1.5.1.2 1-pyrroline-3-hydroxy-5-carboxylate + NAD(P)H - Bos taurus L-hydroxyproline + NAD(P)+ - ir 259226 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H - Saccharolobus solfataricus L-proline + NAD(P)+ - r 403292 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H - Saccharolobus solfataricus P2 L-proline + NAD(P)+ - r 403292 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Vigna radiata var. radiata L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Escherichia coli L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Escherichia coli L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Homo sapiens L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Homo sapiens L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Rattus norvegicus L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Saccharomyces cerevisiae L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Bos taurus L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Tetrahymena pyriformis L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Neurospora crassa L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Hordeum vulgare L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Pisum sativum L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Streptococcus pyogenes L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Anabaena sp. L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Cucurbita moschata L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Chlorella vulgaris var. autotrophica L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Chloroidium saccharophilum L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ reversible at pH values above 8 and higher substrate concentrations, oxidation of L-proline is strictly specific for the L-isomer Acetoanaerobium sticklandii L-proline + NAD(P)+ - r 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ reaction is irreversible at pH 7.4, but reversible at pH 10.3 Cucurbita maxima L-proline + NAD(P)+ - r 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Escherichia coli L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Rattus norvegicus L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Bos taurus L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Pseudomonas aeruginosa L-proline + NAD(P)+ - ir 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ specific for L-isomer Clostridium sporogenes L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ transfers the proS hydrogen at C-4 of the dihydropyridine ring of NAD(P)H to its substrate Rattus norvegicus L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Anabaena sp. PCC 7120 L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NAD(P)H + H+ - Streptococcus pyogenes ATCC 19615 L-proline + NAD(P)+ - ? 259222 1.5.1.2 1-pyrroline-5-carboxylate + NADH - Homo sapiens L-proline + NAD+ - ? 460420 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Escherichia coli L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Homo sapiens L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Rattus norvegicus L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Saccharomyces cerevisiae L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Bos taurus L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Neurospora crassa L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Pisum sativum L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Glycine max L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Arabidopsis thaliana L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Pseudomonas aeruginosa L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Streptococcus pyogenes L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Mycobacterium tuberculosis L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Acetoanaerobium sticklandii L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Clostridium sporogenes L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Setaria italica L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Cucurbita moschata L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Chlorella vulgaris var. autotrophica L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Chloroidium saccharophilum L-proline + NAD+ - r 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Homo sapiens L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Medicago truncatula L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Zymomonas mobilis subsp. mobilis L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Streptococcus pyogenes ATCC 19615 L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADH + H+ - Zymomonas mobilis subsp. mobilis ATCC 31821 L-proline + NAD+ - ? 395296 1.5.1.2 1-pyrroline-5-carboxylate + NADPH - Homo sapiens L-proline + NADP+ - ? 460421 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Escherichia coli L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Rattus norvegicus L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Bos taurus L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Neurospora crassa L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Glycine max L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Pseudomonas aeruginosa L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Streptococcus pyogenes L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Mycobacterium tuberculosis L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Homo sapiens L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Homo sapiens L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Medicago truncatula L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Arabidopsis thaliana L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Trypanosoma cruzi L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Zymomonas mobilis subsp. mobilis L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ activity assay, forward reaction Mycobacterium tuberculosis L-proline + NADP+ - r 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Trypanosoma cruzi CL Brener L-proline + NADP+ - ? 