3.5 6-dihydronicotinamide riboside + O2 - Pseudomonas savastanoi pv. phaseolicola ? - ? 440962 1.6.3.5 alpha-NAD(P)H + H+ + O2 - Homo sapiens beta-NAD(P)+ + H2O2 renalase is selective for the alpha-anomer, which binds with a dissociation constant of about 20 microM. This association precedes monophasic two-electron reduction of the FAD cofactor with a rate constant of 40.2 per s. The reduced enzyme then delivers both electrons to dioxygen in a second-order reaction with a rate constant of about 2900 per M and s. Renalase has modest affinity for its beta-NADP+ product, and the FAD cofactor has a reduction potential of -155 mV that is unaltered by saturating beta-NADP+. Data suggest that the products are formed and released in a kinetically ordered sequence, first beta-NADP+ then H2O2 ? 424652 1.6.3.5 alpha-NAD(P)H + H+ + O2 renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure and slow heart rate Homo sapiens beta-NAD(P)+ + H2O2 - ? 424652 1.6.3.5 alpha-NAD(P)H + H+ + O2 the substrate alpha-dihydropyridyl ring is oxidized by transferring two electrons to the flavin cofactor and the configuration of the ribose C1 is converted from alpha to beta. The reduced FAD cofactor then reoxidizes by reacting with dioxygen to yield hydrogen peroxide Homo sapiens beta-NAD(P)+ + H2O2 - ? 424652 1.6.3.5 alpha-NADH + H+ + O2 - Mus musculus beta-NAD+ + H2O2 - ? 440147 1.6.3.5 alpha-NADH + H+ + O2 - Homo sapiens beta-NAD+ + H2O2 - ? 440147 1.6.3.5 alpha-NADH + H+ + O2 - Pseudomonas savastanoi beta-NAD+ + H2O2 - ? 440147 1.6.3.5 alpha-NADH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola beta-NAD+ + H2O2 - ? 440147 1.6.3.5 alpha-NADH + H+ + O2 - Pseudomonas savastanoi 1448A beta-NAD+ + H2O2 - ? 440147 1.6.3.5 alpha-NADPH + H+ + O2 - Homo sapiens beta-NADP+ + H2O2 - ? 440148 1.6.3.5 alpha-NADPH + H+ + O2 - Pseudomonas savastanoi beta-NADP+ + H2O2 - ? 440148 1.6.3.5 alpha-NADPH + H+ + O2 - Pseudomonas savastanoi pv. phaseolicola beta-NADP+ + H2O2 - ? 440148 1.6.3.5 catecholamine + O2 - Homo sapiens oxidized catecholamine + H2O2 - ? 440187 1.6.3.5 catecholamine + O2 - Homo sapiens oxidized catecholamine + NH3 + H2O2 - ? 441165 1.6.3.5 dopamine + O2 - Homo sapiens ? - ? 386458 1.6.3.5 epinephrine + O2 - Homo sapiens ? - ? 289484 1.6.3.5 L-DOPA + O2 - Homo sapiens ? - ? 386533 1.6.3.5 additional information renalase has an extremely low diaphorase activity, displaying lower kcat but higher kcat/Km for NADH compared to NADPH Homo sapiens ? - ? 89 1.6.3.5 additional information renalase does not catalyze the oxidation of catecholamines Homo sapiens ? - ? 89 1.6.3.5 additional information renalase exhibits a preference for substrates derived from beta-NAD+ over those derived from beta-NADP+ Pseudomonas savastanoi pv. phaseolicola ? - ? 89 1.6.3.5 additional information renalase exhibits a preference for substrates derived from beta-NAD+ over those derived from beta-NADP+ Pseudomonas savastanoi pv. phaseolicola 1448A ? - ? 89 1.6.3.5 NAD(P)H + H+ + tetrazolium - Homo sapiens NAD(P)+ + formazan - ? 441703 1.6.3.5 norepinephrine + O2 - Homo sapiens ? - ? 5164