1.14.19.1 18-fluoro-10-thiaoctadecanoyl-[acyl-carrier protein] + O2 + ferredoxin - Ricinus communis ? - ? 416055 1.14.19.1 ammonium stearate + NADH + O2 - Rattus norvegicus ? - ? 287606 1.14.19.1 heptadecanoate + AH2 + O2 low activity Rattus norvegicus ? - ? 287615 1.14.19.1 additional information stearic and palmitic acids are no substrates Sus scrofa ? - ? 89 1.14.19.1 additional information 12-19 carbon fatty acyl chains undergo 9,10 desaturation. Dephospho-, deamino- and (1-N6-etheno)-CoA analogs of stearoyl-CoA are poorer substrates than stearoyl-CoA Rattus norvegicus ? - ? 89 1.14.19.1 additional information preference for 18-carbon versus 16-carbon chain length fatty acids Arabidopsis sp. ? - ? 89 1.14.19.1 additional information glycerolipid such as phosphatidylcholine is involved as an intermediate substrate Picea glauca ? - ? 89 1.14.19.1 additional information temperature-dependent chain length change is not mediated by a temperature-dependent change in desaturase substrate specificity Psychrobacter urativorans ? - ? 89 1.14.19.1 additional information SCD2 and SCD3 preferentially utilize palmitoyl-CoA Mus musculus ? - ? 89 1.14.19.1 additional information specific for C14-C19 fatty acyl-CoA substrates Rattus norvegicus ? - ? 89 1.14.19.1 additional information not acyl-CoA as substrate but phospholipid Psychrobacter urativorans ? - ? 89 1.14.19.1 additional information biosynthesis of unsaturated fatty acids. Possible substrates: acyl-CoA, acyl-acyl-carrier and acyl chains of phospholipids. The substrate in vivo is saturated phospholipid Psychrobacter urativorans ? - ? 89 1.14.19.1 additional information rate limiting-step in the cellular synthesis of monounsaturated fatty acids mainly oleate and palmitoleate Homo sapiens ? - ? 89 1.14.19.1 additional information key enzyme in the synthesis of unsaturated fatty acyl-CoAs Rattus norvegicus ? - ? 89 1.14.19.1 additional information key enzyme in the synthesis of unsaturated fatty acyl-CoAs Cricetinae ? - ? 89 1.14.19.1 additional information rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids Mus musculus ? - ? 89 1.14.19.1 additional information incorporation of the first unsaturation bond into saturated fatty acids Cyprinus carpio ? - ? 89 1.14.19.1 additional information long-chain polyunsaturated fatty acid biosynthetic pathway Mortierella alpina ? - ? 89 1.14.19.1 additional information fatty acid binding proteins my regulate the accessibility of fatty acids in the desaturation reaction to the active site Gallus gallus ? - ? 89 1.14.19.1 additional information enzyme activity measured by conversion of 14C-stearic acid to 14C-oleic acid, reverse-phase HPLC Homo sapiens ? - ? 89 1.14.19.1 additional information aging human orbitofrontal cortex includes decreasing of polyunsaturated fatty acid composition associates increases in lipogenic gene expression and stearoyl-CoA desaturase activity, overview Homo sapiens ? - ? 89 1.14.19.1 additional information Angus and Wagyu steers consuming high-roughage diets exhibit large differences in adipose tissue fatty acid composition, but there are no differences in terminal measures of CD activity or gene expression, overview Bos taurus ? - ? 89 1.14.19.1 additional information decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview Rattus norvegicus ? - ? 89 1.14.19.1 additional information DesA3 is a membrane-bound stearoyl-CoA desaturase that works together with oxidoreductase Rv3230c, encoded by gene rv3230c, to produce oleic acid, an 55 essential constituent of mycobacterial membrane phospholipids and triglycerides Mycobacterium tuberculosis ? - ? 89 1.14.19.1 additional information due to a population-based, longitudinal cohort study of men, the risk of fracture is highest among men with the highest levels of SCD activity index, overview Homo sapiens ? - ? 89 1.14.19.1 additional information inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview Mesocricetus auratus ? - ? 89 1.14.19.1 additional information role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview Homo sapiens ? - ? 89 1.14.19.1 additional information the enzyme also produces cis-9, trans-11 conjugated linoleic acid and palmitoleoyl-CoA Bos taurus ? - ? 