1.4.3.1 3 meso-2,3-diaminosuccinate + O2 - Bos taurus pyrazine 2,5-dicarboxylic acid + pyrazine 2,6-dicarboxylic acid + 4 H2O + H2O2 + 2 NH3 - ? 258969 1.4.3.1 3 meso-2,3-diaminosuccinate + O2 - Cyprinus carpio pyrazine 2,5-dicarboxylic acid + pyrazine 2,6-dicarboxylic acid + 4 H2O + H2O2 + 2 NH3 - ? 258969 1.4.3.1 3 meso-2,3-diaminosuccinate + O2 - Oncorhynchus mykiss pyrazine 2,5-dicarboxylic acid + pyrazine 2,6-dicarboxylic acid + 4 H2O + H2O2 + 2 NH3 - ? 258969 1.4.3.1 3 meso-2,3-diaminosuccinate + O2 - Seriola quinqueradiata pyrazine 2,5-dicarboxylic acid + pyrazine 2,6-dicarboxylic acid + 4 H2O + H2O2 + 2 NH3 - ? 258969 1.4.3.1 3 meso-2,3-diaminosuccinate + O2 - Carassius langsdorfii pyrazine 2,5-dicarboxylic acid + pyrazine 2,6-dicarboxylic acid + 4 H2O + H2O2 + 2 NH3 - ? 258969 1.4.3.1 cis-2,3-piperidine dicarboxylic acid + H2O + O2 - Bos taurus ? - ? 258968 1.4.3.1 cis-2,3-piperidinedicarboxylate + H2O + O2 - Oncorhynchus mykiss ? - ? 372725 1.4.3.1 cis-2,3-piperidinedicarboxylate + H2O + O2 - Todarodes pacificus ? - ? 372725 1.4.3.1 D-alanine + H2O + O2 C47Ap exhibits 4.5% activity and F18Ep exhibits 2.8% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 396833 1.4.3.1 D-alanine + H2O + O2 low catalytic efficiency with D-alanine Vanrija humicola ? - ? 396833 1.4.3.1 D-alpha-aminoadipic acid + H2O + O2 - Bos taurus 2-oxoadipic acid + NH3 + H2O2 - ? 258965 1.4.3.1 D-aminoadipate + H2O + O2 - Oncorhynchus mykiss ? - ? 372820 1.4.3.1 D-aminoadipate + H2O + O2 - Todarodes pacificus ? - ? 372820 1.4.3.1 D-arginine + H2O + O2 C47Ap exhibit less than 0.1% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 396840 1.4.3.1 D-Asn + H2O + O2 low activity Vanrija humicola 2-oxosuccinamic acid + NH3 + H2O2 - ? 441245 1.4.3.1 D-Asn + H2O + O2 low activity Mus musculus 2-oxosuccinamic acid + NH3 + H2O2 - ? 441245 1.4.3.1 D-Asn + H2O + O2 low activity Homo sapiens 2-oxosuccinamic acid + NH3 + H2O2 - ? 441245 1.4.3.1 D-Asn + H2O + O2 substrate for mutant enzyme H56N Vanrija humicola ? + NH3 + H2O2 - ? 441246 1.4.3.1 D-Asp + H2O + O2 - Caenorhabditis elegans oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 - Pelophylax lessonae oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 - Vanrija humicola oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 high activity Mus musculus oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 high activity Homo sapiens oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 high activity Rattus norvegicus oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 arginine residue 243 is possibly involved in the substrate recognition, active site model, overview Vanrija humicola oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-Asp + H2O + O2 the enzyme shows high activity only with D-aspartate Vanrija humicola oxaloacetate + NH3 + H2O2 - ? 372831 1.4.3.1 D-asparagine + H2O + O2 - Bos taurus 2-oxosuccinamic acid + H2O2 + NH3 - r 258970 1.4.3.1 D-asparagine + H2O + O2 - Octopus vulgaris 2-oxosuccinamic acid + H2O2 + NH3 - ? 258970 1.4.3.1 D-asparagine + H2O + O2 - Mus musculus 2-oxosuccinamic acid + H2O2 + NH3 - ? 258970 1.4.3.1 D-asparagine + H2O + O2 - Homo sapiens 2-oxosuccinamic acid + H2O2 + NH3 - ? 258970 1.4.3.1 D-asparagine + H2O + O2 15% activity compared to D-aspartate Mus musculus ? - ? 396841 1.4.3.1 D-asparagine + H2O + O2 C47Ap exhibits 17% activity and F18Ep exhibits 6.1% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 396841 1.4.3.1 D-aspartate + H2O + O2 - Mus musculus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Homo sapiens oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Rattus norvegicus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Sus scrofa oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Bos taurus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Oryctolagus cuniculus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Ovis aries oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Caenorhabditis