1.5.1.25 1-piperideine 2-carboxylate + NADPH + H+ - Homo sapiens L-pipecolate + NADP+ - ? 440061 1.5.1.25 aminoethyl cysteine ketimine + NADPH + H+ - Homo sapiens thiomorpholine-3-carboxylate - ? 461521 1.5.1.25 cystathionine ketimine + NADH - Sus scrofa cyclothionine + NAD+ - ir 289391 1.5.1.25 cystathionine ketimine + NADH - Bos taurus cyclothionine + NAD+ - ? 289391 1.5.1.25 cystathionine ketimine + NADPH - Sus scrofa cyclothionine + NADP+ - ir 289395 1.5.1.25 cystathionine ketimine + NADPH - Bos taurus cyclothionine + NADP+ - ? 289395 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADH - Sus scrofa ? + NAD+ - ir 289392 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADH - Bos taurus ? + NAD+ - ? 289392 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH - Sus scrofa ? + NADP+ - ir 289396 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH - Bos taurus ? + NADP+ - ? 289396 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH + H+ - Mus musculus L-pipecolate + NADP+ - ? 440209 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH + H+ - Homo sapiens L-pipecolate + NADP+ - ? 440209 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH + H+ - Rattus norvegicus L-pipecolate + NADP+ - ? 440209 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH + H+ - Sus scrofa L-pipecolate + NADP+ - ? 440209 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH + H+ - Bos taurus L-pipecolate + NADP+ - ? 440209 1.5.1.25 DELTA1-piperideine 2-carboxylate + NADPH + H+ - Macropus giganteus L-pipecolate + NADP+ - ? 440209 1.5.1.25 DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ - Mus musculus L-proline + NADP+ - ? 440212 1.5.1.25 DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ - Homo sapiens L-proline + NADP+ - ? 440212 1.5.1.25 DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ - Bos taurus L-proline + NADP+ - ? 440212 1.5.1.25 DELTA2-thiazoline-2-carboxylate + NADPH + H+ - Mus musculus ? + NADP+ - ? 440213 1.5.1.25 DELTA2-thiazoline-2-carboxylate + NADPH + H+ - Homo sapiens ? + NADP+ - ? 440213 1.5.1.25 DELTA2-thiazoline-2-carboxylate + NADPH + H+ - Bos taurus ? + NADP+ - ? 440213 1.5.1.25 glyocylate + methylamine + NADPH + H+ - Homo sapiens sarcosine + NADP+ - ? 441427 1.5.1.25 lanthionine ketimine + NADH - Sus scrofa 1,4-thiomorpholine 3,5-dicarboxylic acid + NAD+ - ir 289390 1.5.1.25 lanthionine ketimine + NADH - Bos taurus 1,4-thiomorpholine 3,5-dicarboxylic acid + NAD+ - ? 289390 1.5.1.25 lanthionine ketimine + NADPH - Sus scrofa 1,4-thiomorpholine 3,5-dicarboxylic acid + NADP+ - ir 289394 1.5.1.25 lanthionine ketimine + NADPH - Bos taurus 1,4-thiomorpholine 3,5-dicarboxylic acid + NADP+ - ? 289394 1.5.1.25 lanthionine ketimine + NADPH + H+ - Homo sapiens thiomorpholine-3,5-dicarboxylate - ? 461637 1.5.1.25 lanthionine ketimine + NADPH + H+ low activity Homo sapiens thiomorpholine-3,5-dicarboxylate - ? 461637 1.5.1.25 additional information the non-sulfur substrates exist in equilibrium with open chain forms at low acidic pH. At neutral pH, they exist predominantly as the enzymatically favorable cyclic ketimine form (in which the ring double bond is in the C=N form), while sulfur-containing cyclic ketimine substrates exist predominantly as the enzymatically unfavorable enamine form (in which the ring double bond is in the C=C form) at neutral pH Homo sapiens ? - ? 89 1.5.1.25 additional information the non-sulfur substrates exist in equilibrium with open chain forms at low acidic pH. At neutral pH, they exist predominantly as the enzymatically favorable cyclic ketimine form (in which the ring double bond is in the C=N form), while sulfur-containing cyclic ketimine substrates exist predominantly as the enzymatically unfavorable enamine form (in which the ring double bond is in the C=C form) at neutral pH Bos taurus ? - ? 