1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ - Escherichia coli (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ - Arabidopsis thaliana (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ - Neisseria meningitidis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants Selaginella moellendorffii (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants Arabidopsis thaliana (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants Vitis vinifera (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme is involved in L-lysine biosynthesis Corynebacterium glutamicum (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ it is proposed that the the domain movement for active site constitution occurs when both cofactor and substrate bind to the enzyme Corynebacterium glutamicum (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme is involved in L-lysine biosynthesis Corynebacterium glutamicum ATCC 13032 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ it is proposed that the the domain movement for active site constitution occurs when both cofactor and substrate bind to the enzyme Corynebacterium glutamicum ATCC 13032 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ the enzyme catalyzes the second committed step in the diaminopimelate/lysine anabolic pathways Bartonella henselae Houston 1 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O - ? 442107 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Escherichia coli (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ? 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Selaginella moellendorffii (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ? 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Vitis vinifera (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ? 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Neisseria meningitidis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ? 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Trichormus variabilis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ? 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Escherichia coli (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ? 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Mycobacterium tuberculosis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ? 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Selaginella moellendorffii (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ? 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Vitis vinifera (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ? 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Neisseria meningitidis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ? 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Mycobacterium tuberculosis H37Rv (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ? 422176 1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O involved in L-lysine biosynthesis Corynebacterium glutamicum (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ - ? 442118 1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O involved in L-lysine biosynthesis Corynebacterium glutamicum ATCC 13032 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ - ? 442118 1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O the enzyme utilizes both NADH and NADPH as cofactors Corynebacterium glutamicum (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - ? 442665 1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O the enzyme utilizes both NADH and NADPH as cofactors Corynebacterium glutamicum ATCC 13032 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - ? 442665 1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O the enzyme utilizes both NADH and NADPH as cofactors Corynebacterium glutamicum (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - ? 442666 1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O the enzyme utilizes both NADH and NADPH as cofactors Corynebacterium glutamicum ATCC 13032 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - ? 442666 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Lactiplantibacillus plantarum 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Brevibacillus brevis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Bacillus subtilis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Zea mays 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Priestia megaterium 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Bacillus cereus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Corynebacterium glutamicum 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Mycobacterium tuberculosis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Thermotoga maritima 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H highest activity during exponential growth phase Brevibacillus brevis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H highest activity during exponential growth phase Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H no regulatory effect of lysine Brevibacillus brevis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H lysine and diaminopimelate biosynthesis pathway Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H determination of metabolic block in the pathway in mutant M-203 Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H essentially involved in cell wall synthesis Mycobacterium tuberculosis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H repressed by lysine Lysinibacillus sphaericus 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H second step in the biosynthesis of meso-diaminopimelate, a bacterial cell wall component, and is involved in L-lysine biosynthesis Mycobacterium tuberculosis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H enzyme is a part of the biosynthetic pathway leading to meso-diaminopimelic acid and L-lysine in bacteria and higher plants Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Lactiplantibacillus plantarum NCIMB 8826 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Mycobacterium tuberculosis H37Rv 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H second step in the biosynthesis of meso-diaminopimelate, a bacterial cell wall component, and is involved in L-lysine biosynthesis Mycobacterium tuberculosis H37Rv 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Bacillus subtilis PCI 219 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ? 258380 1.17.1.8 2,3-dihydrodipicolinate + reduced 3-acetylpyridine adenine dinucleotide - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + oxidized 3-acetylpyridine adenine dinucleotide - ? 258381 1.17.1.8 dihydrodipicolinate + NADH + H+ substrate dihydrodipicolinate is instable Escherichia coli tetrahydrodipicolinate + NAD+ - ? 402605 1.17.1.8 additional information DHDPR accepts (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid as true substrate rather than dihydrodipicolinate, suggesting that DHDPR catalyzes an overall deoxygenation reaction, likely by a dehydratase-reductase route, substrate specificity, overview. A critical role is played by residue His 159 in the catalytic mechanism of DHDPR. Replacement of this residue with an alanine or a glutamine is reported to result in a 150-200fold reduction in catalytic rate as well as a 6fold increase in KM. His 159 has been proposed to act as a general acid during catalysis, providing the proton required after hydride addition. No activity with beta-hydroxypyruvate and 3-fluoropyruvate Escherichia coli ? - ? 89 1.17.1.8 pyridine dicarboxylate + NADH + H+ stable substrate analog, 25 mM phosphate D2O (deuterium water) buffer, pH 7.8 for NMR analysis of binding interactions with saturation transfer difference titration studies at 298 K (25°C) Escherichia coli reduced pyridine dicarboxylate + NAD+ - ? 406524 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Staphylococcus aureus (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ir 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Pseudomonas aeruginosa (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ir 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Mycobacterium tuberculosis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ir 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Staphylococcus aureus MRSA (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ir 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Mycobacterium tuberculosis H37Rv (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ir 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ - Staphylococcus aureus COL (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O - ir 422175 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Staphylococcus aureus (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ir 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Pseudomonas aeruginosa (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ir 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Mycobacterium tuberculosis (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ir 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Staphylococcus aureus MRSA (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ir 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Mycobacterium tuberculosis H37Rv (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ir 422176 1.17.1.8 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ - Staphylococcus aureus COL (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O - ir 422176 1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ - ir 258380 1.17.1.8 (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + NADPH + H+ - Escherichia coli ? - r 451402 1.17.1.8 2,3-dihydrodipicolinate + 3'-NADPH + H+ - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + 3'-NADP+ + H2O - r 451397 1.17.1.8 2,3-dihydrodipicolinate + alpha-NADPH + H+ - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + alpha-NADP+ + H2O - r 451398 1.17.1.8 2,3-dihydrodipicolinate + NADH + H+ - Mycobacterium tuberculosis 2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O - r 451401 1.17.1.8 2,3-dihydrodipicolinate + NADH + H+ - Thermotoga maritima 2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O - r 451401 1.17.1.8 2,3-dihydrodipicolinate + NADH + H+ - Mycobacterium tuberculosis H37Rv 2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O - r 451401 1.17.1.8 2,3-dihydrodipicolinate + NADH + H+ - Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O - r 451401 1.17.1.8 2,3-dihydrodipicolinate + reduced 3-acetylpyridine adenine dinucleotide - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + oxidized 3-acetylpyridine adenine dinucleotide + H2O - r 451396 1.17.1.8 2,3-dihydrodipicolinate + reduced nicotinamide hypoxanthine dinucleotide phosphate - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + oxidized nicotinamide hypoxanthine dinucleotide phosphate + H2O - r 451399 1.17.1.8 2,3-dihydrodipicolinate + thio-NADPH + H+ - Escherichia coli 2,3,4,5-tetrahydrodipicolinate + thio-NADP+ + H2O - r 451400