elegans oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Pagrus major oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Scomber japonicus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Cyprinus carpio oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Oncorhynchus mykiss oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Vanrija humicola oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Mizuhopecten yessoensis oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Meretrix lusoria oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Todarodes pacificus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Octopus vulgaris oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Oncorhynchus keta oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Turbo cornutus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Sardinops melanostictus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Mytilus galloprovincialis oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Paralichthys olivaceus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Seriola quinqueradiata oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Pelophylax lessonae oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Penaeus japonicus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Carassius langsdorfii oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Fusarium sacchari oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Lateolabrax japonicus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Trachurus japonicus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Oncorhynchus masou oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Procambarus clarkii oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Plecoglossus altivelis oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Evynnis tumifrons oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Cololabis saira oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Thamnaconus tessellatus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Verasper variegatus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Pseudopleuronectes yokohamae oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Chaunax fimbriatus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 ferricyanide and 2,6-dichlorophenolindophenol can also act as electron acceptors instead of O2 Oryctolagus cuniculus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 intermediate product is iminoaspartate Xenopus laevis oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 100% activity Mus musculus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 100% activity Caenorhabditis elegans oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 this enzyme is proposed to have a role in the inactivation of the synaptically released D-aspartate Homo sapiens oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 DASPO plays an essential role in the assimilation of D-aspartate and acts as a detoxifying agent for D-aspartate. In the wild-type strain, the induction of ChDASPO activity strictly depends on the presence of D-aspartate and is little affected by the copresence of ammonium chloride, but it is significantly reduced by the copresence of both glucose and ammonium chloride, which, however, did not abolish the induction, allowing considerable expression of ChDASPO Vanrija humicola oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 at least two genes encoding functional DASPOs (C47Ap and F18Ep). The two DASPOs differ in their substrate specificities and possibly also in their subcellular localization Caenorhabditis elegans oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Mus musculus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Homo sapiens oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Rattus norvegicus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Sus scrofa oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Bos taurus oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Ovis aries oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 in the first step of the reaction, which is the only enzymatic step of the whole reaction scheme, DDO catalyzes the dehydrogenation of a D-amino acid to generate the corresponding imino acid, coupled with the reduction of FAD. Subsequently, FAD reoxidizes spontaneously in the presence of O2, producing H2O2, while the imino acid nonenzymatically hydrolyzes to 2-oxo acid and NH3 Caenorhabditis elegans oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Rattus norvegicus Sprague-Dawley oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Caenorhabditis elegans N2 oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Vanrija humicola UJ1 oxaloacetate + NH3 + H2O2 - ? 258958 1.4.3.1 D-aspartate + H2O + O2 - Thermomyces dupontii oxaloacetate + H2O2 + NH3 - ? 460921 1.4.3.1 D-aspartate + H2O + O2 - Mus musculus oxaloacetate + H2O2 + NH3 - ? 460921 1.4.3.1 D-aspartate + H2O + O2 - Caenorhabditis elegans oxaloacetate + H2O2 + NH3 - ? 460921 1.4.3.1 D-aspartate + H2O + O2 - Rattus norvegicus oxaloacetate + H2O2 + NH3 - ? 460921 1.4.3.1 D-aspartate + H2O + O2 - Thermomyces dupontii NBRC 30541 oxaloacetate + H2O2 + NH3 - ? 460921 1.4.3.1 D-aspartate dimethylester + H2O + O2 - Bos taurus oxaloacetic acid dimethylester + H2O2 + NH3 - ? 258972 1.4.3.1 D-aspartate dimethylester + H2O + O2 - Octopus vulgaris oxaloacetic acid dimethylester + H2O2 + NH3 - ? 258972 1.4.3.1 D-aspartic acid-beta-hydroxamate + H2O + O2 - Bos taurus 4-(hydroxyamino)-2,4-dioxobutanoic acid + NH3 + H2O2 - ? 258966 1.4.3.1 D-Gln + H2O + O2 substrate for mutant enzymes H56A and H56N Vanrija humicola ? + NH3 + H2O2 - ? 441249 1.4.3.1 D-Glu + H2O + O2 - Pelophylax lessonae 2-oxoglutarate + NH3 + H2O2 - ? 413343 1.4.3.1 D-Glu + H2O + O2 - Vanrija humicola 2-oxoglutarate + NH3 + H2O2 - ? 413343 1.4.3.1 D-Glu + H2O + O2 low activity Vanrija humicola 2-oxoglutarate + NH3 + H2O2 - ? 413343 1.4.3.1 D-Glu + H2O + O2 preferred substrate Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 413343 1.4.3.1 D-Glu + H2O + O2 low activity Mus musculus 2-oxoglutarate + H2O2 + NH3 - ? 441250 1.4.3.1 D-Glu + H2O + O2 low activity Homo sapiens 2-oxoglutarate + H2O2 + NH3 - ? 441250 1.4.3.1 D-glutamate + H2O + O2 - Homo sapiens 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Rattus norvegicus 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Sus scrofa 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Bos taurus 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Pagrus major 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Cyprinus carpio 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Oncorhynchus mykiss 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Vanrija humicola 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Todarodes pacificus 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Octopus vulgaris 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Seriola quinqueradiata 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Thermomyces dupontii 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Carassius langsdorfii 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Fusarium sacchari 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Mus musculus 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 preferred substrate Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 ferricyanide and 2,6-dichlorophenolindophenol can also act as electron acceptors instead of O2 Oryctolagus cuniculus 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 activity is 2.5fold higher than with D-Asp, F18E3.7a gene product Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 activity is 67% of the activity with D-Asp, C47A10.5 gene product Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 at least two genes encoding functional DASPOs (C47Ap and F18Ep). The two DASPOs differ in their substrate specificities and possibly