89 1.14.19.1 additional information the enzyme reacts with oxidoreductase Rv3230c to produce oleic acid Mycobacterium tuberculosis ? - ? 89 1.14.19.1 additional information heterologous expression in yeast shows that Dpu-DELTA9-KPSE produces E9 mono-unsaturated fatty acids of various chain lengths. When provided with the (7Z)-tetradec-7-enoate, it forms the (7Z,9E)-tetradec-7,9-dienoate unsaturated fatty acids, another biosynthetic intermediate that can be chain-shortened to (5Z,7Z)-dodeca-5,7-dienoate Dendrolimus punctatus ? - ? 89 1.14.19.1 additional information enzyme SCD1 catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA. The reaction requires molecular oxygen, which is activated by a diiron center, and cytochrome b5, which regenerates the di-iron center Mus musculus ? - ? 89 1.14.19.1 additional information in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O Homo sapiens ? - ? 89 1.14.19.1 additional information in addition to molecular oxygen, the SCD1 reaction requires NAD(P)H, cytochrome b5 reductase, and cytochrome b5 through which the electrons flow to SCD and then to molecular O2, which is reduced to H2O Mus musculus ? - ? 89 1.14.19.1 additional information mouse SCD3 isoform preferentially catalyzes palmitoleate synthesis Mus musculus ? - ? 89 1.14.19.1 additional information SCD1 catalyses the DELTA9 desaturation of 12-19 carbon saturated fatty acids to monounsaturated fatty acids Mus musculus ? - ? 89 1.14.19.1 additional information wild-type isozyme SCD3 is an exclusive 16:0 desaturase, while SCD3 enzyme mutant I112A/E113L is also active with stearoyl-CoA Mus musculus ? - ? 89 1.14.19.1 additional information DesA3 is a membrane-bound stearoyl-CoA desaturase that works together with oxidoreductase Rv3230c, encoded by gene rv3230c, to produce oleic acid, an 55 essential constituent of mycobacterial membrane phospholipids and triglycerides Mycobacterium tuberculosis H37Rv ? - ? 89 1.14.19.1 additional information the enzyme reacts with oxidoreductase Rv3230c to produce oleic acid Mycobacterium tuberculosis H37Rv ? - ? 89 1.14.19.1 additional information 12-19 carbon fatty acyl chains undergo 9,10 desaturation. Dephospho-, deamino- and (1-N6-etheno)-CoA analogs of stearoyl-CoA are poorer substrates than stearoyl-CoA Rattus norvegicus Long-Evans ? - ? 89 1.14.19.1 additional information long-chain polyunsaturated fatty acid biosynthetic pathway Mortierella alpina CBS 528.72 / ATCC 32222 ? - ? 89 1.14.19.1 myristic acid + NADH + O2 + ATP + CoA reaction in presence of fatty acid-binding proteins with mixing at speeds between 250 and 500 rpm Gallus gallus myristoleic acid + NAD+ + H2O + ? - ? 377185 1.14.19.1 myristoyl-CoA + AH2 + O2 - Rattus norvegicus ? - ? 287613 1.14.19.1 myristoyl-CoA + AH2 + O2 - Psychrobacter urativorans ? - ? 287613 1.14.19.1 myristoyl-CoA + AH2 + O2 59% activity of the rate with stearoyl-CoA Gallus gallus ? - ? 287613 1.14.19.1 myristoyl-CoA + NADH + O2 59% activity of stearoyl-CoA Gallus gallus ? - ? 287612 1.14.19.1 myristoyl-CoA + NADH + O2 - Gallus gallus myristoleoyl-CoA + NAD+ + H2O - ? 377189 1.14.19.1 N-hydroxy-benzenecarboximidamide + NADH + H+ + O2 - Rattus norvegicus benzamidine + NAD+ + H2O - ? 406018 1.14.19.1 N-hydroxy-benzenecarboximidamide + NADH + H+ + O2 - Sus scrofa benzamidine + NAD+ + H2O - ? 406018 1.14.19.1 nonadecanoate + AH2 + O2 low activity Rattus norvegicus ? - ? 287616 1.14.19.1 nonadecanoyl-CoA + NADH + O2 - Rattus norvegicus ? - ? 287614 1.14.19.1 palmitic acid + AH2 + O2 - Mortierella alpina palmitoleic acid + A + H2O - ? 287611 1.14.19.1 palmitic acid + AH2 + O2 - Picea glauca palmitoleic acid + A + H2O - ? 287611 1.14.19.1 palmitic acid + AH2 + O2 - Mortierella alpina CBS 528.72 / ATCC 32222 palmitoleic acid + A + H2O - ? 287611 1.14.19.1 palmitic acid + reduced acceptor + O2 - Pseudoalteromonas sp. palmitoleic acid + acceptor + H2O - ? 377459 1.14.19.1 palmitic acid + reduced acceptor + O2 preferred substrate Mus musculus palmitoleic acid + acceptor + H2O - ? 377459 1.14.19.1 palmitic acid + reduced acceptor + O2 isozyme Sls-FL2, preferred substrate Spodoptera littoralis palmitoleic acid + acceptor + H2O Z-isomer, both isozymes ? 