89 1.5.1.25 additional information the non-sulfur substrates exist in equilibrium with openchain forms at low acidic pH. At neutral pH, they exist predominantly as the enzymatically favorable cyclic ketimine form (in which the ring double bond is in the C=N form), while sulfur-containing cyclic ketimine substrates exist predominantly as the enzymatically unfavorable enamine form (in which the ring double bond is in the C=C form) at neutral pH Mus musculus ? - ? 89 1.5.1.25 additional information human ketimine reductase/CRYM can utilize alkylamines (such as methylamine and ethylamine) and 2-oxo acids (such as pyruvate and phenylpyruvate) as enzyme substrates. Analysis of reaction intermediates, overview. Mammalian ketimine reductase reaction is known to be enantiospecific and only the L-enantiomer product is formed in vivo. A ketimine reductase/CRYM-catalyzed reaction at neutral pH in the reverse direction is not determined Homo sapiens ? - ? 89 1.5.1.25 additional information in silico docking of substrates and inhibitors using ketimine reductase/CRYM cyrstal structure, PDB ID 4BVA, overview Homo sapiens ? - ? 89 1.5.1.25 additional information reciprocal relationship between thyroid hormone binding and DELTA1-piperideine-2-carboxylate (P2C) binding to ketimine reductase Mus musculus ? - - 89 1.5.1.25 additional information reciprocal relationship between thyroid hormone binding and DELTA1-piperideine-2-carboxylate (P2C) binding to ketimine reductase Homo sapiens ? - - 89 1.5.1.25 additional information purified recombinant human CRYM possesses substantial KR activity. Ketimine reductase is a typical imine reductase Mus musculus ? - - 89 1.5.1.25 additional information purified recombinant human CRYM possesses substantial KR activity. Ketimine reductase is a typical imine reductase. Substrate specificity of recombinant human ketimine reductase (KR) toward DELTA1-piperideine-2-carboxylate (P2CR) and various noncyclized imine intermediates, overview. N-methyl-L-alanine is produced when human KR is incubated in the presence of methylamine, NADPH and pyruvate. Human KR catalyzes the reductive alkylamination of phenylpyruvate and glyoxylate in the presence of methylamine Homo sapiens ? - - 89 1.5.1.25 phenylpyruvate + methylamine + NADPH + H+ - Homo sapiens N-methyl-L-phenylalanine + NADP+ - ? 441869 1.5.1.25 pyruvate + ethylamine + NADPH + H+ - Homo sapiens N-ethyl-L-alanine + NADP+ - ? 441905 1.5.1.25 pyruvate + methylamine + NADPH + H+ - Homo sapiens N-methyl-L-alanine + NADP+ - ? 441906 1.5.1.25 pyruvate + NH3 + NADPH + H+ - Homo sapiens L-alanine + NADP+ - ? 441909 1.5.1.25 S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+ - Mus musculus 1,4-thiomorpholine-3-carboxylate + NADP+ - ? 440393 1.5.1.25 S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+ - Homo sapiens 1,4-thiomorpholine-3-carboxylate + NADP+ - ? 440393 1.5.1.25 S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+ - Rattus norvegicus 1,4-thiomorpholine-3-carboxylate + NADP+ - ? 440393 1.5.1.25 S-(2-aminoethyl)-L-cysteine ketimine + NADPH + H+ - Bos taurus 1,4-thiomorpholine-3-carboxylate + NADP+ - ? 440393 1.5.1.25 S-aminoethylcysteine ketimine + NADH - Bos taurus 1,4-thiomorpholine 3-carboxylic acid + NAD+ - ? 289389 1.5.1.25 S-aminoethylcysteine ketimine + NADH - Sus scrofa 1,4-thiomorpholine 3-carboxylic acid + NAD+ L-enantiomer ir 289389 1.5.1.25 S-aminoethylcysteine ketimine + NADPH - Sus scrofa 1,4-thiomorpholine 3-carboxylic acid + NADP+ - ir 289393 1.5.1.25 S-aminoethylcysteine ketimine + NADPH - Bos taurus 1,4-thiomorpholine 3-carboxylic acid + NADP+ - ? 289393 1.5.1.25 thiomorpholine 3-carboxylate + NAD(P)+ - Mus musculus 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ - ? 461700 1.5.1.25 thiomorpholine 3-carboxylate + NAD(P)+ - Homo sapiens 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ - ? 461700