1.1.1.71 (1R)-1-hydroxy-1-phenylpropan-2-one + NADPH + H+ - Ralstonia sp. (1R)-1-phenylpropane-1,2-diol + NADP+ - ? 438492 1.1.1.71 (2R)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+ - Ralstonia sp. (2R)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+ - ? 438509 1.1.1.71 (2S)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+ - Ralstonia sp. (2S)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+ - ? 438520 1.1.1.71 (4R,6R)-6-pentyloxane-2,4-diol + NAD+ - Starmerella magnoliae (4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+ - ? 458764 1.1.1.71 (4R,6R)-6-pentyloxane-2,4-diol + NAD+ - Starmerella magnoliae DSMZ 70638 (4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADH + H+ - ? 458764 1.1.1.71 (4R,6R)-6-pentyloxane-2,4-diol + NADP+ - Starmerella magnoliae (4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+ - ? 458765 1.1.1.71 (4R,6R)-6-pentyloxane-2,4-diol + NADP+ - Starmerella magnoliae DSMZ 70638 (4R,6R)-4-hydroxy-6-pentyloxan-2-one + NADPH + H+ - ? 458765 1.1.1.71 (4R,6R)-6-butyloxane-2,4-diol + NAD+ - Starmerella magnoliae (4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+ - ? 458762 1.1.1.71 (4R,6R)-6-butyloxane-2,4-diol + NAD+ - Starmerella magnoliae DSMZ 70638 (4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADH + H+ - ? 458762 1.1.1.71 (4R,6R)-6-butyloxane-2,4-diol + NADP+ - Starmerella magnoliae (4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+ - ? 458763 1.1.1.71 (4R,6R)-6-butyloxane-2,4-diol + NADP+ - Starmerella magnoliae DSMZ 70638 (4R,6R)-6-butyl-4-hydroxyoxan-2-one + NADPH + H+ - ? 458763 1.1.1.71 (4R,6S)-6-(chloromethyl)oxane-2,4-diol + NAD+ - Starmerella magnoliae (4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADH + H+ - ? 458766 1.1.1.71 (4R,6S)-6-(chloromethyl)oxane-2,4-diol + NADP+ - Starmerella magnoliae (4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADPH + H+ - ? 458767 1.1.1.71 furfural + NADPH + H+ 5% activity compared to pentanal Pectobacterium atrosepticum (furan-2-yl)methanol + NAD(P)+ - ? 439533 1.1.1.71 furan-2-carbaldehyde + NADPH + H+ - Ralstonia sp. (furan-2-yl)methanol + NADP+ - ? 439532 1.1.1.71 pyridine-2-carbaldehyde + NADPH + H+ - Ralstonia sp. (pyridin-2-yl)methanol + NADP+ - ? 439854 1.1.1.71 rac-1-phenylethanol + NADP+ - Thermoanaerobacter brockii (R)-1-phenylethanol + (S)-1-phenylethanol + NADPH + H+ - ? 439868 1.1.1.71 cis-4-cyclopentene-1,3-diol + NADP+ - Ralstonia sp. (R)-4-hydroxy-2-cyclopentenone + NADPH + H+ - ? 439341 1.1.1.71 rac-1-nonen-4-ol + NADP+ - Thermoanaerobacter brockii (S)-1-nonen-4-ol + 1-nonen-4-one + NADPH + H+ - ? 439866 1.1.1.71 2-bromoacetophenone + NAD(P)H + H+ 8.7% activity compared to acetoin Thermococcus kodakarensis 1-(2-bromophenyl)ethanone + NAD(P)+ - ? 438079 1.1.1.71 1-(2-bromophenyl)ethanol + NAD(P)+ 11.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(2-bromophenyl)ethanone + NAD(P)H + H+ - ? 438046 1.1.1.71 1-(2-chlorophenyl)ethanol + NAD(P)+ 16.4% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(2-chlorophenyl)ethanone + NAD(P)H + H+ - ? 438047 1.1.1.71 1-(3-bromophenyl)ethanol + NAD(P)+ 315% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(3-bromophenyl)ethanone + NAD(P)H + H+ - ? 438048 1.1.1.71 1-(3-chlorophenyl)ethanol + NAD(P)+ 205% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(3-chlorophenyl)ethanone + NAD(P)H + H+ - ? 438049 1.1.1.71 1-(4-bromophenyl)ethanol + NAD(P)+ 167% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(4-bromophenyl)ethanone + NAD(P)H + H+ - ? 438050 1.1.1.71 1-(4-chlorophenyl)ethanone + NAD(P)+ 151% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(4-chlorophenyl)ethanone + NAD(P)H + H+ - ? 438051 1.1.1.71 1-(4-fluorophenyl)ethanol + NAD(P)+ 119% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(4-fluorophenyl)ethanol + NAD(P)H + H+ - ? 438052 1.1.1.71 1-(4-methylphenyl)ethanone + NAD(P)+ 189% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-(4-methylphenyl)ethanol + NAD(P)H + H+ - ? 438053 1.1.1.71 1-butanol + NADP+ - Haloferax volcanii 1-butanal + NADPH + H+ - ? 427829 1.1.1.71 butanal + NADPH + H+ 44% activity compared to pentanal Pectobacterium atrosepticum 1-butanol + NAD(P)+ - ? 439276 1.1.1.71 heptanal + NADPH + H+ 56% activity compared to pentanal Pectobacterium atrosepticum 1-heptanol + NAD(P)+ - ? 439602 1.1.1.71 hexanal + NADPH + H+ 62% activity compared to pentanal Pectobacterium atrosepticum 1-hexanol + NAD(P)+ - ? 439605 1.1.1.71 octanal + NADPH + H+ 55% activity compared to pentanal Pectobacterium atrosepticum 1-octanol + NAD(P)+ - ? 439800 1.1.1.71 pentanal + NADPH + H+ 100% activity Pectobacterium atrosepticum 1-pentanol + NAD(P)+ - ? 439813 1.1.1.71 acetophenone + NADH + H+ - Ralstonia sp. 1-phenylethan-1-ol + NAD+ - r 439014 1.1.1.71 (RS)-1-phenylethanol + NAD+ 100% activity Thermococcus kodakarensis 1-phenylethanone + NADH + H+ - ? 438032 1.1.1.71 (RS)-1-phenylethanol + NADP+ 100% activity Thermococcus kodakarensis 1-phenylethanone + NADPH + H+ - ? 438033 1.1.1.71 1-phenylethanol + NADP+ 35% of the activtiy with 1-propanol Halobacterium sp. 1-phenylethanone + NADPH + H+ - ? 434987 1.1.1.71 1-phenyl-2-propanol + NAD(P)+ 39.1% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-phenylpropan-2-one + NAD(P)H + H+ - ? 438063 1.1.1.71 1-phenyl-1-propanol + NAD(P)+ 13.1% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 1-phenylpropionaldehyde + NAD(P)H + H+ - ? 