1.14.13.83	additional information	biosynthesis of vitamin B12	Pseudomonas denitrificans (nom. rej.)	?	-	?	89	
1.14.13.83	additional information	the enzyme is involved in the mechanism of the ring contraction process during vitamin B12 biosynthesis, comparison to the ring contraction process reaction pathway under anaerobic conditions in Propionibacterium freudenreichii ssp. shermanii, overview	Pseudomonas denitrificans (nom. rej.)	?	-	?	89	
1.14.13.83	precorrin-3 + NADH + H+ + O2	-	Pseudomonas denitrificans (nom. rej.)	precorrin-3x + NAD+ + H2O	-	ir	363719	
1.14.13.83	precorrin-3 + NADH + H+ + O2	biosynthesis of vitamin B12, part of the ring contractase system for oxidative ring contraction	Pseudomonas denitrificans (nom. rej.)	precorrin-3x + NAD+ + H2O	-	ir	363719	
1.14.13.83	precorrin-3A + NADH + H+ + O2	-	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	-	?	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	-	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	-	ir	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	pathway to coenzyme B12, biosynthesis of the corrin macrocycle, catalyzes a complex oxidative reaction involving C20 hydroxylation and gamma-lactone formation from ring-A acetate to C1	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	-	ir	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	first step in the aerobic pathway of viamin B12 biosynthesis	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	-	?	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	the Brucella melitensis enzyme is fully active in vitro (20 mM Tris-HCl buffer, pH 8.0, with 100 mM NaCl, S-adenosyl-L-methionine (SAM), 5-aminolevulinic acid (ALA) and NADPH, aerobic, dark, 4°C) and the mononuclear non-heme iron is reducible by dithionite and then is able to react with NO as oxygen analogue in the presence of the substrate	Brucella melitensis	precorrin-3B + NAD+ + H2O	-	?	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	the Pseudomonas denitrificans enzyme is active in vivo but inactive in vitro (20 mM Tris-HCl buffer, pH 8.0, with 100 mM NaCl, S-adenosyl-L-methionine (SAM), 5-aminolevulinic acid (ALA) and NADPH, aerobic, dark, 4°C), the mononuclear non-heme iron is not reducible and probably rapidly inactivated outside the bacterium	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	-	?	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	the Brucella melitensis enzyme is fully active in vitro (20 mM Tris-HCl buffer, pH 8.0, with 100 mM NaCl, S-adenosyl-L-methionine (SAM), 5-aminolevulinic acid (ALA) and NADPH, aerobic, dark, 4°C) and the mononuclear non-heme iron is reducible by dithionite and then is able to react with NO as oxygen analogue in the presence of the substrate	Brucella melitensis 16M	precorrin-3B + NAD+ + H2O	-	?	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	-	Pseudomonas denitrificans (nom. rej.) SC510 (RifT)	precorrin-3B + NAD+ + H2O	-	ir	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	pathway to coenzyme B12, biosynthesis of the corrin macrocycle, catalyzes a complex oxidative reaction involving C20 hydroxylation and gamma-lactone formation from ring-A acetate to C1	Pseudomonas denitrificans (nom. rej.) SC510 (RifT)	precorrin-3B + NAD+ + H2O	-	ir	363718	
1.14.13.83	precorrin-3A + NADH + O2	-	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	-	?	359083	
1.14.13.83	precorrin-3A + NADH + O2	the enzyme is involved in ring contraction, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed, and cobalt chelation during aerobic synthesis of vitamin B12, the catalytic cycle of CobZ, overview	Rhodobacter capsulatus	precorrin-3B + NAD+ + H2O	-	?	359083	
1.14.13.83	precorrin-3A + NADH + O2	the enzyme generates a hydroxy lactone intermediate	Rhodobacter capsulatus	precorrin-3B + NAD+ + H2O	-	?	359083	
1.14.13.83	precorrin-3A + NADH + O2	-	Pseudomonas denitrificans (nom. rej.) SC510 (RifT)	precorrin-3B + NAD+ + H2O	-	?	359083	
1.14.13.83	precorrin-3A + NADH + H+ + O2	-	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	aerobic incubation with CobG alone, if CobJ and S-adenosyl-L-methionine are included the product is precorrin-4	ir	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	biosynthesis of vitamin B12	Pseudomonas denitrificans (nom. rej.)	precorrin-3B + NAD+ + H2O	aerobic incubation with CobG alone, if CobJ and S-adenosyl-L-methionine are included the product is precorrin-4	ir	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	-	Pseudomonas denitrificans (nom. rej.) G3575	precorrin-3B + NAD+ + H2O	aerobic incubation with CobG alone, if CobJ and S-adenosyl-L-methionine are included the product is precorrin-4	ir	363718	
1.14.13.83	precorrin-3A + NADH + H+ + O2	biosynthesis of vitamin B12	Pseudomonas denitrificans (nom. rej.) G3575	precorrin-3B + NAD+ + H2O	aerobic incubation with CobG alone, if CobJ and S-adenosyl-L-methionine are included the product is precorrin-4	ir	363718