1.2.1.75	malonyl-CoA + NADPH + H+	structural analysis reveals an unexpected reaction cycle in which NADP+ and CoA successively occupy identical binding sites, proposed reaction mechanism	Sulfurisphaera tokodaii	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Sulfurisphaera tokodaii DSM 16993	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	malonyl-CoA + NADPH + H+	structural analysis reveals an unexpected reaction cycle in which NADP+ and CoA successively occupy identical binding sites, proposed reaction mechanism	Sulfurisphaera tokodaii DSM 16993	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Erythrobacter dokdonensis DSW-74	malonate semialdehyde + CoA + NADP+	-	?	423815	
1.2.1.75	additional information	enzyme additionally catalyzes the second reduction step of malonate semialdehyde + NADPH + H+ to 3-hydroxypropionate + NADP+. Reverse reaction starting with 3-hydroxypropionate does not require CoA and probably stops at malonate semialdehyde. No substrates are acetyl-CoA, propionyl-CoA, succinyl-CoA, or glyoxylate	Chloroflexus aurantiacus	?	-	?	89	
1.2.1.75	succinyl-CoA + NADPH + H+	-	Sulfurisphaera tokodaii	succinic semialdehyde + CoA + NADP+	-	?	424096	
1.2.1.75	succinyl-CoA + NADPH + H+	-	Sulfurisphaera tokodaii DSM 16993	succinic semialdehyde + CoA + NADP+	-	?	424096	
1.2.1.75	malonate semialdehyde + coenzyme A + NADP+	-	Sulfurisphaera tokodaii	malonyl-CoA + NADPH + H+	-	r	405760	
1.2.1.75	malonyl-CoA + NADPH + H+	-	Sulfurisphaera tokodaii	malonate semialdehyde + coenzyme A + NADP+	-	r	405763	
1.2.1.75	succinate semialdehyde + coenzyme A + NADP+	-	Sulfurisphaera tokodaii	succinyl-CoA + NADPH + H+	-	r	406706