438062 1.1.1.71 propanal + NADPH + H+ 14% activity compared to pentanal Pectobacterium atrosepticum 1-propanol + NAD(P)+ - ? 439843 1.1.1.71 2,2,2-trifluoroacetophenone + NAD(P)H + H+ 180% activity compared to acetoin Thermococcus kodakarensis 2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+ - ? 438071 1.1.1.71 acetoin + NAD(P)H + H+ 4.5% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 2,3-butanediol + NAD(P)+ - ? 188668 1.1.1.71 2-bromobenzaldehyde + NADPH - Ralstonia sp. 2-bromobenzyl alcohol + NADP+ - r 438711 1.1.1.71 2-bromobenzaldehyde + NADPH + H+ - Ralstonia sp. 2-bromobenzyl alcohol + NADP+ - ? 438710 1.1.1.71 2-butanol + NADP+ 43% of the activity compared to ethanol Haloarcula marismortui 2-butanone + NADPH + H+ - ? 422388 1.1.1.71 2-chloro-1-phenylethanol + NAD(P)+ 0.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis 2-chloro-1-phenylethan-1-one + NAD(P)H + H+ - ? 438081 1.1.1.71 2-cyclohexenone + NADH + H+ - Ralstonia sp. 2-cyclohexenol + NADP+ - r 439371 1.1.1.71 2-cyclohexenol + NADP+ - Ralstonia sp. 2-cyclohexenone + NADH + H+ - r 439370 1.1.1.71 2-fluorobenzaldehyde + NADPH + H+ - Ralstonia sp. 2-fluorobenzyl alcohol + NADP+ - ? 438726 1.1.1.71 2-hydroxy-3-methoxybenzaldehyde + NADPH + H+ - Solanum tuberosum 2-hydroxy-3-methoxybenzyl alcohol + NADP+ - ? 371682 1.1.1.71 methylglyoxal + NADPH + H+ - Moniezia expansa 2-hydroxy-propanal + NADP+ - ? 188576 1.1.1.71 2-methoxybenzaldehyde + NADPH + H+ - Ralstonia sp. 2-methoxybenzyl alcohol + NADP+ - ? 187529 1.1.1.71 2-methoxybenzaldehyde + NADPH + H+ highest activity Solanum tuberosum 2-methoxybenzyl alcohol + NADP+ - ? 187529 1.1.1.71 2-methoxybenzaldehyde + NADPH + H+ - Ralstonia sp. DSM 6428 2-methoxybenzyl alcohol + NADP+ - ? 187529 1.1.1.71 2-hydroxy-2-methyl-1-phenylpropan-1-one + NADPH + H+ - Ralstonia sp. 2-methyl-1-phenylpropan-1,2-diol + NADP+ - ? 438731 1.1.1.71 2-methylbenzaldehyde + NADPH + H+ - Ralstonia sp. 2-methylbenzyl alcohol + NADP+ - ? 438734 1.1.1.71 2-pentanol + NADP+ 67% relative activity as compared to 2-propanol Thermococcus sibiricus 2-pentanone + NADPH + H+ - ? 422467 1.1.1.71 phenylacetaldehyde + NAD(P)H + H+ 18.6% activity compared to acetoin Thermococcus kodakarensis 2-phenylethan-1-ol + NAD(P)+ - ? 438422 1.1.1.71 3,4-dimethoxybenzaldehyde + NADPH + H+ - Solanum tuberosum 3,4-dimethoxybenzyl alcohol + NADP+ - ? 371797 1.1.1.71 3-fluorobenzaldehyde + NADPH - Ralstonia sp. 3-fluorobenzyl alcohol + NADP+ - r 425552 1.1.1.71 3-methoxybenzaldehyde + NADPH + H+ - Ralstonia sp. 3-methoxybenzyl alcohol + NADP+ - ? 438791 1.1.1.71 3-methylbenzaldehyde + NADPH + H+ - Ralstonia sp. 3-methylbenzyl alcohol + NADP+ - ? 438797 1.1.1.71 3-methylcyclohexanone + NADH + H+ - Ralstonia sp. 3-methylcyclohexanol + NAD+ - r 419997 1.1.1.71 4-bromobenzaldehyde + NADPH + H+ - Ralstonia sp. 4-bromobenzyl alcohol + NADP+ - ? 438827 1.1.1.71 4-fluorobenzaldehyde + NADPH + H+ - Ralstonia sp. 4-fluorobenzyl alcohol + NADP+ - ? 438839 1.1.1.71 4-methoxybenzaldehyde + NADPH + H+ - Ralstonia sp. 4-methoxybenzyl alcohol + NADP+ - ? 257303 1.1.1.71 4-methoxybenzaldehyde + NADPH + H+ - Solanum tuberosum 4-methoxybenzyl alcohol + NADP+ - ? 257303 1.1.1.71 4-methoxybenzaldehyde + NADPH + H+ - Ralstonia sp. DSM 6428 4-methoxybenzyl alcohol + NADP+ - ? 257303 1.1.1.71 4-methylbenzaldehyde + NADPH + H+ - Ralstonia sp. 4-methylbenzyl alcohol + NADP+ - ? 438848 1.1.1.71 4-methylpentan-2-one + NADPH + H+ - Ralstonia sp. 4-methylpentan-2-ol + NADP+ - ? 438850 1.1.1.71 4-phenyl-2-butanone + NADH + H+ - Ralstonia sp. 4-phenyl-2-butanol + NAD+ - r 438864 1.1.1.71 (R)-2-hydroxypropiophenone + NADPH + H+ - Ralstonia sp. ? - r 438556 1.1.1.71 (S)-2-hydroxypropiophenone + NADPH + H+ - Ralstonia sp. ? - r 438590 1.1.1.71 1-phenyl-1,2-ethanediol + NAD(P)+ 3.4% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis ? - ? 438061 1.1.1.71 2,5-hexandione + NADH + H+ - Ralstonia sp. ? - r 438704 1.1.1.71 3-methylcyclohexanol + NADP+ - Ralstonia sp. ? - r 438798 1.1.1.71 4-androstene-3,17-dione + NADPH + H+ - Homo sapiens ? - ? 425619 1.1.1.71 4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+ - Homo sapiens ? - ? 438849 1.1.1.71 4-nitroacetophenone + NADPH + H+ - Homo sapiens ? - ? 438856 1.1.1.71 acetohexamide + NADPH + H+ - Homo sapiens ? - ? 384102 1.1.1.71 acetoin + NADPH + H+ 1.9% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae ? - ? 439012 1.1.1.71 D-arabinose + NAD(P)+ 21.4% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis ? - ? 438301 1.1.1.71 dihydroxyacetone + NAD(P)H + H+ 34.8% activity compared to acetoin Thermococcus kodakarensis ? - ? 438320 1.1.1.71 DL-glyceraldehyde + NADPH + H+ - Homo sapiens ? - ? 426340 1.1.1.71 estrone + NADPH + H+ - Homo sapiens ? - ? 439513 1.1.1.71 ethyl pyruvate + NAD(P)H + H+ 294% activity compared to acetoin Thermococcus kodakarensis ? - ? 438334 1.1.1.71 glycoaldehyde + NADPH + H+ 5% activity compared to pentanal Pectobacterium atrosepticum ? - ? 439583 1.1.1.71 L-arabinose + NAD(P)+ 5.2% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis ? - ? 373545 1.1.1.71 meso-2,3-butanediol + NAD+ 272% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis ? - ? 438394 1.1.1.71 meso-2,3-butanediol + NADP+ 272% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis ? - ? 438395 1.1.1.71 methyl benzoylformate + NAD(P)H + H+ 67% activity compared to acetoin Thermococcus kodakarensis ? - ? 