386031 1.5.1.2 1-pyrroline-5-carboxylate + NADPH + H+ - Zymomonas mobilis subsp. mobilis ATCC 31821 L-proline + NADP+ - ? 386031 1.5.1.2 3,4-dehydro-DL-proline + NADPH - Escherichia coli ? - ? 259227 1.5.1.2 3,4-dehydro-L-proline + NAD+ activity assay Homo sapiens ? - ? 387306 1.5.1.2 DELTA1-piperideine-6-carboxylate + NADPH - Escherichia coli L-pipecolic acid + NADP+ - ir 259228 1.5.1.2 DELTA1-pyrroline-5-carboxylate + NADH + H+ - Acetoanaerobium sticklandii L-proline + NAD+ - r 407197 1.5.1.2 L-pipecolate + NAD+ - Homo sapiens DELTA1-piperideine 6-carboxylate + NADH + H+ - ? 461631 1.5.1.2 L-pipecolate + NADP+ - Homo sapiens DELTA1-piperideine 6-carboxylate + NADPH + H+ - ? 461632 1.5.1.2 L-Pro + NAD(P)+ the enzyme plays a role as a downstream effector in p53-mediated apoptosis of renal carcinoma cells Homo sapiens 1-pyrroline-5-carboxylate + NAD(P)H - ? 371018 1.5.1.2 L-Pro + NAD+ - Rattus norvegicus 1-pyrroline-5-carboxylate + NADH - ? 373621 1.5.1.2 L-Pro + NADP+ - Rattus norvegicus 1-pyrroline-5-carboxylate + NADPH - ? 373622 1.5.1.2 L-proline + NAD(P)+ - Drosophila melanogaster 1-pyrroline-5-carboxylate + NAD(P)H + H+ - r 371019 1.5.1.2 L-proline + NAD(P)+ - Homo sapiens 1-pyrroline-5-carboxylate + NAD(P)H + H+ - r 371019 1.5.1.2 L-proline + NAD(P)+ first step in proline metabolism the hepatocyte nuclear factors HNF4alpha and HNF1alpüha regulate proline metabolism in adult liver Mus musculus 1-pyrroline-5-carboxylate + NAD(P)H + H+ - ? 371019 1.5.1.2 L-proline + NAD(P)+ - Saccharolobus solfataricus 1-pyrroline-5-carboxylate + NAD(P)H - r 405643 1.5.1.2 L-proline + NAD(P)+ - Saccharolobus solfataricus P2 1-pyrroline-5-carboxylate + NAD(P)H - r 405643 1.5.1.2 L-proline + NAD+ - Acetoanaerobium sticklandii 1-pyrroline-5-carboxylate + NADH + H+ - r 451655 1.5.1.2 L-proline + NAD+ - Clostridium sporogenes 1-pyrroline-5-carboxylate + NADH + H+ - r 451655 1.5.1.2 L-proline + NADP+ - Neisseria meningitidis 1-pyrroline-5-carboxylate + NADPH + H+ - r 386545 1.5.1.2 L-proline + NADP+ - Streptococcus pyogenes 1-pyrroline-5-carboxylate + NADPH + H+ - r 386545 1.5.1.2 L-proline benzyl ester + NAD+ 24% of activity with proline Hordeum vulgare L-pyrroline-5-carboxy benzyl ester + NADH - ? 259225 1.5.1.2 L-proline methyl ester + NAD+ 16% of activity with proline Hordeum vulgare 1-pyrroline-5-carboxy methyl ester + NADH - ? 259223 1.5.1.2 L-proline t-butyl ester + NAD+ 10% of activity with proline Hordeum vulgare 1-pyrroline-5-carboxy tert-butylester + NADH - ? 259224 1.5.1.2 L-thioproline + NAD(P)+ - Saccharolobus solfataricus 1-pyrroline-3-thio-5-carboxylate + NAD(P)H - r 405657 1.5.1.2 L-thioproline + NAD(P)+ - Saccharolobus solfataricus P2 1-pyrroline-3-thio-5-carboxylate + NAD(P)H - r 405657 1.5.1.2 additional information not: D-proline, L-hydroxyproline, L-azatidine-2-carboxylate, no other amino acids Hordeum vulgare ? - ? 89 1.5.1.2 piperideine-6-carboxylate + NADH + H+ - Homo sapiens L-pipecolic acid + NAD+ L-pipecolic acid is the sole product ir 439831 1.5.1.2 piperideine-6-carboxylate + NADPH + H+ - Homo sapiens L-pipecolic acid + NADP+ L-pipecolic acid is the sole product ir 439832 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ - Escherichia coli L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ - Glycine max L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ - Pseudomonas aeruginosa L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ final reaction of proline synthesis Pisum sativum L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Phaseolus vulgaris L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Lupinus luteus L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Pisum sativum L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Glycine max L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Arachis hypogaea L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Medicago sativa L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Vigna unguiculata L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Cajanus cajan L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Chlorella vulgaris var. autotrophica L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ discussion of role in vivo Chloroidium saccharophilum L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ ping pong mechanism Chlorella vulgaris var. autotrophica L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ ping pong mechanism Chloroidium saccharophilum L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ transfer of reducing equivalents from host plants to symbiotic partner Glycine max L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ third enzyme in proline pathway Homo sapiens L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ linkage to hexose monophosphate pathway Homo sapiens L-proline + NAD(P)+ - ? 370172 1.5.1.2 pyrroline-5-carboxylate + NAD(P)H + H+ transfer of reducing equivalents into mitochondria, linkage to pentose phosphate pathway Rattus norvegicus L-proline + NAD(P)+ - ? 370172