also in their subcellular localization Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 14% activity compared to D-aspartate Mus musculus 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 C47Ap exhibits 247% activity and F18Ep exhibits 67% activity compared to D-aspartate as substrate Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 preferred substrate. It is possible that excess amounts of D-Glu are as toxic for Caenorhabditis elegans as they are for the silkworm, and that Caenorhabditis elegans needs DDOs to deaminate D-Glu and thereby neutralize the toxicity of diet-derived D-Glu Caenorhabditis elegans 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Rattus norvegicus Sprague-Dawley 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Thermomyces dupontii NBRC 30541 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamate + H2O + O2 - Vanrija humicola UJ1 2-oxoglutarate + NH3 + H2O2 - ? 258959 1.4.3.1 D-glutamine + H2O + O2 - Bos taurus 2-oxoglutaric acid + H2O2 + NH3 - ? 258971 1.4.3.1 D-glutamine + H2O + O2 - Octopus vulgaris 2-oxoglutaric acid + H2O2 + NH3 - ? 258971 1.4.3.1 D-glutamine + H2O + O2 - Thermomyces dupontii 2-oxoglutaric acid + H2O2 + NH3 - ? 258971 1.4.3.1 D-glutamine + H2O + O2 - Thermomyces dupontii NBRC 30541 2-oxoglutaric acid + H2O2 + NH3 - ? 258971 1.4.3.1 D-His + H2O + O2 low activity Mus musculus 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2 - ? 372919 1.4.3.1 D-His + H2O + O2 low activity Homo sapiens 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2 - ? 372919 1.4.3.1 D-histidine + H2O + O2 - Mus musculus 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2 - ? 460953 1.4.3.1 D-histidine + H2O + O2 - Homo sapiens 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2 - ? 460953 1.4.3.1 D-homocysteic acid + H2O + O2 - Bos taurus 2-oxo-4-sulfobutanoic acid + NH3 + H2O2 - ? 258963 1.4.3.1 D-homocysteic acid + H2O + O2 - Oncorhynchus mykiss 2-oxo-4-sulfo-butanoate + NH3 + H2O2 - ? 372921 1.4.3.1 D-homocysteic acid + H2O + O2 - Todarodes pacificus 2-oxo-4-sulfo-butanoate + NH3 + H2O2 - ? 372921 1.4.3.1 D-hydroxyglutarate + H2O + O2 - Oncorhynchus mykiss ? - ? 372922 1.4.3.1 D-hydroxyglutarate + H2O + O2 - Todarodes pacificus ? - ? 372922 1.4.3.1 D-Leu + H2O + O2 substrate for mutant enzyme H56N Vanrija humicola ? + NH3 + H2O2 - ? 289409 1.4.3.1 D-Met + H2O + O2 substrate for mutant enzymes H56A and H56N Vanrija humicola 4-(methylsulfonyl)-2-oxobutanoate + NH3 + H2O2 - ? 441256 1.4.3.1 D-methionine + H2O + O2 1.8% activity compared to D-aspartate Mus musculus 4-(methylsulfonyl)-2-oxobutanoic acid + NH3 + H2O2 - ? 396917 1.4.3.1 D-methionine + H2O + O2 C47Ap exhibits 3.8% activity and F18Ep exhibits 2.4% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 396919 1.4.3.1 D-Phe + H2O + O2 substrate for mutant enzymes H56A and H56N Vanrija humicola ? + NH3 + H2O2 - ? 441259 1.4.3.1 D-Pro + H2O + O2 low activity Mus musculus 2-oxopentanoic acid + NH3 + H2O2 - ? 372962 1.4.3.1 D-Pro + H2O + O2 low activity Homo sapiens 2-oxopentanoic acid + NH3 + H2O2 - ? 372962 1.4.3.1 D-proline + H2O + O2 - Bos taurus 2-oxopentanoic acid + NH3 + H2O2 - ? 258961 1.4.3.1 D-proline + H2O + O2 - Octopus vulgaris 2-oxopentanoic acid + NH3 + H2O2 - ? 258961 1.4.3.1 D-proline + H2O + O2 - Homo sapiens ? + H2O2 + NH3 - ? 460969 1.4.3.1 D-proline + H2O + O2 - Mus musculus ? + NH3 + H2O2 - ? 460970 1.4.3.1 D-thiazolidine-2-carboxylate + H2O + O2 - Bos taurus (ethylthio)oxoacetic acid + H2O2 + NH3 - ? 258973 1.4.3.1 DL-2-amino-3-phosphonopropanoic acid + H2O + O2 - Bos taurus 2-oxo-3-phosphonopropanoic acid + NH3 + H2O2 - ? 258964 1.4.3.1 DL-cysteic acid + H2O + O2 - Bos taurus 2-oxo-3-sulfopropionic acid + NH3 + H2O2 - ? 258962 1.4.3.1 glycyl-D-aspartic acid + H2O + O2 - Bos taurus ? - ? 