438397 1.1.1.71 methylglyoxal + NADPH + H+ 29% activity compared to pentanal Pectobacterium atrosepticum ? - ? 405858 1.1.1.71 additional information the enzyme plays an important role in potato defence response to Erwinia carotovora Solanum tuberosum ? - ? 89 1.1.1.71 additional information not: conferyl aldehyde and sinapaldehyde, the enzyme exhibits an absolute requirement for NADPH as cofactor and can not be substituted by NADH Solanum tuberosum ? - ? 89 1.1.1.71 additional information the enzyme does not accept methanol, 2-propanol, glycerol or glucose as substrates Haloarcula marismortui ? - ? 89 1.1.1.71 additional information HvADH2 accepts a broad range of substrates, no activity with methanol Haloferax volcanii ? - ? 89 1.1.1.71 additional information no oxidation of methanol, methoxyethanol, ethylene glycol, or D-galactose. No reduction of acetone, cyclopentanone, D-arabinose, D-xylose, D-glucose or cellobiose Thermococcus sibiricus ? - ? 89 1.1.1.71 additional information preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol Halobacterium salinarum ? - ? 89 1.1.1.71 additional information no substrates: methanol, glycerol Halobacterium sp. ? - ? 89 1.1.1.71 additional information in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. In high-ethanol-producing (ethanologen) strains of Thermoanaerobacterium saccharolyticum, both ALDH and ADH activities show increased NADPH-linked activity Thermoanaerobacterium saccharolyticum ? - ? 89 1.1.1.71 additional information in wild-type strains, NADH is the preferred cofactor for both aldehyde dehydrogenase ALDH and alcohol dehydrogenase ADH activities. The AdhE protein of the ethanologenic strain of Clostridium thermocellum has acquired high NADPH-linked ADH activity while maintaining NADH-linked ALDH and ADH activities at wild-type levels Acetivibrio thermocellus ? - ? 89 1.1.1.71 additional information no activity with D-arabinose, L-arabinose, acetophenone, and 4-chloroacetophenone Thermococcus kodakarensis ? - ? 89 1.1.1.71 additional information 4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates Homo sapiens ? - ? 89 1.1.1.71 additional information no activity with dihydroxyacetone, hydroxyacetone, and acetone Klebsiella pneumoniae ? - ? 89 1.1.1.71 additional information no activity with glyoxal, methanal, and ethanal Pectobacterium atrosepticum ? - ? 89 1.1.1.71 additional information no activity with methanol and ethanol Ralstonia sp. ? - ? 89 1.1.1.71 additional information the enzyme shows no oxidative activities towards alcoholic compounds Pectobacterium atrosepticum ? - ? 89 1.1.1.71 additional information lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA Starmerella magnoliae ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii ? - - 89 1.1.1.71 additional information lactol substrates (4R,6S)-6-(chloromethyl)oxane-2,4-diol and (4R,6R)-6-butyloxane-2,4-diol for the biocatalytic oxidations are obtained from 2-deoxy-D-ribose 5-phosphate aldolase (DERA) catalyzed reactions of the corresponding acceptor aldehydes chloroacetaldehyde and pentanal, respectively and at least two equivalents of acetaldehyde as described previously. Development of an efficient biocatalytic process on pilot plant scale to oxidize the aliphatic hydroxylactol substrate (4R,6R)-6-butyloxane-2,4-diol to the corresponding lactone product (4R,6R)-6-butyl-4-hydroxyoxan-2-one employing the wild-type alcohol dehydrogenase ADHA Starmerella magnoliae DSMZ 70638 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii DSM 12428 ? - - 89 1.1.1.71 additional information preference for short-chain alcohol substrates, particularly for 1-propanol (100%) and ethanol (84%), no activity with glycerol or methanol Halobacterium salinarum NRC 1 ? - ? 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii NBRC 100139 ? - - 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii JCM 9974 ? - - 89 1.1.1.71 additional information no activity with methanol and ethanol Ralstonia sp. DSM 6428 ? - ? 89 1.1.1.71 additional information no activity with dihydroxyacetone, hydroxyacetone, and acetone Klebsiella pneumoniae DSM2026 ? - ? 89 1.1.1.71 additional information no activity with glyoxal, methanal, and ethanal Pectobacterium atrosepticum DSM18077 ? - ? 89 1.1.1.71 additional information the enzyme shows no oxidative activities towards alcoholic compounds Pectobacterium atrosepticum DSM18077 ? - ? 89 1.1.1.71 additional information no substrates: methanol, glycerol Halobacterium sp. NRC-1 ? - ? 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii ATCC 700860 ? - - 89 1.1.1.71 additional information HvADH2 accepts a broad range of substrates, no activity with methanol Haloferax volcanii DSM 3757 ? - ? 89 1.1.1.71 additional information substrate specificity of Ni-PhADH for alcohol oxidation reactions and aldehyde reduction reactions, overview. No activity with 2-butanol, tert-butanol, and 2,3-butanediol Pyrococcus horikoshii OT-3 ? - - 89 1.1.1.71 additional information no activity with glyoxal, methanal, and ethanal Pectobacterium atrosepticum DSM 18077 ? - ? 89 1.1.1.71 additional information the enzyme shows no oxidative activities towards alcoholic compounds Pectobacterium atrosepticum DSM 18077 ? - ? 89 1.1.1.71 pyruvic aldehyde + NAD(P)H + H+ 328% activity compared to acetoin Thermococcus kodakarensis ? - ? 