1.14.11.32 (R,S)-tetrahydropalmatine + 2-oxoglutarate + O2 a protoberberine, O-demethylation, 16.6% of activity with protopine Papaver somniferum ? - ? 425176 1.14.11.32 (S)-isocorydine + 2-oxoglutarate + O2 a aporphine, O-demethylation, 6.1% of activity with protopine Papaver somniferum ? - ? 425211 1.14.11.32 (S)-reticuline + 2-oxoglutarate + O2 a 1-benzylisoquinoline, O-demethylation, 16.2% of activity with protopine Papaver somniferum ? - ? 425214 1.14.11.32 (S)-scoulerine + 2-oxoglutarate + O2 a 1-benzylisoquinoline, O-demethylation, 70.4% of activity with protopine Papaver somniferum ? - ? 425215 1.14.11.32 allocryptopine + 2-oxoglutarate + O2 a protopine, O-demethylation, 50.1% of activity with protopine Papaver somniferum ? - ? 425903 1.14.11.32 codeine + 2-oxoglutarate + O2 - Papaver somniferum morphine + formaldehyde + succinate + CO2 - ? 404686 1.14.11.32 codeine + 2-oxoglutarate + O2 - Papaver orientale morphine + formaldehyde + succinate + CO2 - ? 404686 1.14.11.32 codeine + 2-oxoglutarate + O2 alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde Papaver somniferum morphine + formaldehyde + succinate + CO2 - ? 404686 1.14.11.32 codeine + 2-oxoglutarate + O2 a morphinan, O-demethylation, 89.8% of activity with protopine Papaver somniferum morphine + formaldehyde + succinate + CO2 - ? 404686 1.14.11.32 cryptopine + 2-oxoglutarate + O2 a protopine, O-demethylation, 37.7% of activity with protopine Papaver somniferum ? - ? 426154 1.14.11.32 additional information no activity with (S)-reticuline, papaverine, (S)-corytuberine, pavine, salutaridine, oripavine, noscapine Papaver somniferum ? - ? 89 1.14.11.32 neopine + 2-oxoglutarate + O2 - Papaver somniferum neomorphine + formaldehyde + succinate + CO2 - ? 440348 1.14.11.32 O-demethylcryptopine + 2-oxoglutarate + O2 a protopine, O-demethylation, 40.8% of activity with protopine Papaver somniferum ? - ? 426861 1.14.11.32 protopine + 2-oxoglutarate + O2 best substrate Papaver somniferum ? - ? 426965 1.14.11.32 scoulerine + 2-oxoglutarate + O2 120% of the activity with codeine Papaver somniferum 3-O-demethylscoulerine + formaldehyde + succinate + CO2 - ? 406648 1.14.11.32 thebaine + 2-oxoglutarate + O2 - Papaver somniferum oripavine + formaldehyde + succinate + CO2 - ? 406754 1.14.11.32 thebaine + 2-oxoglutarate + O2 - Papaver orientale oripavine + formaldehyde + succinate + CO2 - ? 406754 1.14.11.32 thebaine + 2-oxoglutarate + O2 25% of the activity with codeine. Alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde Papaver somniferum oripavine + formaldehyde + succinate + CO2 - ? 406754 1.14.11.32 thebaine + 2-oxoglutarate + O2 a morphinan, O-demethylation, 80.5% of activity with protopine Papaver somniferum ? - ? 427115