258967 1.4.3.1 L-asparagine + H2O + O2 C47Ap exhibits 2.6% activity and F18Ep exhibits less than 0.1% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 397552 1.4.3.1 L-glutamine + H2O + O2 C47Ap exhibits 1.3% activity and F18Ep exhibits 0.3% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 397598 1.4.3.1 meso-2,3-diaminosuccinate + H2O + O2 - Oncorhynchus mykiss ? - ? 373806 1.4.3.1 meso-2,3-diaminosuccinate + H2O + O2 - Todarodes pacificus ? - ? 373806 1.4.3.1 additional information chemical modification with phenylglyoxal results in irreversible loss of activity towards dicarboxylic D-amino acids, paralleled with a transient appearance of activity versus monocarboxylic ones Bos taurus ? - ? 89 1.4.3.1 additional information D-alanine,D-proline and L-asparagine are no substrates Mus musculus ? - ? 89 1.4.3.1 additional information no detectable activity with L-alanine, L-methionine, and L-arginine Caenorhabditis elegans ? - ? 89 1.4.3.1 additional information H2O2 that is generated in the enzymatic reaction catalyzed by Caenorhabditis elegans DDO-1 and DDO-2 is conceivably degraded by catalase colocalized with each DDO Caenorhabditis elegans ? - ? 89 1.4.3.1 additional information all Caenorhabditis elegans DDOs exhibit the highest catalytic efficiency for D-Glu, but their efficiencies differ considerably for D-Glu, D-Asp, and NMDA. The isozymes show only very low or undetectable levels of activity against the neutral and basic D-amino acids and no activity with L-amino acids and N-methyl-L-Asp Caenorhabditis elegans ? - ? 89 1.4.3.1 additional information Arg216, Tyr223, Arg237, Arg278, and Ser308 residues of DDO are presumed to be important in catalytic activity and substrate binding Sus scrofa ? - ? 89 1.4.3.1 additional information Arg216, Tyr223, Arg237, Arg278, and Ser308 residues of DDO are presumed to be important in catalytic activity and substrate binding, overview Mus musculus ? - ? 89 1.4.3.1 additional information D-AspO activity linearly increases with increasing D-Asp incubation times Pelophylax lessonae ? - ? 89 1.4.3.1 additional information in contrast to the mammalian and Cryptococcus humicola DDOs, the three kinds of Caenorhabditis elegans DDOs show relatively higher catalytic efficiency against D-Glu than against D-Asp and NMDA Caenorhabditis elegans ? - ? 89 1.4.3.1 additional information structure-function relationships of DDO, overview Mus musculus ? - ? 89 1.4.3.1 additional information structure-function relationships of DDO, overview Homo sapiens ? - ? 89 1.4.3.1 additional information substrate specificities of wild-type and mutants DDOs, overview Vanrija humicola ? - ? 89 1.4.3.1 additional information no activity with D-Ala, D-Ser, D-Pro, D-Val, D-Thr, D-Ile, D-Leu, D-Gln, D-Met, D-Phe, D-Tyr, D-Trp, D-Lys, D-His, D-Arg, and Gly Vanrija humicola ? - ? 89 1.4.3.1 additional information the enzyme exhibits low activities towards D-Glu and N-methyl-D-Glu, D-Asn, D-Pro and D-His. There is no activity detected towards D-Gln, D-Ser, D-Thr, D-Tyr, D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Met, D-Trp, D-cysteine, D-Lys, D-Arg, L-Asp, L-Glu, N-methyl-L-Glu, L-Asn, L-Gln, L-Ser, L-Thr, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Pro, L-Phe, L-Met, L-Trp, L-cysteine, L-Lys, L-Arg, L-His, or Gly Homo sapiens ? - ? 89 1.4.3.1 additional information the enzyme exhibits no activity towards D-Gln, D-Ser, D-Thr, D-Ala, D-Val, D-Leu, D-Phe, D-Met, D-Trp, D-cysteine, D-Lys, D-Arg, L-Asp, L-Glu, L-Asn, L-Gln, L-Ser, L-Thr, L-Ala, L-Val, L-Leu, L-Phe, L-Met, L-Trp, L-cysteine, L-Lys, L-Arg, or L-His Mus musculus ? - ? 89 1.4.3.1 additional information no substrates: D-Asn, D-Gln, D-Ser, D-Thr, D-Tyr, D-Ala, D-Val, D-Leu, D-Ile, D-Pro, D-Phe, D-Met, D-Trp, D-Cys, D-Lys, D-Arg, D-His, L-Asp, L-Glu, LAsn, L-Gln, L-Ser, L-Thr, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Pro, L-Phe, L-Met, L-Trp, L-Cys, L-Lys, L-Arg, L-His, and Gly Caenorhabditis elegans ? - - 89 1.4.3.1 N-acetyl-DL-aspartate + H2O + O2 - Oncorhynchus mykiss oxaloacetate + acetylamine + H2O2 - ? 373906 1.4.3.1 N-acetyl-DL-aspartate + H2O + O2 - Todarodes pacificus oxaloacetate + acetylamine + H2O2 - ? 