438436 1.1.1.71 1,2-propanediol + NAD+ - Pyrococcus horikoshii ? + NADH + H+ - r 422248 1.1.1.71 1,3-propanediol + NAD+ - Pyrococcus horikoshii ? + NADH + H+ - r 458819 1.1.1.71 1,4-butanediol + NAD+ - Pyrococcus horikoshii ? + NADH + H+ - r 440481 1.1.1.71 2,3-pentanedione + NADPH + H+ - Thermococcus sibiricus ? + NADP+ - ? 187573 1.1.1.71 2,3-pentanedione + NADPH + H+ - Thermococcus sibiricus DSM 12597 ? + NADP+ - ? 187573 1.1.1.71 3-methyl-2-pentanone + NADPH + H+ 13% relative activity as compared to pyruvaldehyde Thermococcus sibiricus ? + NADP+ - ? 427985 1.1.1.71 dimethylglyoxal + NADPH + H+ 270% relative activity as compared to pyruvaldehyde Thermococcus sibiricus ? + NADP+ - ? 428592 1.1.1.71 dimethylglyoxal + NADPH + H+ 270% of the activity with pyruvaldehyde Thermococcus sibiricus ? + NADP+ - ? 428592 1.1.1.71 ethyl acetoacetate + NADPH + H+ - Starmerella magnoliae ? + NADP+ - r 459651 1.1.1.71 glyoxylic acid + NADPH + H+ 36% relative activity as compared to pyruvaldehyde Thermococcus sibiricus ? + NADP+ - ? 428660 1.1.1.71 pyruvaldehyde + NADPH + H+ - Thermococcus sibiricus ? + NADP+ - ? 428901 1.1.1.71 (2S,5S)-2,5-hexanediol + NADP+ - Thermococcus sibiricus ? + NADPH + H+ - ? 427760 1.1.1.71 (2S,5S)-2,5-hexanediol + NADP+ - Thermococcus sibiricus DSM 12597 ? + NADPH + H+ - ? 427760 1.1.1.71 1,3-butanediol + NADP+ 91% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 427812 1.1.1.71 3-methylbutanal + NADP+ about% of the activity with 1-butanol Haloferax volcanii ? + NADPH + H+ - ? 427988 1.1.1.71 cellobiose + NADP+ 71% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428479 1.1.1.71 cellobiose + NADP+ 71% of the activity with 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428479 1.1.1.71 D-arabinose + NADP+ 200% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428516 1.1.1.71 D-glucose + NADP+ 146% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 405285 1.1.1.71 D-glucose + NADP+ 146% of the activity with 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 405285 1.1.1.71 D-mannose + NADP+ 48% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428531 1.1.1.71 D-ribose + NADP+ 35% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428534 1.1.1.71 D-xylose + NADP+ 246% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428545 1.1.1.71 D-xylose + NADP+ 246% of the activity with 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428545 1.1.1.71 isoamyl alcohol + NADP+ about 80% of the activity with 1-butanol Haloferax volcanii ? + NADPH + H+ - ? 428710 1.1.1.71 L-arabinose + NADP+ 17% relative activity as compared to 2-propanol Thermococcus sibiricus ? + NADPH + H+ - ? 428721 1.1.1.71 ethanol + NAD(P)+ 0.5% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis acetaldehyde + NAD(P)H + H+ - ? 438333 1.1.1.71 ethanol + NAD+ - Pyrococcus horikoshii acetaldehyde + NADH + H+ - r 384669 1.1.1.71 ethanol + NAD+ enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+ Haloarcula marismortui acetaldehyde + NADH + H+ - ? 384669 1.1.1.71 ethanol + NADP+ - Saccharomyces cerevisiae acetaldehyde + NADPH + H+ - r 187591 1.1.1.71 ethanol + NADP+ enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+ Haloarcula marismortui acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ 36% relative activity as compared to 2-propanol Thermococcus sibiricus acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ 85% compared to activity with 1-propanol Halobacterium salinarum acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ about 50% of the activity with 1-butanol Haloferax volcanii acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ 84% of the activtiy with 1-propanol Halobacterium sp. acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ 85% compared to activity with 1-propanol Halobacterium salinarum NRC 1 acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ - Saccharomyces cerevisiae D273-10B acetaldehyde + NADPH + H+ - r 187591 1.1.1.71 ethanol + NADP+ 84% of the activtiy with 1-propanol Halobacterium sp. NRC-1 acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 ethanol + NADP+ about 50% of the activity with 1-butanol Haloferax volcanii DSM 3757 acetaldehyde + NADPH + H+ - ? 187591 1.1.1.71 2-propanol + NADP+ - Thermococcus sibiricus acetone + NADPH - ? 371771 1.1.1.71 2-propanol + NADP+ - Thermococcus sibiricus DSM 12597 acetone + NADPH - ? 371771 1.1.1.71 2-propanol + NADP+ - Thermococcus sibiricus acetone + NADPH + H+ - ? 383788 1.1.1.71 2-propanol + NADP+ 25% compared to activity with 1-propanol Halobacterium salinarum acetone + NADPH + H+ - ? 383788 1.1.1.71 2-propanol + NADP+ 25% compared to activity with 1-propanol Halobacterium salinarum NRC 1 acetone + NADPH + H+ - ? 383788 1.1.1.71 2-propanol + NADP+ - Thermococcus sibiricus DSM 12597 acetone + NADPH + H+ - ? 383788 1.1.1.71 rac-1-phenylethanol + NAD(P)+ - Rhodococcus ruber acetophenone + (R)-1-phenylethanol + NAD(P)H + H+ - ? 439867 1.1.1.71 1-phenylethanol + NADP+ 35% compared to activity with 1-propanol Halobacterium salinarum acetophenone + NADPH + H+ - ? 427836 1.1.1.71 allyl alcohol + NADP+ - Leuconostoc mesenteroides acrylaldehyde + NADPH - r 188561 1.1.1.71 allyl alcohol + NADP+ 28% of activity with hexan-1-ol Acinetobacter calcoaceticus acrylaldehyde + NADPH - r 188561 1.1.1.71 allyl alcohol + NADP+ - Leuconostoc mesenteroides IFO 3426 acrylaldehyde + NADPH - r 188561 1.1.1.71 all-trans-retinol + NADP+ - Homo sapiens all-trans-retinal + NADPH + H+ - r 370852 1.1.1.71 all-trans-retinal + NADPH + H+ - Homo sapiens all-trans-retinol + NADP+ - ? 