377459 1.14.19.1 palmitic acid + reduced acceptor + O2 - Pseudoalteromonas sp. MLY15 palmitoleic acid + acceptor + H2O - ? 377459 1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Mus musculus palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442509 1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Bos taurus palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442509 1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Homo sapiens palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442509 1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Tigriopus kingsejongensis palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442509 1.14.19.1 palmitoyl-CoA + AH2 + O2 - Cyprinus carpio palmitoleoyl-CoA + A - ? 287609 1.14.19.1 palmitoyl-CoA + AH2 + O2 - Psychrobacter urativorans palmitoleoyl-CoA + A - ? 287609 1.14.19.1 palmitoyl-CoA + AH2 + O2 62% activity of the rate with stearoyl-CoA Gallus gallus palmitoleoyl-CoA + A - ? 287609 1.14.19.1 palmitoyl-CoA + AH2 + O2 - Cyprinus carpio L. palmitoleoyl-CoA + A - ? 287609 1.14.19.1 palmitoyl-CoA + AH2 + O2 - Mus musculus palmitoleoyl-CoA + A + H2O - ? 370223 1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 - Mus musculus palmitoleoyl-CoA + ferricytochrome b5 + H2O - ? 406325 1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ - Homo sapiens palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O - ? 394945 1.14.19.1 palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ a key step in triglyceride synthesis in the fatty acid metabolic network Homo sapiens palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O - ? 394945 1.14.19.1 palmitoyl-CoA + NAD(P)H + O2 - Bos taurus palmitoleate + NAD(P)+ + H2O - ? 287610 1.14.19.1 palmitoyl-CoA + NADH + H+ + O2 - Mus musculus palmitoleoyl-CoA + NAD+ + H2O - ? 406326 1.14.19.1 palmitoyl-CoA + NADH + H+ + O2 13% conversion Homo sapiens palmitoleoyl-CoA + NAD+ + H2O - ? 406326 1.14.19.1 palmitoyl-CoA + NADH + H+ + O2 main substrate Homo sapiens palmitoleoyl-CoA + NAD+ + H2O - ? 406326 1.14.19.1 palmitoyl-CoA + NADH + O2 - Gallus gallus palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 - Mus musculus palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 - Rattus norvegicus palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 - Sus scrofa palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 - Bos taurus palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 slight activity Lentinula edodes palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 62% activity of stearoyl-CoA Gallus gallus palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADH + O2 SCD activity of microsomal fraction Bos taurus palmitoleoyl-CoA + NAD+ + H2O - ? 287608 1.14.19.1 palmitoyl-CoA + NADPH + O2 - Mycolicibacterium phlei ? - ? 287607 1.14.19.1 palmitoyl-CoA + NADPH + O2 Angus and American Wagyu steers, corn-fed steers for 8 mo (short-fed) or 16 mo (long-fed), and hay-fed steers fed for 12 mo (short-fed) and 20 mo (long-fed) Bos taurus palmitoleoyl-CoA + NADP+ + H2O - ? 389512 1.14.19.1 palmitoyl-CoA + NADPH + O2 + H+ - Bos taurus palmitoleoyl-CoA + NADP+ + H2O - ? 398064 1.14.19.1 stearate + AH2 + O2 - Cyprinus carpio oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 - Psychrobacter urativorans oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 - Mortierella alpina oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 - Picea glauca oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 maximum activity Rattus norvegicus oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 biosynthesis of unsaturated fatty acid, synthesis of triacylglycerol from oleate Rattus norvegicus oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 - Cyprinus carpio L. oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + AH2 + O2 - Mortierella alpina CBS 528.72 / ATCC 32222 oleate + A + 2 H2O - ? 287603 1.14.19.1 stearate + reduced acceptor + O2 - Gallus gallus oleate + acceptor + H2O - ? 377791 1.14.19.1 stearate + reduced acceptor + O2 - Mus musculus oleate + acceptor + H2O - ? 377791 1.14.19.1 stearate + reduced acceptor + O2 isozyme Sls-FL1, preferred substrate Spodoptera littoralis oleate + acceptor + H2O Z-isomer, both isozymes ? 