1.1.1.81 2,3-butandione + NAD(P)H 33 mM, 12% of activity with hydroxypyruvate Paracoccus denitrificans butan-2-ol-3-one + NAD(P)+ - ? 188669 1.1.1.81 2-dehydro-D-gluconate + NADPH + H+ - Sinorhizobium meliloti D-gluconate + NADP+ - ? 422394 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Bos taurus D-glycerate + NAD+ - r 451098 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Methylosinus trichosporium D-glycerate + NAD+ - ir 451098 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Hyphomicrobium methylovorum GM2 D-glycerate + NAD+ - r 451098 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Methylotuvimicrobium alcaliphilum D-glycerate + NAD+ - ir 451098 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Methylococcus capsulatus D-glycerate + NAD+ - ir 451098 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Methylococcus capsulatus Bath D-glycerate + NAD+ - ir 451098 1.1.1.81 3-hydroxypyruvate + NADH + H+ - Methylotuvimicrobium alcaliphilum 20Z D-glycerate + NAD+ - ir 451098 1.1.1.81 3-hydroxypyruvate + NADPH + H+ - Methylosinus trichosporium D-glycerate + NADP+ - ir 459034 1.1.1.81 3-hydroxypyruvate + NADPH + H+ - Methylotuvimicrobium alcaliphilum D-glycerate + NADP+ - ir 459034 1.1.1.81 3-hydroxypyruvate + NADPH + H+ - Methylococcus capsulatus D-glycerate + NADP+ - ir 459034 1.1.1.81 3-hydroxypyruvate + NADPH + H+ - Sinorhizobium meliloti D-glycerate + NADP+ - ? 459034 1.1.1.81 3-hydroxypyruvate + NADPH + H+ - Methylococcus capsulatus Bath D-glycerate + NADP+ - ir 459034 1.1.1.81 3-hydroxypyruvate + NADPH + H+ - Methylotuvimicrobium alcaliphilum 20Z D-glycerate + NADP+ - ir 459034 1.1.1.81 4-hydroxyphenylpyruvate + NADPH + H+ - Arabidopsis thaliana 3-(4-hydroxyphenyl)lactate + NADP+ - ? 459072 1.1.1.81 4-hydroxyphenylpyruvate + NADPH + H+ reaction of EC 1.1.1.237 Arabidopsis thaliana 3-(4-hydroxyphenyl)lactate + NADP+ - ? 459072 1.1.1.81 acetoin + NAD(P)H + H+ 33 mM, 14% of activity with hydroxypyruvate Paracoccus denitrificans 2,3-butanediol + NAD(P)+ - ? 188668 1.1.1.81 D-glycerate + NAD+ - Arabidopsis thaliana hydroxypyruvate + NADH + H+ - ? 436452 1.1.1.81 D-glycerate + NAD+ - Homo sapiens hydroxypyruvate + NADH + H+ - ? 436452 1.1.1.81 D-glycerate + NAD+ - Bos taurus 3-hydroxypyruvate + NADH + H+ - r 451099 1.1.1.81 D-glycerate + NAD+ - Methylorubrum extorquens AM1 3-hydroxypyruvate + NADH + H+ - r 451099 1.1.1.81 D-glycerate + NADP+ - Arabidopsis thaliana hydroxypyruvate + NADPH + H+ - r 438307 1.1.1.81 DL-glycerate + NAD+ - Bos taurus 3-hydroxypyruvate + NADH + H+ - r 451101 1.1.1.81 glyoxylate + NAD(P)H - Mus musculus glycolate + NAD(P)+ - ? 188647 1.1.1.81 glyoxylate + NAD(P)H - Homo sapiens glycolate + NAD(P)+ - ? 188647 1.1.1.81 glyoxylate + NAD(P)H - Sus scrofa glycolate + NAD(P)+ - ? 188647 1.1.1.81 glyoxylate + NAD(P)H activity with hydroxypyruvate and NADPH is 2fold higher than with other pair of reactants Spinacia oleracea glycolate + NAD(P)+ - ir 188647 1.1.1.81 glyoxylate + NAD(P)H 33 mM, 15% activity Paracoccus denitrificans glycolate + NAD(P)+ - ? 188647 1.1.1.81 glyoxylate + NAD(P)H cofactor NADH, 15% of activity with hydroxypyruvate, cofactor NADPH, 1.5% of activity with hydroxypyruvate Methylorubrum extorquens AM1 glycolate + NAD(P)+ - ? 188647 1.1.1.81 glyoxylate + NAD(P)H the enzyme is involved in removal of the metabolic by-product from liver Homo sapiens glycolate + NAD(P)+ - ? 188647 1.1.1.81 glyoxylate + NAD(P)H + H+ - Arabidopsis thaliana glycolate + NAD(P)+ - ? 405334 1.1.1.81 glyoxylate + NADH - Pyrococcus horikoshii OT3 glycolate + NAD+ - ? 187982 1.1.1.81 glyoxylate + NADH + H+ 24% of the activity with 3-hydroxypyruvate Methylosinus trichosporium glycolate + NAD+ - ir 397361 1.1.1.81 glyoxylate + NADH + H+ 60% of the activity with 3-hydroxypyruvate Methylotuvimicrobium alcaliphilum glycolate + NAD+ - ir 397361 1.1.1.81 glyoxylate + NADH + H+ 97% of the activity with 3-hydroxypyruvate Methylococcus capsulatus glycolate + NAD+ - ir 397361 1.1.1.81 glyoxylate + NADH + H+ 97% of the activity with 3-hydroxypyruvate Methylococcus capsulatus Bath glycolate + NAD+ - ir 397361 1.1.1.81 glyoxylate + NADH + H+ 60% of the activity with 3-hydroxypyruvate Methylotuvimicrobium alcaliphilum 20Z glycolate + NAD+ - ir 397361 1.1.1.81 glyoxylate + NADPH - Pyrococcus horikoshii OT3 glycolate + NADP+ - ? 187805 1.1.1.81 glyoxylate + NADPH + H+ - Arabidopsis thaliana glycolate + NADP+ - ? 394866 1.1.1.81 glyoxylate + NADPH + H+ - Sinorhizobium meliloti glycolate + NADP+ - ? 