187638 1.1.1.71 benzylalcohol + NAD+ - Pyrococcus horikoshii benzaldehyde + NADH + H+ - r 384275 1.1.1.71 benzyl alcohol + NADP+ - Acinetobacter calcoaceticus benzaldehyde + NADPH - r 187589 1.1.1.71 benzyl alcohol + NADP+ - Ralstonia sp. benzaldehyde + NADPH - r 187589 1.1.1.71 benzyl alcohol + NADP+ - Ralstonia sp. DSM 6428 benzaldehyde + NADPH - r 187589 1.1.1.71 1-phenylmethanol + NADP+ 180% relative activity as compared to 2-propanol Thermococcus sibiricus benzaldehyde + NADPH + H+ - ? 427837 1.1.1.71 benzyl alcohol + NADP+ 20% compared to activity with 1-propanol Halobacterium salinarum benzaldehyde + NADPH + H+ - ? 404469 1.1.1.71 benzyl alcohol + NADP+ about% of the activity with 1-butanol Haloferax volcanii benzaldehyde + NADPH + H+ - ? 404469 1.1.1.71 benzyl alcohol + NADP+ 180% of the activity with 2-propanol Thermococcus sibiricus benzaldehyde + NADPH + H+ - ? 404469 1.1.1.71 benzyl alcohol + NADP+ about% of the activity with 1-butanol Haloferax volcanii DSM 3757 benzaldehyde + NADPH + H+ - ? 404469 1.1.1.71 benzaldehyde + NAD(P)H - Rattus norvegicus benzyl alcohol + NAD(P)+ - ? 165076 1.1.1.71 benzaldehyde + NADPH - Ralstonia sp. benzyl alcohol + NADP+ - r 187480 1.1.1.71 benzaldehyde + NADPH - Ralstonia sp. DSM 6428 benzyl alcohol + NADP+ - r 187480 1.1.1.71 benzaldehyde + NADPH + H+ - Solanum tuberosum benzyl alcohol + NADP+ - ? 372517 1.1.1.71 butanal + NAD(P)H + H+ - Rattus norvegicus butan-1-ol + NAD(P)+ - ? 188581 1.1.1.71 butanal + NADPH + H+ - Saccharomyces cerevisiae butan-1-ol + NADP+ - r 435366 1.1.1.71 butanal + NADPH + H+ - Clostridium beijerinckii butan-1-ol + NADP+ - r 435366 1.1.1.71 butanal + NADPH + H+ - Saccharomyces cerevisiae D273-10B butan-1-ol + NADP+ - r 435366 1.1.1.71 acetoin + NAD(P)+ 100% activity Thermococcus kodakarensis butan-2,3-dione + NAD(P)H + H+ - ? 438129 1.1.1.71 butan-2-one + NADPH + H+ - Ralstonia sp. butan-2-ol + NADP+ - ? 439274 1.1.1.71 2-butanol + NAD(P)+ 22.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis butan-2-one + NAD(P)H + H+ - ? 438080 1.1.1.71 butan-2-ol + NADP+ - Ralstonia sp. butan-2-one + NADPH + H+ - ? 439272 1.1.1.71 1-butanol + NAD(P)+ 2.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis butanal + NAD(P)H + H+ - ? 438055 1.1.1.71 1-butanol + NAD+ - Pyrococcus horikoshii butanal + NADH + H+ - r 383560 1.1.1.71 1-butanol + NAD+ - Pyrococcus horikoshii DSM 12428 butanal + NADH + H+ - r 383560 1.1.1.71 1-butanol + NAD+ - Pyrococcus horikoshii NBRC 100139 butanal + NADH + H+ - r 383560 1.1.1.71 1-butanol + NAD+ - Pyrococcus horikoshii JCM 9974 butanal + NADH + H+ - r 383560 1.1.1.71 1-butanol + NAD+ - Pyrococcus horikoshii ATCC 700860 butanal + NADH + H+ - r 383560 1.1.1.71 1-butanol + NAD+ - Pyrococcus horikoshii OT-3 butanal + NADH + H+ - r 383560 1.1.1.71 1-butanol + NADP+ 80% relative activity as compared to 2-propanol Thermococcus sibiricus butanal + NADPH - ? 371483 1.1.1.71 butan-1-ol + NADP+ - Leuconostoc mesenteroides butanal + NADPH - r 188562 1.1.1.71 butan-1-ol + NADP+ 36.3% of activity with hexan-1-ol Acinetobacter calcoaceticus butanal + NADPH - r 188562 1.1.1.71 butan-1-ol + NADP+ - Leuconostoc mesenteroides IFO 3426 butanal + NADPH - r 188562 1.1.1.71 1-butanol + NADP+ - Pyrococcus horikoshii butanal + NADPH + H+ - r 395234 1.1.1.71 1-butanol + NADP+ 117% of the activity compared to ethanol Haloarcula marismortui butanal + NADPH + H+ - ? 395234 1.1.1.71 1-butanol + NADP+ 80% compared to activity with 1-propanol Halobacterium salinarum butanal + NADPH + H+ - ? 395234 1.1.1.71 1-butanol + NADP+ 80% of the activtiy with 1-propanol Halobacterium sp. butanal + NADPH + H+ - ? 395234 1.1.1.71 1-butanol + NADP+ 80% compared to activity with 1-propanol Halobacterium salinarum NRC 1 butanal + NADPH + H+ - ? 395234 1.1.1.71 1-butanol + NADP+ 80% of the activtiy with 1-propanol Halobacterium sp. NRC-1 butanal + NADPH + H+ - ? 395234 1.1.1.71 butan-1-ol + NADP+ - Saccharomyces cerevisiae butanal + NADPH + H+ - r 435361 1.1.1.71 butan-1-ol + NADP+ - Saccharomyces cerevisiae D273-10B butanal + NADPH + H+ - r 435361 1.1.1.71 butan-1,4-diol + NADP+ 29% of activity with hexan-1-ol Acinetobacter calcoaceticus butandialdehyde + NADPH - r 188563 1.1.1.71 butyraldehyde + NADPH + H+ 118.4% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae butanol + NADP+ - ? 384385 1.1.1.71 butyraldehyde + NADPH + H+ 118.4% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM2026 butanol + NADP+ - ? 384385 1.1.1.71 (S)-2-butanol + NADP+ 196% relative activity as compared to 2-propanol Thermococcus sibiricus butanone + NADPH - ? 427803 1.1.1.71 (S)-2-butanol + NADP+ 196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol Thermococcus sibiricus butanone + NADPH + H+ - ? 434959 1.1.1.71 2-butanol + NADP+ 30% compared to activity with 1-propanol Halobacterium salinarum butanone + NADPH + H+ - ? 427897 1.1.1.71 2-butanol + NADP+ about 25% of the activity with 1-butanol Haloferax volcanii butanone + NADPH + H+ - ? 427897 1.1.1.71 2-butanol + NADP+ 30% of the activtiy with 1-propanol Halobacterium sp. butanone + NADPH + H+ - ? 427897 1.1.1.71 cinnamaldehyde + NADPH + H+ - Solanum tuberosum cinnamyl alcohol + NADP+ - ? 