377791 1.14.19.1 stearic acid + AH2 + O2 - Homo sapiens oleic acid + A + H2O - ? 389792 1.14.19.1 stearic acid + AH2 + O2 the enzyme shows a preference for C18 saturated fatty acids Bombus lucorum oleic acid + A + H2O - ? 389792 1.14.19.1 stearic acid + reduced acceptor + O2 - Pseudoalteromonas sp. oleic acid + acceptor + H2O - ? 406690 1.14.19.1 stearic acid + reduced acceptor + O2 - Pseudoalteromonas sp. MLY15 oleic acid + acceptor + H2O - ? 406690 1.14.19.1 stearoyl-acyl-carrier protein + AH2 + O2 - Arabidopsis sp. oleoyl-acyl-carrier protein + A + H2O - ? 287617 1.14.19.1 stearoyl-acyl-carrier protein + AH2 + O2 insertion of a cis double bond between the 9 and 10 position, essential step in fatty acid biosynthesis Spinacia oleracea oleoyl-acyl-carrier protein + A + H2O - ? 287617 1.14.19.1 stearoyl-acyl-carrier protein + AH2 + O2 key regulator of fatty acid desaturation of carbons 9 and 10 Arabidopsis sp. oleoyl-acyl-carrier protein + A + H2O - ? 287617 1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Mus musculus oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442562 1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Bos taurus oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442562 1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Homo sapiens oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442562 1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ - Tigriopus kingsejongensis oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O - ? 442562 1.14.19.1 stearoyl-CoA + AH2 + H+ + O2 - Homo sapiens oleoyl-CoA + A + H2O - ? 406692 1.14.19.1 stearoyl-CoA + AH2 + H+ + O2 - Rattus norvegicus oleoyl-CoA + A + H2O - ? 406692 1.14.19.1 stearoyl-CoA + AH2 + O2 - Gallus gallus oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Mus musculus oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Homo sapiens oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Rattus norvegicus oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Neurospora crassa oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Mycolicibacterium phlei oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Arabidopsis sp. oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Cyprinus carpio oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 also other fatty acyl-CoA substrates Rattus norvegicus oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 oleic acid biosynthesis Fusarium oxysporum oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 activity measured via the generation of tritium enriched water from the substrate 9,10-3H-steaoryl-CoA Rattus norvegicus oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Mus musculus C57/BL6J oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Cyprinus carpio L. oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + AH2 + O2 - Rattus norvegicus Long-Evans oleoyl-CoA + A + H2O - ? 287605 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + H+ + O2 - Bos taurus oleoyl-CoA + ferricytochrome b5 + H2O - ? 406693 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 - Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O - ? 406694 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 - Rattus norvegicus oleoyl-CoA + ferricytochrome b5 + H2O - ? 406694 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - Rattus norvegicus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - Mesocricetus auratus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - Bos taurus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ a key step in triglyceride synthesis in the fatty acid metabolic network Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ essential enzyme activity, regulation mechanism, overview Mycobacterium tuberculosis oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, deficiency of isozyme SCD1 leads to activation of the metabolic pathways that promote fatty acid beta-oxidation in mice, enzyme regulation in the heart in a hormone-dependent fashion, overview Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity, overview Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, it is also involved in familial combined hyperlipidemia, fatty acid desaturation