1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Synechococcus sp. biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Anabaena sp. biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Synechocystis sp. biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Prochlorococcus sp. biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Nostoc punctiforme biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin (3Z)-phytochromobilin is involved as intermediate Mesotaenium caldariorum biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Prochlorococcus sp. CCMP1378 / MED4 biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 (3Z)-phycocyanobilin + oxidized ferredoxin - Synechococcus sp. WH8102 biliverdin IXa + reduced ferredoxin - ? 287687 1.3.7.5 biliverdin IXa + reduced ferredoxin - Synechococcus sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 388230 1.3.7.5 biliverdin IXa + reduced ferredoxin - Anabaena sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 388230 1.3.7.5 biliverdin IXa + reduced ferredoxin - Nostoc sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 388230 1.3.7.5 biliverdin IXa + reduced ferredoxin - Anabaena sp. PCC 7120 (3Z)-phycocyanobilin + oxidized ferredoxin - ? 388230 1.3.7.5 biliverdin IXa + reduced ferredoxin - Nostoc sp. PCC 7120 (3Z)-phycocyanobilin + oxidized ferredoxin - ? 388230 1.3.7.5 biliverdin IXa + reduced ferredoxin - Synechococcus sp. W8020 (3Z)-phycocyanobilin + oxidized ferredoxin - ? 388230 1.3.7.5 biliverdin IXa diamide + reduced ferredoxin activity only at pH 6.0 Anabaena sp. ? + oxidized ferredoxin - ? 425218 1.3.7.5 biliverdin IXa diamide + reduced ferredoxin activity only at pH 6.0 Anabaena sp. PCC 7120 ? + oxidized ferredoxin - ? 425218 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin - Synechocystis sp. PCC 6803 (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin - Chlamydomonas reinhardtii (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin - Acaryochloris marina (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin via reaction intermediate 181,182-difydrobiliverdin (18EtBV) Synechocystis sp. PCC 6803 (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin via the intermediate 181,182-dihydrobiliverdin (181/182-DHBV) Acaryochloris marina (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin via the intermediate 181/182-dihydrobiliverdin (181/182-DHBV) Acaryochloris marina (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin - Chlamydomonas reinhardtii 4A+ (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin - Acaryochloris marina MBIC 11017 (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin via the intermediate 181,182-dihydrobiliverdin (181/182-DHBV) Acaryochloris marina MBIC 11017 (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin IXalpha + 4 reduced ferredoxin via the intermediate 181/182-dihydrobiliverdin (181/182-DHBV) Acaryochloris marina MBIC 11017 (3Z)-phycocyanobilin + 4 oxidized ferredoxin - ? 460158 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin - Synechococcus sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin - Anabaena sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin - Synechocystis sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin - Thermosynechococcus vestitus (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin spinach or Synechococcus ferredoxin Anabaena sp. (3Z)-phycocyanobilin + oxidized ferredoxin pigment I is a bona fide intermediate ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin Synechococcus ferredoxin Anabaena sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin proton-donating role of the carboxylic acid side chain of residue Glu76 for exo-vinyl reduction, structural basis for the reduction regiospecificity of PcyA, overview Synechocystis sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin PcyA catalyzes the multi-step reduction of biliverdin IXalpha to produce 3Z/3E-phycocyanobilin Synechocystis sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha Synechococcus sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin recombinant Synechocystis sp. PCC7002 ferredoxin Synechocystis sp. (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin - Synechococcus sp. PCC 7335 (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha Synechococcus sp. PCC 7335 (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin Ixalpha + reduced ferredoxin - Synechococcus sp. 7002 (3Z)-phycocyanobilin + oxidized ferredoxin - ? 370879 1.3.7.5 biliverdin IXalpha + reduced ferredoxin Synechococcus ferredoxin Anabaena sp. (3E)-phycocyanobilin + oxidized ferredoxin - ? 