372712 1.1.1.71 cis-4-heptenal + NAD(P)+ - Leuconostoc mesenteroides cis-4-heptenol + NAD(P)H - ? 188579 1.1.1.71 cis-hex-3-en-1-ol + NADP+ 18.7% of activity with hexan-1ol Acinetobacter calcoaceticus cis-hex-3-en-1-al + NADPH - r 188567 1.1.1.71 citral + NAD(P)H - Rattus norvegicus citrol + NAD(P)+ - ? 188588 1.1.1.71 cyclohexanone + NAD(P)H + H+ 19.1% activity compared to acetoin Thermococcus kodakarensis cyclohexanol + NAD(P)+ - ? 438297 1.1.1.71 cyclohexanone + NADH + H+ - Ralstonia sp. cyclohexanol + NAD+ - r 372796 1.1.1.71 cyclohexanone + NADH + H+ - Ralstonia sp. cyclohexanol + NADP+ - r 439369 1.1.1.71 cyclohexanol + NAD(P)+ 52.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis cyclohexanone + NAD(P)H + H+ - ? 438296 1.1.1.71 cyclohexanol + NAD+ - Pyrococcus horikoshii cyclohexanone + NADH + H+ - r 384491 1.1.1.71 cyclohexanol + NADP+ - Ralstonia sp. cyclohexanone + NADH + H+ - r 439367 1.1.1.71 D-arabinose + NADP+ 200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose Thermococcus sibiricus D-arabitol + NADPH + H+ - ? 435425 1.1.1.71 mannitol + NADP+ 6.5% of activity with hexan-1-ol Acinetobacter calcoaceticus D-mannose + NADPH - r 188566 1.1.1.71 ribitol + NADP+ 4% of activity with hexan-1-ol Acinetobacter calcoaceticus D-ribose + NADPH - r 188565 1.1.1.71 decanal + NAD(P)H - Rattus norvegicus decan-1-ol + NAD(P)+ - ? 188584 1.1.1.71 decan-1-ol + NADP+ decrease in enzyme activity with increase in chain length Acinetobacter calcoaceticus decanal + NADPH - r 188569 1.1.1.71 dodecanal + NAD(P)H - Rattus norvegicus dodecan-1-ol + NAD(P)+ - ? 188585 1.1.1.71 dodecan-1-ol + NADP+ decrease in enzyme activity with increase in chain length Acinetobacter calcoaceticus dodecanal + NADPH - r 188570 1.1.1.71 ethanol + NADP+ - Leuconostoc mesenteroides ethanal + NADPH + H+ - r 188558 1.1.1.71 ethanol + NADP+ oxidation rate at 5% of reduction rate Moniezia expansa ethanal + NADPH + H+ - r 188558 1.1.1.71 ethanol + NADP+ 8.5% of activity with hexan-1-ol Acinetobacter calcoaceticus ethanal + NADPH + H+ - r 188558 1.1.1.71 ethanol + NADP+ - Leuconostoc mesenteroides IFO 3426 ethanal + NADPH + H+ - r 188558 1.1.1.71 ethanal + NAD(P)H - Rattus norvegicus ethanol + NAD(P)+ - ? 188557 1.1.1.71 acetaldehyde + NADH + H+ - Cucumis melo ethanol + NAD+ - r 139564 1.1.1.71 acetaldehyde + NADH + H+ - Acetivibrio thermocellus ethanol + NAD+ - ? 139564 1.1.1.71 acetaldehyde + NADH + H+ - Thermoanaerobacterium saccharolyticum ethanol + NAD+ - ? 139564 1.1.1.71 acetaldehyde + NADPH - Ralstonia sp. ethanol + NADP+ - r 439002 1.1.1.71 acetaldehyde + NADPH + H+ - Cucumis melo ethanol + NADP+ - r 139551 1.1.1.71 acetaldehyde + NADPH + H+ - Haloarcula marismortui ethanol + NADP+ - ? 139551 1.1.1.71 acetaldehyde + NADPH + H+ - Halobacterium sp. ethanol + NADP+ - ? 139551 1.1.1.71 acetaldehyde + NADPH + H+ - Acetivibrio thermocellus ethanol + NADP+ - ? 139551 1.1.1.71 acetaldehyde + NADPH + H+ - Thermoanaerobacterium saccharolyticum ethanol + NADP+ - ? 139551 1.1.1.71 acetaldehyde + NADPH + H+ 2.2% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae ethanol + NADP+ - ? 139551 1.1.1.71 acetaldehyde + NADPH + H+ 2.2% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM2026 ethanol + NADP+ - ? 139551 1.1.1.71 acetaldehyde + NADPH + H+ - Halobacterium sp. NRC-1 ethanol + NADP+ - ? 139551 1.1.1.71 farnesyl aldehyde + NAD(P)H - Rattus norvegicus farnesol + NAD(P)+ - ? 188590 1.1.1.71 methanol + NAD(P)+ 0.2% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis formaldehyde + NAD(P)H + H+ - ? 438396 1.1.1.71 methanol + NAD+ - Pyrococcus horikoshii formaldehyde + NADH + H+ - r 186834 1.1.1.71 methanol + NAD+ - Pyrococcus horikoshii DSM 12428 formaldehyde + NADH + H+ - r 186834 1.1.1.71 methanol + NAD+ - Pyrococcus horikoshii NBRC 100139 formaldehyde + NADH + H+ - r 186834 1.1.1.71 methanol + NAD+ - Pyrococcus horikoshii JCM 9974 formaldehyde + NADH + H+ - r 186834 1.1.1.71 methanol + NAD+ - Pyrococcus horikoshii ATCC 700860 formaldehyde + NADH + H+ - r 186834 1.1.1.71 methanol + NAD+ - Pyrococcus horikoshii OT-3 formaldehyde + NADH + H+ - r 186834 1.1.1.71 glycerol + NADP+ 16% relative activity as compared to 2-propanol Thermococcus sibiricus glyceraldehyde + NADPH + H+ - ? 414663 1.1.1.71 ethanediol + NADP+ - Moniezia expansa glyoxal + NADPH - ? 188559 1.1.1.71 ethanediol + NADP+ 8.5% of activity with hexan-1-ol Acinetobacter calcoaceticus glyoxal + NADPH - r 188559 1.1.1.71 heptanal + NAD(P)H - Rattus norvegicus heptan-1-ol + NAD(P)+ - ? 188582 1.1.1.71 2-heptanol + NAD(P)+ 61.6% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis heptan-2-one + NAD(P)H + H+ - ? 438083 1.1.1.71 heptan-4-one + NADPH + H+ - Ralstonia sp. heptan-4-ol + NADP+ - ? 439601 1.1.1.71 1-heptanol + NAD(P)+ 3.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis heptanal + NAD(P)H + H+ - ? 438057 1.1.1.71 1-heptanol + NAD+ - Pyrococcus horikoshii heptanal + NADH + H+ - r 383568 1.1.1.71 1-heptanol + NAD+ - Pyrococcus horikoshii DSM 12428 heptanal + NADH + H+ - r 383568 1.1.1.71 1-heptanol + NAD+ - Pyrococcus horikoshii NBRC 100139 heptanal + NADH + H+ - r 383568 1.1.1.71 1-heptanol + NAD+ - Pyrococcus horikoshii JCM 9974 heptanal + NADH + H+ - r 383568 1.1.1.71 1-heptanol + NAD+ - Pyrococcus horikoshii ATCC 700860 heptanal + NADH + H+ - r 383568 1.1.1.71 1-heptanol + NAD+ - Pyrococcus horikoshii OT-3 heptanal + NADH + H+ - r 383568 1.1.1.71 heptan-1-ol + NADP+ - Acinetobacter calcoaceticus heptanal + NADPH - r 188572 1.1.1.71 hexan-1-ol + NADP+ - Ralstonia sp. hexaldehyde + NADPH + H+ - ? 