index, overview Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview Mesocricetus auratus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, overview Bos taurus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, which plays an important role in lipid metabolism and body weight control, overview Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ stearoyl-CoA desaturase 2 is uniquely and absolutely required for adipogenesis, SCD2 also controls the maintenance of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1, polysome profile analysis, overview Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ stearoyl-CoA desaturase converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis, elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ the enzyme catalyzes the desaturation from saturated to monounsaturated fatty acids Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ DesA3 expressed as a fusion with either a C-terminal His6 or c-myc tag has consistently higher activity and stability than native DesA3 having the native C-terminal sequence of LAA Mycobacterium tuberculosis oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ essential enzyme activity, regulation mechanism, overview Mycobacterium tuberculosis H37Rv oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ DesA3 expressed as a fusion with either a C-terminal His6 or c-myc tag has consistently higher activity and stability than native DesA3 having the native C-terminal sequence of LAA Mycobacterium tuberculosis H37Rv oleoyl-CoA + ferricytochrome b5 + H2O - ? 394997 1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ - Rattus norvegicus ? - ? 434403 1.14.19.1 stearoyl-CoA + NAD(P)H + O2 - Fusarium oxysporum oleoyl-CoA + NAD(P)+ + H2O - ? 287602 1.14.19.1 stearoyl-CoA + NAD(P)H + O2 fatty acid desaturation Rattus norvegicus oleoyl-CoA + NAD(P)+ + H2O - ? 287602 1.14.19.1 stearoyl-CoA + NADH + H+ + O2 - Mus musculus oleoyl-CoA + NAD+ + H2O - ? 406695 1.14.19.1 stearoyl-CoA + NADH + H+ + O2 - Homo sapiens oleoyl-CoA + NAD+ + H2O - ? 406695 1.14.19.1 stearoyl-CoA + NADH + H+ + O2 - Rattus norvegicus oleoyl-CoA + NAD+ + H2O - ? 406695 1.14.19.1 stearoyl-CoA + NADH + H+ + O2 - Sus scrofa oleoyl-CoA + NAD+ + H2O - ? 406695 1.14.19.1 stearoyl-CoA + NADH + H+ + O2 45% conversion Homo sapiens oleoyl-CoA + NAD+ + H2O - ? 406695 1.14.19.1 stearoyl-CoA + NADH + H+ + O2 main substrate Homo sapiens oleoyl-CoA + NAD+ + H2O - ? 406695 1.14.19.1 stearoyl-CoA + NADH + O2 - Gallus gallus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 - Mus musculus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 - Rattus norvegicus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 - Sus scrofa oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 - Bos taurus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 high activity Lentinula edodes oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 preferred substrate for SCD1 Mus musculus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 maximal activity Rattus norvegicus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 terminal component in the enzyme system Rattus norvegicus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 Scd-/- and wild-type mice are fed with 20% high fat diets, fat-free basal mix is supplemented with 20% by weight of tristearin or triolein and 1% by weight corn oil Mus musculus oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 terminal component in the enzyme system Rattus norvegicus Long-Evans oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADH + O2 - Rattus norvegicus Long-Evans oleoyl-CoA + NAD+ + H2O - ? 287601 1.14.19.1 stearoyl-CoA + NADPH + H+ + O2 - Mus musculus oleoyl-CoA + NADP+ + H2O - ? 406697 1.14.19.1 stearoyl-CoA + NADPH + H+ + O2 - Bos taurus oleoyl-CoA + NADP+ + H2O - ? 406697 1.14.19.1 stearoyl-CoA + NADPH + H+ + O2 - Plasmodium falciparum oleoyl-CoA + NADP+ + H2O - ? 406697 1.14.19.1 stearoyl-CoA + NADPH + O2 - Bos taurus oleoyl-CoA + NADP+ + H2O - ? 287600 1.14.19.1 stearoyl-CoA + NADPH + O2 - Mycolicibacterium phlei oleoyl-CoA + NADP+ + H2O - ? 287600 1.14.19.1 trans-2-hexadecenoyl-CoA + ferrocytochrome b5 + O2 + H+ - Rattus norvegicus ? - ? 434437