394866 1.1.1.81 hydroxypyruvate + NAD(P)H - Paracoccus denitrificans D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Paracoccus denitrificans D-glycerate + NAD(P)+ + H+ - r 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Mus musculus D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Homo sapiens D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Rattus norvegicus D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Sus scrofa D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Bos taurus D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Hordeum vulgare D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Spinacia oleracea D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Spinacia oleracea D-glycerate + NAD(P)+ + H+ - ir 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Pisum sativum D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Zea mays D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Cucumis sativus D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Delftia acidovorans D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Delftia acidovorans D-glycerate + NAD(P)+ + H+ - r 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Cucurbita pepo D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Citrullus lanatus subsp. vulgaris D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Methylobacterium organophilum D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Hyphomicrobium methylovorum GM2 D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Methylorubrum extorquens AM1 D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Nicotiana tabacum cv. SR1 D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H cofactor NADPH, 80% of activity with NADH, rate of oxidation reaction: 1.5% of reduction reaction only with cofactor NADH Methylorubrum extorquens AM1 D-glycerate + NAD(P)+ + H+ - r 188665 1.1.1.81 hydroxypyruvate + NAD(P)H - Methylobacterium organophilum XX D-glycerate + NAD(P)+ + H+ - ? 188665 1.1.1.81 hydroxypyruvate + NAD(P)H + H+ - Arabidopsis thaliana D-glycerate + NAD(P)+ - ? 402698 1.1.1.81 hydroxypyruvate + NADH - Pyrococcus horikoshii OT3 D-glycerate + NAD+ - ? 187983 1.1.1.81 hydroxypyruvate + NADH + H+ - Delftia acidovorans D-glycerate + NAD+ - r 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Chlorella vulgaris D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Pyrococcus horikoshii D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Hyphomicrobium methylovorum GM2 D-glycerate + NAD+ - r 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Methylorubrum extorquens AM1 D-glycerate + NAD+ - r 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Pyrococcus yayanosii D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Pyrococcus furiosus D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Arabidopsis thaliana D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ low activity Arabidopsis thaliana D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ isoform HPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate Arabidopsis thaliana D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ isoform HPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly Arabidopsis thaliana D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ isoform HPR3 prefers NADPH over NADH and glyoxylate over hydroxypyvruvate Arabidopsis thaliana D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ - Pyrococcus yayanosii CH1 D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADH + H+ low activity Arabidopsis thaliana Col-0 D-glycerate + NAD+ - ? 397450 1.1.1.81 hydroxypyruvate + NADPH - Pyrococcus horikoshii OT3 D-glycerate + NADP+ - ? 384904 1.1.1.81 hydroxypyruvate + NADPH - Arabidopsis thaliana D-glycerate + NADP+ - ? 384904 1.1.1.81 hydroxypyruvate + NADPH + H+ - Pyrococcus horikoshii D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Methylobacterium sp. D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Arabidopsis thaliana D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Arabidopsis thaliana D-glycerate + NADP+ - r 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Pyrococcus yayanosii D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Pyrococcus furiosus D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ best substrate Arabidopsis thaliana D-glycerate + NADP+ - r 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ key enzyme of the serine cycle Methylobacterium sp. D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ isoform HPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate Arabidopsis thaliana D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ isoform HPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly Arabidopsis thaliana D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ isoform HPR3 prefers NADPH over NADH and glyoxylate over hydroxypyvruvate Arabidopsis thaliana D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Pyrococcus yayanosii CH1 D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Arabidopsis thaliana Col-0 D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Arabidopsis thaliana Col-0 D-glycerate + NADP+ - r 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ - Methylobacterium sp. MB200 D-glycerate + NADP+ - ? 394875 1.1.1.81 hydroxypyruvate + NADPH + H+ key enzyme of the serine cycle Methylobacterium sp. MB200 D-glycerate + NADP+ - ? 394875 1.1.1.81 additional information enzyme deficiency leads to primary hyperoxaluria type 2 with increased urinary oxalate levels, formation of kidney stones, and renal failure Homo sapiens ? - ? 89 1.1.1.81 additional information the enzyme is transcriptionally regulated by the peroxisome proliferator-activated receptor alpha, PPARalpha, in liver, overview Mus musculus ? - ? 89 1.1.1.81 additional information structural basis of enzyme substrate specificity, active site structure and substrate binding, no activity with pyruvate, overview Homo sapiens ? - ? 89 1.1.1.81 additional information the enzyme GLYR1 has negligible hydroxypyruvate dependent activity with NADPH Arabidopsis thaliana ? - ? 89 1.1.1.81 additional information HPR3 prefers NADPH over NADH and converts glycerate to hydroxypyruvate, the purified recombinant HPR3 shows similar activity with hydroxypyruvate and glyoxylate Arabidopsis thaliana ? - ? 89 1.1.1.81 additional information the recombinant AtHPR1 prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate Arabidopsis thaliana ? - ? 89 1.1.1.81 additional information the recombinant AtHPR2 prefers NADPH over NADH but utilizes hydroxypyruvate and glyoxylate similarly Arabidopsis thaliana ? - ? 89 1.1.1.81 additional information enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate Methylosinus trichosporium ? - - 89 1.1.1.81 additional information enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate Methylotuvimicrobium alcaliphilum ? - - 89 1.1.1.81 additional information enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate Methylococcus capsulatus ? - - 89 1.1.1.81 additional information isoform HPPR2 has both hydroxyphenylpyruvate reductase and hydroxypyruvate reductase activities Arabidopsis thaliana ? - - 89 1.1.1.81 additional information enzyme HPR2 shows relaxed substrate and cofactor specificity, it also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79). Irreversibility of the HPR2 reaction has been reported Arabidopsis thaliana ? - - 89 1.1.1.81 additional information the enzyme also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79) Arabidopsis thaliana ? - - 89 1.1.1.81 additional information enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate Methylococcus capsulatus Bath ? - - 89 1.1.1.81 additional information isoform HPPR2 has both hydroxyphenylpyruvate reductase and hydroxypyruvate reductase activities Arabidopsis thaliana Col-0 ? - - 89 1.1.1.81 additional information enzyme HPR2 shows relaxed substrate and cofactor specificity, it also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79). Irreversibility of the HPR2 reaction has been reported Arabidopsis thaliana Col-0 ? - - 89 1.1.1.81 additional information the enzyme also has glyoxylate reductase (NADP+) activity (EC 1.1.1.79) Arabidopsis thaliana Col-0 ? - - 89 1.1.1.81 additional information enzyme catalyzes NAD(P)H-dependent reduction of hydroxypyruvate or glyoxylate, but does not catalyze the reverse reactions of D-glycerate or glycolate oxidation. No substrates: pyruvate, lactate, oxaloacetate, and 2-oxoglutarate Methylotuvimicrobium alcaliphilum 20Z ? - - 89 1.1.1.81 oxaloacetate + NAD(P)H 33 mM, 32% of activity with hydroxypyruvate Paracoccus denitrificans malate + NAD(P)+ - ? 188667 1.1.1.81 phenylpyruvate + NADPH + H+ - Arabidopsis thaliana D-phenyllactate + NADP+ - ? 426932 1.1.1.81 phenylpyruvate + NADPH + H+ - Arabidopsis thaliana phenyllactate + NADP+ - ? 459867 1.1.1.81 phenylpyruvate + NADPH + H+ - Sinorhizobium meliloti phenyllactate + NADP+ - ? 459867 1.1.1.81 pyruvate + NADPH + H+ - Sinorhizobium meliloti lactate + NADP+ - ? 187803