372574 1.3.7.5 biliverdin IXalpha + reduced ferredoxin - Nostoc sp. PCC 7120 = FACHB-418 phycocyanobilin + oxidized ferredoxin - ? 395320 1.3.7.5 biliverdin IXalpha + reduced ferredoxin - Anabaena sp. phycocyanobilin + oxidized ferredoxin with biliverdins containing a single endovinyl group, such as BV IXalpha, PcyA can generate a mixture of 3E and 3Z products ? 395320 1.3.7.5 biliverdin IXalpha + reduced ferredoxin recombinant ferredoxin from Synechococcus sp. PCC7002 Anabaena sp. phycocyanobilin + oxidized ferredoxin with biliverdins containing a single endovinyl group, such as BV IXalpha, PcyA can generate a mixture of 3E and 3Z products ? 395320 1.3.7.5 biliverdin IXalpha + reduced ferredoxin - Anabaena sp. PCC 7120 phycocyanobilin + oxidized ferredoxin with biliverdins containing a single endovinyl group, such as BV IXalpha, PcyA can generate a mixture of 3E and 3Z products ? 395320 1.3.7.5 biliverdin IXalpha + reduced ferredoxin recombinant ferredoxin from Synechococcus sp. PCC7002 Anabaena sp. PCC 7120 phycocyanobilin + oxidized ferredoxin with biliverdins containing a single endovinyl group, such as BV IXalpha, PcyA can generate a mixture of 3E and 3Z products ? 395320 1.3.7.5 biliverdin IXalpha 12-monoamide + reduced ferredoxin - Anabaena sp. phycocyanobilin 12-monoamide + oxidized ferredoxin products are corresponding phycocyanobilin monoamides with a mix of the 3E and 3Z forms ? 426030 1.3.7.5 biliverdin IXalpha 12-monoamide + reduced ferredoxin - Anabaena sp. PCC 7120 phycocyanobilin 12-monoamide + oxidized ferredoxin products are corresponding phycocyanobilin monoamides with a mix of the 3E and 3Z forms ? 426030 1.3.7.5 biliverdin IXalpha 8-monoamide + reduced ferredoxin - Anabaena sp. phycocyanobilin 8-monoamide + oxidized ferredoxin products are corresponding phycocyanobilin monoamides with a mix of the 3E and 3Z forms ? 426031 1.3.7.5 biliverdin XIII + reduced ferredoxin - Anabaena sp. phycocyanobilin + oxidized ferredoxin biliverdin XIII contains two endovinyl groups, so PcyA can convert either (or both) to an ethylidene ? 426032 1.3.7.5 biliverdin XIIIalpha + reduced ferredoxin - Anabaena sp. (3E)-isophytochromobilin + oxidized ferredoxin - ? 372575 1.3.7.5 biliverdin XIIIalpha + reduced ferredoxin Synechococcus ferredoxin Anabaena sp. (3E)-isophytochromobilin + oxidized ferredoxin - ? 372575 1.3.7.5 biliverdin XIIIalpha + reduced ferredoxin - Anabaena sp. (3Z)-isophytochromobilin + oxidized ferredoxin - ? 372576 1.3.7.5 biliverdin XIIIalpha + reduced ferredoxin Synechococcus ferredoxin Anabaena sp. (3Z)-isophytochromobilin + oxidized ferredoxin - ? 372576 1.3.7.5 biliverdin XIIIalpha + reduced ferredoxin - Synechocystis sp. ? + oxidized ferredoxin - ? 414377 1.3.7.5 biliverdin XIIIalpha + reduced ferredoxin a synthetic substrate that lacks an exo-vinyl group Synechocystis sp. ? + oxidized ferredoxin - ? 414377 1.3.7.5 biliverdin XIIIalpha monoamide + reduced ferredoxin - Anabaena sp. ? + oxidized ferredoxin mixture of products ? 426033 1.3.7.5 additional information semisynthesis of mono- and diamides of biliverdin IXalpha, that function as substrates. The enzyme is accommodating to amidation of the propionic acid side chains of biliverdin IXalpha, which does not require free carboxylic acid side chains to yield its phytobilin product, phycocyanobilin. Bilin amides are assembled with BV-type apophytochromes, demonstrating a role for the 8-propionate in the formation of the spectroscopically native Pr dark states of the biliprotein photosensors. Neither ionizable propionate side chain proves to be essential to primary photoisomerization for BV-type phytochrome. No activity with biliverdin XIIIalpha diamide , but biliverdinXIII diacid is converted into the iso-PthetaB product with moderate yield Anabaena sp. ? - ? 89 1.3.7.5 additional information semisynthesis of mono- and diamides of biliverdin IXalpha, that function as substrates. The enzyme is accommodating to amidation of the propionic acid side chains of biliverdin IXalpha, which does not require free carboxylic acid side chains to yield its phytobilin product, phycocyanobilin. Bilin amides are assembled with BV-type apophytochromes, demonstrating a role for the 8-propionate in the formation of the spectroscopically native Pr dark states of the biliprotein photosensors. Neither ionizable propionate side chain proves to be essential to primary photoisomerization for BV-type phytochrome. No activity with biliverdin XIIIalpha diamide , but biliverdinXIII diacid is converted into the iso-PthetaB product with moderate yield Anabaena sp. PCC 7120 ? - ? 89