373906 1.4.3.1 N-methyl-D-Asp + H2O + O2 - Caenorhabditis elegans oxaloacetate + methylamine + H2O2 - ? 413481 1.4.3.1 N-methyl-D-Asp + H2O + O2 - Pelophylax lessonae oxaloacetate + methylamine + H2O2 - ? 413481 1.4.3.1 N-methyl-D-Asp + H2O + O2 - Vanrija humicola oxaloacetate + methylamine + H2O2 - ? 413481 1.4.3.1 N-methyl-D-Asp + H2O + O2 high activity Mus musculus oxaloacetate + methylamine + H2O2 - ? 413481 1.4.3.1 N-methyl-D-Asp + H2O + O2 high activity Homo sapiens oxaloacetate + methylamine + H2O2 - ? 413481 1.4.3.1 N-methyl-D-asparagine + H2O + O2 - Caenorhabditis elegans ? - r 451577 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Homo sapiens oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Rattus norvegicus oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Bos taurus oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Pagrus major oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Cyprinus carpio oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Oncorhynchus mykiss oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Vanrija humicola oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Octopus vulgaris oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Seriola quinqueradiata oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Thermomyces dupontii oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Carassius langsdorfii oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Fusarium sacchari oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Mus musculus oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Sus scrofa oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 activity is 1.1fold higher than with D-Asp, C47A10.5 gene product Caenorhabditis elegans oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 activity is 3.1fold higher than with D-Asp, F18E3.7a gene product Caenorhabditis elegans oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 83% activity compared to D-aspartate Mus musculus oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 C47Ap exhibits 313% activity and F18Ep exhibits 110% activity compared to D-aspartate as substrate Caenorhabditis elegans oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Rattus norvegicus Sprague-Dawley oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Thermomyces dupontii NBRC 30541 oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Vanrija humicola UJ1 oxaloacetate + CH3NH2 + H2O2 - ? 258960 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Mus musculus oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Homo sapiens oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Rattus norvegicus oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Sus scrofa oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Bos taurus oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Ovis aries oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Caenorhabditis elegans oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Oncorhynchus mykiss oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Todarodes pacificus oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-aspartate + H2O + O2 - Vanrija humicola oxaloacetate + methylamine + H2O2 - ? 260689 1.4.3.1 N-methyl-D-Glu + H2O + O2 low activity Mus musculus 2-oxoglutarate + methylamine + H2O2 - ? 441677 1.4.3.1 N-methyl-D-Glu + H2O + O2 low activity Homo sapiens 2-oxoglutarate + methylamine + H2O2 - ? 441677 1.4.3.1 N-methyl-L-Asp + H2O + O2 low activity Mus musculus oxaloacetate + methylamine + H2O2 - ? 441679 1.4.3.1 N-methyl-L-Asp + H2O + O2 low activity Homo sapiens oxaloacetate + methylamine + H2O2 - ? 441679 1.4.3.1 N-methyl-L-asparagine + H2O + O2 C47Ap exhibits 6.7% activity and F18Ep exhibits 1.1% activity compared to D-aspartate as substrate Caenorhabditis elegans ? - ? 397899 1.4.3.1 N-methyl-L-aspartate + H2O + O2 4% activity compared to D-aspartate Mus musculus ? - ? 397900