439603 1.1.1.71 hexanal + NAD(P)H + H+ 12.9% activity compared to acetoin Thermococcus kodakarensis hexan-1-ol + NAD(P)+ - ? 438358 1.1.1.71 hexanal + NADPH + H+ - Ralstonia sp. hexan-1-ol + NADP+ - ? 437607 1.1.1.71 2-hexanone + NAD(P)H + H+ 3.6% activity compared to acetoin Thermococcus kodakarensis hexan-2-ol + NAD(P)+ - ? 438085 1.1.1.71 hexan-2-one + NADPH + H+ - Ralstonia sp. hexan-2-ol + NADP+ - ? 439604 1.1.1.71 2-hexanol + NAD(P)+ 38.7% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis hexan-2-one + NAD(P)H + H+ - ? 438084 1.1.1.71 1-hexanol + NAD(P)+ 2.8% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis hexanal + NAD(P)H + H+ - ? 438058 1.1.1.71 1-hexanol + NAD+ - Pyrococcus horikoshii hexanal + NADH + H+ - r 383570 1.1.1.71 1-hexanol + NAD+ - Pyrococcus horikoshii DSM 12428 hexanal + NADH + H+ - r 383570 1.1.1.71 1-hexanol + NAD+ - Pyrococcus horikoshii NBRC 100139 hexanal + NADH + H+ - r 383570 1.1.1.71 1-hexanol + NAD+ - Pyrococcus horikoshii JCM 9974 hexanal + NADH + H+ - r 383570 1.1.1.71 1-hexanol + NAD+ - Pyrococcus horikoshii ATCC 700860 hexanal + NADH + H+ - r 383570 1.1.1.71 1-hexanol + NAD+ - Pyrococcus horikoshii OT-3 hexanal + NADH + H+ - r 383570 1.1.1.71 hexan-1-ol + NADP+ - Bacillus subtilis hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Escherichia coli hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Saccharomyces cerevisiae hexanal + NADPH - r 188556 1.1.1.71 hexan-1-ol + NADP+ - Rhodococcus rhodochrous hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Pseudomonas aeruginosa hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Pseudomonas putida hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Acinetobacter calcoaceticus hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Acinetobacter calcoaceticus hexanal + NADPH - r 188556 1.1.1.71 hexan-1-ol + NADP+ - Mycobacterium tuberculosis hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Rhodotorula graminis hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Streptomyces rimosus hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Moniezia expansa hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Streptomyces rimosus 4018 hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Rhodococcus rhodochrous NCIMB 13259 hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Pseudomonas putida NCIMB 9494 hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Rhodotorula graminis KGX 39 hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Saccharomyces cerevisiae D273-10B hexanal + NADPH - r 188556 1.1.1.71 hexan-1-ol + NADP+ - Bacillus subtilis NCIMB 3610 hexanal + NADPH - ? 188556 1.1.1.71 hexan-1-ol + NADP+ - Escherichia coli ML30 hexanal + NADPH - ? 188556 1.1.1.71 hexanal + NADPH + H+ - Solanum tuberosum hexanol + NADP+ - ? 165073 1.1.1.71 hydrocinnamaldehyde + NADPH + H+ - Solanum tuberosum hydrocinnamyl alcohol + NADP+ - ? 373439 1.1.1.71 pyruvaldehyde + NADPH + H+ - Thermococcus sibiricus lactaldehyde + NADP+ - ? 423978 1.1.1.71 pyruvaldehyde + NADPH + H+ - Thermococcus sibiricus DSM 12597 lactaldehyde + NADP+ - ? 423978 1.1.1.71 linolenyl aldehyde + NAD(P)H - Rattus norvegicus linolenol + NAD(P)+ - ? 188589 1.1.1.71 linoleyl aldehyde + NAD(P)H - Rattus norvegicus linoleol + NAD(P)+ - ? 188591 1.1.1.71 formaldehyde + NADPH + H+ - Ralstonia sp. methanol + NADP+ - ? 437552 1.1.1.71 octan-1-ol + NADP+ - Ralstonia sp. octaldehyde + NADPH + H+ - ? 439797 1.1.1.71 octanal + NAD(P)H + H+ - Rattus norvegicus octan-1-ol + NAD(P)+ - ? 188583 1.1.1.71 octan-2-one + NADPH + H+ - Ralstonia sp. octan-2-ol + NADP+ - ? 439799 1.1.1.71 2-octanol + NAD(P)+ 45.8% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis octan-2-one + NAD(P)H + H+ - ? 438091 1.1.1.71 1-octanol + NAD(P)+ 2.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis octanal + NAD(P)H + H+ - ? 438059 1.1.1.71 1-octanol + NAD+ - Pyrococcus horikoshii octanal + NADH + H+ - r 383576 1.1.1.71 octan-1-ol + NADP+ decrease in enzyme activity with increase in chain length Acinetobacter calcoaceticus octanal + NADPH - r 188568 1.1.1.71 octan-1-ol + NADP+ - Saccharomyces cerevisiae octanal + NADPH + H+ - r 435672 1.1.1.71 octanal + NADPH + H+ - Solanum tuberosum octanol + NADP+ - ? 374084 1.1.1.71 oleyl aldehyde + NAD(P)H - Rattus norvegicus oleol + NAD(P)+ - ? 188592 1.1.1.71 pentan-1-ol + NADP+ - Ralstonia sp. pentaldehyde + NADPH + H+ - ? 439812 1.1.1.71 2-pentanol + NAD(P)+ 30.2% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis pentan-2-one + NAD(P)H + H+ - ? 438098 1.1.1.71 2-pentanol + NADP+ 67% of the activity with 2-propanol Thermococcus sibiricus pentan-2-one + NADPH + H+ - ? 435063 1.1.1.71 1-pentanol + NAD(P)+ 2.8% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis pentanal + NAD(P)H + H+ - ? 438060 1.1.1.71 1-pentanol + NAD+ - Pyrococcus horikoshii pentanal + NADH + H+ - r 383578 1.1.1.71 pentan-1-ol + NADP+ - Saccharomyces cerevisiae pentanal + NADPH - ? 188564 1.1.1.71 pentan-1-ol + NADP+ - Leuconostoc mesenteroides pentanal + NADPH - r 188564 1.1.1.71 pentan-1-ol + NADP+ 4% of activity with hexan-1-ol Acinetobacter calcoaceticus pentanal + NADPH - r 188564 1.1.1.71 pentan-1-ol + NADP+ - Saccharomyces cerevisiae D273-10B pentanal + NADPH - ? 188564 1.1.1.71 pentan-1-ol + NADP+ - Leuconostoc mesenteroides IFO 3426 pentanal + NADPH - r 188564 1.1.1.71 1-pentanol + NADP+ 74% of the activity compared to ethanol Haloarcula marismortui pentanal + NADPH + H+ - ? 403283 1.1.1.71 1-pentanol + NADP+ about 75% of the activity with 1-butanol Haloferax volcanii pentanal + NADPH + H+ - ? 403283 1.1.1.71 1-pentanol + NADP+ about 75% of the activity with 1-butanol Haloferax volcanii DSM 3757 pentanal + NADPH + H+ - ? 403283 1.1.1.71 2-phenylethanol + NAD(P)+ 0.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis phenylacetaldehyde + NAD(P)H + H+ - ? 438099 1.1.1.71 acrolein + NADPH + H+ 41.8% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae prop-2-en-1-ol + NADP+ - ? 439096 1.1.1.71 3-hydroxypropionaldehyde + NADPH + H+ 100% activity Klebsiella pneumoniae propan-1,3-diol + NADP+ - ? 438788 1.1.1.71 3-hydroxypropionaldehyde + NADPH + H+ 100% activity Klebsiella pneumoniae DSM2026 propan-1,3-diol + NADP+ - ? 438788 1.1.1.71 acetone + NAD(P)H + H+ 4.1% activity compared to acetoin Thermococcus kodakarensis propan-2-ol + NAD(P)+ - ? 438130 1.1.1.71 acetone + NADH + H+ - Ralstonia sp. propan-2-ol + NAD+ - r 396195 1.1.1.71 2-propanol + NAD(P)+ 5.3% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis propan-2-one + NAD(P)H + H+ - ? 438100 1.1.1.71 propan-2-ol + NADP+ - Ralstonia sp. propan-2-one + NADPH + H+ - ? 439840 1.1.1.71 1-propanol + NAD+ - Pyrococcus horikoshii propanal + NADH + H+ - r 383587 1.1.1.71 1-propanol + NAD+ dual cofactor dependency, NAD+ shows 60% of the activity with NADP+ Halobacterium salinarum propanal + NADH + H+ - ? 383587 1.1.1.71 1-propanol + NAD+ dual cofactor dependency, NAD+ shows 60% of the activity with NADP+ Halobacterium salinarum NRC 1 propanal + NADH + H+ - ? 383587 1.1.1.71 propan-1-ol + NADP+ oxidation rate at 5% of reduction rate Moniezia expansa propanal + NADPH - r 188560 1.1.1.71 propan-1-ol + NADP+ 28% of activity with hexan-1-ol Acinetobacter calcoaceticus propanal + NADPH - r 188560 1.1.1.71 1-propanol + NADP+ - Thermococcus sibiricus propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ - Halobacterium sp. propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ 137% of the activity compared to ethanol Haloarcula marismortui propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ about 60% of the activity with 1-butanol Haloferax volcanii propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ dual cofactor dependency, NAD+ shows 60% of the activity with NADP+ Halobacterium salinarum propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ - Halobacterium sp. NRC-1 propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ - Thermococcus sibiricus DSM 12597 propanal + NADPH + H+ - ? 403291 1.1.1.71 1-propanol + NADP+ about 60% of the activity with 1-butanol Haloferax volcanii DSM 3757 propanal + NADPH + H+ - ? 403291 1.1.1.71 propionaldehyde + NADPH + H+ 37.1% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae propanol + NADP+ - ? 406481 1.1.1.71 propionaldehyde + NADPH + H+ 37.1% activity compared to 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM2026 propanol + NADP+ - ? 406481 1.1.1.71 1-propanol + NAD(P)+ 1.2% activity compared to (RS)-1-phenylethanol Thermococcus kodakarensis propionaldehyde + NAD(P)H + H+ - ? 438064 1.1.1.71 propan-1-ol + NADP+ - Ralstonia sp. propionaldehyde + NADPH + H+ - ? 439838 1.1.1.71 retinal + NAD(P)H - Rattus norvegicus retinol + NAD(P)+ - ? 188554 1.1.1.71 retinaldehyde + NADH - Rattus norvegicus retinol + NAD+ - r 383355 1.1.1.71 retinaldehyde + NADH - Leuconostoc mesenteroides retinol + NAD+ - ? 383355 1.1.1.71 retinaldehyde + NADH - Cucumis melo retinol + NAD+ - ? 383355 1.1.1.71 retinaldehyde + NADH - Homo sapiens retinol + NAD+ - ? 383355 1.1.1.71 retinaldehyde + NADH the enzyme is involved in retinol and vitamin A metabolism, retinoic acid is important in intestinal epithelial cell proliferation and differentiation, the enzyme also plays a role in dietary conversion of beta-carotene to retinol via retinaldehyde Rattus norvegicus retinol + NAD+ - r 383355 1.1.1.71 salicylaldehye + NADPH + H+ - Solanum tuberosum salicylalcohol + NADP+ - ? 374623 1.1.1.71 tetradecanal + NAD(P)H - Rattus norvegicus tetradecan-1-ol + NAD(P)+ - ? 188586 1.1.1.71 trans-2,cis-6-nonadienal + NAD(P)+ - Leuconostoc mesenteroides trans-2,cis-6-nonadienol + NAD(P)H - ? 188580 1.1.1.71 trans-2,cis-6-nonadienal + NADPH + H+ - Solanum tuberosum trans-2,cis-6-nonadienol + NADP+ - ? 374729 1.1.1.71 cis-2-butenol + NAD(P)H - Leuconostoc mesenteroides trans-2-butenal + NAD(P)+ - ? 188577 1.1.1.71 cis-2-butenol + NAD(P)H - Leuconostoc mesenteroides IFO 3426 trans-2-butenal + NAD(P)+ - ? 188577 1.1.1.71 trans-2-hexenal + NADPH + H+ - Solanum tuberosum trans-2-hexenol + NADP+ - ? 374735 1.1.1.71 trans-2-nonenal + NADPH + H+ - Moniezia expansa trans-2-nonen-1-ol + NADP+ - ? 188573 1.1.1.71 trans-2-nonenal + NADPH + H+ - Solanum tuberosum trans-2-nonenol + NADP+ - ? 374738 1.1.1.71 trans-2-octenal + NADPH + H+ - Moniezia expansa trans-2-octen-1-ol + NADP+ - ? 188574 1.1.1.71 trans-2-pentenol + NAD(P)+ - Leuconostoc mesenteroides trans-2-pentenal + NAD(P)H - ? 188578 1.1.1.71 trans-trans-2,4-decadienal + NADPH + H+ - Moniezia expansa trans-trans-2,4-decadienol + NADP+ - ? 188575 1.1.1.71 vanillyl alcohol + NAD+ - Equus caballus vanillin + NADH + H+ - ? 439983